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Conserved domains on  [gi|351721324|ref|NP_001234930|]
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protein SET isoform 4 [Homo sapiens]

Protein Classification

NAP domain-containing protein( domain architecture ID 10469758)

NAP domain-containing protein similar to Saccharomyces cerevisiae nucleosome assembly protein (NAP) and Homo sapiens protein SET

CATH:  3.30.1120.90
Gene Ontology:  GO:0042393|GO:0003682|GO:0006334
SCOP:  4003454

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
NAP pfam00956
Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the ...
21-210 9.18e-34

Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.


:

Pssm-ID: 460010  Cd Length: 203  Bit Score: 121.12  E-value: 9.18e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324   21 IEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQkrseliakipnfwvttfvNHPQVSALLGEEDEEALHYLTRVE 100
Cdd:pfam00956   3 VNALKKLQKEHEKLEAEFQEEVHELEKKYAALYQPLYK------------------NLPLLSEMITERDEPALKHLKDIK 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324  101 VTEFEDIKsGYRIDFYFDENPYFENKVLSKEFHLNESGDP----SSKSTEIKWKSGKDLTKRS-SQTQNKASRK-----R 170
Cdd:pfam00956  65 IEYPLDEP-GFTLEFHFAPNPYFTNTVLTKTYYYQDEPDGpeiiKAEGTEIDWKEGKNVTVKTvKKKQRNKGTGqtrtvT 143
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 351721324  171 QHEEPESFFTWFTDHSDAGAD------------------ELGEVIKDDIWPNPLQYYL 210
Cdd:pfam00956 144 KTVPTESFFNFFSPPEVPEDEdeddeedeeleerleldyEIGEDIKDKIIPRAVLYFT 201
 
Name Accession Description Interval E-value
NAP pfam00956
Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the ...
21-210 9.18e-34

Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.


Pssm-ID: 460010  Cd Length: 203  Bit Score: 121.12  E-value: 9.18e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324   21 IEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQkrseliakipnfwvttfvNHPQVSALLGEEDEEALHYLTRVE 100
Cdd:pfam00956   3 VNALKKLQKEHEKLEAEFQEEVHELEKKYAALYQPLYK------------------NLPLLSEMITERDEPALKHLKDIK 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324  101 VTEFEDIKsGYRIDFYFDENPYFENKVLSKEFHLNESGDP----SSKSTEIKWKSGKDLTKRS-SQTQNKASRK-----R 170
Cdd:pfam00956  65 IEYPLDEP-GFTLEFHFAPNPYFTNTVLTKTYYYQDEPDGpeiiKAEGTEIDWKEGKNVTVKTvKKKQRNKGTGqtrtvT 143
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 351721324  171 QHEEPESFFTWFTDHSDAGAD------------------ELGEVIKDDIWPNPLQYYL 210
Cdd:pfam00956 144 KTVPTESFFNFFSPPEVPEDEdeddeedeeleerleldyEIGEDIKDKIIPRAVLYFT 201
PTZ00008 PTZ00008
(NAP-S) nucleosome assembly protein-S; Provisional
34-210 3.01e-26

(NAP-S) nucleosome assembly protein-S; Provisional


Pssm-ID: 185394  Cd Length: 185  Bit Score: 101.04  E-value: 3.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324  34 LNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLgEEDEEALHYLTRVEVTEFEDIKSGYRI 113
Cdd:PTZ00008   3 LDEECAKEQMNIQRQFDEKKKPLFEKRQEIIEKIPGFWADTLRRHPALSYLV-PEDIDILEHLKKIDLEDNLDNNGSYKI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324 114 DFYFDE--NPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDltkRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGAD 191
Cdd:PTZ00008  82 TLIFDEkaKEFMEPLVLVKHVIFKNNQEKVVEVTKIKWKEGKS---PIAAAEKARSDLDDECIVWSIFEWFTEEEWQDRP 158
                        170
                 ....*....|....*....
gi 351721324 192 ELGEVIKDDIWPNPLQYYL 210
Cdd:PTZ00008 159 DVGEIIRREIWHAPLLYYL 177
GIM5 COG1730
Prefoldin subunit 5 [Posttranslational modification, protein turnover, chaperones];
14-54 2.58e-03

Prefoldin subunit 5 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441336 [Multi-domain]  Cd Length: 145  Bit Score: 37.19  E-value: 2.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 351721324  14 EKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQ 54
Cdd:COG1730   90 EKDLDEAIEYLEKRIKELEKALEKLEEELQELEEEYEELEQ 130
 
Name Accession Description Interval E-value
NAP pfam00956
Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the ...
21-210 9.18e-34

Nucleosome assembly protein (NAP); NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.


