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Conserved domains on  [gi|313151224|ref|NP_001186226|]
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BRCA1-A complex subunit RAP80 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIR_RAP80-like cd20912
ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related ...
 272-329 4.19e-33

ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains; RAP80 and ABRAXAS are integral subunits of the BRCA1-A complex which also contains MERIT40 (Mediator of Rap80 Interactions and Targeting 40 kD, also known as BABAM1), BRE (also known as BABAM2, BRCC45 and BRCC4), and BRCC36 (also known as BRCC3). BRCA1-A functions in DNA double-strand break (DSB) repair. RAP80 interacts with the ABRAXAS, MERIT40, and BRE subunits. It is the interaction with ABRAXAS that drives specific incorporation of RAP80 into BRCA1-A. RAP80 contains one SUMO-interacting motif (SIM), two ubiquitin-interacting motifs (UIMs), this AIR, and two zinc finger motifs (ZnF). The SIM and UIM domains recruit BRCA1-A to sites of DNA damage. The AIR is integral in the interaction of RAP80 with the ABRAXAS, MERIT40, and BRE subunits.


:

Pssm-ID: 411022  Cd Length: 59  Bit Score: 121.28  E-value: 4.19e-33
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 313151224 272 GTVNYFWGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPP 329
Cdd:cd20912    1 GRVHYYWGVPFCPKGVDPNQYTKVILCQLEVYEKSLKEAQRQLLRKLAFGKPVLPGPH 58
RAP80_UIM super family cl39632
RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 ...
 72-128 1.83e-21

RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 protein present in Homo sapiens. RAP80 is fundamental for protein recruitment in the DNA damage response. The N-terminal domain is a ubiquitin-interacting motif (UIM). RAP80 is involved in multivalent recognition of polyUb chains through N-terminal domain.


The actual alignment was detected with superfamily member pfam18282:

Pssm-ID: 436382 [Multi-domain]  Cd Length: 57  Bit Score: 87.95  E-value: 1.83e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 313151224   72 AKRKIAQMTEEEQFALALKMSEQEAREVNSQEEEEEELLRKAIAESLNSCRPSDASA 128
Cdd:pfam18282   1 AKRKIAHMSEDEQFALALKMSEQEAMELNNQEEEEEELLRKAIAESLNSCQLPAASA 57
 
Name Accession Description Interval E-value
AIR_RAP80-like cd20912
ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related ...
 272-329 4.19e-33

ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains; RAP80 and ABRAXAS are integral subunits of the BRCA1-A complex which also contains MERIT40 (Mediator of Rap80 Interactions and Targeting 40 kD, also known as BABAM1), BRE (also known as BABAM2, BRCC45 and BRCC4), and BRCC36 (also known as BRCC3). BRCA1-A functions in DNA double-strand break (DSB) repair. RAP80 interacts with the ABRAXAS, MERIT40, and BRE subunits. It is the interaction with ABRAXAS that drives specific incorporation of RAP80 into BRCA1-A. RAP80 contains one SUMO-interacting motif (SIM), two ubiquitin-interacting motifs (UIMs), this AIR, and two zinc finger motifs (ZnF). The SIM and UIM domains recruit BRCA1-A to sites of DNA damage. The AIR is integral in the interaction of RAP80 with the ABRAXAS, MERIT40, and BRE subunits.


Pssm-ID: 411022  Cd Length: 59  Bit Score: 121.28  E-value: 4.19e-33
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 313151224 272 GTVNYFWGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPP 329
Cdd:cd20912    1 GRVHYYWGVPFCPKGVDPNQYTKVILCQLEVYEKSLKEAQRQLLRKLAFGKPVLPGPH 58
RAP80_UIM pfam18282
RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 ...
 72-128 1.83e-21

RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 protein present in Homo sapiens. RAP80 is fundamental for protein recruitment in the DNA damage response. The N-terminal domain is a ubiquitin-interacting motif (UIM). RAP80 is involved in multivalent recognition of polyUb chains through N-terminal domain.


Pssm-ID: 436382 [Multi-domain]  Cd Length: 57  Bit Score: 87.95  E-value: 1.83e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 313151224   72 AKRKIAQMTEEEQFALALKMSEQEAREVNSQEEEEEELLRKAIAESLNSCRPSDASA 128
Cdd:pfam18282   1 AKRKIAHMSEDEQFALALKMSEQEAMELNNQEEEEEELLRKAIAESLNSCQLPAASA 57
 
Name Accession Description Interval E-value
AIR_RAP80-like cd20912
ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related ...
 272-329 4.19e-33

ABRAXAS Interacting Region (AIR) of Receptor-Associated Protein 80 (RAP80), and related domains; RAP80 and ABRAXAS are integral subunits of the BRCA1-A complex which also contains MERIT40 (Mediator of Rap80 Interactions and Targeting 40 kD, also known as BABAM1), BRE (also known as BABAM2, BRCC45 and BRCC4), and BRCC36 (also known as BRCC3). BRCA1-A functions in DNA double-strand break (DSB) repair. RAP80 interacts with the ABRAXAS, MERIT40, and BRE subunits. It is the interaction with ABRAXAS that drives specific incorporation of RAP80 into BRCA1-A. RAP80 contains one SUMO-interacting motif (SIM), two ubiquitin-interacting motifs (UIMs), this AIR, and two zinc finger motifs (ZnF). The SIM and UIM domains recruit BRCA1-A to sites of DNA damage. The AIR is integral in the interaction of RAP80 with the ABRAXAS, MERIT40, and BRE subunits.


Pssm-ID: 411022  Cd Length: 59  Bit Score: 121.28  E-value: 4.19e-33
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 313151224 272 GTVNYFWGIPFCPDGVDPNQYTKVILCQLEVYQKSLKMAQRQLLNKKGFGEPVLPRPP 329
Cdd:cd20912    1 GRVHYYWGVPFCPKGVDPNQYTKVILCQLEVYEKSLKEAQRQLLRKLAFGKPVLPGPH 58
RAP80_UIM pfam18282
RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 ...
 72-128 1.83e-21

RAP80 N-terminal ubiquitin interaction motif; This is the N-terminal domain found in RAP80 protein present in Homo sapiens. RAP80 is fundamental for protein recruitment in the DNA damage response. The N-terminal domain is a ubiquitin-interacting motif (UIM). RAP80 is involved in multivalent recognition of polyUb chains through N-terminal domain.


Pssm-ID: 436382 [Multi-domain]  Cd Length: 57  Bit Score: 87.95  E-value: 1.83e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 313151224   72 AKRKIAQMTEEEQFALALKMSEQEAREVNSQEEEEEELLRKAIAESLNSCRPSDASA 128
Cdd:pfam18282   1 AKRKIAHMSEDEQFALALKMSEQEAMELNNQEEEEEELLRKAIAESLNSCQLPAASA 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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