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Conserved domains on  [gi|339717806|ref|NP_001229930|]
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germ cell-less homolog 1 family member [Mus musculus]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 1000760)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 80-188 1.56e-42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18305:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 115  Bit Score: 147.04  E-value: 1.56e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  80 YQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLII--KNIDTRSLHFVFGALYTDaDLSI 157
Cdd:cd18305    6 YQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIpdDNITVEALNVVFGSLYRD-EIEI 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 339717806 158 TPLEVPQVLAAACLLRVDRVIQQCEGIMKET 188
Cdd:cd18305   85 KPSRVVSILAAATLLQLDGLIQQCSEVMKET 115
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 189-266 1.06e-25

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18495:

Pssm-ID: 475122  Cd Length: 78  Bit Score: 100.01  E-value: 1.06e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 339717806 189 INRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFL 266
Cdd:cd18495    1 ISAKTVCSYYEAACMYGLTEVKKKCLEWLLRNLMTSQNVTLLRELSIELMEQLIASPNLFVMQVEMDVYTLLKKWLFL 78
 
Name Accession Description Interval E-value
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-188 1.56e-42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 147.04  E-value: 1.56e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  80 YQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLII--KNIDTRSLHFVFGALYTDaDLSI 157
Cdd:cd18305    6 YQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIpdDNITVEALNVVFGSLYRD-EIEI 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 339717806 158 TPLEVPQVLAAACLLRVDRVIQQCEGIMKET 188
Cdd:cd18305   85 KPSRVVSILAAATLLQLDGLIQQCSEVMKET 115
BACK_GCL cd18495
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein germ cell-less ...
 189-266 1.06e-25

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; The GCL protein is a nuclear envelope protein highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in Drosophila embryos. Both human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L) may function in spermatogenesis. They may also be substrate-specific adaptors of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350570  Cd Length: 78  Bit Score: 100.01  E-value: 1.06e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 339717806 189 INRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFL 266
Cdd:cd18495    1 ISAKTVCSYYEAACMYGLTEVKKKCLEWLLRNLMTSQNVTLLRELSIELMEQLIASPNLFVMQVEMDVYTLLKKWLFL 78
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 80-189 1.91e-12

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 63.43  E-value: 1.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806   80 YQNLFLDGHDSDIKIRALGKTWCLHKVFLC-QSGYFANILKGTWRESHhgVINLIIKNIDTRSLHFVFGALYTDAdlSIT 158
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAaCSPYFKALFSGQESESS--VSEITLDDVSPEDFEALLEFMYTGK--LIS 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 339717806  159 PLEVPQVLAAACLLRVDRVIQQCEGIMKETI 189
Cdd:pfam00651  77 EENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 91-189 7.94e-10

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 55.77  E-value: 7.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806    91 DIKIRALGKTWCLHKVFLCQ-SGYFANILKGTWRESHHGVINLIikNIDTRSLHFVFGALYTDaDLSITPLEVPQVLAAA 169
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAhSPYFKALFSSDFKESDKSEIYLD--DVSPEDFRALLNFLYTG-KLDLPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 339717806   170 CLLRVDRVIQQCEGIMKETI 189
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97
PHA03098 PHA03098
kelch-like protein; Provisional
 89-256 4.77e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 42.83  E-value: 4.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  89 DSDIKIRALGKTWCLHK-VFLCQSGYFANILKGtwreshHGVINLIIKNIDTRSLHFVFGALYTDAdLSITPLEVPQVLA 167
Cdd:PHA03098  11 DESIIIVNGGGIIKVHKiILSSSSEYFKKMFKN------NFKENEINLNIDYDSFNEVIKYIYTGK-INITSNNVKDILS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806 168 AACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVhpsvaLYKevDLKLMYL------L 241
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIEL-----IYN--DPDFIYLskneliK 156

                        170
                 ....*....|....*
gi 339717806 242 ALSSDLLVMQKEIDV 256
Cdd:PHA03098 157 ILSDDKLNVSSEDVV 171
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 194-264 7.60e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 36.17  E-value: 7.60e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 339717806   194 VCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLaLSSDLLVMQKEIDVYTTLKIWM 264
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLEL-LSSDDLNVSSEEEVFEAVLRWV 70
 
Name Accession Description Interval E-value
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-188 1.56e-42

