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Conserved domains on  [gi|309747095|ref|NP_001185471|]
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hydrocephalus-inducing protein homolog isoform c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASH pfam15780
Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal ...
 541-640 3.22e-22

Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal domain of abnormal spindle-like microcephaly-associated protein are found in proteins associated with cilia, flagella, the centrosome and the Golgi complex. The domain is also found in Hydin and OCRL whose deficiencies are associated with hydrocephalus and Lowe oculocerebrorenal syndrome (OCRL), respectively. The fact that Human ASPM protein carries an ASH domain indicates possible roles for ASPM in sperm flagellar or in ependymal cells' cilia. The presence of ASH in centrosomal and ciliary proteins indicates that ASPM may possess roles not only in mitotic spindle regulation, but also in ciliary and flagellar function.


:

Pssm-ID: 464865 [Multi-domain]  Cd Length: 98  Bit Score: 91.96  E-value: 3.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309747095  541 EGIIEPSGVQAiQISFSSTILGNFEEEFLVNVNGSPEPVkLTIRGCVIGPTFHFNVPALHFgDVSFGFPHTLICSLNNTS 620
Cdd:pfam15780   2 VLLLAPFSRQP-FVCFGDVPVGTSAERLLTVVNPSEEPA-EVKVSKVPAPTKGFSVSPLEF-TVQPGESQTLTVTWTPTE 78

                          90       100
                  ....*....|....*....|
gi 309747095  621 LIPMTYKLRIPGDGLGHKSI 640
Cdd:pfam15780  79 EGAVRETLQFTVNDVGKHQV 98
choice_anch_D super family cl44405
choice-of-anchor D domain; This HMM describes a repeat domain just over 100 amino acids long ...
 230-309 7.31e-03

choice-of-anchor D domain; This HMM describes a repeat domain just over 100 amino acids long and usually found in tandem copies. Members appear to be extracellular proteins that have some C-terminal anchoring domain, such as type IX secrection (T9SS) or PEP-CTERM.


The actual alignment was detected with superfamily member NF012200:

Pssm-ID: 467954 [Multi-domain]  Cd Length: 107  Bit Score: 37.22  E-value: 7.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309747095 230 PDKLNFSTCPVKYSTQKILLVRNIGNKNAVFH-----IKTCRPFSIEPA-IGTLNVGESMQLEVEFEPQSVGDHSGRLIV 303
Cdd:NF012200  21 PASIDFGNVRVGDTASQTVTITNTGTAALTIEgltisGTNAGDFTVSGNsPTTLAAGGSCTLTVTFDPTAAGARSGTLTI 100


                 ....*.
gi 309747095 304 CYDTGE 309
Cdd:NF012200 101 ASNDAG 106
 
Name Accession Description Interval E-value
ASH pfam15780
Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal ...
 541-640 3.22e-22

Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal domain of abnormal spindle-like microcephaly-associated protein are found in proteins associated with cilia, flagella, the centrosome and the Golgi complex. The domain is also found in Hydin and OCRL whose deficiencies are associated with hydrocephalus and Lowe oculocerebrorenal syndrome (OCRL), respectively. The fact that Human ASPM protein carries an ASH domain indicates possible roles for ASPM in sperm flagellar or in ependymal cells' cilia. The presence of ASH in centrosomal and ciliary proteins indicates that ASPM may possess roles not only in mitotic spindle regulation, but also in ciliary and flagellar function.


