|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
969-1275 |
3.52e-162 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 490.17 E-value: 3.52e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 969 AIKNTQNLIQMPYGCGEQNMVLFAPSIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGDHDGkgQG 1048
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1049 NTWLTAFVLKSFSQAQAFIFIDESHITDAFTWLSHQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITVALLESLPPDT 1128
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1129 HPVVSKALSCLESSWENIeqggngSFVYTKALMAYAFALAGnQEKRNEILKSLDKEAIKEDNSIHWERPqkPMKSARSLY 1208
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 406035338 1209 KPQASSAEVEMNAYVILARLTAQsapsPKDLALSMGTIKWLTKQQNSRGGFSSTQDTVVALDALSKY 1275
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
749-839 |
2.92e-38 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
:
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 138.10 E-value: 2.92e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 749 TWVWDLVTVNSSGAAELEMTVPDTITEWKAGALCLSNDTGLGLSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNY 828
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 406035338 829 LPTSLPMAVQL 839
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
129-1351 |
1.73e-36 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 151.39 E-value: 1.73e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 129 VFVQTDKPVYKPGQSVKFRIVSMDKNLHPLNELfPL-AYIEDP---KINRImQWQDikTENGLKQLSFSLSAEPIQGPYK 204
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPdgkEVRRQ-TLTL--NEFGGYSFSFPLPEDAPTGTWR 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 205 IVI-LKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVYDEIISVTACATYTYGKPVPGR---VKISLCHGNPSF----- 275
Cdd:COG2373 447 LELyVDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkveGEVTLRPARTAFpgypg 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 276 -------RSQTKSACKEEDSELDNNGCSTQEVNITEFRLKENYLKVRqafhVNATVTEEGtGSEFSGSGRIEVkRTRNKF 348
Cdd:COG2373 527 yrfgdpdEEFEPEELDLGEGTLDADGKASLSLPLPDAPDAPGPLRAT----VEASVFESG-GRPVTRSATVPV-HPADFY 600
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 349 LFLKAD--SHFRHGIPFFVKVRLVNIKGDPIPNQQV---FIK----------AQGAGFTNAT-----------TTDQHGL 402
Cdd:COG2373 601 VGIRLPlfDGDPEGAPATFEVVAVDPDGKPVAGKGLkveLYReewryvwyksDDGGWRYESQekeepvaegtlTTGADGP 680
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 403 AKFSIDTSGISRYILnikvyhkeenscihsscTAERHAEAHHTAYAVY-----------------SLSK-SYIYLDTeAG 464
Cdd:COG2373 681 ASLSLTPVEWGRYRL-----------------EVKDPDGGLATSVRFYaggnaswgaerpdrlelSLDKeSYKPGET-AK 742
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 465 VLpcnqshtVQAHFilKGQVLgvlpqivfhylVMAQGS-ILQTgnHTHQVEPGESPVqgnfalEIPVEFSMVPMAkmliY 543
Cdd:COG2373 743 LL-------IQSPF--AGRAL-----------VTVERDgVLET--QWVDVKGGGTTV------EIPVTEDWAPNA----Y 790
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 544 ---TILPDGEVIAD--------SVKFQVEKCLRH-EVHLSfSPSQSLPASQTHMRVTASPQSlcG------LRAVDQSVL 605
Cdd:COG2373 791 vsaTLVRPGDSTANdmparaygVAPLPVDPPARRlKVELT-APEKLRPGETLTVTVKVKGAA--GkaaevtLAAVDEGIL 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 606 LLKPEAelSPSliydlpgmqeskfiPRSHYpfededgcviYRPRVIGKLTYSVpygrekdvfrymrdtgltaltnlklrt 685
Cdd:COG2373 868 NLTGYK--TPD--------------PLDFF----------YGKRALGVETRDL--------------------------- 894
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 686 fcfdYDMVPLAVPAARSSDLFNSDGYGSwrsarvKSLPPKKAphkdpppkdpvietiRNYFPETWVWD-LVTVNSSGAAE 764
Cdd:COG2373 895 ----YGRLIGAFGGAAGALRSGGDGALG------RGGNPKPP---------------RKRFKPVALFSgPVKTDADGKAT 949
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 765 LEMTVPDTITEWKAGALCLSnDTGLGlSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMAVQLEASPD 844
Cdd:COG2373 950 VSFDLPDFNGTLRVMAVAWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGG 1027
