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Conserved domains on  [gi|589269150|ref|NP_001277131|]
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seizure protein 6 homolog isoform 3 [Homo sapiens]

Protein Classification

CUB domain-containing protein( domain architecture ID 13042673)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 291-401 1.33e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.41  E-value: 1.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 291 CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNVEApPVYDSYEVE 366
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTSS-PLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 589269150 367 YLPIEgLLSSGKHFFVELSTDSSGAAAGMALRYEA 401
Cdd:cd00041   80 TLPPP-IISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 468-577 5.86e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.01  E-value: 5.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 468 CSGEITDSA-GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-----DVLTFYDGDDLTARVLGQYSGPR 541
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 589269150 542 SHFKLFTSMADVTIQFQSDPGTSvlgyQQGFVIHFF 577
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVT----GRGFKATYS 112
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 585-641 9.04e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 69.41  E-value: 9.04e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 589269150 585 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQ 641
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 585-770 2.78e-14

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 73.92  E-value: 2.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 585 CPELPEIPNGWKSPSQPELvhGTVVTYQCYPGYQVVGSSVLMCQW----DLTWSEDLPSCQRVtSCHDPGDVEHSRRLIS 660
Cdd:PHA02927  86 CPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGY 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 661 SPKFPVGATVQYICDQGFVLMGSSILTChdrqaGSPKWSDrAPKClleQLKPCHGLSAPENGARSPEKQLHPAGATIHFS 740
Cdd:PHA02927 163 EDFYTDGSVVTYSCNSGYSLIGNSGVLC-----SGGEWSD-PPTC---QIVKCPHPTISNGYLSSGFKRSYSYNDNVDFK 233

                        170       180       190
                 ....*....|....*....|....*....|
gi 589269150 741 CAPGYVLKGQASIKCVPGHPshWSDPPPIC 770
Cdd:PHA02927 234 CKYGYKLSGSSSSTCSPGNT--WQPELPKC 261
Sushi pfam00084
Sushi repeat (SCR repeat);
407-464 7.35e-11

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 7.35e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 589269150  407 CYEPF-VKYGNFSSSTPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPAC 464
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTITCQE--DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 232-288 1.64e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.92  E-value: 1.64e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 589269150 232 CHFPRRPAYGDVTV--TSLHPGGSARFHCATGYQLKGARHLTCLNATQpfWDSKEPVCI 288
Cdd:cd00033    1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG--WSPPPPTCE 57
CUB super family cl00049
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 119-227 3.81e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


The actual alignment was detected with superfamily member cd00041:

Pssm-ID: 412131 [Multi-domain]  Cd Length: 113  Bit Score: 43.56  E-value: 3.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 119 CSWNFSGP-EGSLDSPtDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGET-----VTVEGLGGPDPLPLANQSFL 192
Cdd:cd00041    1 CGGTLTAStSGTISSP-NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPSTSSPLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 589269150 193 LRGQVIRSPTHQAALRFQSLPPPAGPGtFHFHYQA 227
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRG-FKATYSA 113
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 291-401 1.33e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.41  E-value: 1.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 291 CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNVEApPVYDSYEVE 366
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTSS-PLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 589269150 367 YLPIEgLLSSGKHFFVELSTDSSGAAAGMALRYEA 401
Cdd:cd00041   80 TLPPP-IISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 468-577 5.86e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.01  E-value: 5.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 468 CSGEITDSA-GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-----DVLTFYDGDDLTARVLGQYSGPR 541
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 589269150 542 SHFKLFTSMADVTIQFQSDPGTSvlgyQQGFVIHFF 577
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVT----GRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 301-399 6.48e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 82.44  E-value: 6.48e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150   301 GRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNVEApPVYDSYEVEYLPIEGLLSS 376
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASS-PLLGRFCGSEAPPPVISSS 79

                           90       100
                   ....*....|....*....|...
gi 589269150   377 GKHFFVELSTDSSGAAAGMALRY 399
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 477-576 1.36e-17

