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Conserved domains on  [gi|558472777|ref|NP_001273739|]
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DDB1- and CUL4-associated factor 10 isoform b [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11457048)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-161 4.57e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 4.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777  10 LTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVKNIEY 88
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAF 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 558472777  89 DTNTRLLVTSGFDGNVIIWDTNRYTedgCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDLTKSL 161
Cdd:COG2319  255 SPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGKLL 323
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 344-382 9.23e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 9.23e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 558472777   344 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 382
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-161 4.57e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 4.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777  10 LTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVKNIEY 88
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAF 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 558472777  89 DTNTRLLVTSGFDGNVIIWDTNRYTedgCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDLTKSL 161
Cdd:COG2319  255 SPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-146 2.11e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 2.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777   9 VLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKLnTKVCTLHGHTSWVKNIE 87
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVA 226

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777  88 YDTNTRLLVTSGFDGNVIIWDtnryTEDGCPHKKFF-HTRFLMRMRLTPDcSKMLISTSS 146
Cdd:cd00200  227 FSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSgHTNSVTSLAWSPD-GKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 71-108 7.45e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.45e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 558472777    71 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 108
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
70-108 2.39e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 558472777   70 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 108
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 51-108 8.51e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 8.51e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558472777  51 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 108
Cdd:PTZ00420  89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 344-382 9.23e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 9.23e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 558472777   344 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 382
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-161 4.57e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 4.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777  10 LTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVKNIEY 88
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAF 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 558472777  89 DTNTRLLVTSGFDGNVIIWDTNRYTedgCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDLTKSL 161
Cdd:COG2319  255 SPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGKLL 323
WD40 COG2319
WD40 repeat [General function prediction only];
9-385 7.93e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 7.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777   9 VLTVACEQTEVLLFDpISSKHIKTLSEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVKNIE 87
Cdd:COG2319   92 LLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVA 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777  88 YDTNTRLLVTSGFDGNVIIWDTnryTEDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDLTKSLEVGSyp 167
Cdd:COG2319  170 FSPDGKLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLWDLATGKLLRTLT-- 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777 168 ilrarrttsssdlttsssssgprvsgspcHHSDSNSS------EKHMsrASqregVSPRNSL---EVVTPEVLGE-SDHG 237
Cdd:COG2319  244 -----------------------------GHSGSVRSvafspdGRLL--AS----GSADGTVrlwDLATGELLRTlTGHS 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777 238 NCITSLQLHPKGwATLLrcSSNSDDEecTCVYEFQEGAPVRPVSPRcslrlthyieeanvgRGYIKELCFSPDGRMI-SS 316
Cdd:COG2319  289 GGVNSVAFSPDG-KLLA--SGSDDGT--VRLWDLATGKLLRTLTGH---------------TGAVRSVAFSPDGKTLaSG 348

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 558472777 317 PHGYGIRLLgfdkqcselvdclpkEASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 385
Cdd:COG2319  349 SDDGTVRLW---------------DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-146 2.11e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 2.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777   9 VLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKLnTKVCTLHGHTSWVKNIE 87
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVA 226

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777  88 YDTNTRLLVTSGFDGNVIIWDtnryTEDGCPHKKFF-HTRFLMRMRLTPDcSKMLISTSS 146
Cdd:cd00200  227 FSPDGYLLASGSEDGTIRVWD----LRTGECVQTLSgHTNSVTSLAWSPD-GKRLASGSA 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-163 1.36e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777   1 MLSRSHRSVLTVACEQTeVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGH 79
Cdd:cd00200   58 AASADGTYLASGSSDKT-IRLWDLETGECVRTL-TGHTSYVSSVAFSpDGRILSSSSRDKTIKVWDVET-GKCLTTLRGH 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777  80 TSWVKNIEYDTNTRLLVTSGFDGNVIIWDTNrytedGCPHKKFF--HTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDL 157
Cdd:cd00200  135 TDWVNSVAFSPDGTFVASSSQDGTIKLWDLR-----TGKCVATLtgHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLST 208