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 845 FTavPVGNDQDSYCLGANGRHTSSWLVTPKSLGNVNFSVSAEAQqspepcgsevatvpetGRKDTVVKVLIVEPEGIKRE 924
Cdd:COG2373 1028 LT--LEGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPANPLVT 1089
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 925 HTFSSLLcasDAELSETLSLLLPPTVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPSIYVLKyLNET 1004
Cdd:COG2373 1090 RATSGVL---APGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEA 1165
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1005 QQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGdhdGKGQGNTWLTAFVLKSFSQAQAF-IFIDESHITDAFTWLSH 1083
Cdd:COG2373 1166 LGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRN 1242
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1084 QQKDSGcfrssgslfnnAMKGGVDDEITLSAYI--TVALLESLPPDThpvvskalscLESSWENIEQGGNGsfvYTKALM 1161
Cdd:COG2373 1243 YLRNPW-----------EIEYDDAYRLAVRAYAlyVLARAGKADLGD----------LRYLYDRRKDALSP---LAKAQL 1298
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1162 AYAFALAGNQEKRNEILKSLDKEAIKEDNSIHWerpqkpmksaRSLYkpqasSAEVEMNAYVIlaRLTAQSAPSPKDLAl 1241
Cdd:COG2373 1299 AAALALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALAL--ALLAELGPDAPLAP- 1360
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1242 smGTIKWLTKQQNSrGGFSSTQDTVVALDALSKYGAATfsKSQKTPSVTVQSSGsffQKFQVDNSNRLLLQQVSLPDI-P 1320
Cdd:COG2373 1361 --KLARWLAKALKS-GRWLSTQETAWALLALAAYARAA--GASPDFTATLTLDG---KTLPLTGRGPLARVTLPAAELlA 1432
|
1290 1300 1310
....*....|....*....|....*....|.
gi 406035338 1321 GNYTVSVSGEGCVYAQTMLRYNLPLEKQQPA 1351
Cdd:COG2373 1433 GPLTITNTGDGPLYYTLTLSGYPAEGPPPAA 1463
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1385-1475 |
1.06e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 124.99 E-value: 1.06e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1385 PASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNN-VLLYLDQVTNQTLSFSFIIQQDIPVKNLQPAIVKVYDY 1463
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDDGkVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 406035338 1464 YETDEVAFAEYS 1475
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
969-1275 |
3.52e-162 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 490.17 E-value: 3.52e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 969 AIKNTQNLIQMPYGCGEQNMVLFAPSIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGDHDGkgQG 1048
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1049 NTWLTAFVLKSFSQAQAFIFIDESHITDAFTWLSHQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITVALLESLPPDT 1128
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1129 HPVVSKALSCLESSWENIeqggngSFVYTKALMAYAFALAGnQEKRNEILKSLDKEAIKEDNSIHWERPqkPMKSARSLY 1208
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 406035338 1209 KPQASSAEVEMNAYVILARLTAQsapsPKDLALSMGTIKWLTKQQNSRGGFSSTQDTVVALDALSKY 1275
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
959-1275 |
4.85e-156 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 474.48 E-value: 4.85e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 959 FSVMGDILSSAIK----NTQNLIQMPYGCGEQNMVLFAPSIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELNYKHKDG 1034
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1035 SYSAFGDhdgkGQGNTWLTAFVLKSFSQAQAFIFIDESHITDAFTWLSHQQKDSGCFRSSGSLFNNAMKGGVDDEITLSA 1114
Cdd:pfam07678 81 SYSAFGH----SPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1115 YITVALLESLP-----PDTHPVVSKALSCLESsweniEQGGNGSFVYTKALMAYAFALAGNQEKRNEILKSLDKEAIKED 1189
Cdd:pfam07678 157 YVTIALLEALDingllQRVHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1190 NSIHWERPQKPMKSARSLYKPQASSAEVEMNAYVILARLTaqsapsPKDLALSMGTIKWLTKQQNSRGGFSSTQDTVVAL 1269
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYLL------LGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 406035338 1270 DALSKY 1275