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 78.97  E-value: 1.36e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150   477 GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-----DVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMA 551
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|....*.
gi 589269150   552 D-VTIQFQSDPGTSVlgyqQGFVIHF 576
Cdd:smart00042  81 NsLTLTFVSDSSVQK----RGFSARY 102
CUB pfam00431
CUB domain;
291-399 1.85e-16

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 75.79  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150  291 CGGVIRNATtGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNvEAPPVYDSYEVE 366
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDecgyDYVEIRDGPS-ASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 589269150  367 YLPiEGLLSSGKHFFVELSTDSSGAAAGMALRY 399
Cdd:pfam00431  79 GIP-EDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 585-641 9.04e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 69.41  E-value: 9.04e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 589269150 585 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQ 641
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 585-640 1.46e-14

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 68.71  E-value: 1.46e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 589269150   585 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 640
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CUB pfam00431
CUB domain;
468-576 1.69e-14

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 70.40  E-value: 1.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150  468 CSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIML-----DIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRS 542
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLtfqdfELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 589269150  543 HFKLFTSMADVTIQFQSDPGTSvlgyQQGFVIHF 576
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQ----KRGFKATY 110
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 585-770 2.78e-14

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 73.92  E-value: 2.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 585 CPELPEIPNGWKSPSQPELvhGTVVTYQCYPGYQVVGSSVLMCQW----DLTWSEDLPSCQRVtSCHDPGDVEHSRRLIS 660
Cdd:PHA02927  86 CPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGY 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 661 SPKFPVGATVQYICDQGFVLMGSSILTChdrqaGSPKWSDrAPKClleQLKPCHGLSAPENGARSPEKQLHPAGATIHFS 740
Cdd:PHA02927 163 EDFYTDGSVVTYSCNSGYSLIGNSGVLC-----SGGEWSD-PPTC---QIVKCPHPTISNGYLSSGFKRSYSYNDNVDFK 233

                        170       180       190
                 ....*....|....*....|....*....|
gi 589269150 741 CAPGYVLKGQASIKCVPGHPshWSDPPPIC 770
Cdd:PHA02927 234 CKYGYKLSGSSSSTCSPGNT--WQPELPKC 261
Sushi pfam00084
Sushi repeat (SCR repeat);
585-640 2.06e-12

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.52  E-value: 2.06e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 589269150  585 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 640
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 713-771 1.11e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 60.55  E-value: 1.11e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 589269150 713 CHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPICR 771
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN--GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 646-705 4.51e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 58.69  E-value: 4.51e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150   646 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDrqagSPKWSDRAPKC 705
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLE----NGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
407-464 7.35e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 7.35e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 589269150  407 CYEPF-VKYGNFSSSTPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPAC 464
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTITCQE--DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 410-465 1.35e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.78  E-value: 1.35e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 589269150 410 PFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPACR 465
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTL-VGSSTITCTE--NGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 410-464 4.23e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.30  E-value: 4.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 589269150   410 PFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPAC 464
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTL-IGSSTITCLE--NGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
646-705 1.34e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.03  E-value: 1.34e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150  646 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDrqagSPKWSDRAPKC 705
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQE----DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 232-288 1.64e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.92  E-value: 1.64e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 589269150 232 CHFPRRPAYGDVTV--TSLHPGGSARFHCATGYQLKGARHLTCLNATQpfWDSKEPVCI 288
Cdd:cd00033    1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG--WSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 232-287 2.15e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 45.60  E-value: 2.15e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 589269150   232 CHFPRRPAYGDVTVTS--LHPGGSARFHCATGYQLKGARHLTCLNATQpfWDSKEPVC 287
Cdd:smart00032   1 CPPPPDIENGTVTSSSgtYSYGDTVTYSCDPGYTLIGSSTITCLENGT--WSPPPPTC 56
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 119-227 3.81e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 43.56  E-value: 3.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 119 CSWNFSGP-EGSLDSPtDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGET-----VTVEGLGGPDPLPLANQSFL 192
Cdd:cd00041    1 CGGTLTAStSGTISSP-NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPSTSSPLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 589269150 193 LRGQVIRSPTHQAALRFQSLPPPAGPGtFHFHYQA 227
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRG-FKATYSA 113
Sushi pfam00084
Sushi repeat (SCR repeat);
232-287 7.60e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 41.33  E-value: 7.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 589269150  232 CHFPRRPAYGDVTVT--SLHPGGSARFHCATGYQLKGARHLTCLnaTQPFWDSKEPVC 287
Cdd:pfam00084   1 CPPPPDIPNGKVSATknEYNYGASVSYECDPGYRLVGSPTITCQ--EDGTWSPPFPEC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 579-640 6.27e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 42.67  E-value: 6.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 589269150 579 VPRNDTCP----ELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 640
Cdd:PHA02831 130 VPKYPVCKlircKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKC 195
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 291-401 1.33e-24

