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Conserved domains on  [gi|666335651|ref|NP_001287962|]
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sodium/potassium/calcium exchanger 1 isoform 5 [Homo sapiens]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 1-1000 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 1450.19  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651     1 MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPS 80
Cdd:TIGR00927    1 MGKLIRMGTQERRLLRPKRLHWSRLLFLLGMLIIGSTYQHLRRPQGLPSLWAAVSSQQPIKLASRDLSNDEMMMVSSDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651    81 KPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTS-SRTLTYYTSTSS 159
Cdd:TIGR00927   81 KSSSEMEGEMLAPQATVGRDEATPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTPATpSRALNHYISTSG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   160 RQIVKKYTPTPRGEMKSYSPTQVREKV-KYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLK 238
Cdd:TIGR00927  161 RQRVKSYTPKPRGEVKSSSPTQTREKVrKYTPSPLGRMVNSYAPSTFMTMPRSHGITPRTTVKDSEITATYKMLETNPSK 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   239 RIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPAT 318
Cdd:TIGR00927  241 RTAGKTTPTPLKGMTDNTPTFLTREVETDLLTSPRSVVEKNTLTTPRRVESNSSTNHWGLVGKNNLTTPQGTVLEHTPAT 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   319 SEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVK 398
Cdd:TIGR00927  321 SEGQVTISIMTGSSPAETKASTAAWKIRNPLSRTSAPAVRIASATFRGLEKNPSTAPSTPATPRVRAVLTTQVHHCVVVK 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   399 PTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFV 478
Cdd:TIGR00927  401 PAPAVPTTPSPSLTTALFPEAPSPSPSALPPGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFV 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   479 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPL 558
Cdd:TIGR00927  481 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPL 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   559 FRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKlpslltrg 638
Cdd:TIGR00927  561 FRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSK-------- 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   639 ssstslhnstirstiyqlmlhsldplrevrlakekeeeslnqGARAQPQAKAESKPEEEEPAklpavTVTPAPVPDIKGD 718
Cdd:TIGR00927  633 ------------------------------------------GDVAEAEHTGERTGEEGERP-----TEAEGENGEESGG 665

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   719 QKENPGGQEDVAEAESTGEMPGEEG-ETAGEGETEEKSG--------------GETQPEG---EGETETQGKGEE----- 775
Cdd:TIGR00927  666 EAEQEGETETKGENESEGEIPAERKgEQEGEGEIEAKEAdhkgeteaeeveheGETEAEGtedEGEIETGEEGEEvedeg 745

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   776 ---CEDENEAEGKGDN--------------EGEDEGEIHA-EDGEMKGNEG----------------------------- 808
Cdd:TIGR00927  746 egeAEGKHEVETEGDRketehegeteaegkEDEDEGEIQAgEDGEMKGDEGaegkvehegeteagekdehegqsetqadd 825

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   809 -----ETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEeeeeekgNEEPLSLDW 883
Cdd:TIGR00927  826 tevkdETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEE-------NEEPLSLEW 898

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   884 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAG 963
Cdd:TIGR00927  899 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAG 978

                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 666335651   964 TSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGV 1000
Cdd:TIGR00927  979 TSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGL 1015
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 1-1000 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 1450.19  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651     1 MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPS 80
Cdd:TIGR00927    1 MGKLIRMGTQERRLLRPKRLHWSRLLFLLGMLIIGSTYQHLRRPQGLPSLWAAVSSQQPIKLASRDLSNDEMMMVSSDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651    81 KPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTS-SRTLTYYTSTSS 159
Cdd:TIGR00927   81 KSSSEMEGEMLAPQATVGRDEATPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTPATpSRALNHYISTSG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   160 RQIVKKYTPTPRGEMKSYSPTQVREKV-KYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLK 238
Cdd:TIGR00927  161 RQRVKSYTPKPRGEVKSSSPTQTREKVrKYTPSPLGRMVNSYAPSTFMTMPRSHGITPRTTVKDSEITATYKMLETNPSK 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   239 RIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPAT 318
Cdd:TIGR00927  241 RTAGKTTPTPLKGMTDNTPTFLTREVETDLLTSPRSVVEKNTLTTPRRVESNSSTNHWGLVGKNNLTTPQGTVLEHTPAT 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   319 SEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVK 398
Cdd:TIGR00927  321 SEGQVTISIMTGSSPAETKASTAAWKIRNPLSRTSAPAVRIASATFRGLEKNPSTAPSTPATPRVRAVLTTQVHHCVVVK 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   399 PTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFV 478
Cdd:TIGR00927  401 PAPAVPTTPSPSLTTALFPEAPSPSPSALPPGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFV 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   479 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPL 558
Cdd:TIGR00927  481 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPL 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   559 FRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKlpslltrg 638
Cdd:TIGR00927  561 FRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSK-------- 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   639 ssstslhnstirstiyqlmlhsldplrevrlakekeeeslnqGARAQPQAKAESKPEEEEPAklpavTVTPAPVPDIKGD 718
Cdd:TIGR00927  633 ------------------------------------------GDVAEAEHTGERTGEEGERP-----TEAEGENGEESGG 665

