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Conserved domains on  [gi|320461722|ref|NP_001189364|]
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sodium channel protein type 1 subunit alpha isoform 1 [Homo sapiens]

Protein Classification

Na_trans_assoc and Ion_trans domain-containing protein( domain architecture ID 11999294)

protein containing domains Na_trans_cytopl, Na_trans_assoc, Ion_trans, and Na_channel_gate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
555-718 7.80e-105

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 463401  Cd Length: 163  Bit Score: 331.70  E-value: 7.80e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   555 SLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAV 634
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSRSHPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   635 FPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNgTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAM 714
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSPGGQLLPEVILDKPATGDS-TTTEEELRKRRLSSYQLSMDYLEEPFQRQRAV 159

                   ....
gi 320461722   715 SIAS 718
Cdd:pfam11933  160 SAAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1006-1213 1.24e-63

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 461936  Cd Length: 195  Bit Score: 215.28  E-value: 1.24e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1006 DNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQK-ILDEIKPLDDLNNKKDSCMSNHTAeigkdldyLKDVNGtts 1084
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLpKKKPLTELKDARSKLTNQIANHTS--------LKKAPG--- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1085 gigtgssvEKYIIDEsDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGS----TVDI- 1159
Cdd:pfam06512   70 --------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQLEDDDSSSsegsTVDLq 140
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 320461722  1160 -GAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFR 1213
Cdd:pfam06512  141 dPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1217-1492 1.34e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 214.05  E-value: 1.34e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1217 HNWFETFIVFMILLSSGALAFEDIYIDQRKTiKTMLEYADKVFTYIFILEMLLKWVAYGY-QTYFTNAWCWLDFLIVDVS 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1296 LVSLTANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1375
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1376 CINTTTGDRfdiedvnnhtdclkliernetarwknvkvNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRnvelqpkyeE 1455
Cdd:pfam00520  158 WENPDNGRT-----------------------------NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK---------G 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 320461722  1456 SLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1492
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1540-1796 9.47e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.10  E-value: 9.47e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1540 RQVFDISIMILICLNMVTMMVETDDQSEYVTT-ILSRINLVFIVLFTGECVLKLISLR--HYYFTIGWNIFDFVVVILSI 1616
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1617 VGMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1696
Cdd:pfam00520   81 ISLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1697 R--EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPpdcdpnkvnpgssvkgdcgnPSVGIFFFVSYIIISF 1774
Cdd:pfam00520  156 KtwENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGG 215
                          250       260
                   ....*....|....*....|..
gi 320461722  1775 LVVVNMYIAVILENFSVATEES 1796
Cdd:pfam00520  216 FLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
767-980 7.47e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.79  E-value: 7.47e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   767 DPFVDLAITICIVLNTLFMAMEHYPMTDH-FNNVLTVGNLVFTGIFTAEMFLKIIAMDP-YYYFQEGWNIFDGFIVTLSL 844
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   845 VELGLANVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkdcvc 921
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   922 KIASDCQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGN 980
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
127-433 1.31e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 170.91  E-value: 1.31e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   127 HSLFSMLIMCTILTNCVFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKIIARGFCledFTFLRDPWNWLDFTVIT 199
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   200 FAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 275
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   276 kciqwpptnasleehsieknitvnyngtlinetvfefdwksyiqdsryhyflegfldallcgnssdagqcpegymcvkaG 355
Cdd:pfam00520  158 -------------------------------------------------------------------------------W 158
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461722   356 RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQAT 433
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1484-1536 4.55e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.59  E-value: 4.55e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 320461722 1484 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFD 1536
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
555-718 7.80e-105

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 331.70  E-value: 7.80e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   555 SLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAV 634
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSRSHPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   635 FPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNgTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAM 714
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSPGGQLLPEVILDKPATGDS-TTTEEELRKRRLSSYQLSMDYLEEPFQRQRAV 159

                   ....
gi 320461722   715 SIAS 718
Cdd:pfam11933  160 SAAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1006-1213 1.24e-63