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
749-839 |
2.92e-38 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 138.10 E-value: 2.92e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 749 TWVWDLVTVNSSGAAELEMTVPDTITEWKAGALCLSNDTGLGLSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNY 828
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 406035338 829 LPTSLPMAVQL 839
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
129-1351 |
1.73e-36 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 151.39 E-value: 1.73e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 129 VFVQTDKPVYKPGQSVKFRIVSMDKNLHPLNELfPL-AYIEDP---KINRImQWQDikTENGLKQLSFSLSAEPIQGPYK 204
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPdgkEVRRQ-TLTL--NEFGGYSFSFPLPEDAPTGTWR 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 205 IVI-LKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVYDEIISVTACATYTYGKPVPGR---VKISLCHGNPSF----- 275
Cdd:COG2373 447 LELyVDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkveGEVTLRPARTAFpgypg 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 276 -------RSQTKSACKEEDSELDNNGCSTQEVNITEFRLKENYLKVRqafhVNATVTEEGtGSEFSGSGRIEVkRTRNKF 348
Cdd:COG2373 527 yrfgdpdEEFEPEELDLGEGTLDADGKASLSLPLPDAPDAPGPLRAT----VEASVFESG-GRPVTRSATVPV-HPADFY 600
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 349 LFLKAD--SHFRHGIPFFVKVRLVNIKGDPIPNQQV---FIK----------AQGAGFTNAT-----------TTDQHGL 402
Cdd:COG2373 601 VGIRLPlfDGDPEGAPATFEVVAVDPDGKPVAGKGLkveLYReewryvwyksDDGGWRYESQekeepvaegtlTTGADGP 680
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 403 AKFSIDTSGISRYILnikvyhkeenscihsscTAERHAEAHHTAYAVY-----------------SLSK-SYIYLDTeAG 464
Cdd:COG2373 681 ASLSLTPVEWGRYRL-----------------EVKDPDGGLATSVRFYaggnaswgaerpdrlelSLDKeSYKPGET-AK 742
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 465 VLpcnqshtVQAHFilKGQVLgvlpqivfhylVMAQGS-ILQTgnHTHQVEPGESPVqgnfalEIPVEFSMVPMAkmliY 543
Cdd:COG2373 743 LL-------IQSPF--AGRAL-----------VTVERDgVLET--QWVDVKGGGTTV------EIPVTEDWAPNA----Y 790
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 544 ---TILPDGEVIAD--------SVKFQVEKCLRH-EVHLSfSPSQSLPASQTHMRVTASPQSlcG------LRAVDQSVL 605
Cdd:COG2373 791 vsaTLVRPGDSTANdmparaygVAPLPVDPPARRlKVELT-APEKLRPGETLTVTVKVKGAA--GkaaevtLAAVDEGIL 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 606 LLKPEAelSPSliydlpgmqeskfiPRSHYpfededgcviYRPRVIGKLTYSVpygrekdvfrymrdtgltaltnlklrt 685
Cdd:COG2373 868 NLTGYK--TPD--------------PLDFF----------YGKRALGVETRDL--------------------------- 894
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 686 fcfdYDMVPLAVPAARSSDLFNSDGYGSwrsarvKSLPPKKAphkdpppkdpvietiRNYFPETWVWD-LVTVNSSGAAE 764
Cdd:COG2373 895 ----YGRLIGAFGGAAGALRSGGDGALG------RGGNPKPP---------------RKRFKPVALFSgPVKTDADGKAT 949
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 765 LEMTVPDTITEWKAGALCLSnDTGLGlSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMAVQLEASPD 844
Cdd:COG2373 950 VSFDLPDFNGTLRVMAVAWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGG 1027
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 845 FTavPVGNDQDSYCLGANGRHTSSWLVTPKSLGNVNFSVSAEAQqspepcgsevatvpetGRKDTVVKVLIVEPEGIKRE 924
Cdd:COG2373 1028 LT--LEGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPANPLVT 1089
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 925 HTFSSLLcasDAELSETLSLLLPPTVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPSIYVLKyLNET 1004
Cdd:COG2373 1090 RATSGVL---APGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEA 1165
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1005 QQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGdhdGKGQGNTWLTAFVLKSFSQAQAF-IFIDESHITDAFTWLSH 1083
Cdd:COG2373 1166 LGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRN 1242
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1084 QQKDSGcfrssgslfnnAMKGGVDDEITLSAYI--TVALLESLPPDThpvvskalscLESSWENIEQGGNGsfvYTKALM 1161
