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Conserved domains on  [gi|325652033|ref|NP_001191786|]
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elongin-C isoform a [Homo sapiens]

Protein Classification

elongin-C( domain architecture ID 13034545)

elongin-C (EloC) is a component of elongin, a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_EloC cd18321
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 18-112 2.28e-64

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins; Elongin-C is also called elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, or transcription elongation factor B polypeptide 1 (TCEB1). It is a component of SIII (also known as elongin), which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. It forms a regulatory complex with subunit B or elongin-B (BC) that enhances the activity of the transcriptionally active subunit A. The BC complex also functions as an adaptor protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC (VHL) and the suppressors of cytokine signaling (SOCS) box ubiquitin ligase family. Elongin-C belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349630  Cd Length: 95  Bit Score: 189.72  E-value: 2.28e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325652033  18 YVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAP 97
Cdd:cd18321    1 YVKLISSDGHEFIVDREAAMVSGTIKAMLSGPGQFAENETNEVRFPEISSHILEKVCEYFYYKVRYTNSSTEIPEFPIPP 80

                         90
                 ....*....|....*
gi 325652033  98 EIALELLMAANFLDC 112
Cdd:cd18321   81 EIALELLMAANFLDC 95
 
Name Accession Description Interval E-value
BTB_POZ_EloC cd18321
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 18-112 2.28e-64

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins; Elongin-C is also called elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, or transcription elongation factor B polypeptide 1 (TCEB1). It is a component of SIII (also known as elongin), which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. It forms a regulatory complex with subunit B or elongin-B (BC) that enhances the activity of the transcriptionally active subunit A. The BC complex also functions as an adaptor protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC (VHL) and the suppressors of cytokine signaling (SOCS) box ubiquitin ligase family. Elongin-C belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349630  Cd Length: 95  Bit Score: 189.72  E-value: 2.28e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325652033  18 YVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAP 97
Cdd:cd18321    1 YVKLISSDGHEFIVDREAAMVSGTIKAMLSGPGQFAENETNEVRFPEISSHILEKVCEYFYYKVRYTNSSTEIPEFPIPP 80

                         90
                 ....*....|....*
gi 325652033  98 EIALELLMAANFLDC 112
Cdd:cd18321   81 EIALELLMAANFLDC 95
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 16-112 7.87e-37

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


Pssm-ID: 214704  Cd Length: 104  Bit Score: 120.48  E-value: 7.87e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325652033    16 AMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENEtNEVNFREIPSHVLSKVCMYFTYKVRYTNS-------ST 88
Cdd:smart00512   1 SKYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENN-NPIPLPNVTSKILSKVIEYCEHHVDDPPSvadkddiPT 79

                           90       100
                   ....*....|....*....|....*
gi 325652033    89 EIPEFP-IAPEIALELLMAANFLDC 112
Cdd:smart00512  80 WDAEFLkIDQETLFELILAANYLDI 104
Skp1_POZ pfam03931
Skp1 family, tetramerization domain;
17-79 2.19e-07

Skp1 family, tetramerization domain;


Pssm-ID: 397838  Cd Length: 60  Bit Score: 44.21  E-value: 2.19e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325652033   17 MYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGqfaeneTNEVNFREIPSHVLSKVCMYFTY 79
Cdd:pfam03931   1 PKIVLQSSDGESFEVEEAVARKSKTIKHMIEDDG------DDPIPLPNVTSKILEKVIEYCKH 57
 
Name Accession Description Interval E-value
BTB_POZ_EloC cd18321
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 18-112 2.28e-64

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins; Elongin-C is also called elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, or transcription elongation factor B polypeptide 1 (TCEB1). It is a component of SIII (also known as elongin), which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. It forms a regulatory complex with subunit B or elongin-B (BC) that enhances the activity of the transcriptionally active subunit A. The BC complex also functions as an adaptor protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC (VHL) and the suppressors of cytokine signaling (SOCS) box ubiquitin ligase family. Elongin-C belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349630  Cd Length: 95  Bit Score: 189.72  E-value: 2.28e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325652033  18 YVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAP 97
Cdd:cd18321    1 YVKLISSDGHEFIVDREAAMVSGTIKAMLSGPGQFAENETNEVRFPEISSHILEKVCEYFYYKVRYTNSSTEIPEFPIPP 80

                         90
                 ....*....|....*
gi 325652033  98 EIALELLMAANFLDC 112
Cdd:cd18321   81 EIALELLMAANFLDC 95
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 16-112 7.87e-37

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


Pssm-ID: 214704  Cd Length: 104  Bit Score: 120.48  E-value: 7.87e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325652033    16 AMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENEtNEVNFREIPSHVLSKVCMYFTYKVRYTNS-------ST 88
Cdd:smart00512   1 SKYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENN-NPIPLPNVTSKILSKVIEYCEHHVDDPPSvadkddiPT 79

                           90       100
                   ....*....|....*....|....*
gi 325652033    89 EIPEFP-IAPEIALELLMAANFLDC 112
Cdd:smart00512  80 WDAEFLkIDQETLFELILAANYLDI 104
BTB_POZ_SKP1 cd18322
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 18-111 3.56e-14

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349631  Cd Length: 120  Bit Score: 63.38  E-value: 3.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325652033  18 YVKLISSDGHEFIVKREHALTSGTIKAMLSGpgqfAENETNEVNFREIPSHVLSKVCMYFTYKV---------RYTNSST 88
Cdd:cd18322    1 KIKLQSSDGEIFEVDEEVARQSVTIKNMLED----LGYDDDPIPLPNVTSKILKKVIEWCEHHKddpppeidlDSEKRTD 76

                         90       100
                 ....*....|....*....|....*...
gi 325652033  89 EIPEF-----PIAPEIALELLMAANFLD 111
Cdd:cd18322   77 DIPEWdaeflKVDQDTLFELILAANYLD 104
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-110 6.77e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 61.53  E-value: 6.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325652033  22 ISSDGHEFIVKREHALTSGTIKAMLSgPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNssteipefpiaPEIAL 101
Cdd:cd01165    3 LVVEGEKFHVNKELLAQSSEYFRALF-RGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLD-----------ASNLL 70


                 ....*....
gi 325652033 102 ELLMAANFL 110
Cdd:cd01165   71 ELLEAANFL 79
Skp1_POZ pfam03931
Skp1 family, tetramerization domain;
17-79 2.19e-07

Skp1 family, tetramerization domain;


Pssm-ID: 397838  Cd Length: 60  Bit Score: 44.21  E-value: 2.19e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325652033   17 MYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGqfaeneTNEVNFREIPSHVLSKVCMYFTY 79
Cdd:pfam03931   1 PKIVLQSSDGESFEVEEAVARKSKTIKHMIEDDG------DDPIPLPNVTSKILEKVIEYCKH 57
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 43-110 9.73e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 36.12  E-value: 9.73e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325652033  43 KAMLSGPgqFAENETN-----EVNFREIPSHVLSKVcMYFTYkvryTNSsTEIPefpiaPEIALELLMAANFL 110
Cdd:cd18296   44 KALLRDH--FAESEENngsipVVTLHDVSPEVFAIV-LYYIY----TDD-TDLP-----PENAYDVLYVADMY 103
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-110 5.99e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 33.30  E-value: 5.99e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325652033  43 KAMLSGPgqFAENETNEVNFREIPSHVLSKVCMYFtykvrYTNssteipEFPIAPEIALELLMAANFL 110
Cdd:cd18186   28 RAMFSSG--MKESSSSEIELDDVSPEAFEALLDYI-----YTG------ELELSEENVEELLAAADKL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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