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Conserved domains on  [gi|544063410|ref|NP_001269604|]
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inactive serine protease PAMR1 isoform c [Homo sapiens]

Protein Classification

coagulation factor; serine protease( domain architecture ID 10035774)

coagulation factor is a vitamin K-dependent protein S1 family serine peptidase, similar to human coagulation factor X that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting; trypsin-like serine protease catalyzes the cleavage of specific peptide bonds in protein substrates using an active site serine as the nucleophile; contains C-terminal DNA polymerase III subunits gamma and tau

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
421-678 1.59e-41

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 150.89  E-value: 1.59e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 421 RWPWQAAIYRRTSGVHdgslhkgawflvCSGALVNERTVVVAAHCVTDlgkvtmIKTADLKVVLGKFYRDddRDEKTIQS 500
Cdd:cd00190   11 SFPWQVSLQYTGGRHF------------CGGSLISPRWVLTAAHCVYS------SAPSNYTVRLGSHDLS--SNEGGGQV 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 501 LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWnvlADVRSPGFKNDTLRSG 580
Cdd:cd00190   71 IKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGY--NLPAGTTCTVSGW---GRTSEGGPLPDVLQEV 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 581 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCAsWEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDktC-SH 659
Cdd:cd00190  146 NVPIVSNAECKRAYSYGGT---ITDNMLCA-GGLEGGKDACQGDSGGPLVCNDNG------RGVLVGIVSWGSG--CaRP 213
                        250
                 ....*....|....*....
gi 544063410 660 RLSTAFTKVLPFKDWIERN 678
Cdd:cd00190  214 NYPGVYTRVSSYLDWIQKT 232
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
88-194 5.38e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 122.91  E-value: 5.38e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410  88 CGQVLRAPKGQILL-----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNE 162
Cdd:cd00041    1 CGGTLTASTSGTISspnypNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80
                         90       100       110
                 ....*....|....*....|....*....|..
gi 544063410 163 RPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYE 194
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
240-303 9.94e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.47  E-value: 9.94e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544063410 240 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI 303
Cdd:cd00033    1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
200-232 2.09e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 2.09e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 544063410 200 SSSPCFHDGTCVlDKAGSYKCACLAGYTGQRCE 232
Cdd:cd00054    7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
368-403 1.60e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.14  E-value: 1.60e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 544063410 368 TQLQYECiSPFYRRLGSSRRTCLRTGKWSGRAPSCI 403
Cdd:cd00033   23 STVTYSC-NEGYTLVGSSTITCTENGGWSPPPPTCE 57
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
421-678 1.59e-41

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 150.89  E-value: 1.59e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 421 RWPWQAAIYRRTSGVHdgslhkgawflvCSGALVNERTVVVAAHCVTDlgkvtmIKTADLKVVLGKFYRDddRDEKTIQS 500
Cdd:cd00190   11 SFPWQVSLQYTGGRHF------------CGGSLISPRWVLTAAHCVYS------SAPSNYTVRLGSHDLS--SNEGGGQV 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 501 LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWnvlADVRSPGFKNDTLRSG 580
Cdd:cd00190   71 IKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGY--NLPAGTTCTVSGW---GRTSEGGPLPDVLQEV 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 581 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCAsWEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDktC-SH 659
Cdd:cd00190  146 NVPIVSNAECKRAYSYGGT---ITDNMLCA-GGLEGGKDACQGDSGGPLVCNDNG------RGVLVGIVSWGSG--CaRP 213
                        250
                 ....*....|....*....
gi 544063410 660 RLSTAFTKVLPFKDWIERN 678
Cdd:cd00190  214 NYPGVYTRVSSYLDWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
421-675 4.84e-39