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 147.04  E-value: 1.56e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  80 YQNLFLDGHDSDIKIRALGKTWCLHKVFLCQSGYFANILKGTWRESHHGVINLII--KNIDTRSLHFVFGALYTDaDLSI 157
Cdd:cd18305    6 YQTLFLNGENSDITICALGREWKLHKIYLCQSGYFASMFSGSWKESKETVINLEIpdDNITVEALNVVFGSLYRD-EIEI 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 339717806 158 TPLEVPQVLAAACLLRVDRVIQQCEGIMKET 188
Cdd:cd18305   85 KPSRVVSILAAATLLQLDGLIQQCSEVMKET 115
BACK_GCL cd18495
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein germ cell-less ...
 189-266 1.06e-25

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; The GCL protein is a nuclear envelope protein highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in Drosophila embryos. Both human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L) may function in spermatogenesis. They may also be substrate-specific adaptors of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350570  Cd Length: 78  Bit Score: 100.01  E-value: 1.06e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 339717806 189 INRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLALSSDLLVMQKEIDVYTTLKIWMFL 266
Cdd:cd18495    1 ISAKTVCSYYEAACMYGLTEVKKKCLEWLLRNLMTSQNVTLLRELSIELMEQLIASPNLFVMQVEMDVYTLLKKWLFL 78
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 80-189 1.91e-12

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 63.43  E-value: 1.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806   80 YQNLFLDGHDSDIKIRALGKTWCLHKVFLC-QSGYFANILKGTWRESHhgVINLIIKNIDTRSLHFVFGALYTDAdlSIT 158
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAaCSPYFKALFSGQESESS--VSEITLDDVSPEDFEALLEFMYTGK--LIS 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 339717806  159 PLEVPQVLAAACLLRVDRVIQQCEGIMKETI 189
Cdd:pfam00651  77 EENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_BTBD16 cd18291
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-197 5.30e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349600  Cd Length: 114  Bit Score: 59.77  E-value: 5.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  90 SDIKIRALGKTWCLHKVFLCQSGYFANILKGTwreshhgVINLIIKN--IDTRSLHFVFGALYtDADLSITPLEVPQVLA 167
Cdd:cd18291   13 PDVVLECLGSFWELHSPYLCKSETLAELLKPV-------TISLNINDplVTKEAFAVALGNLY-NSEVEVNVEDAVGVLA 84

                         90       100       110
                 ....*....|....*....|....*....|
gi 339717806 168 AACLLRVDRVIQQCEGIMKETINRNTVCSY 197
Cdd:cd18291   85 AAALLRFPTLFQKCVKVMISSISSSTVCKF 114
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-172 1.81e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 57.18  E-value: 1.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  90 SDIKIRALGKTWCLHKVFLC-QSGYFANILKGTWRESHHGVINliIKNIDTRSLHFVFGALYTDaDLSITPLEVPQVLAA 168
Cdd:cd18186    2 CDVTLVVGGREFPAHRAVLAaRSPYFRAMFSSGMKESSSSEIE--LDDVSPEAFEALLDYIYTG-ELELSEENVEELLAA 78


                 ....
gi 339717806 169 ACLL 172
Cdd:cd18186   79 ADKL 82
BACK_BTBD16 cd18492
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 16 (BTBD16); ...
 189-270 2.35e-10

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB-domain-containing Kelch-like protein. Its function remains unclear. BTBD16 SNPs may be bipolar disorder (BD) genetic susceptibility variants exhibiting genetic background-dependent effects.


Pssm-ID: 350567  Cd Length: 97  Bit Score: 57.30  E-value: 2.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806 189 INRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALY-KEVDLKLMYLLALSSDLLVMQkEIDVYTTLKIWMFLY 267
Cdd:cd18492    1 IKSSTVCKFHRAACKYKQESLATACERWLELNLVPQLSSQIYlRDLPLELLHKILKSPRLFTFN-EYSLYKTLCYWVFLQ 79


                 ...
gi 339717806 268 LNP 270
Cdd:cd18492   80 LNP 82
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 82-175 2.35e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 58.04  E-value: 2.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  82 NLFLDGHDSDIKIRALGKTWCLHKVFLC-QSGYFANILKGTWRESHHGVINLIIKNIDTRS--LHFVFGALyTDADLSIT 158
Cdd:cd18286   10 QLFLNGEDSDITIKVDGKTFKAHRCILCaRSSYFAAMLSGSWAESNSSEITLTGVSHAAVSfvLLFIYGGV-LDLPDDVN 88