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 99.41  E-value: 1.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 291 CGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNVEApPVYDSYEVE 366
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPncsyDYLEIYDGPSTSS-PLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 589269150 367 YLPIEgLLSSGKHFFVELSTDSSGAAAGMALRYEA 401
Cdd:cd00041   80 TLPPP-IISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 468-577 5.86e-21

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 89.01  E-value: 5.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 468 CSGEITDSA-GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-----DVLTFYDGDDLTARVLGQYSGPR 541
Cdd:cd00041    1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPSTSSPLLGRFCGST 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 589269150 542 SHFKLFTSMADVTIQFQSDPGTSvlgyQQGFVIHFF 577
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVT----GRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 301-399 6.48e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 82.44  E-value: 6.48e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150   301 GRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNVEApPVYDSYEVEYLPIEGLLSS 376
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDnceyDYVEIYDGPSASS-PLLGRFCGSEAPPPVISSS 79

                           90       100
                   ....*....|....*....|...
gi 589269150   377 GKHFFVELSTDSSGAAAGMALRY 399
Cdd:smart00042  80 SNSLTLTFVSDSSVQKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 477-576 1.36e-17

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 78.97  E-value: 1.36e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150   477 GVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPG-----DVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMA 551
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|....*.
gi 589269150   552 D-VTIQFQSDPGTSVlgyqQGFVIHF 576
Cdd:smart00042  81 NsLTLTFVSDSSVQK----RGFSARY 102
CUB pfam00431
CUB domain;
291-399 1.85e-16

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 75.79  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150  291 CGGVIRNATtGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDD----DRLIIRNGDNvEAPPVYDSYEVE 366
Cdd:pfam00431   1 CGGVLTDSS-GSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDecgyDYVEIRDGPS-ASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 589269150  367 YLPiEGLLSSGKHFFVELSTDSSGAAAGMALRY 399
Cdd:pfam00431  79 GIP-EDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 585-641 9.04e-15

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 69.41  E-value: 9.04e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 589269150 585 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQ 641
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 585-640 1.46e-14

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 68.71  E-value: 1.46e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 589269150   585 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 640
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CUB pfam00431
CUB domain;
468-576 1.69e-14

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 70.40  E-value: 1.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150  468 CSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIML-----DIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRS 542
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLtfqdfELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 589269150  543 HFKLFTSMADVTIQFQSDPGTSvlgyQQGFVIHF 576
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQ----KRGFKATY 110
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 585-770 2.78e-14

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 73.92  E-value: 2.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 585 CPELPEIPNGWKSPSQPELvhGTVVTYQCYPGYQVVGSSVLMCQW----DLTWSEDLPSCQRVtSCHDPGDVEHSRRLIS 660
Cdd:PHA02927  86 CPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQLIGESKSYCELgstgSMVWNPEAPICESV-KCQSPPSISNGRHNGY 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 661 SPKFPVGATVQYICDQGFVLMGSSILTChdrqaGSPKWSDrAPKClleQLKPCHGLSAPENGARSPEKQLHPAGATIHFS 740
Cdd:PHA02927 163 EDFYTDGSVVTYSCNSGYSLIGNSGVLC-----SGGEWSD-PPTC---QIVKCPHPTISNGYLSSGFKRSYSYNDNVDFK 233