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 143.97  E-value: 4.84e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410   421 RWPWQAAIYRRTsgvhdgslhkgaWFLVCSGALVNERTVVVAAHCVTDLGKvtmiktADLKVVLGKFYRDDDRDEKTIQs 500
Cdd:smart00020  12 SFPWQVSLQYGG------------GRHFCGGSLISPRWVLTAAHCVRGSDP------SNIRVRLGSHDLSSGEEGQVIK- 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410   501 lqISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWNVLADvrSPGFKNDTLRSG 580
Cdd:smart00020  73 --VSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNY--NVPAGTTCTVSGWGRTSE--GAGSLPDTLQEV 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410   581 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCASWePTAPSDICTAETGGIAAVSfpgraspEPRWHLMGLVSWSYDktC-SH 659
Cdd:smart00020 147 NVPIVSNATCRRAYSGGGA---ITDNMLCAGG-LEGGKDACQGDSGGPLVCN-------DGRWVLVGIVSWGSG--CaRP 213
                          250
                   ....*....|....*.
gi 544063410   660 RLSTAFTKVLPFKDWI 675
Cdd:smart00020 214 GKPGVYTRVSSYLDWI 229
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
422-679 5.31e-36

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 136.32  E-value: 5.31e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 422 WPWQAAIYRRTsgvhdgslhkGAWFLVCSGALVNERTVVVAAHCVTDLGkvtmikTADLKVVLGkfyrDDDRDEKTIQSL 501
Cdd:COG5640   42 YPWMVALQSSN----------GPSGQFCGGTLIAPRWVLTAAHCVDGDG------PSDLRVVIG----STDLSTSGGTVV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 502 QISAIILHPNYDPILLDADIAILKLldkARISTRVQPICLAASRDLSTSFQEshITVAGWNVLADvrSPGFKNDTLRSGV 581
Cdd:COG5640  102 KVARIVVHPDYDPATPGNDIALLKL---ATPVPGVAPAPLATSADAAAPGTP--ATVAGWGRTSE--GPGSQSGTLRKAD 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 582 VSVVDSLLCEeqhedhGIPVSVTDNMFCASwEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDkTCSHRL 661
Cdd:COG5640  175 VPVVSDATCA------AYGGFDGGTMLCAG-YPEGGKDACQGDSGGPLVVKDGG------GWVLVGVVSWGGG-PCAAGY 240
                        250
                 ....*....|....*...
gi 544063410 662 STAFTKVLPFKDWIERNM 679
Cdd:COG5640  241 PGVYTRVSAYRDWIKSTA 258
Trypsin pfam00089
Trypsin;
422-675 1.00e-34

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 131.41  E-value: 1.00e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410  422 WPWQAAIYRRTSGvhdgslhkgawfLVCSGALVNERTVVVAAHCVTDLGkvtmiktaDLKVVLGKfyRDDDRDEKTIQSL 501
Cdd:pfam00089  12 FPWQVSLQLSSGK------------HFCGGSLISENWVLTAAHCVSGAS--------DVKVVLGA--HNIVLREGGEQKF 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410  502 QISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTsfQESHITVAGW-NVLADVRSpgfknDTLRSG 580
Cdd:pfam00089  70 DVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLP--VGTTCTVSGWgNTKTLGPS-----DTLQEV 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410  581 VVSVVDSLLCEEQHedhgiPVSVTDNMFCASWEptaPSDICTAETGGIAAVSFPgraspeprwHLMGLVSWSYDktCSH- 659
Cdd:pfam00089 143 TVPVVSRETCRSAY-----GGTVTDTMICAGAG---GKDACQGDSGGPLVCSDG---------ELIGIVSWGYG--CASg 203
                         250
                  ....*....|....*.
gi 544063410  660 RLSTAFTKVLPFKDWI 675
Cdd:pfam00089 204 NYPGVYTPVSSYLDWI 219
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
88-194 5.38e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 122.91  E-value: 5.38e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410  88 CGQVLRAPKGQILL-----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNE 162
Cdd:cd00041    1 CGGTLTASTSGTISspnypNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80
                         90       100       110
                 ....*....|....*....|....*....|..
gi 544063410 163 RPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYE 194
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
88-193 8.73e-28

