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Conserved domains on  [gi|1371543690|ref|NP_001236788|]
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cytochrome b5 [Glycine max]

Protein Classification

cytochrome b5-like heme/steroid binding domain-containing protein( domain architecture ID 10445738)

cytochrome b5-like heme/steroid binding domain-containing protein such as cytochrome b5, a membrane-bound hemoprotein that functions as an electron carrier for several membrane-bound oxygenases and Arabidopsis thaliana steroid-binding proteins

CATH:  3.10.120.10
Gene Ontology:  GO:0097159|GO:0016020
PubMed:  12537557|7893819

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 10-82 3.81e-34

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


:

Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 113.49  E-value: 3.81e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1371543690  10 TLAEVSQHNNAKDCWLVIHGKVYNVTKFLEDHPGGDEVLLSSTGKDATNDFEDIGHSTSAV-AMMDEFYVGDID 82
Cdd:pfam00173   1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDAAeKLLKKYRIGELA 74
GH20_hexosaminidase super family cl02948
Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of ...
 64-122 2.02e-04

Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. These enzymes are broadly distributed in microorganisms, plants and animals, and play roles in various key physiological and pathological processes. These processes include cell structural integrity, energy storage, cellular signaling, fertilization, pathogen defense, viral penetration, the development of carcinomas, inflammatory events and lysosomal storage disorders. The GH20 enzymes include the eukaryotic beta-N-acetylhexosaminidases A and B, the bacterial chitobiases, dispersin B, and lacto-N-biosidase. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by the solvent or the enzyme, but by the substrate itself.


The actual alignment was detected with superfamily member pfam00728:

Pssm-ID: 445966  Cd Length: 344  Bit Score: 39.59  E-value: 2.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1371543690  64 GHSTSAVAMMDEFYVGDIDTSTIPSKVKYTPPKQPHYNQDKTPEFIIRILQFLVPLFIL 122
Cdd:pfam00728 102 GHARAALAAYPELGCGCGADSPWVSVQWGPPEGQLNPGNEKTYTFLDNVFDEVADLFPS 160
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 10-82 3.81e-34

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 113.49  E-value: 3.81e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1371543690  10 TLAEVSQHNNAKDCWLVIHGKVYNVTKFLEDHPGGDEVLLSSTGKDATNDFEDIGHSTSAV-AMMDEFYVGDID 82
Cdd:pfam00173   1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDAAeKLLKKYRIGELA 74
PLN02252 PLN02252
nitrate reductase [NADPH]
 7-95 1.68e-28

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 109.00  E-value: 1.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371543690   7 KVFTLAEVSQHNNAKDCWLVIHGKVYNVTKFLEDHPGGDEVLLSSTGKDATNDFEDIgHSTSAVAMMDEFYVGDIDTSTI 86
Cdd:PLN02252  518 KQYTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKDHPGGADSILINAGTDCTEEFDAI-HSDKAKKMLEDYRIGELVTTGA 596


                  ....*....
gi 1371543690  87 PSKVKYTPP 95
Cdd:PLN02252  597 AASSSASSH 605
CYB5 COG5274
Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport ...
 4-80 1.38e-24

Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism];


Pssm-ID: 444085 [Multi-domain]  Cd Length: 93  Bit Score: 90.10  E-value: 1.38e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1371543690   4 ERNKVFTLAEVSQHNNAKDCWLVIHGKVYNVTKFLEDHPGGDEVLLSSTGKDATNDFEDI-GHSTSAVAMMDEFYVGD 80
Cdd:COG5274    13 APEKTYTLAEVATHNTLSDCWMAIDGNVYDLTEYIPKHPGGEAVILRWCGKDATEAFNTKhPHSPKAERLLESYRIGR 90
Glyco_hydro_20 pfam00728
Glycosyl hydrolase family 20, catalytic domain; This domain has a TIM barrel fold.
 64-122 2.02e-04

Glycosyl hydrolase family 20, catalytic domain; This domain has a TIM barrel fold.