                        170       180       190
                 ....*....|....*....|....*....|
gi 589269150 741 CAPGYVLKGQASIKCVPGHPshWSDPPPIC 770
Cdd:PHA02927 234 CKYGYKLSGSSSSTCSPGNT--WQPELPKC 261
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 606-767 1.36e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 71.99  E-value: 1.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 606 GTVVTYQCYPGY--QVVGSSVLMCQ---WDLtwsedLPSCQRvTSCHDPGDVEHSRRLISSPKFpvGATVQYICDQGFVL 680
Cdd:PHA02927  47 GDTIEYLCLPGYrkQKMGPIYAKCTgtgWTL-----FNQCIK-RRCPSPRDIDNGQLDIGGVDF--GSSITYSCNSGYQL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 681 MGSSILTCHDRQAGSPKWSDRAPKCllEQLKpCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGhp 760
Cdd:PHA02927 119 IGESKSYCELGSTGSMVWNPEAPIC--ESVK-CQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG-- 193


                 ....*..
gi 589269150 761 sHWSDPP 767
Cdd:PHA02927 194 -EWSDPP 199
Sushi pfam00084
Sushi repeat (SCR repeat);
585-640 2.06e-12

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 62.52  E-value: 2.06e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 589269150  585 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 640
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 713-771 1.11e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 60.55  E-value: 1.11e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 589269150 713 CHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPICR 771
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN--GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 646-705 4.51e-11

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 58.69  E-value: 4.51e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150   646 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDrqagSPKWSDRAPKC 705
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLE----NGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
407-464 7.35e-11

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 7.35e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 589269150  407 CYEPF-VKYGNFSSSTPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPAC 464
Cdd:pfam00084   1 CPPPPdIPNGKVSATKNEYNYGASVSYECDPGYRL-VGSPTITCQE--DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 646-705 7.59e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 58.24  E-value: 7.59e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 646 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDrqagSPKWSDRAPKC 705
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTE----NGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 713-770 2.73e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.38  E-value: 2.73e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 589269150   713 CHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPIC 770
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN--GTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 410-465 1.35e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.78  E-value: 1.35e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 589269150 410 PFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPACR 465
Cdd:cd00033    5 PVPENGTVTGSKGSYSYGSTVTYSCNEGYTL-VGSSTITCTE--NGGWSPPPPTCE 57
PHA02639 PHA02639
EEV host range protein; Provisional
 646-771 3.57e-09

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 58.91  E-value: 3.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 646 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTChDRQAGSPKWSDRAPKCLleqLKPCHGLSAPENGARS 725
Cdd:PHA02639  22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTC-IKDKNNAIWSNKAPFCM---LKECNDPPSIINGKIY 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 589269150 726 PEKQLHPAGATIHFSC----APGYVLKGQASIKCVpgHPSHWSDPPPICR 771
Cdd:PHA02639  98 NKREMYKVGDEIYYVCnehkGVQYSLVGNEKITCI--QDKSWKPDPPICK 145
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 410-464 4.23e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.30  E-value: 4.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 589269150   410 PFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLeQGSIIIECVDphDPQWNETEPAC 464
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTL-IGSSTITCLE--NGTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 585-706 9.75e-09

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 57.36  E-value: 9.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 585 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDlTWSeDLPSCQrVTSCHDPGDVEHSRRLISSPKF 664
Cdd:PHA02927 148 CQSPPSISNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGG-EWS-DPPTCQ-IVKCPHPTISNGYLSSGFKRSY 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 589269150 665 PVGATVQYICDQGFVLMGSSILTChdrqagSP--KWSDRAPKCL 706
Cdd:PHA02927 225 SYNDNVDFKCKYGYKLSGSSSSTC------SPgnTWQPELPKCV 262
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 584-706 5.16e-08