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 107.77  E-value: 8.73e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410   88 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNER 163
Cdd:pfam00431   1 CGGVLTDSSGSISSpnypNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80
                          90       100       110
                  ....*....|....*....|....*....|
gi 544063410  164 PAPIQSIGSSLHVLFHSDGSKNFDGFHAIY 193
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
102-193 1.23e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 107.09  E-value: 1.23e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410   102 ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNERPAP-IQSIGSSLHVLFHS 180
Cdd:smart00042  10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNSLTLTFVS 89
                           90
                   ....*....|...
gi 544063410   181 DGSKNFDGFHAIY 193
Cdd:smart00042  90 DSSVQKRGFSARY 102
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
240-303 9.94e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.47  E-value: 9.94e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544063410 240 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI 303
Cdd:cd00033    1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
240-302 3.83e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 3.83e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544063410   240 CSDPGGPVNGYqkITGGPGLINgrhakIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 302
Cdd:smart00032   1 CPPPPDIENGT--VTSSSGTYS-----YGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
240-302 7.35e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.12  E-value: 7.35e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544063410  240 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 302
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNE-------YNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
216-313 1.15e-06

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 50.42  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 216 GSYKCACLAGYTGQRCENlleerncsdPGGPVNGYQKITGGPGLINGRHAKI------GTVVSFFCNNSYVLSGNEKRTC 289
Cdd:PHA02927 120 GESKSYCELGSTGSMVWN---------PEAPICESVKCQSPPSISNGRHNGYedfytdGSVVTYSCNSGYSLIGNSGVLC 190
                         90       100
                 ....*....|....*....|....*
gi 544063410 290 qQNGEWSgKQPIC-IKACREPKISD 313
Cdd:PHA02927 191 -SGGEWS-DPPTCqIVKCPHPTISN 213
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
200-232 2.09e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 2.09e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 544063410 200 SSSPCFHDGTCVlDKAGSYKCACLAGYTGQRCE 232
Cdd:cd00054    7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
200-232 7.48e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 7.48e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 544063410   200 SSSPCFHDGTCVlDKAGSYKCACLAGYT-GQRCE 232
Cdd:smart00179   7 SGNPCQNGGTCV-NTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
199-230 7.81e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 7.81e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 544063410  199 CSSSPCFHDGTCVlDKAGSYKCACLAGYTGQR 230
Cdd:pfam00008   1 CAPNPCSNGGTCV-DTPGGYTCICPEGYTGKR 31
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
368-403 1.60e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.14  E-value: 1.60e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 544063410 368 TQLQYECiSPFYRRLGSSRRTCLRTGKWSGRAPSCI 403
Cdd:cd00033   23 STVTYSC-NEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
368-402 2.75e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.43  E-value: 2.75e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 544063410   368 TQLQYECISPfYRRLGSSRRTCLRTGKWSGRAPSC 402
Cdd:smart00032  23 DTVTYSCDPG-YTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
367-402 6.60e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 38.25  E-value: 6.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 544063410  367 HTQLQYECISPFYRRlGSSRRTCLRTGKWSGRAPSC 402
Cdd:pfam00084  22 GASVSYECDPGYRLV-GSPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
421-678 1.59e-41

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 150.89  E-value: 1.59e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 421 RWPWQAAIYRRTSGVHdgslhkgawflvCSGALVNERTVVVAAHCVTDlgkvtmIKTADLKVVLGKFYRDddRDEKTIQS 500
Cdd:cd00190   11 SFPWQVSLQYTGGRHF------------CGGSLISPRWVLTAAHCVYS------SAPSNYTVRLGSHDLS--SNEGGGQV 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 501 LQISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWnvlADVRSPGFKNDTLRSG 580
Cdd:cd00190   71 IKVKKVIVHPNYNPSTYDNDIALLKLKRPVTLSDNVRPICLPSSGY--NLPAGTTCTVSGW---GRTSEGGPLPDVLQEV 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 581 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCAsWEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDktC-SH 659
Cdd:cd00190  146 NVPIVSNAECKRAYSYGGT---ITDNMLCA-GGLEGGKDACQGDSGGPLVCNDNG------RGVLVGIVSWGSG--CaRP 213
                        250
                 ....*....|....*....
gi 544063410 660 RLSTAFTKVLPFKDWIERN 678
Cdd:cd00190  214 NYPGVYTRVSSYLDWIQKT 232
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
421-675 4.84e-39