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 215.28  E-value: 1.24e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1006 DNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQK-ILDEIKPLDDLNNKKDSCMSNHTAeigkdldyLKDVNGtts 1084
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLpKKKPLTELKDARSKLTNQIANHTS--------LKKAPG--- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1085 gigtgssvEKYIIDEsDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGS----TVDI- 1159
Cdd:pfam06512   70 --------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQLEDDDSSSsegsTVDLq 140
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 320461722  1160 -GAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFR 1213
Cdd:pfam06512  141 dPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1217-1492 1.34e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 214.05  E-value: 1.34e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1217 HNWFETFIVFMILLSSGALAFEDIYIDQRKTiKTMLEYADKVFTYIFILEMLLKWVAYGY-QTYFTNAWCWLDFLIVDVS 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1296 LVSLTANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1375
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1376 CINTTTGDRfdiedvnnhtdclkliernetarwknvkvNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRnvelqpkyeE 1455
Cdd:pfam00520  158 WENPDNGRT-----------------------------NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK---------G 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 320461722  1456 SLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1492
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1540-1796 9.47e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.10  E-value: 9.47e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1540 RQVFDISIMILICLNMVTMMVETDDQSEYVTT-ILSRINLVFIVLFTGECVLKLISLR--HYYFTIGWNIFDFVVVILSI 1616
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1617 VGMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1696
Cdd:pfam00520   81 ISLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1697 R--EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPpdcdpnkvnpgssvkgdcgnPSVGIFFFVSYIIISF 1774
Cdd:pfam00520  156 KtwENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGG 215
                          250       260
                   ....*....|....*....|..
gi 320461722  1775 LVVVNMYIAVILENFSVATEES 1796
Cdd:pfam00520  216 FLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
767-980 7.47e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.79  E-value: 7.47e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   767 DPFVDLAITICIVLNTLFMAMEHYPMTDH-FNNVLTVGNLVFTGIFTAEMFLKIIAMDP-YYYFQEGWNIFDGFIVTLSL 844
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   845 VELGLANVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkdcvc 921
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   922 KIASDCQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGN 980
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
127-433 1.31e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 170.91  E-value: 1.31e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   127 HSLFSMLIMCTILTNCVFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKIIARGFCledFTFLRDPWNWLDFTVIT 199
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   200 FAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 275
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   276 kciqwpptnasleehsieknitvnyngtlinetvfefdwksyiqdsryhyflegfldallcgnssdagqcpegymcvkaG 355
Cdd:pfam00520  158 -------------------------------------------------------------------------------W 158
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461722   356 RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQAT 433
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1484-1536 4.55e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.59  E-value: 4.55e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 320461722 1484 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFD 1536
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
555-718 7.80e-105

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 331.70  E-value: 7.80e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   555 SLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAV 634
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSRSHPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   635 FPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNgTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAM 714
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSPGGQLLPEVILDKPATGDS-TTTEEELRKRRLSSYQLSMDYLEEPFQRQRAV 159

                   ....
gi 320461722   715 SIAS 718
Cdd:pfam11933  160 SAAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1006-1213 1.24e-63

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 215.28  E-value: 1.24e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1006 DNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQK-ILDEIKPLDDLNNKKDSCMSNHTAeigkdldyLKDVNGtts 1084
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLpKKKPLTELKDARSKLTNQIANHTS--------LKKAPG--- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1085 gigtgssvEKYIIDEsDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGS----TVDI- 1159
Cdd:pfam06512   70 --------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSKQQEQLEDDDSSSsegsTVDLq 140
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 320461722  1160 -GAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFR 1213
Cdd:pfam06512  141 dPEEELEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1217-1492 1.34e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 214.05  E-value: 1.34e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1217 HNWFETFIVFMILLSSGALAFEDIYIDQRKTiKTMLEYADKVFTYIFILEMLLKWVAYGY-QTYFTNAWCWLDFLIVDVS 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1296 LVSLTANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1375
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1376 CINTTTGDRfdiedvnnhtdclkliernetarwknvkvNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRnvelqpkyeE 1455
Cdd:pfam00520  158 WENPDNGRT-----------------------------NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK---------G 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 320461722  1456 SLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1492
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1540-1796 9.47e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.10  E-value: 9.47e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1540 RQVFDISIMILICLNMVTMMVETDDQSEYVTT-ILSRINLVFIVLFTGECVLKLISLR--HYYFTIGWNIFDFVVVILSI 1616
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTtVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1617 VGMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK 1696
Cdd:pfam00520   81 ISLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1697 R--EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPpdcdpnkvnpgssvkgdcgnPSVGIFFFVSYIIISF 1774
Cdd:pfam00520  156 KtwENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGG 215
                          250       260
                   ....*....|....*....|..
gi 320461722  1775 LVVVNMYIAVILENFSVATEES 1796
Cdd:pfam00520  216 FLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
767-980 7.47e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.79  E-value: 7.47e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   767 DPFVDLAITICIVLNTLFMAMEHYPMTDH-FNNVLTVGNLVFTGIFTAEMFLKIIAMDP-YYYFQEGWNIFDGFIVTLSL 844
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   845 VELGLANVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkdcvc 921
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   922 KIASDCQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLTVFMMVMVIGN 980
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
127-433 1.31e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 170.91  E-value: 1.31e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   127 HSLFSMLIMCTILTNCVFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKIIARGFCledFTFLRDPWNWLDFTVIT 199
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   200 FAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 275
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722   276 kciqwpptnasleehsieknitvnyngtlinetvfefdwksyiqdsryhyflegfldallcgnssdagqcpegymcvkaG 355
Cdd:pfam00520  158 -------------------------------------------------------------------------------W 158
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320461722   356 RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQAT 433
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1484-1536 4.55e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.59  E-value: 4.55e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 320461722 1484 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFD 1536
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1578-1790 7.62e-05

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 46.12  E-value: 7.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1578 LVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAelIEKYFVSPTLFRVI-----------RLARIGRI 1646
Cdd:pfam08016   18 VVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLN--IYRDFLADRLIKSVeaspvtfidfdRVAQLDNL 95
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1647 LRLIKG----------------AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAyvkrevgiDDMFNFETF 1710
Cdd:pfam08016   96 YRIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG--------TQAPNFSNF 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320461722  1711 GNSMICLFQITTSA-GWDGLlapilnskppdcdpnkvnpgssvkgDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1789
Cdd:pfam08016  168 VKSILTLFRTILGDfGYNEI-------------------------FSGNRVLGPLLFLTFVFLVIFILLNLFLAIINDSY 222

                   .
gi 320461722  1790 S 1790
Cdd:pfam08016  223 V 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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