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 55.48  E-value: 5.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 584 TCPELP----EIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDlTWSEdLPSCQRvtSCHDPgdvEHSRRLI 659
Cdd:PHA02954 124 TCPNAEcqplQLEHGSCQPVKEKYSFGEHITINCDVGYEVIGASYISCTAN-SWNV-IPSCQQ--KCDIP---SLSNGLI 196

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 589269150 660 SSPKFPVGATVQYICDQGFVLMGSSILTCHDrqagsPKWSDRAPKCL 706
Cdd:PHA02954 197 SGSTFSIGGVIHLSCKSGFTLTGSPSSTCID-----GKWNPVLPICV 238
Sushi pfam00084
Sushi repeat (SCR repeat);
646-705 1.34e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 49.03  E-value: 1.34e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150  646 CHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDrqagSPKWSDRAPKC 705
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQE----DGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 232-288 1.64e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 45.92  E-value: 1.64e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 589269150 232 CHFPRRPAYGDVTV--TSLHPGGSARFHCATGYQLKGARHLTCLNATQpfWDSKEPVCI 288
Cdd:cd00033    1 CPPPPVPENGTVTGskGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG--WSPPPPTCE 57
PHA02639 PHA02639
EEV host range protein; Provisional
 585-770 1.82e-06

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 50.82  E-value: 1.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 585 CPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWD---LTWSEDLPSCQrVTSCHDPGDVEHSRRLISS 661
Cdd:PHA02639  22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDknnAIWSNKAPFCM-LKECNDPPSIINGKIYNKR 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 662 PKFPVGATVQYICDQ----GFVLMGSSILTCHDRQAgspkWSDRAPKCLLEQLKpchgLSAPENGARS--PEKQLHPAGA 735
Cdd:PHA02639 101 EMYKVGDEIYYVCNEhkgvQYSLVGNEKITCIQDKS----WKPDPPICKMINCR----FPALQNGYINgiPSNKKFYYKT 172

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 589269150 736 TIHFSCAPGYVLKGQASIKCvpGHPSHWSDPPPIC 770
Cdd:PHA02639 173 RVGFSCKSGFDLVGEKYSTC--NINATWFPSIPTC 205
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 232-287 2.15e-06

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 45.60  E-value: 2.15e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 589269150   232 CHFPRRPAYGDVTVTS--LHPGGSARFHCATGYQLKGARHLTCLNATQpfWDSKEPVC 287
Cdd:smart00032   1 CPPPPDIENGTVTSSSgtYSYGDTVTYSCDPGYTLIGSSTITCLENGT--WSPPPPTC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 585-706 1.38e-05

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 47.68  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 585 CPELPEIPNGWKSPSQPELVHGTVVTYQC----YPGYQVVGSSVLMCqWDLTWSEDLPSCqRVTSCHDPGdVEHSRRLIS 660
Cdd:PHA02831  78 CKDPVTILNGYIKNKKDQYSFGDSVTYACkvnkLEKYSIVGNETVKC-INKQWVPKYPVC-KLIRCKYPA-LQNGFLNVF 154

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 589269150 661 SPKFPVGATVQYICDQGFVLMGSSILTCHDRQAgspkWSDRAPKCL 706
Cdd:PHA02831 155 EKKFYYGDIVNFKCKKGFILLGSSVSTCDINSI----WYPGIPKCV 196
Sushi pfam00084
Sushi repeat (SCR repeat);
713-770 2.41e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.49  E-value: 2.41e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 589269150  713 CHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGhpSHWSDPPPIC 770
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED--GTWSPPFPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 583-705 3.51e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 46.09  E-value: 3.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 583 DTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPG-----YQVVGSSVLMCQWDLTWSEDLPSCQrVTSCHDPG-DVEHSR 656
Cdd:PHA02817  22 NKCCYPPSIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCK-IIRCRFPAlQNGFVN 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 589269150 657 RLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAgspkWSDRAPKC 705
Cdd:PHA02817 101 GIPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSS----WIPKVPIC 145
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 119-227 3.81e-05