Cdd:COG2373 1243 YLRNPW-----------EIEYDDAYRLAVRAYAlyVLARAGKADLGD----------LRYLYDRRKDALSP---LAKAQL 1298
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1162 AYAFALAGNQEKRNEILKSLDKEAIKEDNSIHWerpqkpmksaRSLYkpqasSAEVEMNAYVIlaRLTAQSAPSPKDLAl 1241
Cdd:COG2373 1299 AAALALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALAL--ALLAELGPDAPLAP- 1360
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1242 smGTIKWLTKQQNSrGGFSSTQDTVVALDALSKYGAATfsKSQKTPSVTVQSSGsffQKFQVDNSNRLLLQQVSLPDI-P 1320
Cdd:COG2373 1361 --KLARWLAKALKS-GRWLSTQETAWALLALAAYARAA--GASPDFTATLTLDG---KTLPLTGRGPLARVTLPAAELlA 1432
|
1290 1300 1310
....*....|....*....|....*....|.
gi 406035338 1321 GNYTVSVSGEGCVYAQTMLRYNLPLEKQQPA 1351
Cdd:COG2373 1433 GPLTITNTGDGPLYYTLTLSGYPAEGPPPAA 1463
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1385-1475 |
1.06e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 124.99 E-value: 1.06e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1385 PASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNN-VLLYLDQVTNQTLSFSFIIQQDIPVKNLQPAIVKVYDY 1463
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDDGkVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 406035338 1464 YETDEVAFAEYS 1475
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
457-607 |
4.23e-30 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 116.68 E-value: 4.23e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 457 IYLDTEAGVLPCNQSHTVQAHFILKGQVlgvlPQIVFHYLVMAQGSILQTGNHTHQVEpgespvqgnfaLEIPVEFSMVP 536
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTV----ERDGFTYLVLSKGQIVVVGRGGVTTS-----------FSLPVTAEMAP 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 406035338 537 MAKMLIYTI---LPDGEVIADSVKFQVEKCLRHEVHLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLL 607
Cdd:pfam07703 66 SARVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
969-1275 |
3.52e-162 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 490.17 E-value: 3.52e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 969 AIKNTQNLIQMPYGCGEQNMVLFAPSIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGDHDGkgQG 1048
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDK--SG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1049 NTWLTAFVLKSFSQAQAFIFIDESHITDAFTWLSHQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITVALLESLPPDT 1128
Cdd:cd02897 79 STWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1129 HPVVSKALSCLESSWENIeqggngSFVYTKALMAYAFALAGnQEKRNEILKSLDKEAIKEDNSIHWERPqkPMKSARSLY 1208
Cdd:cd02897 159 RPVVEKALSCLEAALDSI------SDPYTLALAAYALTLAG-SEKRPEALKKLDELAISEDGTKHWSRP--PPSEEGPSY 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 406035338 1209 KPQASSAEVEMNAYVILARLTAQsapsPKDLALSMGTIKWLTKQQNSRGGFSSTQDTVVALDALSKY 1275
Cdd:cd02897 230 YWQAPSAEVEMTAYALLALLSAG----GEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
959-1275 |
4.85e-156 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 474.48 E-value: 4.85e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 959 FSVMGDILSSAIK----NTQNLIQMPYGCGEQNMVLFAPSIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELNYKHKDG 1034
Cdd:pfam07678 1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1035 SYSAFGDhdgkGQGNTWLTAFVLKSFSQAQAFIFIDESHITDAFTWLSHQQKDSGCFRSSGSLFNNAMKGGVDDEITLSA 1114
Cdd:pfam07678 81 SYSAFGH----SPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1115 YITVALLESLP-----PDTHPVVSKALSCLESsweniEQGGNGSFVYTKALMAYAFALAGNQEKRNEILKSLDKEAIKED 1189
Cdd:pfam07678 157 YVTIALLEALDingllQRVHPSIRKALTYLEQ-----AQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1190 NSIHWERPQKPMKSARSLYKPQASSAEVEMNAYVILARLTaqsapsPKDLALSMGTIKWLTKQQNSRGGFSSTQDTVVAL 1269
Cdd:pfam07678 232 NSRYWERDEKSDPQGVPEYPPQAPSLEVETTAYALLAYLL------LGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVAL 305
|
....*.