Pssm-ID: 464865 [Multi-domain]  Cd Length: 98  Bit Score: 91.96  E-value: 3.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309747095  541 EGIIEPSGVQAiQISFSSTILGNFEEEFLVNVNGSPEPVkLTIRGCVIGPTFHFNVPALHFgDVSFGFPHTLICSLNNTS 620
Cdd:pfam15780   2 VLLLAPFSRQP-FVCFGDVPVGTSAERLLTVVNPSEEPA-EVKVSKVPAPTKGFSVSPLEF-TVQPGESQTLTVTWTPTE 78

                          90       100
                  ....*....|....*....|
gi 309747095  621 LIPMTYKLRIPGDGLGHKSI 640
Cdd:pfam15780  79 EGAVRETLQFTVNDVGKHQV 98
choice_anch_D NF012200
choice-of-anchor D domain; This HMM describes a repeat domain just over 100 amino acids long ...
 230-309 7.31e-03

choice-of-anchor D domain; This HMM describes a repeat domain just over 100 amino acids long and usually found in tandem copies. Members appear to be extracellular proteins that have some C-terminal anchoring domain, such as type IX secrection (T9SS) or PEP-CTERM.


Pssm-ID: 467954 [Multi-domain]  Cd Length: 107  Bit Score: 37.22  E-value: 7.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309747095 230 PDKLNFSTCPVKYSTQKILLVRNIGNKNAVFH-----IKTCRPFSIEPA-IGTLNVGESMQLEVEFEPQSVGDHSGRLIV 303
Cdd:NF012200  21 PASIDFGNVRVGDTASQTVTITNTGTAALTIEgltisGTNAGDFTVSGNsPTTLAAGGSCTLTVTFDPTAAGARSGTLTI 100


                 ....*.
gi 309747095 304 CYDTGE 309
Cdd:NF012200 101 ASNDAG 106
 
Name Accession Description Interval E-value
ASH pfam15780
Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal ...
 541-640 3.22e-22

Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal domain of abnormal spindle-like microcephaly-associated protein are found in proteins associated with cilia, flagella, the centrosome and the Golgi complex. The domain is also found in Hydin and OCRL whose deficiencies are associated with hydrocephalus and Lowe oculocerebrorenal syndrome (OCRL), respectively. The fact that Human ASPM protein carries an ASH domain indicates possible roles for ASPM in sperm flagellar or in ependymal cells' cilia. The presence of ASH in centrosomal and ciliary proteins indicates that ASPM may possess roles not only in mitotic spindle regulation, but also in ciliary and flagellar function.


Pssm-ID: 464865 [Multi-domain]  Cd Length: 98  Bit Score: 91.96  E-value: 3.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309747095  541 EGIIEPSGVQAiQISFSSTILGNFEEEFLVNVNGSPEPVkLTIRGCVIGPTFHFNVPALHFgDVSFGFPHTLICSLNNTS 620
Cdd:pfam15780   2 VLLLAPFSRQP-FVCFGDVPVGTSAERLLTVVNPSEEPA-EVKVSKVPAPTKGFSVSPLEF-TVQPGESQTLTVTWTPTE 78

                          90       100
                  ....*....|....*....|
gi 309747095  621 LIPMTYKLRIPGDGLGHKSI 640
Cdd:pfam15780  79 EGAVRETLQFTVNDVGKHQV 98
choice_anch_D NF012200
choice-of-anchor D domain; This HMM describes a repeat domain just over 100 amino acids long ...
 230-309 7.31e-03

choice-of-anchor D domain; This HMM describes a repeat domain just over 100 amino acids long and usually found in tandem copies. Members appear to be extracellular proteins that have some C-terminal anchoring domain, such as type IX secrection (T9SS) or PEP-CTERM.


Pssm-ID: 467954 [Multi-domain]  Cd Length: 107  Bit Score: 37.22  E-value: 7.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 309747095 230 PDKLNFSTCPVKYSTQKILLVRNIGNKNAVFH-----IKTCRPFSIEPA-IGTLNVGESMQLEVEFEPQSVGDHSGRLIV 303
Cdd:NF012200  21 PASIDFGNVRVGDTASQTVTITNTGTAALTIEgltisGTNAGDFTVSGNsPTTLAAGGSCTLTVTFDPTAAGARSGTLTI 100


                 ....*.
gi 309747095 304 CYDTGE 309
Cdd:NF012200 101 ASNDAG 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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