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 43.56  E-value: 3.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 119 CSWNFSGP-EGSLDSPtDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGET-----VTVEGLGGPDPLPLANQSFL 192
Cdd:cd00041    1 CGGTLTAStSGTISSP-NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsydyLEIYDGPSTSSPLLGRFCGS 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 589269150 193 LRGQVIRSPTHQAALRFQSLPPPAGPGtFHFHYQA 227
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRG-FKATYSA 113
Sushi pfam00084
Sushi repeat (SCR repeat);
232-287 7.60e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 41.33  E-value: 7.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 589269150  232 CHFPRRPAYGDVTVT--SLHPGGSARFHCATGYQLKGARHLTCLnaTQPFWDSKEPVC 287
Cdd:pfam00084   1 CPPPPDIPNGKVSATknEYNYGASVSYECDPGYRLVGSPTITCQ--EDGTWSPPFPEC 56
PHA02831 PHA02831
EEV host range protein; Provisional
 579-640 6.27e-04

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 42.67  E-value: 6.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 589269150 579 VPRNDTCP----ELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSC 640
Cdd:PHA02831 130 VPKYPVCKlircKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKC 195
PHA02639 PHA02639
EEV host range protein; Provisional
 585-706 1.67e-03

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 41.57  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 585 CPELPEIPNGWKSPSQPELVHGTVVTYQC--YPG--YQVVGSSVLMCQWDLTWSEDLPSCQRVtSCHDPG-DVEHSRRLI 659
Cdd:PHA02639  85 CNDPPSIINGKIYNKREMYKVGDEIYYVCneHKGvqYSLVGNEKITCIQDKSWKPDPPICKMI-NCRFPAlQNGYINGIP 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 589269150 660 SSPKFPVGATVQYICDQGFVLMGSSILTCHDrqagSPKWSDRAPKCL 706
Cdd:PHA02639 164 SNKKFYYKTRVGFSCKSGFDLVGEKYSTCNI----NATWFPSIPTCV 206
PHA02831 PHA02831
EEV host range protein; Provisional
 611-824 2.12e-03

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 40.75  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 611 YQCYPGYQVVgssVLMCQwDLTWSEDlPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICD----QGFVLMGSSIL 686
Cdd:PHA02831  48 YKCNNNFDKV---FVTCN-NGSWSTK-NMCIGKRNCKDPVTILNGYIKNKKDQYSFGDSVTYACKvnklEKYSIVGNETV 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 687 TCHDRQagspkWSDRAPKCLLEQLKpchgLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCvpGHPSHWSDP 766
Cdd:PHA02831 123 KCINKQ-----WVPKYPVCKLIRCK----YPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTC--DINSIWYPG 191

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 589269150 767 PPICRAASLDGFYNSRSL--DVAKAPAASST---LDAAHIAAAIFLPLVAMVLLVGGVYFYFS 824
Cdd:PHA02831 192 IPKCVKDKVHNEIQPNYLfdDLDEDFNNSTTnynMQQNIITIIILLSIICFIFVLGLIALFLS 254
PHA02817 PHA02817
EEV Host range protein; Provisional
 639-770 2.92e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 40.31  E-value: 2.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589269150 639 SCQRVTSCHDPgDVEHSRRLISSPKFPVGATVQYICDQG-----FVLMGSSILTCHDrqagSPKWSDRAPKClleQLKPC 713
Cdd:PHA02817  18 LCDLNKCCYPP-SIKNGYIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEK----DGKWNKEFPVC---KIIRC 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 589269150 714 HgLSAPENGARS--PEKQLHPAGATIHFSCAPGYVLKGQASIKCvpGHPSHWSDPPPIC 770
Cdd:PHA02817  90 R-FPALQNGFVNgiPDSKKFYYESEVSFSCKPGFVLIGTKYSVC--GINSSWIPKVPIC 145
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 585-642 9.71e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 38.87  E-value: 9.71e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 589269150 585 CPElPEIPNGWKSPS-QPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQR 642
Cdd:PHA02927 206 CPH-PTISNGYLSSGfKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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