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Conserved domains on  [gi|770478874|ref|NP_001292486|]
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thioredoxin-like protein 4A isoform 3 [Homo sapiens]

Protein Classification

DIM1 family thioredoxin-like protein( domain architecture ID 10791280)

DIM1 family thioredoxin-like protein similar to human thioredoxin-like protein 4A (TXNL4A or DIM1) that plays a role in pre-mRNA splicing as a component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as a component of the precatalytic spliceosome

CATH:  3.40.30.10
Gene Ontology:  GO:0000398|GO:0005681|GO:0005682|GO:0046540
PubMed:  15558583|10049365
SCOP:  3000031

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00410 PLN00410
U5 snRNP protein, DIM1 family; Provisional
 1-134 8.33e-96

U5 snRNP protein, DIM1 family; Provisional


:

Pssm-ID: 215109  Cd Length: 142  Bit Score: 271.68  E-value: 8.33e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478874   1 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEV--------KNFAVIYLVDITEVPDFNKMYELYDPCT 72
Cdd:PLN00410   1 MSYLLPHLHSGWAVDQAILAEEERLVVIRFGHDWDETCMQMDEVlasvaetiKNFAVIYLVDITEVPDFNTMYELYDPCT 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 770478874  73 VMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 134
Cdd:PLN00410  81 VMFFFRNKHIMIDLGTGNNNKINWALKDKQEFIDIVETVYRGARKGRGLVISPKDYSTKYRY 142
 
Name Accession Description Interval E-value
PLN00410 PLN00410
U5 snRNP protein, DIM1 family; Provisional
 1-134 8.33e-96

U5 snRNP protein, DIM1 family; Provisional


Pssm-ID: 215109  Cd Length: 142  Bit Score: 271.68  E-value: 8.33e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478874   1 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEV--------KNFAVIYLVDITEVPDFNKMYELYDPCT 72
Cdd:PLN00410   1 MSYLLPHLHSGWAVDQAILAEEERLVVIRFGHDWDETCMQMDEVlasvaetiKNFAVIYLVDITEVPDFNTMYELYDPCT 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 770478874  73 VMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 134
Cdd:PLN00410  81 VMFFFRNKHIMIDLGTGNNNKINWALKDKQEFIDIVETVYRGARKGRGLVISPKDYSTKYRY 142
DIM1 pfam02966
Mitosis protein DIM1;
4-128 7.08e-84

Mitosis protein DIM1;


Pssm-ID: 460768  Cd Length: 133  Bit Score: 241.42  E-value: 7.08e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478874    4 MLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDE--------VKNFAVIYLVDITEVPDFNKMYELYDPCTVMF 75
Cdd:pfam02966   1 LLPHLRTGWHVDQAILSEEDKLVVIRFGRDEDPVCMQMDEilykiaekVSNFAVIYLVDIDEVPDFNKMYELYDPVTIMF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 770478874   76 FFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDY 128
Cdd:pfam02966  81 FYNNKHMMIDFGTGDNNKLNFSFEDKQELIDIIETIYRGAMKGKGLVVSPIDY 133
DIM1 cd02954
Dim1 family; Dim1 is also referred to as U5 small nuclear ribonucleoprotein particle (snRNP) ...
 10-115 7.02e-70

Dim1 family; Dim1 is also referred to as U5 small nuclear ribonucleoprotein particle (snRNP)-specific 15kD protein. It is a component of U5 snRNP, which pre-assembles with U4/U6 snRNPs to form a [U4/U6:U5] tri-snRNP complex required for pre-mRNA splicing. Dim1 interacts with multiple splicing-associated proteins, suggesting that it functions at multiple control points in the splicing of pre-mRNA as part of a large spliceosomal complex involving many protein-protein interactions. U5 snRNP contains seven core proteins (common to all snRNPs) and nine U5-specific proteins, one of which is Dim1. Dim1 adopts a thioredoxin fold but does not contain the redox active CXXC motif. It is essential for G2/M phase transition, as a consequence to its role in pre-mRNA splicing.