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   719 QKENPGGQEDVAEAESTGEMPGEEG-ETAGEGETEEKSG--------------GETQPEG---EGETETQGKGEE----- 775
Cdd:TIGR00927  666 EAEQEGETETKGENESEGEIPAERKgEQEGEGEIEAKEAdhkgeteaeeveheGETEAEGtedEGEIETGEEGEEvedeg 745

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   776 ---CEDENEAEGKGDN--------------EGEDEGEIHA-EDGEMKGNEG----------------------------- 808
Cdd:TIGR00927  746 egeAEGKHEVETEGDRketehegeteaegkEDEDEGEIQAgEDGEMKGDEGaegkvehegeteagekdehegqsetqadd 825

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   809 -----ETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEeeeeekgNEEPLSLDW 883
Cdd:TIGR00927  826 tevkdETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEE-------NEEPLSLEW 898

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   884 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAG 963
Cdd:TIGR00927  899 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAG 978

                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 666335651   964 TSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGV 1000
Cdd:TIGR00927  979 TSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGL 1015
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 458-602 6.90e-32

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 121.56  E-value: 6.90e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   458 HVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNIL 537
Cdd:pfam01699    1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   538 FVIGTCSLFS-----REILNLTwWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKW 602
Cdd:pfam01699   81 LVLGLSALIGpvkvdSLLLKLD-LGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
475-600 1.10e-24

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 105.22  E-value: 1.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651  475 EYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSReiLNLT 554
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 666335651  555 WWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTM 600
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL 125
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 949-1012 2.54e-12

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 69.29  E-value: 2.54e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 666335651  949 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGVGSCEMFQHGAIH 1012
Cdd:PRK10734  205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISPGEIN 268
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 1-1000 0e+00

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 1450.19  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651     1 MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPS 80
Cdd:TIGR00927    1 MGKLIRMGTQERRLLRPKRLHWSRLLFLLGMLIIGSTYQHLRRPQGLPSLWAAVSSQQPIKLASRDLSNDEMMMVSSDPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651    81 KPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTS-SRTLTYYTSTSS 159
Cdd:TIGR00927   81 KSSSEMEGEMLAPQATVGRDEATPSIAMENTPSPPRRTAKITPTTPKNNYSPTAAGTERVKEDTPATpSRALNHYISTSG 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   160 RQIVKKYTPTPRGEMKSYSPTQVREKV-KYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLK 238
Cdd:TIGR00927  161 RQRVKSYTPKPRGEVKSSSPTQTREKVrKYTPSPLGRMVNSYAPSTFMTMPRSHGITPRTTVKDSEITATYKMLETNPSK 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   239 RIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPAT 318
Cdd:TIGR00927  241 RTAGKTTPTPLKGMTDNTPTFLTREVETDLLTSPRSVVEKNTLTTPRRVESNSSTNHWGLVGKNNLTTPQGTVLEHTPAT 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   319 SEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVK 398
Cdd:TIGR00927  321 SEGQVTISIMTGSSPAETKASTAAWKIRNPLSRTSAPAVRIASATFRGLEKNPSTAPSTPATPRVRAVLTTQVHHCVVVK 400

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   399 PTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFV 478
Cdd:TIGR00927  401 PAPAVPTTPSPSLTTALFPEAPSPSPSALPPGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFV 480

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   479 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPL 558
Cdd:TIGR00927  481 PALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPL 560