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 143.97  E-value: 4.84e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410   421 RWPWQAAIYRRTsgvhdgslhkgaWFLVCSGALVNERTVVVAAHCVTDLGKvtmiktADLKVVLGKFYRDDDRDEKTIQs 500
Cdd:smart00020  12 SFPWQVSLQYGG------------GRHFCGGSLISPRWVLTAAHCVRGSDP------SNIRVRLGSHDLSSGEEGQVIK- 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410   501 lqISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDlsTSFQESHITVAGWNVLADvrSPGFKNDTLRSG 580
Cdd:smart00020  73 --VSKVIIHPNYNPSTYDNDIALLKLKEPVTLSDNVRPICLPSSNY--NVPAGTTCTVSGWGRTSE--GAGSLPDTLQEV 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410   581 VVSVVDSLLCEEQHEDHGIpvsVTDNMFCASWePTAPSDICTAETGGIAAVSfpgraspEPRWHLMGLVSWSYDktC-SH 659
Cdd:smart00020 147 NVPIVSNATCRRAYSGGGA---ITDNMLCAGG-LEGGKDACQGDSGGPLVCN-------DGRWVLVGIVSWGSG--CaRP 213
                          250
                   ....*....|....*.
gi 544063410   660 RLSTAFTKVLPFKDWI 675
Cdd:smart00020 214 GKPGVYTRVSSYLDWI 229
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
422-679 5.31e-36

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 136.32  E-value: 5.31e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 422 WPWQAAIYRRTsgvhdgslhkGAWFLVCSGALVNERTVVVAAHCVTDLGkvtmikTADLKVVLGkfyrDDDRDEKTIQSL 501
Cdd:COG5640   42 YPWMVALQSSN----------GPSGQFCGGTLIAPRWVLTAAHCVDGDG------PSDLRVVIG----STDLSTSGGTVV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 502 QISAIILHPNYDPILLDADIAILKLldkARISTRVQPICLAASRDLSTSFQEshITVAGWNVLADvrSPGFKNDTLRSGV 581
Cdd:COG5640  102 KVARIVVHPDYDPATPGNDIALLKL---ATPVPGVAPAPLATSADAAAPGTP--ATVAGWGRTSE--GPGSQSGTLRKAD 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 582 VSVVDSLLCEeqhedhGIPVSVTDNMFCASwEPTAPSDICTAETGGIAAVSFPGraspepRWHLMGLVSWSYDkTCSHRL 661
Cdd:COG5640  175 VPVVSDATCA------AYGGFDGGTMLCAG-YPEGGKDACQGDSGGPLVVKDGG------GWVLVGVVSWGGG-PCAAGY 240
                        250
                 ....*....|....*...
gi 544063410 662 STAFTKVLPFKDWIERNM 679
Cdd:COG5640  241 PGVYTRVSAYRDWIKSTA 258
Trypsin pfam00089
Trypsin;
422-675 1.00e-34