Pssm-ID: 239252  Cd Length: 114  Bit Score: 205.22  E-value: 7.02e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478874  10 NGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDE--------VKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKH 81
Cdd:cd02954    1 SGWAVDQAILSEEEKVVVIRFGRDWDPVCMQMDEvlakiaedVSNFAVIYLVDIDEVPDFNKMYELYDPPTVMFFFRNKH 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 770478874  82 IMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGA 115
Cdd:cd02954   81 MKIDLGTGNNNKINWVFEDKQEFIDIIETIYRGA 114
 
Name Accession Description Interval E-value
PLN00410 PLN00410
U5 snRNP protein, DIM1 family; Provisional
 1-134 8.33e-96

U5 snRNP protein, DIM1 family; Provisional


Pssm-ID: 215109  Cd Length: 142  Bit Score: 271.68  E-value: 8.33e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478874   1 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEV--------KNFAVIYLVDITEVPDFNKMYELYDPCT 72
Cdd:PLN00410   1 MSYLLPHLHSGWAVDQAILAEEERLVVIRFGHDWDETCMQMDEVlasvaetiKNFAVIYLVDITEVPDFNTMYELYDPCT 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 770478874  73 VMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 134
Cdd:PLN00410  81 VMFFFRNKHIMIDLGTGNNNKINWALKDKQEFIDIVETVYRGARKGRGLVISPKDYSTKYRY 142
DIM1 pfam02966
Mitosis protein DIM1;
4-128 7.08e-84

Mitosis protein DIM1;


Pssm-ID: 460768  Cd Length: 133  Bit Score: 241.42  E-value: 7.08e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478874    4 MLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDE--------VKNFAVIYLVDITEVPDFNKMYELYDPCTVMF 75
Cdd:pfam02966   1 LLPHLRTGWHVDQAILSEEDKLVVIRFGRDEDPVCMQMDEilykiaekVSNFAVIYLVDIDEVPDFNKMYELYDPVTIMF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 770478874   76 FFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDY 128
Cdd:pfam02966  81 FYNNKHMMIDFGTGDNNKLNFSFEDKQELIDIIETIYRGAMKGKGLVVSPIDY 133
DIM1 cd02954
Dim1 family; Dim1 is also referred to as U5 small nuclear ribonucleoprotein particle (snRNP) ...
 10-115 7.02e-70

Dim1 family; Dim1 is also referred to as U5 small nuclear ribonucleoprotein particle (snRNP)-specific 15kD protein. It is a component of U5 snRNP, which pre-assembles with U4/U6 snRNPs to form a [U4/U6:U5] tri-snRNP complex required for pre-mRNA splicing. Dim1 interacts with multiple splicing-associated proteins, suggesting that it functions at multiple control points in the splicing of pre-mRNA as part of a large spliceosomal complex involving many protein-protein interactions. U5 snRNP contains seven core proteins (common to all snRNPs) and nine U5-specific proteins, one of which is Dim1. Dim1 adopts a thioredoxin fold but does not contain the redox active CXXC motif. It is essential for G2/M phase transition, as a consequence to its role in pre-mRNA splicing.


Pssm-ID: 239252  Cd Length: 114  Bit Score: 205.22  E-value: 7.02e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478874  10 NGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDE--------VKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKH 81
Cdd:cd02954    1 SGWAVDQAILSEEEKVVVIRFGRDWDPVCMQMDEvlakiaedVSNFAVIYLVDIDEVPDFNKMYELYDPPTVMFFFRNKH 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 770478874  82 IMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGA 115
Cdd:cd02954   81 MKIDLGTGNNNKINWVFEDKQEFIDIIETIYRGA 114
DLP cd02986
Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% ...
 13-115 4.68e-25

Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to interact with the U5 small nuclear ribonucleoprotein particle (snRNP)-specific 102kD protein (or Prp6). Dim1 protein, also known as U5 snRNP-specific 15kD protein is a component of U5 snRNP, which pre-assembles with U4/U6 snRNPs to form a [U4/U6:U5] tri-snRNP complex required for pre-mRNA splicing. Dim1 adopts a thioredoxin fold but does not contain the redox active CXXC motif.


Pssm-ID: 239284  Cd Length: 114  Bit Score: 91.82  E-value: 4.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 770478874  13 QVDQAILSEEDRVVVIRFGHDWDPTCMKMDE--------VKNFAVIYLVDITEVPDFNKMYEL-YDPCTVmFFFRNKHIM 83
Cdd:cd02986    4 EVDQAIKSTAEKVLVLRFGRDEDAVCLQLDDilsktshdLSKMASIYLVDVDKVPVYTQYFDIsYIPSTI-FFFNGQHMK 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 770478874  84 IDLGTGNNNKINWAMEDKQEMVDIIETVYRGA 115
Cdd:cd02986   83 VDYGSPDHTKFVGSFKTKQDFIDLIEVIYRGA 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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