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   559 FRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKlpslltrg 638
Cdd:TIGR00927  561 FRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSK-------- 632

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   639 ssstslhnstirstiyqlmlhsldplrevrlakekeeeslnqGARAQPQAKAESKPEEEEPAklpavTVTPAPVPDIKGD 718
Cdd:TIGR00927  633 ------------------------------------------GDVAEAEHTGERTGEEGERP-----TEAEGENGEESGG 665

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   719 QKENPGGQEDVAEAESTGEMPGEEG-ETAGEGETEEKSG--------------GETQPEG---EGETETQGKGEE----- 775
Cdd:TIGR00927  666 EAEQEGETETKGENESEGEIPAERKgEQEGEGEIEAKEAdhkgeteaeeveheGETEAEGtedEGEIETGEEGEEvedeg 745

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   776 ---CEDENEAEGKGDN--------------EGEDEGEIHA-EDGEMKGNEG----------------------------- 808
Cdd:TIGR00927  746 egeAEGKHEVETEGDRketehegeteaegkEDEDEGEIQAgEDGEMKGDEGaegkvehegeteagekdehegqsetqadd 825

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   809 -----ETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEeeeeekgNEEPLSLDW 883
Cdd:TIGR00927  826 tevkdETGEQELNAENQGEAKQDEKGVDGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEEE-------NEEPLSLEW 898

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   884 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAG 963
Cdd:TIGR00927  899 PETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAG 978

                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 666335651   964 TSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGV 1000
Cdd:TIGR00927  979 TSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGL 1015
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 457-611 6.25e-45

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 164.80  E-value: 6.25e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   457 LHVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNI 536
Cdd:TIGR00367    1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 666335651   537 LFVIGTCSLFSrEILNLTWWpLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYvftMKWNKHIEVWVK 611
Cdd:TIGR00367   81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVY---LLFLVKNERWVK 150
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 914-1011 4.86e-34

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 133.22  E-value: 4.86e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   914 ESRKFFVFTFL---GSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVG 990
Cdd:TIGR00367  163 NRRPQIFFSLVlliIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIG 242

                           90       100
                   ....*....|....*....|.
gi 666335651   991 SNIFDITVGVGSCEMFQHGAI 1011
Cdd:TIGR00367  243 SNIFNILVGLGVPSLFMPIPV 263
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 458-602 6.90e-32

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 121.56  E-value: 6.90e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   458 HVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNIL 537
Cdd:pfam01699    1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   538 FVIGTCSLFS-----REILNLTwWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKW 602
Cdd:pfam01699   81 LVLGLSALIGpvkvdSLLLKLD-LGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 918-1003 1.43e-25

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.45  E-value: 1.43e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   918 FFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 997
Cdd:pfam01699    1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80


                   ....*.
gi 666335651   998 VGVGSC 1003
Cdd:pfam01699   81 LVLGLS 86
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
475-600 1.10e-24

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 105.22  E-value: 1.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651  475 EYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSReiLNLT 554
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 666335651  555 WWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTM 600
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
907-1011 1.09e-21

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 96.74  E-value: 1.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651  907 VPDVRRQESRKFFVFTFLGSIMwIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVS 986
Cdd:COG0530   142 LEEKPKMSLWKALLLLVLGLAL-LVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVG 220

                          90       100
                  ....*....|....*....|....*
gi 666335651  987 SSVGSNIFDITVGVGSCEMFQHGAI 1011
Cdd:COG0530   221 NIIGSNIFNILLVLGIGALITPIPV 245
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
462-600 6.24e-18

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 85.57  E-value: 6.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651  462 MMYVFVALA--IVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFV 539
Cdd:COG0530   154 LLLLVLGLAllVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLV 233

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 666335651  540 IGTCSLFSReiLNLTWWPLFRDVSFYILDLIMLILFFL-DSLIAWWESLLLLLAYAFYVFTM 600
Cdd:COG0530   234 LGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLALYLAYLALL 293
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 465-586 9.81e-13

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 70.05  E-value: 9.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   465 VFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCS 544
Cdd:TIGR00367  177 IGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPS 256

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 666335651   545 LFSR-EILNLTwwpLFRDVSFYILDLIMLILFF-LDSLIAWWES 586
Cdd:TIGR00367  257 LFMPiPVEPLA---YNLDAPVMVIVTLLLMLFFkTSMKLGRWEG 297
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 949-1012 2.54e-12