gi 406035338 1270 DALSKY 1275
Cdd:pfam07678 306 QALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
969-1275 |
2.05e-113 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 358.62 E-value: 2.05e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 969 AIKNTQNLIQMPYGCGEQNMVLFAPSIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGDHDgkgQG 1048
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSD---SG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1049 NTWLTAFVLKSFSQAQAFIFIDESHITDAFTWLSHQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITVALLESLPPDt 1128
Cdd:cd02891 78 STWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKAC- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1129 HPVVSKALSCLESSWENIEQggngsfVYTKALMAYAFALAGNQEKRNEILKSLDKEAIKEDNSIHWErpqkpmksaRSLY 1208
Cdd:cd02891 157 DASIEKALAYLETQLDGLLD------PYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHWS---------LSWP 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 406035338 1209 KPQASSAEVEMNAYVILARLtaqsapSPKDLALSMGTIKWLTKQQNSRGGFSSTQDTVVALDALSKY 1275
Cdd:cd02891 222 GDYGSSLRVEATAYALLALL------KLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
970-1275 |
8.13e-80 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 265.29 E-value: 8.13e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 970 IKNTQNLIQMPYGCGEQNMVLFAPSIYVLKYLNETQQ---LTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGDhdgkG 1046
Cdd:cd02896 2 PEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKN----R 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1047 QGNTWLTAFVLKSFSQAQAFIFIDESHITDAFTWLSHQQKDSGCFRSSGSLFNNAMKGGV---DDEITLSAYITVALLES 1123
Cdd:cd02896 78 PSSTWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQEA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1124 LP------PDTHPVVSKALSCLESSWENIEQggngsfVYTKALMAYAFALAGNQEKRNEiLKSLDKEAIKEDNSIHWERP 1197
Cdd:cd02896 158 RSicppevQNLDQSIRKAISYLENQLPNLQR------PYALAITAYALALADSPLSHAA-NRKLLSLAKRDGNGWYWWTI 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 406035338 1198 QKPMksarsLYKPQASSAEVEMNAYVILARLtaqsapSPKDLALSMGTIKWLTKQQNSRGGFSSTQDTVVALDALSKY 1275
Cdd:cd02896 231 DSPY-----WPVPGPSAITVETTAYALLALL------KLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
969-1275 |
1.53e-66 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 227.43 E-value: 1.53e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 969 AIKNTQNLIQMPYG--------CGEQNMVLFAPSIYVLKYLNETQqltekIKSKALGYLRAGYQRELNYKHKDGSYSAFG 1040
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATG-----IRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1041 DHDgkgQGNTWLTAFVLKSFSQAQAFIFIDESHITDAFTWLSHQQKDSGCFRSSGSLFNNAMkgGVDDEITLSAYITVAL 1120
Cdd:cd00688 76 GND---YPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHRIG--GDESDVRLTAYALIAL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1121 LESLPPDTHPVVSKALSCLESS--WENIEQGGNGSFVYTKALMAYAFALAG--NQEKRNEILKSLDKEAIKEDNSIHWer 1196
Cdd:cd00688 151 ALLGKLDPDPLIEKALDYLLSCqnYDGGFGPGGESHGYGTACAAAALALLGdlDSPDAKKALRWLLSRQRPDGGWGEG-- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1197 pqkpmksaRSLYKPQASSAEVEMNAYVILARLtaqsapSPKDLALSMGTIKWLTKQQNSRGGFSS-------TQDTVVAL 1269
Cdd:cd00688 229 --------RDRTNKLSDSCYTEWAAYALLALG------KLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFAL 294
|
....*.
