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Conserved domains on  [gi|313747452|ref|NP_001186406|]
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transmembrane protein 60 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM203 super family cl10951
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ...
 25-134 8.36e-07

Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases.


The actual alignment was detected with superfamily member pfam10269:

Pssm-ID: 448049  Cd Length: 245  Bit Score: 46.29  E-value: 8.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313747452   25 LKLDEKAPWNWFLIFIPVWIFDTILLVMLIVKMAGRCKSGFDPRNGSQNIKKKtwYLIAMLLKLAFCLALCAKLQQFTT- 103
Cdd:pfam10269   1 LKLDHTVSWSWWKVFAPLWIFHALVARGRFVAAIVWRSLPASRPEDRHWAPFH--AVVATPLLLAFELLLCIYLESTYVg 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 313747452  104 ----MKLAYVFIPLWALLIggmIELGYNIFYVRRD 134
Cdd:pfam10269  79 lsgaLDWTIVFLPLLALEV---VILVDNIRMCRAL 110
 
Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 25-134 8.36e-07

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


Pssm-ID: 402059  Cd Length: 245  Bit Score: 46.29  E-value: 8.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313747452   25 LKLDEKAPWNWFLIFIPVWIFDTILLVMLIVKMAGRCKSGFDPRNGSQNIKKKtwYLIAMLLKLAFCLALCAKLQQFTT- 103
Cdd:pfam10269   1 LKLDHTVSWSWWKVFAPLWIFHALVARGRFVAAIVWRSLPASRPEDRHWAPFH--AVVATPLLLAFELLLCIYLESTYVg 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 313747452  104 ----MKLAYVFIPLWALLIggmIELGYNIFYVRRD 134
Cdd:pfam10269  79 lsgaLDWTIVFLPLLALEV---VILVDNIRMCRAL 110
TMEM203 cd22816
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ...
 21-122 1.39e-03

Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases.


Pssm-ID: 439364  Cd Length: 131  Bit Score: 36.13  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313747452  21 IMLVLKLDEKAPWNWFLIFIPVWIFD---TILLVMLIVKMagrcksgFDPRNGSQNIKKKTWYLIAMLLKLAFCLALCAK 97
Cdd:cd22816   29 VLLALKLEGHLSASWWTVFSPLFAADglsAYFCVIVFVRL-------YQEGEKRLAVLRLFWSLTVLSLIFVFEMLLCQK 101

                         90       100
                 ....*....|....*....|....*
gi 313747452  98 LQQFTTMKLAYVFIPLWALLIGGMI 122
Cdd:cd22816  102 LEGQNELWYSLVFSPLFILLQLLMI 126
 
Name Accession Description Interval E-value
Tmemb_185A pfam10269
Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that ...
 25-134 8.36e-07

Transmembrane Fragile-X-F protein; This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B.


Pssm-ID: 402059  Cd Length: 245  Bit Score: 46.29  E-value: 8.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313747452   25 LKLDEKAPWNWFLIFIPVWIFDTILLVMLIVKMAGRCKSGFDPRNGSQNIKKKtwYLIAMLLKLAFCLALCAKLQQFTT- 103
Cdd:pfam10269   1 LKLDHTVSWSWWKVFAPLWIFHALVARGRFVAAIVWRSLPASRPEDRHWAPFH--AVVATPLLLAFELLLCIYLESTYVg 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 313747452  104 ----MKLAYVFIPLWALLIggmIELGYNIFYVRRD 134
Cdd:pfam10269  79 lsgaLDWTIVFLPLLALEV---VILVDNIRMCRAL 110
TMEM203 cd22816
Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative ...
 21-122 1.39e-03

Transmembrane protein 203; Transmembrane protein 203 (TMEM203) is a conserved putative transmembrane protein that functions as a regulator of signaling pathways activated in response to diverse bacterial and viral stimuli. It has been shown in humans to be an intracellular regulator of STimulator of IFN Genes (STING)-mediated signaling and to interact with the pleiotropic inositol phosphate signaling pathway protein IP3R. In T-cells of patients with systemic lupus erythematosus (SLE), a disease characterized by the over-expression of type I interferons (IFN1), elevated TMEM203 mRNA levels are associated with disease activity. Thus, identification of TMEM203 may elucidate the control of STING-mediated innate immune responses, and provide a potential novel mechanism for therapeutic interventions in STING-associated inflammatory diseases.


Pssm-ID: 439364  Cd Length: 131  Bit Score: 36.13  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313747452  21 IMLVLKLDEKAPWNWFLIFIPVWIFD---TILLVMLIVKMagrcksgFDPRNGSQNIKKKTWYLIAMLLKLAFCLALCAK 97
Cdd:cd22816   29 VLLALKLEGHLSASWWTVFSPLFAADglsAYFCVIVFVRL-------YQEGEKRLAVLRLFWSLTVLSLIFVFEMLLCQK 101

                         90       100
                 ....*....|....*....|....*
gi 313747452  98 LQQFTTMKLAYVFIPLWALLIGGMI 122
Cdd:cd22816  102 LEGQNELWYSLVFSPLFILLQLLMI 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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