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Conserved domains on  [gi|118402582|ref|NP_001246|]
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cell division cycle protein 20 homolog [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
190-471 1.21e-53

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.89  E-value: 1.21e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 190 VDWSS-GNVLAVA-LDNSVYLWSASSGDILQLLqmEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSH 267
Cdd:COG2319  126 VAFSPdGKTLASGsADGTVRLWDLATGKLLRTL--TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 268 SARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHhVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggw 345
Cdd:COG2319  204 TGAVRSVAFspDGKLLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE--- 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 346 vPLQTFTQHQGAVKAVAWCPwQSNVLATGGgtSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHgfAQNQ 424
Cdd:COG2319  280 -LLRTLTGHSGGVNSVAFSP-DGKLLASGS--DDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGS--DDGT 353

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 118402582 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471
Cdd:COG2319  354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
190-471 1.21e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.89  E-value: 1.21e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 190 VDWSS-GNVLAVA-LDNSVYLWSASSGDILQLLqmEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSH 267
Cdd:COG2319  126 VAFSPdGKTLASGsADGTVRLWDLATGKLLRTL--TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 268 SARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHhVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggw 345
Cdd:COG2319  204 TGAVRSVAFspDGKLLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE--- 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 346 vPLQTFTQHQGAVKAVAWCPwQSNVLATGGgtSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHgfAQNQ 424
Cdd:COG2319  280 -LLRTLTGHSGGVNSVAFSP-DGKLLASGS--DDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGS--DDGT 353

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 118402582 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471
Cdd:COG2319  354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-471 1.98e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.67  E-value: 1.98e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 190 VDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQmeQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSH 267
Cdd:cd00200   15 VAFSpDGKLLATGsGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 268 SARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHhVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggw 345
Cdd:cd00200   93 TSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 346 vPLQTFTQHQGAVKAVAWCPwQSNVLATGGgtSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHgfAQNQ 424
Cdd:cd00200  169 -CVATLTGHTGEVNSVAFSP-DGEKLLSSS--SDGTIKLWDLSTGKCLGTLRGHENgVNSVAFSPDGYLLASGS--EDGT 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 118402582 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471
Cdd:cd00200  243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 302-336 6.17e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 6.17e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 118402582   302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
302-336 5.68e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 5.68e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 118402582  302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 229-418 3.03e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 3.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 229 ISSVAWikeGNYLAVGTSSAE----VQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSG------------- 288
Cdd:PLN00181 535 LSGICW---NSYIKSQVASSNfegvVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGsvklwsinqgvsi 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 289 -----------------------------HIHHHDVRVAEHHVATLSGHSQEVCGLRWApDGRHLASGGNDNLVNVWPSA 339
Cdd:PLN00181 612 gtiktkaniccvqfpsesgrslafgsadhKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 340 PGEGGW--VPLQTFTQHQGaVKAVAWCPWQSNVLATGGGTSDRHI------------RIWNVCSGACLSAVDAHSQVCSI 405
Cdd:PLN00181 691 MSISGIneTPLHSFMGHTN-VKNFVGLSVSDGYIATGSETNEVFVyhkafpmpvlsyKFKTIDPVSGLEVDDASQFISSV 769

                        250
                 ....*....|...
gi 118402582 406 LWSPHYKELISGH 418
Cdd:PLN00181 770 CWRGQSSTLVAAN 782
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
190-471 1.21e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.89  E-value: 1.21e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 190 VDWSS-GNVLAVA-LDNSVYLWSASSGDILQLLqmEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSH 267
Cdd:COG2319  126 VAFSPdGKTLASGsADGTVRLWDLATGKLLRTL--TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 268 SARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHhVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggw 345
Cdd:COG2319  204 TGAVRSVAFspDGKLLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE--- 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 346 vPLQTFTQHQGAVKAVAWCPwQSNVLATGGgtSDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHgfAQNQ 424
Cdd:COG2319  280 -LLRTLTGHSGGVNSVAFSP-DGKLLASGS--DDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGS--DDGT 353