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 69.29  E-value: 2.54e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 666335651  949 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGVGSCEMFQHGAIH 1012
Cdd:PRK10734  205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISPGEIN 268
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
941-1001 2.57e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 68.62  E-value: 2.57e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 666335651  941 AHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGVG 1001
Cdd:COG0530     8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILG 68
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 944-1006 1.61e-10

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 63.50  E-value: 1.61e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 666335651   944 VGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGVGSCEMF 1006
Cdd:TIGR00367   28 IARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIF 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 462-543 1.40e-09

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 62.12  E-value: 1.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   462 MMYVFVALAIVCDEyFVPALGVITDK-----------------LQI-SEDVAGATFMAAGGSAPELFTSLIGV----FIS 519
Cdd:TIGR00845   82 MVYMFLGVSIIADR-FMASIEVITSQekeitikkpngettvttVRIwNETVSNLTLMALGSSAPEILLSVIEVcghnFEA 160

                           90       100
                   ....*....|....*....|....
gi 666335651   520 hSNVGIGTIVGSAVFNILFVIGTC 543
Cdd:TIGR00845  161 -GDLGPSTIVGSAAFNMFIIIAIC 183
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 483-547 1.13e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 55.04  E-value: 1.13e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 666335651  483 VITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFS 547
Cdd:PRK10734  199 VLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALIS 263
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 937-1012 1.54e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 54.27  E-value: 1.54e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 666335651  937 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGVGSCEMFQHGAIH 1012
Cdd:PRK10734   22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTVH 97
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 453-605 1.27e-06

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 52.46  E-value: 1.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651  453 GWVVLHVFgMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSlIGVFISHS--NVGIGTIVG 530
Cdd:PLN03151  139 GYAVLGVW-LVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLG 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651  531 SAVFNILFVIGTCSL-FSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWN----KH 605
Cdd:PLN03151  217 GAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANeilrKH 296
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 906-1001 7.56e-05

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 46.68  E-value: 7.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651  906 TVPDvrrQESRKFFVFTFLG----SIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGlG 981
Cdd:PLN03151  471 TEPD---RPPRRFLIPWVLGgfimSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-G 546

                          90       100
                  ....*....|....*....|...
gi 666335651  982 D---MAVSSSVGSNIFDITVGVG 1001
Cdd:PLN03151  547 DgvqIAMSGCYAGPMFNTLVGLG 569
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 950-1006 1.39e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 46.14  E-value: 1.39e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 666335651   950 ISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGVGSCEMF 1006
Cdd:TIGR00927  492 ISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALF 548
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 922-1001 1.08e-03

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 43.24  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   922 TFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG-DMAVSSSVGSNIFDITVGV 1000
Cdd:TIGR00845  758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLGI 837


                   .
gi 666335651  1001 G 1001
Cdd:TIGR00845  838 G 838
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 103-360 3.38e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 3.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   103 TLSMTVENIPSMPK-----RTAKMIPTTT----------KNNYSPTAAGTERRKEDT----PTSSRTLTYYTSTSSR--- 160
Cdd:pfam05109  388 TFDITVSGLGTAPKtliitRTATNATTTThkvifskapeSTTTSPTLNTTGFAAPNTttglPSSTHVPTNLTAPASTgpt 467

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   161 -QIVKKYTPTPRGEMKSYSPTqvrekvkyTPSPRGRRVGTYVPSTFMTMETSHAITPrtTVKDSDITATYKILETNSLKR 239
Cdd:pfam05109  468 vSTADVTSPTPAGTTSGASPV--------TPSPSPRDNGTESKAPDMTSPTSAVTTP--TPNATSPTPAVTTPTPNATSP 537

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335651   240 IMEETTPTTLKgmfdSTPTfltheveanvltsprsvmeKNNLFPPRRVESNSSAHPWGLVGKSNPKTpqgTVLLHTPATS 319
Cdd:pfam05109  538 TLGKTSPTSAV----TTPT-------------------PNATSPTPAVTTPTPNATIPTLGKTSPTS---AVTTPTPNAT 591

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 666335651   320 EGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTA 360
Cdd:pfam05109  592 SPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTG 632
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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