                         90
                 ....*....|....*..
gi 339717806 159 PLEvpqVLAAACLLRVD 175
Cdd:cd18286   89 LGE---LLSLADMYGLD 102
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 91-189 7.94e-10

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 55.77  E-value: 7.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806    91 DIKIRALGKTWCLHKVFLCQ-SGYFANILKGTWRESHHGVINLIikNIDTRSLHFVFGALYTDaDLSITPLEVPQVLAAA 169
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAhSPYFKALFSSDFKESDKSEIYLD--DVSPEDFRALLNFLYTG-KLDLPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 339717806   170 CLLRVDRVIQQCEGIMKETI 189
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 80-195 7.30e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 48.64  E-value: 7.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  80 YQNLFLDGHDSDIKIRALGKTWCLHKVFL-CQSGYFANILKGTWRESHHGVINLiiKNIDTRSLHFVFGALYTdADLSIT 158
Cdd:cd18264   19 YQSLRAEGFLCDVVLEAEGNEFPAHRSLLaCSSDYFRALFKDYTQESKARVIHL--PVVSAAGLQRVLDFIYT-SWLSLS 95

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 339717806 159 PLEVPQVLAAACLLRVDRVIQQCEGIMKETINRNTVC 195
Cdd:cd18264   96 LDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCC 132
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-187 2.33e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 46.51  E-value: 2.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  91 DIKIRALGKTWCLHKVFL-CQSGYFANILKGTWRESHHGVINliIKNIDTRSLHFVFGALYTdADLSITPLEVPQVLAAA 169
Cdd:cd18238   17 DVTLKVGEKSIHCHRLVLaCVSPYFRAMFTSEMAESKQDSIT--IKDIDEEAVELLVDFAYT-GKLTLTVDNVQSLLYAA 93

                         90
                 ....*....|....*...
gi 339717806 170 CLLRVDRVIQQCEGIMKE 187
Cdd:cd18238   94 SLLQVEEVAKACCEFMKD 111
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-190 3.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 43.45  E-value: 3.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  90 SDIKIRALGKTWCLHKVFLCQ-SGYFANILKGTWRESHHGVINLiiKNIDTRSLHFVFGALYTdADLSITPLEVPQVLAA 168
Cdd:cd18270   27 TDIVLIVEGTEFPCHKMVLATcSSYFRAMFMSGLSESKQTHVHL--RNVDAATLQIIITYAYT-GNLAINDSTVEQLYET 103

                         90       100
                 ....*....|....*....|..
gi 339717806 169 ACLLRVDRVIQQCEGIMKETIN 190
Cdd:cd18270  104 ACFLQVEDVLQRCREYLIKKIN 125
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-189 4.68e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 43.16  E-value: 4.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  91 DIKIRALGKTWCLHKVFLCQSG-YFANILKGTWRESHHGVINliIKNIDTRSLHFVFGALYTdADLSITPLEVPQVLAAA 169
Cdd:cd18256   22 DVQLQVGMELFSVHRLVLAASSpYFAALFAGGMSESSKDVVQ--IHGVEPDIFHILLDFIYT-GVVEVTVSNVQELLVAA 98

                         90       100
                 ....*....|....*....|
gi 339717806 170 CLLRVDRVIQQCEGIMKETI 189
Cdd:cd18256   99 DMLQLTEVVEICCEFLKGQL 118
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-190 1.89e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 41.37  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  78 DAYQNLFLDGHDSDIKIRALGKTWCLHKVFLCQ-SGYFANILKGTWRESHHGviNLIIKNIDTRSLHFVFGALYTdADLS 156
Cdd:cd18236   13 NGLENLRLENSLTDVILCVDSQEFSCHRVVLAAaSNYFRAMFCNDLKEKYEE--KIIIKGVDAETMQILLDYTYT-SKVL 89

                         90       100       110
                 ....*....|....*....|....*....|....
gi 339717806 157 ITPLEVPQVLAAACLLRVDRVIQQCEGIMKETIN 190
Cdd:cd18236   90 ITKQNVQRVLEAASLFQFLRMVDACASFLTEALH 123
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 90-181 2.40e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 40.61  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  90 SDIKIRALGKTWCLHK-VFLCQSGYFANILKGtwrESHHGVINLII-KNIDTRSLHFVFGALYTdADLSITPLEVPQVLA 167
Cdd:cd18332   20 TDVTLLVGGTPLRAHKaVLIACSGFFYSIFSG---RVGEGVSVLTLpSGLEARGFQLLLDFMYT-SRLPLTPRTVPAVLA 95