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 118402582 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471
Cdd:COG2319  354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
197-471 3.48e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.03  E-value: 3.48e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 197 VLAVALDNSVYLWSASSGDILQLLQmeQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW 276
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLT--GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 277 --NSYILSSGSRSGHIHHHDVRVAEhHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggwvPLQTFTQH 354
Cdd:COG2319  171 spDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK----LLRTLTGH 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 355 QGAVKAVAWCPwQSNVLATGGGtsDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHgfAQNQLVIWKYPTM 433
Cdd:COG2319  246 SGSVRSVAFSP-DGRLLASGSA--DGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGS--DDGTVRLWDLATG 320

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 118402582 434 AKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-471 1.98e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.67  E-value: 1.98e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 190 VDWS-SGNVLAVA-LDNSVYLWSASSGDILQLLQmeQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSH 267
Cdd:cd00200   15 VAFSpDGKLLATGsGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 268 SARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHhVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggw 345
Cdd:cd00200   93 TSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 346 vPLQTFTQHQGAVKAVAWCPwQSNVLATGGgtSDRHIRIWNVCSGACLSAVDAHSQ-VCSILWSPHYKELISGHgfAQNQ 424
Cdd:cd00200  169 -CVATLTGHTGEVNSVAFSP-DGEKLLSSS--SDGTIKLWDLSTGKCLGTLRGHENgVNSVAFSPDGYLLASGS--EDGT 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 118402582 425 LVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471
Cdd:cd00200  243 IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
189-470 2.03e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.23  E-value: 2.03e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 189 LVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHS 268
Cdd:COG2319   41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 269 ARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEhHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggwv 346
Cdd:COG2319  121 GAVRSVAFspDGKTLASGSADGTVRLWDLATGK-LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK---- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 347 PLQTFTQHQGAVKAVAWCPwQSNVLATGGGtsDRHIRIWNVCSGACLSAVDAHS-QVCSILWSPHYKELISGHgfAQNQL 425
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSP-DGKLLASGSA--DGTVRLWDLATGKLLRTLTGHSgSVRSVAFSPDGRLLASGS--ADGTV 270

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 118402582 426 VIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
Cdd:COG2319  271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
190-387 2.48e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.50  E-value: 2.48e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 190 VDWSS-GNVLAVA-LDNSVYLWSASSGDILQLLqmEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSH 267
Cdd:COG2319  210 VAFSPdGKLLASGsADGTVRLWDLATGKLLRTL--TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 268 SARVGSLSW--NSYILSSGSRSGHIHHHDVRVAEHhVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggw 345
Cdd:COG2319  288 SGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKL-LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--- 363

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 118402582 346 vPLQTFTQHQGAVKAVAWCPwQSNVLATGGGtsDRHIRIWNV 387
Cdd:COG2319  364 -LLRTLTGHTGAVTSVAFSP-DGRTLASGSA--DGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 301-470 1.63e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.63e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 301 HVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggwvPLQTFTQHQGAVKAVAWCPWqSNVLATGGgtSDR 380
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE----LLRTLKGHTGPVRDVAASAD-GTYLASGS--SDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 381 HIRIWNVCSGACLSAVDAHSQ-VCSILWSPHyKELISGhGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVA 459
Cdd:cd00200   74 TIRLWDLETGECVRTLTGHTSyVSSVAFSPD-GRILSS-SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVA 151