gi 406035338 1270 DALSKY 1275
Cdd:cd00688 295 LALSLY 300
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
749-839 |
2.92e-38 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 138.10 E-value: 2.92e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 749 TWVWDLVTVNSSGAAELEMTVPDTITEWKAGALCLSNDTGLGLSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNY 828
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 406035338 829 LPTSLPMAVQL 839
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
129-1351 |
1.73e-36 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 151.39 E-value: 1.73e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 129 VFVQTDKPVYKPGQSVKFRIVSMDKNLHPLNELfPL-AYIEDP---KINRImQWQDikTENGLKQLSFSLSAEPIQGPYK 204
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPdgkEVRRQ-TLTL--NEFGGYSFSFPLPEDAPTGTWR 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 205 IVI-LKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVYDEIISVTACATYTYGKPVPGR---VKISLCHGNPSF----- 275
Cdd:COG2373 447 LELyVDPKPALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkveGEVTLRPARTAFpgypg 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 276 -------RSQTKSACKEEDSELDNNGCSTQEVNITEFRLKENYLKVRqafhVNATVTEEGtGSEFSGSGRIEVkRTRNKF 348
Cdd:COG2373 527 yrfgdpdEEFEPEELDLGEGTLDADGKASLSLPLPDAPDAPGPLRAT----VEASVFESG-GRPVTRSATVPV-HPADFY 600
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 349 LFLKAD--SHFRHGIPFFVKVRLVNIKGDPIPNQQV---FIK----------AQGAGFTNAT-----------TTDQHGL 402
Cdd:COG2373 601 VGIRLPlfDGDPEGAPATFEVVAVDPDGKPVAGKGLkveLYReewryvwyksDDGGWRYESQekeepvaegtlTTGADGP 680
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 403 AKFSIDTSGISRYILnikvyhkeenscihsscTAERHAEAHHTAYAVY-----------------SLSK-SYIYLDTeAG 464
Cdd:COG2373 681 ASLSLTPVEWGRYRL-----------------EVKDPDGGLATSVRFYaggnaswgaerpdrlelSLDKeSYKPGET-AK 742
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 465 VLpcnqshtVQAHFilKGQVLgvlpqivfhylVMAQGS-ILQTgnHTHQVEPGESPVqgnfalEIPVEFSMVPMAkmliY 543
Cdd:COG2373 743 LL-------IQSPF--AGRAL-----------VTVERDgVLET--QWVDVKGGGTTV------EIPVTEDWAPNA----Y 790
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 544 ---TILPDGEVIAD--------SVKFQVEKCLRH-EVHLSfSPSQSLPASQTHMRVTASPQSlcG------LRAVDQSVL 605
Cdd:COG2373 791 vsaTLVRPGDSTANdmparaygVAPLPVDPPARRlKVELT-APEKLRPGETLTVTVKVKGAA--GkaaevtLAAVDEGIL 867
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 606 LLKPEAelSPSliydlpgmqeskfiPRSHYpfededgcviYRPRVIGKLTYSVpygrekdvfrymrdtgltaltnlklrt 685
Cdd:COG2373 868 NLTGYK--TPD--------------PLDFF----------YGKRALGVETRDL--------------------------- 894
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 686 fcfdYDMVPLAVPAARSSDLFNSDGYGSwrsarvKSLPPKKAphkdpppkdpvietiRNYFPETWVWD-LVTVNSSGAAE 764
Cdd:COG2373 895 ----YGRLIGAFGGAAGALRSGGDGALG------RGGNPKPP---------------RKRFKPVALFSgPVKTDADGKAT 949
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 765 LEMTVPDTITEWKAGALCLSnDTGLGlSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMAVQLEASPD 844
Cdd:COG2373 950 VSFDLPDFNGTLRVMAVAWS-DDRFG-SAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGG 1027
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 845 FTavPVGNDQDSYCLGANGRHTSSWLVTPKSLGNVNFSVSAEAQqspepcgsevatvpetGRKDTVVKVLIVEPEGIKRE 924
Cdd:COG2373 1028 LT--LEGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGG----------------GESDAREVELPVRPANPLVT 1089
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 925 HTFSSLLcasDAELSETLSLLLPPTVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPSIYVLKyLNET 1004
Cdd:COG2373 1090 RATSGVL---APGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEA 1165