Pssm-ID: 425840  Cd Length: 344  Bit Score: 39.59  E-value: 2.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1371543690  64 GHSTSAVAMMDEFYVGDIDTSTIPSKVKYTPPKQPHYNQDKTPEFIIRILQFLVPLFIL 122
Cdd:pfam00728 102 GHARAALAAYPELGCGCGADSPWVSVQWGPPEGQLNPGNEKTYTFLDNVFDEVADLFPS 160
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 10-82 3.81e-34

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 113.49  E-value: 3.81e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1371543690  10 TLAEVSQHNNAKDCWLVIHGKVYNVTKFLEDHPGGDEVLLSSTGKDATNDFEDIGHSTSAV-AMMDEFYVGDID 82
Cdd:pfam00173   1 TLEELSKHNGDGDCWVAINGKVYDVTKFLKEHPGGEDVILSAAGKDATDAFEAIGHSEDAAeKLLKKYRIGELA 74
PLN02252 PLN02252
nitrate reductase [NADPH]
 7-95 1.68e-28

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 109.00  E-value: 1.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371543690   7 KVFTLAEVSQHNNAKDCWLVIHGKVYNVTKFLEDHPGGDEVLLSSTGKDATNDFEDIgHSTSAVAMMDEFYVGDIDTSTI 86
Cdd:PLN02252  518 KQYTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKDHPGGADSILINAGTDCTEEFDAI-HSDKAKKMLEDYRIGELVTTGA 596


                  ....*....
gi 1371543690  87 PSKVKYTPP 95
Cdd:PLN02252  597 AASSSASSH 605
CYB5 COG5274
Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport ...
 4-80 1.38e-24

Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism];


Pssm-ID: 444085 [Multi-domain]  Cd Length: 93  Bit Score: 90.10  E-value: 1.38e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1371543690   4 ERNKVFTLAEVSQHNNAKDCWLVIHGKVYNVTKFLEDHPGGDEVLLSSTGKDATNDFEDI-GHSTSAVAMMDEFYVGD 80
Cdd:COG5274    13 APEKTYTLAEVATHNTLSDCWMAIDGNVYDLTEYIPKHPGGEAVILRWCGKDATEAFNTKhPHSPKAERLLESYRIGR 90
PLN03198 PLN03198
delta6-acyl-lipid desaturase; Provisional
 4-82 5.00e-17

delta6-acyl-lipid desaturase; Provisional


Pssm-ID: 178739 [Multi-domain]  Cd Length: 526  Bit Score: 75.88  E-value: 5.00e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1371543690   4 ERNKVFTLAEVSQHNNAKDCWLVIHGKVYNVTKFLEDHPGGdEVLLSSTGKDATNDFEDIgHSTSAVAMMDEFYVGDID 82
Cdd:PLN03198  101 KKSKSHLLSEVAAHNKPNDCWIVIKNKVYDVSDFAAEHPGG-SVISTYFGRDGTDAFSSF-HAASTWKILQDFYIGDVD 177
PLN03199 PLN03199
delta6-acyl-lipid desaturase-like protein; Provisional
 4-97 2.80e-12

delta6-acyl-lipid desaturase-like protein; Provisional


Pssm-ID: 178740 [Multi-domain]  Cd Length: 485  Bit Score: 62.36  E-value: 2.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371543690   4 ERNKVFTLAEVSQHNNAKDCWLVIHGKVYNVTKFlEDHPGGdEVLLSSTGKDATNDFEDIgHSTSAVAMMDEFYVGDIdt 83
Cdd:PLN03199   21 EKPQKISWQEVKKHASPDDAWIIHQNKVYDVSNW-HDHPGG-AVIFTHAGDDMTDIFAAF-HAPGSQALMKKFYIGDL-- 95

                          90
                  ....*....|....
gi 1371543690  84 stIPSKVKYTPPKQ 97
Cdd:PLN03199   96 --IPESTEHKDPQQ 107
Glyco_hydro_20 pfam00728
Glycosyl hydrolase family 20, catalytic domain; This domain has a TIM barrel fold.
 64-122 2.02e-04

Glycosyl hydrolase family 20, catalytic domain; This domain has a TIM barrel fold.


Pssm-ID: 425840  Cd Length: 344  Bit Score: 39.59  E-value: 2.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1371543690  64 GHSTSAVAMMDEFYVGDIDTSTIPSKVKYTPPKQPHYNQDKTPEFIIRILQFLVPLFIL 122
Cdd:pfam00728 102 GHARAALAAYPELGCGCGADSPWVSVQWGPPEGQLNPGNEKTYTFLDNVFDEVADLFPS 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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