                         90
                 ....*....|....
gi 339717806 168 AACLLRVDRVIQQC 181
Cdd:cd18332   96 AATYLQMEHVVETC 109
PHA03098 PHA03098
kelch-like protein; Provisional
 89-256 4.77e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 42.83  E-value: 4.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  89 DSDIKIRALGKTWCLHK-VFLCQSGYFANILKGtwreshHGVINLIIKNIDTRSLHFVFGALYTDAdLSITPLEVPQVLA 167
Cdd:PHA03098  11 DESIIIVNGGGIIKVHKiILSSSSEYFKKMFKN------NFKENEINLNIDYDSFNEVIKYIYTGK-INITSNNVKDILS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806 168 AACLLRVDRVIQQCEGIMKETINRNTVCSYYLAAETYRLKAVKTRCFEWLLCNLMVhpsvaLYKevDLKLMYL------L 241
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIEL-----IYN--DPDFIYLskneliK 156

                        170
                 ....*....|....*
gi 339717806 242 ALSSDLLVMQKEIDV 256
Cdd:PHA03098 157 ILSDDKLNVSSEDVV 171
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 91-192 9.68e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 39.03  E-value: 9.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  91 DIKIRALGKTWCLHKVFLCQS-GYFANILKGTWRESH------HGVINLIIKNIdtrsLHFVfgalYTdADLSITPLEVP 163
Cdd:cd18251   25 DVVLVVEGKPIEAHRILLAAScDYFRGMFAGGLREMQqtevliHGVSYNAMCKI----LDFI----YT-SELELSLDNVQ 95

                         90       100       110
                 ....*....|....*....|....*....|
gi 339717806 164 QVLAAACLLRVDRVIQ-QCEGIMKETINRN 192
Cdd:cd18251   96 ETLTAACQLQIPEVIGfCCDFLMSWVDNEN 125
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 78-182 2.85e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 37.88  E-value: 2.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  78 DAYQNLFLDGHDSDIKIR-ALGKTWCLHKVFLCQ-SGYFANILKGTWRESHHGVINLiiKNIDTRSLHFVFGALYTdADL 155
Cdd:cd18252   10 DAFRTFYLDGLFTDITLQcASGQIFHCHKAALAAcSSYFKVMFTADMKEKSNNVIKL--SGIDHDILEALVNYVYT-SQI 86

                         90       100
                 ....*....|....*....|....*..
gi 339717806 156 SITPLEVPQVLAAACLLRVDRVIQQCE 182
Cdd:cd18252   87 CITERNVQSLLEAADLLQFISVKKACE 113
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 83-132 4.91e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 37.10  E-value: 4.91e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 339717806  83 LFLDGHDSDIKIRALGKTWCLHKVFL-CQSGYFANILKGTWRESHHGVINL 132
Cdd:cd18263    7 LWEKGVGCDVQLEADGSIFRVHRVILaAGSDYFRAMFTSGMKESTQSVVQL 57
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 84-187 5.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 36.46  E-value: 5.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339717806  84 FLDGHDSDIKIRALGKTWCLHKVFL-CQSGYFANILKGTWRESHHGVInliiknIDTRSLHFVFGA----LYTDaDLSIT 158
Cdd:cd18298    7 FNDPRTSDLKFRVDGKYIYVHKAILkIRCEYFRSMFQSHWNEDDKNVI------EIDQYSYPVYYAflryLYTD-QVDLP 79

                         90       100
                 ....*....|....*....|....*....
gi 339717806 159 PLEVPQVLAAACLLRVDRVIQQCEGIMKE 187
Cdd:cd18298   80 PEDAIGLLDLANSYCEERLKKLCEDIIKQ 108
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 194-264 7.60e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 36.17  E-value: 7.60e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 339717806   194 VCSYYLAAETYRLKAVKTRCFEWLLCNLMVHPSVALYKEVDLKLMYLLaLSSDLLVMQKEIDVYTTLKIWM 264
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLEL-LSSDDLNVSSEEEVFEAVLRWV 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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