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 131.41  E-value: 1.00e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410  422 WPWQAAIYRRTSGvhdgslhkgawfLVCSGALVNERTVVVAAHCVTDLGkvtmiktaDLKVVLGKfyRDDDRDEKTIQSL 501
Cdd:pfam00089  12 FPWQVSLQLSSGK------------HFCGGSLISENWVLTAAHCVSGAS--------DVKVVLGA--HNIVLREGGEQKF 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410  502 QISAIILHPNYDPILLDADIAILKLLDKARISTRVQPICLAASRDLSTsfQESHITVAGW-NVLADVRSpgfknDTLRSG 580
Cdd:pfam00089  70 DVEKIIVHPNYNPDTLDNDIALLKLESPVTLGDTVRPICLPDASSDLP--VGTTCTVSGWgNTKTLGPS-----DTLQEV 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410  581 VVSVVDSLLCEEQHedhgiPVSVTDNMFCASWEptaPSDICTAETGGIAAVSFPgraspeprwHLMGLVSWSYDktCSH- 659
Cdd:pfam00089 143 TVPVVSRETCRSAY-----GGTVTDTMICAGAG---GKDACQGDSGGPLVCSDG---------ELIGIVSWGYG--CASg 203
                         250
                  ....*....|....*.
gi 544063410  660 RLSTAFTKVLPFKDWI 675
Cdd:pfam00089 204 NYPGVYTPVSSYLDWI 219
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
88-194 5.38e-33

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 122.91  E-value: 5.38e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410  88 CGQVLRAPKGQILL-----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNE 162
Cdd:cd00041    1 CGGTLTASTSGTISspnypNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80
                         90       100       110
                 ....*....|....*....|....*....|..
gi 544063410 163 RPAPIQSIGSSLHVLFHSDGSKNFDGFHAIYE 194
Cdd:cd00041   81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
88-193 8.73e-28

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 107.77  E-value: 8.73e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410   88 CGQVLRAPKGQILL----ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNER 163
Cdd:pfam00431   1 CGGVLTDSSGSISSpnypNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80
                          90       100       110
                  ....*....|....*....|....*....|
gi 544063410  164 PAPIQSIGSSLHVLFHSDGSKNFDGFHAIY 193
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
102-193 1.23e-27

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 107.09  E-value: 1.23e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410   102 ESYPLNAHCEWTIHAKPGFVIQLRFVMLSLEFDYMCQYDYVEVRDGDNRDGQIIKRVCGNERPAP-IQSIGSSLHVLFHS 180
Cdd:smart00042  10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNSLTLTFVS 89
                           90
                   ....*....|...
gi 544063410   181 DGSKNFDGFHAIY 193
Cdd:smart00042  90 DSSVQKRGFSARY 102
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
240-303 9.94e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 57.47  E-value: 9.94e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544063410 240 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPICI 303
Cdd:cd00033    1 CPPPPVPENGTVTGSKGS-------YSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
240-302 3.83e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 3.83e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544063410   240 CSDPGGPVNGYqkITGGPGLINgrhakIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 302
Cdd:smart00032   1 CPPPPDIENGT--VTSSSGTYS-----YGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
240-302 7.35e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 52.12  E-value: 7.35e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544063410  240 CSDPGGPVNGYQKITGGPglingrhAKIGTVVSFFCNNSYVLSGNEKRTCQQNGEWSGKQPIC 302
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNE-------YNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
216-313 1.15e-06

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 50.42  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 216 GSYKCACLAGYTGQRCENlleerncsdPGGPVNGYQKITGGPGLINGRHAKI------GTVVSFFCNNSYVLSGNEKRTC 289
Cdd:PHA02927 120 GESKSYCELGSTGSMVWN---------PEAPICESVKCQSPPSISNGRHNGYedfytdGSVVTYSCNSGYSLIGNSGVLC 190
                         90       100
                 ....*....|....*....|....*
gi 544063410 290 qQNGEWSgKQPIC-IKACREPKISD 313
Cdd:PHA02927 191 -SGGEWS-DPPTCqIVKCPHPTISN 213
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
200-232 2.09e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 2.09e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 544063410 200 SSSPCFHDGTCVlDKAGSYKCACLAGYTGQRCE 232
Cdd:cd00054    7 SGNPCQNGGTCV-NTVGSYRCSCPPGYTGRNCE 38
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
448-560 1.06e-05