                 ....*.
gi 558472777 158 TKSLEV 163
Cdd:cd00200  209 GKCLGT 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-146 1.53e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 1.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777   6 HRSVLTVACEQTEVLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVK 84
Cdd:cd00200   20 DGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLET-GECVRTLTGHTSYVS 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 558472777  85 NIEYDTNTRLLVTSGFDGNVIIWDTNRYTEDGCPHkkfFHTRFLMRMRLTPDcsKMLISTSS 146
Cdd:cd00200   98 SVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR---GHTDWVNSVAFSPD--GTFVASSS 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-108 3.52e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 3.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777  19 VLLFDPISSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWDLRKlNTKVCTLHGHTSWVKNIEYDTNTRLLVT 97
Cdd:cd00200  201 IKLWDLSTGKCLGTL-RGHENGVNSVAFSpDGYLLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAWSPDGKRLAS 278

                         90
                 ....*....|.
gi 558472777  98 SGFDGNVIIWD 108
Cdd:cd00200  279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-385 1.68e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777   2 LSRSHRSVLTVACEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLFATCSDDTTIALWDLRkLNTKVCTLHGHTS 81
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAA-AGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777  82 WVKNIEYDTNTRLLVTSGFDGNVIIWDTNRyteDGCPHKKFFHTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDLTKSL 161
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLAT---GLLLRTLTGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDLATGKLL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777 162 EVgsypiLRarrttsssdlttsssssgprvsgspcHHSDSNSS------EKHMsrASqregVSPRNSL---EVVTPEVLG 232
Cdd:COG2319  156 RT-----LT--------------------------GHSGAVTSvafspdGKLL--AS----GSDDGTVrlwDLATGKLLR 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777 233 E-SDHGNCITSLQLHPKGwaTLLrcSSNSDDEECTcVYEFQEGAPVRpvsprcslRLTHYieeanvgRGYIKELCFSPDG 311
Cdd:COG2319  199 TlTGHTGAVRSVAFSPDG--KLL--ASGSADGTVR-LWDLATGKLLR--------TLTGH-------SGSVRSVAFSPDG 258

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 558472777 312 RMISSPHGYG-IRLlgFDkqcselvdclpkeASPLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 385
Cdd:COG2319  259 RLLASGSADGtVRL--WD-------------LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 71-108 7.45e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.45e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 558472777    71 TKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 108
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
70-108 2.39e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.39e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 558472777   70 NTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWD 108
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 51-108 8.51e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 8.51e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558472777  51 LFATCSDDTTIALWDLRKLNTKV-------CTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVIIWD 108
Cdd:PTZ00420  89 ILASGSEDLTIRVWEIPHNDESVkeikdpqCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWD 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-385 1.29e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777  37 HEDCVNNIRFL-DNRLFATCSDDTTIALWDLrKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnrytED 115
Cdd:cd00200    8 HTGGVTCVAFSpDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL----ET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777 116 GCPHKKFF-HTRFLMRMRLTPDcSKMLISTSSGYLLILHDLDltkslevgsypilrarrttsssdlttsssssgprvsgs 194
Cdd:cd00200   83 GECVRTLTgHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVE-------------------------------------- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777 195 pchhsdsnssekhmsrasqregvsprnslevvtpevlgesdHGNCITSLQLHpkgwatllrcssnsddeectcvyefqeg 274
Cdd:cd00200  124 -----------------------------------------TGKCLTTLRGH---------------------------- 134

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777 275 apvrpvsprcslrlthyieeanvgRGYIKELCFSPDGRMISSPHGYG-IRLlgFDkqcselvdclpkeASPLRVIRSLYS 353
Cdd:cd00200  135 ------------------------TDWVNSVAFSPDGTFVASSSQDGtIKL--WD-------------LRTGKCVATLTG 175

                        330       340       350
                 ....*....|....*....|....*....|..
gi 558472777 354 HNDVVLTTKFSPTHCQIASGCLSGRVSLYQPK 385
Cdd:cd00200  176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 73-161 3.33e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472777  73 VCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDTnryteDGCPHKKFF--HTRFLMRMRLTPDcSKMLISTSSGYLL 150
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-----ETGELLRTLkgHTGPVRDVAASAD-GTYLASGSSDKTI 75

                         90
                 ....*....|.
gi 558472777 151 ILHDLDLTKSL 161
Cdd:cd00200   76 RLWDLETGECV 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 26-65 7.26e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 7.26e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 558472777    26 SSKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 65
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
27-65 3.26e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 558472777   27 SKHIKTLsEAHEDCVNNIRFL-DNRLFATCSDDTTIALWD 65
Cdd:pfam00400   1 GKLLKTL-EGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 344-382 9.23e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 9.23e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 558472777   344 PLRVIRSLYSHNDVVLTTKFSPTHCQIASGCLSGRVSLY 382
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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