                        170
                 ....*....|.
gi 118402582 460 SAAADETLRLW 470
Cdd:cd00200  152 SSSQDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
238-470 1.52e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 1.52e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 238 GNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHH-HDVRVAEHHVATLSGHSQEVCGLR 316
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLlLLDAAAGALLATLLGHTAAVLSVA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 317 WAPDGRHLASGGNDNLVNVWPSAPGEggwvPLQTFTQHQGAVKAVAWCPwQSNVLATGGgtSDRHIRIWNVCSGACLSAV 396
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGL----LLRTLTGHTGAVRSVAFSP-DGKTLASGS--ADGTVRLWDLATGKLLRTL 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 118402582 397 DAHSQ-VCSILWSPHYKELISGHGfaQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
Cdd:COG2319  159 TGHSGaVTSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
316-471 1.49e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 1.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 316 RWAPDGRHLASGGNDNLVNVWPSAPGeggwVPLQTFTQHQGAVKAVAWCPWQSNVLATGGgtsDRHIRIWNVCSGACLSA 395
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALG----ALLLLLLGLAAAVASLAASPDGARLAAGAG---DLTLLLLDAAAGALLAT 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 118402582 396 VDAH-SQVCSILWSPHYKELISGhgFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471
Cdd:COG2319   74 LLGHtAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 302-336 6.17e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 6.17e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 118402582   302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
302-336 5.68e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 5.68e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 118402582  302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW 336
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 432-470 1.46e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.46e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 118402582   432 TMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 345-386 2.96e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.96e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 118402582   345 WVPLQTFTQHQGAVKAVAWCPwQSNVLATGGgtSDRHIRIWN 386
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSP-DGKYLASGS--DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
436-470 5.06e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 5.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 118402582  436 VAELKGHTSRVLSLTMSPDGATVASAAADETLRLW 470
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 229-418 3.03e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 3.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 229 ISSVAWikeGNYLAVGTSSAE----VQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSG------------- 288
Cdd:PLN00181 535 LSGICW---NSYIKSQVASSNfegvVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGsvklwsinqgvsi 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 289 -----------------------------HIHHHDVRVAEHHVATLSGHSQEVCGLRWApDGRHLASGGNDNLVNVWPSA 339
Cdd:PLN00181 612 gtiktkaniccvqfpsesgrslafgsadhKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 340 PGEGGW--VPLQTFTQHQGaVKAVAWCPWQSNVLATGGGTSDRHI------------RIWNVCSGACLSAVDAHSQVCSI 405
Cdd:PLN00181 691 MSISGIneTPLHSFMGHTN-VKNFVGLSVSDGYIATGSETNEVFVyhkafpmpvlsyKFKTIDPVSGLEVDDASQFISSV 769

                        250
                 ....*....|...
gi 118402582 406 LWSPHYKELISGH 418
Cdd:PLN00181 770 CWRGQSSTLVAAN 782
WD40 COG2319
WD40 repeat [General function prediction only];
190-256 8.87e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 8.87e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 118402582 190 VDWSS-GNVLAVA-LDNSVYLWSASSGDILQLLQmeQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQ 256
Cdd:COG2319  336 VAFSPdGKTLASGsDDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
345-386 1.18e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 118402582  345 WVPLQTFTQHQGAVKAVAWCPwQSNVLATGGgtSDRHIRIWN 386
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGS--DDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 436-482 1.65e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 1.65e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 118402582 436 VAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRRE 482
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK 48
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 198-278 1.00e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582  198 LAVAL-DNSVYLwSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSW 276
Cdd:pfam12894  10 IALATeDGELLL-HRLNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88


                  ..
gi 118402582  277 NS 278
Cdd:pfam12894  89 GE 90
WD40 COG2319
WD40 repeat [General function prediction only];
366-472 1.16e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 366 WQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGfaQNQLVIWKYPTMAKVAELKGHTSR 445
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAG--DLTLLLLDAAAGALLATLLGHTAA 80

                         90       100
                 ....*....|....*....|....*..
gi 118402582 446 VLSLTMSPDGATVASAAADETLRLWRC 472
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDL 107
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 274-364 4.98e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 4.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582  274 LSWNSY--ILSSGSRSGHIHHHdvRVAEHHVATLSG--HSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEggwvPLQ 349
Cdd:pfam12894   1 MSWCPTmdLIALATEDGELLLH--RLNWQRVWTLSPdkEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGK----IVH 74

                          90
                  ....*....|....*
gi 118402582  350 TFTQHQGAVKAVAWC 364
Cdd:pfam12894  75 HFSAGSDLITCLGWG 89
PTZ00421 PTZ00421
coronin; Provisional
 301-435 6.27e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.11  E-value: 6.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118402582 301 HVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVNVWPSAPGEGGwvplQTFTQHQGAVKAVAWcPWQSNVLATggGTSD 379
Cdd:PTZ00421 117 PIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAV----EVIKCHSDQITSLEW-NLDGSLLCT--TSKD 189

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 118402582 380 RHIRIWNVCSGACLSAVDAH----SQVCsiLWSPHyKELISGHGFA---QNQLVIWKYPTMAK 435
Cdd:PTZ00421 190 KKLNIIDPRDGTIVSSVEAHasakSQRC--LWAKR-KDLIITLGCSksqQRQIMLWDTRKMAS 249
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 369-406 8.64e-03

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 38.38  E-value: 8.64e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 118402582 369 NVLATGGgtSDRHIRIWNVCSGACLSAVDAHSQVCSIL 406
Cdd:cd22850  290 PYLASGG--LDRYLRVFDIETRELLAKVYLGKQILTVV 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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