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 46.59  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 448 VCSGALVNERTVVVAAHCVTDLGKVTmiKTADLKVVLGkfYRDDDRdektiQSLQISAIILHPNYDP-ILLDADIAILKL 526
Cdd:COG3591   13 VCTGTLIGPNLVLTAGHCVYDGAGGG--WATNIVFVPG--YNGGPY-----GTATATRFRVPPGWVAsGDAGYDYALLRL 83
                         90       100       110
                 ....*....|....*....|....*....|....
gi 544063410 527 ldKARISTRVQPICLAASRDLSTsfqESHITVAG 560
Cdd:COG3591   84 --DEPLGDTTGWLGLAFNDAPLA---GEPVTIIG 112
EGF_CA smart00179
Calcium-binding EGF-like domain;
200-232 7.48e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 7.48e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 544063410   200 SSSPCFHDGTCVlDKAGSYKCACLAGYT-GQRCE 232
Cdd:smart00179   7 SGNPCQNGGTCV-NTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
199-230 7.81e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 7.81e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 544063410  199 CSSSPCFHDGTCVlDKAGSYKCACLAGYTGQR 230
Cdd:pfam00008   1 CAPNPCSNGGTCV-DTPGGYTCICPEGYTGKR 31
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
368-403 1.60e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 40.14  E-value: 1.60e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 544063410 368 TQLQYECiSPFYRRLGSSRRTCLRTGKWSGRAPSCI 403
Cdd:cd00033   23 STVTYSC-NEGYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
368-402 2.75e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.43  E-value: 2.75e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 544063410   368 TQLQYECISPfYRRLGSSRRTCLRTGKWSGRAPSC 402
Cdd:smart00032  23 DTVTYSCDPG-YTLIGSSTITCLENGTWSPPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
238-313 3.93e-04

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 43.11  E-value: 3.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544063410 238 RNCSDPGGPVNGyqkitggpGLINGRHA-KIGTVVSFFCNN----SYVLSGNEKRTCQQNGEWSGKQPIC-IKACREPKI 311
Cdd:PHA02639  83 KECNDPPSIING--------KIYNKREMyKVGDEIYYVCNEhkgvQYSLVGNEKITCIQDKSWKPDPPICkMINCRFPAL 154

                 ..
gi 544063410 312 SD 313
Cdd:PHA02639 155 QN 156
Sushi pfam00084
Sushi repeat (SCR repeat);
367-402 6.60e-04

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 38.25  E-value: 6.60e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 544063410  367 HTQLQYECISPFYRRlGSSRRTCLRTGKWSGRAPSC 402
Cdd:pfam00084  22 GASVSYECDPGYRLV-GSPTITCQEDGTWSPPFPEC 56
PHA02639 PHA02639
EEV host range protein; Provisional
266-309 8.87e-04

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 41.96  E-value: 8.87e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 544063410 266 KIGTVVSFFCNNSYVLSGNEKRTC---QQNGEWSGKQPIC-IKACREP 309
Cdd:PHA02639  41 EIGKLIEYTCNTDYALIGDRFRTCikdKNNAIWSNKAPFCmLKECNDP 88
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
200-232 1.27e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 1.27e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 544063410 200 SSSPCFHDGTCVlDKAGSYKCACLAGYTGQ-RCE 232
Cdd:cd00053    4 ASNPCSNGGTCV-NTPGSYRCVCPPGYTGDrSCE 36
PHA02817 PHA02817
EEV Host range protein; Provisional
267-313 2.72e-03

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 39.92  E-value: 2.72e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 544063410 267 IGTVVSFFCNNS-----YVLSGNEKRTCQQNGEWSGKQPIC-IKACREPKISD 313
Cdd:PHA02817  44 IGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCkIIRCRFPALQN 96
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
258-308 9.77e-03

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 38.53  E-value: 9.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 544063410 258 GLINGRHAKIGTVVSFFCNNSYVLSGNEKRTCqQNGEWSGKQPICIKACRE 308
Cdd:PHA02954 194 GLISGSTFSIGGVIHLSCKSGFTLTGSPSSTC-IDGKWNPVLPICVRSNEE 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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