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Conserved domains on  [gi|530677957|ref|NP_001268968|]
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leucine-rich repeat-containing protein 51 [Bos taurus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 705725)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_9 super family cl25994
Leucine-rich repeat;
89-173 4.81e-12

Leucine-rich repeat;


The actual alignment was detected with superfamily member pfam14580:

Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 61.32  E-value: 4.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957   89 NDLTSIDPVLTTFF-NLSVLYLHGNSIQRLGEVNKLAALPRLRSLTLHGNPIEEEKGYRQYVLCTLPHITTFDFSGVTKA 167
Cdd:pfam14580  74 NRICRIGEGLGEALpNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQK 153


                  ....*.
gi 530677957  168 DRTTAE 173
Cdd:pfam14580 154 ERQAAE 159
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
89-173 4.81e-12

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 61.32  E-value: 4.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957   89 NDLTSIDPVLTTFF-NLSVLYLHGNSIQRLGEVNKLAALPRLRSLTLHGNPIEEEKGYRQYVLCTLPHITTFDFSGVTKA 167
Cdd:pfam14580  74 NRICRIGEGLGEALpNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQK 153


                  ....*.
gi 530677957  168 DRTTAE 173
Cdd:pfam14580 154 ERQAAE 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-163 8.20e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 8.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957  52 QSLWLNNNVLTDLRDfnhAVSQLlehpENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAALPRLRS 131
Cdd:COG4886  162 KSLDLSNNQLTDLPE---ELGNL----TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLET 232

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530677957 132 LTLHGNPIEEEKGyrqyvLCTLPHITTFDFSG 163
Cdd:COG4886  233 LDLSNNQLTDLPE-----LGNLTNLEELDLSN 259
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-178 2.36e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957  85 DLSFNDLTSIDPvLTTFFNLSVLYLHGNSIQRLGEVNK-LAALPRLRSLTLHGNPIEEEKGYRQYVLCTLPHITTFDFSG 163
Cdd:cd21340  126 NISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204

                         90
                 ....*....|....*
gi 530677957 164 VTKADRTTAEVWKRM 178
Cdd:cd21340  205 ITDTERQFLKRLKAR 219
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
89-173 4.81e-12

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 61.32  E-value: 4.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957   89 NDLTSIDPVLTTFF-NLSVLYLHGNSIQRLGEVNKLAALPRLRSLTLHGNPIEEEKGYRQYVLCTLPHITTFDFSGVTKA 167
Cdd:pfam14580  74 NRICRIGEGLGEALpNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQK 153


                  ....*.
gi 530677957  168 DRTTAE 173
Cdd:pfam14580 154 ERQAAE 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-163 8.20e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 8.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957  52 QSLWLNNNVLTDLRDfnhAVSQLlehpENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAALPRLRS 131
Cdd:COG4886  162 KSLDLSNNQLTDLPE---ELGNL----TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLET 232

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530677957 132 LTLHGNPIEEEKGyrqyvLCTLPHITTFDFSG 163
Cdd:COG4886  233 LDLSNNQLTDLPE-----LGNLTNLEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-163 1.37e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957  52 QSLWLNNNVLTDLrdfnhavSQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEvnkLAALPRLRS 131
Cdd:COG4886  185 KELDLSNNQITDL-------PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEE 254

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530677957 132 LTLHGNPIEEEKgyrqyVLCTLPHITTFDFSG 163
Cdd:COG4886  255 LDLSNNQLTDLP-----PLANLTNLKTLDLSN 281
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 5.99e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 5.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957  52 QSLWLNNNVLTDLRDfnhAVSQLlehpENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAALPRLRS 131
Cdd:COG4886  139 KELDLSNNQLTDLPE---PLGNL----TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEE 209

                         90
                 ....*....|
gi 530677957 132 LTLHGNPIEE 141
Cdd:COG4886  210 LDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-141 1.08e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957  52 QSLWLNNNVLTDLrdfNHAVSQLlehpENLAWIDLSFNDLTSIdPVLTTFFNLSVLYLHGNSIQRLGEvnkLAALPRLRS 131
Cdd:COG4886  208 EELDLSGNQLTDL---PEPLANL----TNLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPP---LANLTNLKT 276

                         90
                 ....*....|
gi 530677957 132 LTLHGNPIEE 141
Cdd:COG4886  277 LDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-141 1.36e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957  61 LTDLRDFNHAVSQLLEHPENLAWIDLSFNDLTSIDPVLTTFFNLSVLYLHGNSIQRLGEVnkLAALPRLRSLTLHGNPIE 140
Cdd:COG4886   95 LTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLT 172


                 .
gi 530677957 141 E 141
Cdd:COG4886  173 D 173
LRR_8 pfam13855
Leucine rich repeat;
80-139 8.18e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 8.18e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530677957   80 NLAWIDLSFNDLTSIDPvlTTFFNLS---VLYLHGNSIQRLGEvNKLAALPRLRSLTLHGNPI 139
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD--GAFKGLSnlkVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-178 2.36e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957  85 DLSFNDLTSIDPvLTTFFNLSVLYLHGNSIQRLGEVNK-LAALPRLRSLTLHGNPIEEEKGYRQYVLCTLPHITTFDFSG 163
Cdd:cd21340  126 NISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKE 204

                         90
                 ....*....|....*
gi 530677957 164 VTKADRTTAEVWKRM 178
Cdd:cd21340  205 ITDTERQFLKRLKAR 219
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 86-141 3.81e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 3.81e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530677957  86 LSFND--LTSIDpVLTTFFNLSVLYLHGNSIQRLgevNKLAALPRLRSLTLHGNPIEE 141
Cdd:cd21340    7 LYLNDknITKID-NLSLCKNLKVLYLYDNKITKI---ENLEFLTNLTHLYLQNNQIEK 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-173 4.65e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 4.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957  52 QSLWLNNNVLTDLRDfnhavsqlLEHPENLAWIDLSFNDLTSIdPVLTTFFNLSVLYLHGNSIQRLgEVNKLAALPRLRS 131
Cdd:COG4886  231 ETLDLSNNQLTDLPE--------LGNLTNLEELDLSNNQLTDL-PPLANLTNLKTLDLSNNQLTDL-KLKELELLLGLNS 300

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 530677957 132 LTLHGNPIEEEKGYRQYVLCTLPHITTFDFSGVTKADRTTAE 173
Cdd:COG4886  301 LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 48-139 2.33e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530677957  48 KSMTQsLWLNNNVLTDLRDfnhavsqlLEHPENLAWIDLSFNDLTSIDPvLTTFFNLSVLYLHGNSIQRLGEvnkLAALP 127
Cdd:cd21340    2 KRITH-LYLNDKNITKIDN--------LSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN---LENLV 68

                         90
                 ....*....|..
gi 530677957 128 RLRSLTLHGNPI 139
Cdd:cd21340   69 NLKKLYLGGNRI 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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