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1005 QQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGdhdGKGQGNTWLTAFVLKSFSQAQAF-IFIDESHITDAFTWLSH 1083
Cdd:COG2373 1166 LGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWP---GGSESDPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRN 1242
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1084 QQKDSGcfrssgslfnnAMKGGVDDEITLSAYI--TVALLESLPPDThpvvskalscLESSWENIEQGGNGsfvYTKALM 1161
Cdd:COG2373 1243 YLRNPW-----------EIEYDDAYRLAVRAYAlyVLARAGKADLGD----------LRYLYDRRKDALSP---LAKAQL 1298
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1162 AYAFALAGNQEKRNEILKSLDKEAIKEDNSIHWerpqkpmksaRSLYkpqasSAEVEMNAYVIlaRLTAQSAPSPKDLAl 1241
Cdd:COG2373 1299 AAALALLGDKARAEELLAAALARLRETGARDYW----------YGDY-----GSPLRDQALAL--ALLAELGPDAPLAP- 1360
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1242 smGTIKWLTKQQNSrGGFSSTQDTVVALDALSKYGAATfsKSQKTPSVTVQSSGsffQKFQVDNSNRLLLQQVSLPDI-P 1320
Cdd:COG2373 1361 --KLARWLAKALKS-GRWLSTQETAWALLALAAYARAA--GASPDFTATLTLDG---KTLPLTGRGPLARVTLPAAELlA 1432
|
1290 1300 1310
....*....|....*....|....*....|.
gi 406035338 1321 GNYTVSVSGEGCVYAQTMLRYNLPLEKQQPA 1351
Cdd:COG2373 1433 GPLTITNTGDGPLYYTLTLSGYPAEGPPPAA 1463
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1385-1475 |
1.06e-33 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 124.99 E-value: 1.06e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 1385 PASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNN-VLLYLDQVTNQTLSFSFIIQQDIPVKNLQPAIVKVYDY 1463
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDDGkVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 406035338 1464 YETDEVAFAEYS 1475
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
457-607 |
4.23e-30 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 116.68 E-value: 4.23e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 457 IYLDTEAGVLPCNQSHTVQAHFILKGQVlgvlPQIVFHYLVMAQGSILQTGNHTHQVEpgespvqgnfaLEIPVEFSMVP 536
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTV----ERDGFTYLVLSKGQIVVVGRGGVTTS-----------FSLPVTAEMAP 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 406035338 537 MAKMLIYTI---LPDGEVIADSVKFQVEKCLRHEVHLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLL 607
Cdd:pfam07703 66 SARVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
348-443 |
1.37e-29 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 113.50 E-value: 1.37e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 348 FLFLKADSHFRHGIPFFVKVRLVNIKGDPIPNQQVFIKAQGAGFTNATTTDQHGLAKFSIDTSGISRyILNIKVYHKEEN 427
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPGNAA-SLSITVKTKDPD 79
|
90
....*....|....*.
gi 406035338 428 SCIHSSCTAERHAEAH 443
Cdd:pfam17789 80 LCPEHQALAEMYAEAY 95
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
223-309 |
1.11e-23 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 96.19 E-value: 1.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 223 EFVLPRFGVDVKVPNAISVYDEIISVTACATYTYGKPVPGRVKISLCHgnpsfRSQTKSACKEEDS-ELDNNGCSTQEVN 301
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCL-----KDDSKRKCFESFSkELDKDGCGSASLS 75
|
....*...
gi 406035338 302 ITEFRLKE 309
Cdd:pfam17791 76 TEEFQLTF 83
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
129-221 |
2.54e-20 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 86.99 E-value: 2.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 406035338 129 VFVQTDKPVYKPGQSVKFRIVSMDKNLHPLNELFPLAYIEDPKINRIMQWQDIKTENGLKQLSFSLSAEPIQGPYKIVIL 208
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90
....*....|....
gi 406035338 209 K-QSGVKEEHSFTV 221
Cdd:pfam01835 82 DgAGGSLGSGSFRV 95
|
|
| |