Pssm-ID: 460010  Cd Length: 203  Bit Score: 121.12  E-value: 9.18e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324   21 IEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQkrseliakipnfwvttfvNHPQVSALLGEEDEEALHYLTRVE 100
Cdd:pfam00956   3 VNALKKLQKEHEKLEAEFQEEVHELEKKYAALYQPLYK------------------NLPLLSEMITERDEPALKHLKDIK 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324  101 VTEFEDIKsGYRIDFYFDENPYFENKVLSKEFHLNESGDP----SSKSTEIKWKSGKDLTKRS-SQTQNKASRK-----R 170
Cdd:pfam00956  65 IEYPLDEP-GFTLEFHFAPNPYFTNTVLTKTYYYQDEPDGpeiiKAEGTEIDWKEGKNVTVKTvKKKQRNKGTGqtrtvT 143
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 351721324  171 QHEEPESFFTWFTDHSDAGAD------------------ELGEVIKDDIWPNPLQYYL 210
Cdd:pfam00956 144 KTVPTESFFNFFSPPEVPEDEdeddeedeeleerleldyEIGEDIKDKIIPRAVLYFT 201
PTZ00008 PTZ00008
(NAP-S) nucleosome assembly protein-S; Provisional
34-210 3.01e-26

(NAP-S) nucleosome assembly protein-S; Provisional


Pssm-ID: 185394  Cd Length: 185  Bit Score: 101.04  E-value: 3.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324  34 LNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLgEEDEEALHYLTRVEVTEFEDIKSGYRI 113
Cdd:PTZ00008   3 LDEECAKEQMNIQRQFDEKKKPLFEKRQEIIEKIPGFWADTLRRHPALSYLV-PEDIDILEHLKKIDLEDNLDNNGSYKI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324 114 DFYFDE--NPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDltkRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGAD 191
Cdd:PTZ00008  82 TLIFDEkaKEFMEPLVLVKHVIFKNNQEKVVEVTKIKWKEGKS---PIAAAEKARSDLDDECIVWSIFEWFTEEEWQDRP 158
                        170
                 ....*....|....*....
gi 351721324 192 ELGEVIKDDIWPNPLQYYL 210
Cdd:PTZ00008 159 DVGEIIRREIWHAPLLYYL 177
PTZ00007 PTZ00007
(NAP-L) nucleosome assembly protein -L; Provisional
16-254 1.49e-20

(NAP-L) nucleosome assembly protein -L; Provisional


Pssm-ID: 240226 [Multi-domain]  Cd Length: 337  Bit Score: 89.08  E-value: 1.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324  16 EQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAK----------IPNFWVTTFVNHPQVSALL 85
Cdd:PTZ00007  38 EQRETLKKLQLLQKEFDDLEVEYNAELRKLRSKYEDLYNPIYDKRKEALVQnggaeigtpgLPQFWLTAMKNNNTLGSAI 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324  86 GEEDEEALHYLTRVEVTEFEDIK-SGYRIDFYFDENPYFENKVLSKEFHL------NESGDPSSKSTEIKWKSGKDLTKR 158
Cdd:PTZ00007 118 EEHDEPILSYLSDISCEYTEPNKqEGFILVFTFAPNPFFSNTVLTKTYHMkvldgdDEPLLSNTVATEIDWKQGKDVTKK 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351721324 159 --SSQTQNKASR----KRQHEEPESFFTWFTDHSDAGADEL---------------------GEVIKDDIWPNPLQYYLV 211
Cdd:PTZ00007 198 vvTKKQRHKKTKetrtVTETVDRESFFNFFTSHEVPSDEELekmskheiaelemivetdyeiGITIRDKLIPYAVYWFLG 277
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 351721324 212 PDMDDEEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDE 254
Cdd:PTZ00007 278 EAIDEDSDYSSDEDDDDYDSYDSSDSASSDSNSDVDTNEEDDR 320
GIM5 COG1730
Prefoldin subunit 5 [Posttranslational modification, protein turnover, chaperones];
14-54 2.58e-03

Prefoldin subunit 5 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441336 [Multi-domain]  Cd Length: 145  Bit Score: 37.19  E-value: 2.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 351721324  14 EKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQ 54
Cdd:COG1730   90 EKDLDEAIEYLEKRIKELEKALEKLEEELQELEEEYEELEQ 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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