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Conserved domains on  [gi|291084570|ref|NP_001166987|]
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MAP7 domain-containing protein 3 isoform 2 [Homo sapiens]

Protein Classification

MAP7 domain-containing protein( domain architecture ID 12064852)

MAP7 domain-containing protein such as MAP7D1 (microtubule-associated protein 7 domain containing 1) identified as a novel substrate of doublecortin-like kinase 1 (DCLK1)

Gene Ontology:  GO:0005737

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
570-710 5.34e-17

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


:

Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 78.93  E-value: 5.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291084570  570 KSTAGIMNAEAATKILTELRRLAREQREKEEEERQREEMQQRVIKKS-KDMAKEAVGGQAEDHLKLKDGQQQNETKKKKG 648
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEElRRRAEEERARREEEARRLEEERRREEEERQRK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 291084570  649 WLD----------QEDQEAPLQKGDAKIKAQEEADKRKKEHERIMLQNLQERLERKKRIEEIMKRTRKTDVN 710
Cdd:pfam05672  81 AEEeaeereqreqEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKRIEEIMKRTRKSDQA 152
DUF4639 super family cl25621
Domain of unknown function (DUF4639); This family of proteins is found in eukaryotes. Proteins ...
368-451 5.92e-04

Domain of unknown function (DUF4639); This family of proteins is found in eukaryotes. Proteins in this family are typically between 161 and 601 amino acids in length.


The actual alignment was detected with superfamily member pfam15479:

Pssm-ID: 464739  Cd Length: 580  Bit Score: 43.26  E-value: 5.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291084570  368 PEASLEAPPEVSL----EALPEVSVEAAPEGSLEAPPKGSAEVApkeSVKGSPKESMEASPEAMVKASPKTSLEASMEAS 443
Cdd:pfam15479 171 QMESWEPSPELRVtpgpPPTPELFQEAGPGGPLEEPDGQARSHL---SSAGSLNASFQPSVEVAPAGSPHPSLELSQVAS 247

                  ....*...
gi 291084570  444 PKAKARDA 451
Cdd:pfam15479 248 PQASAERA 255
 
Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
570-710 5.34e-17

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 78.93  E-value: 5.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291084570  570 KSTAGIMNAEAATKILTELRRLAREQREKEEEERQREEMQQRVIKKS-KDMAKEAVGGQAEDHLKLKDGQQQNETKKKKG 648
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEElRRRAEEERARREEEARRLEEERRREEEERQRK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 291084570  649 WLD----------QEDQEAPLQKGDAKIKAQEEADKRKKEHERIMLQNLQERLERKKRIEEIMKRTRKTDVN 710
Cdd:pfam05672  81 AEEeaeereqreqEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKRIEEIMKRTRKSDQA 152
DUF4639 pfam15479
Domain of unknown function (DUF4639); This family of proteins is found in eukaryotes. Proteins ...
368-451 5.92e-04

Domain of unknown function (DUF4639); This family of proteins is found in eukaryotes. Proteins in this family are typically between 161 and 601 amino acids in length.


Pssm-ID: 464739  Cd Length: 580  Bit Score: 43.26  E-value: 5.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291084570  368 PEASLEAPPEVSL----EALPEVSVEAAPEGSLEAPPKGSAEVApkeSVKGSPKESMEASPEAMVKASPKTSLEASMEAS 443
Cdd:pfam15479 171 QMESWEPSPELRVtpgpPPTPELFQEAGPGGPLEEPDGQARSHL---SSAGSLNASFQPSVEVAPAGSPHPSLELSQVAS 247

                  ....*...
gi 291084570  444 PKAKARDA 451
Cdd:pfam15479 248 PQASAERA 255
PRK11633 PRK11633
cell division protein DedD; Provisional
348-473 3.47e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.99  E-value: 3.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291084570 348 IEALPKVD--LETVPKVSIVASPEASLEAPPEVslealpEVSVEAAPEGSLEAPPKGSAEVAPKESVKGSPKESMEASPE 425
Cdd:PRK11633  53 PDMMPAATqaLPTQPPEGAAEAVRAGDAAAPSL------DPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVE 126
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 291084570 426 AMVKASPKTSLEASMEASPKAKA--------RDAPKKSEMdkqalipIAKKRLSSY 473
Cdd:PRK11633 127 APPAPKPEPKPVVEEKAAPTGKAyvvqlgalKNADKVNEI-------VAKLRLSGY 175
 
Name Accession Description Interval E-value
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
570-710 5.34e-17

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 78.93  E-value: 5.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291084570  570 KSTAGIMNAEAATKILTELRRLAREQREKEEEERQREEMQQRVIKKS-KDMAKEAVGGQAEDHLKLKDGQQQNETKKKKG 648
Cdd:pfam05672   1 KPSAGTTDAEEAARILAEKRRQAREQREREEQERLEKEEEERLRKEElRRRAEEERARREEEARRLEEERRREEEERQRK 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 291084570  649 WLD----------QEDQEAPLQKGDAKIKAQEEADKRKKEHERIMLQNLQERLERKKRIEEIMKRTRKTDVN 710
Cdd:pfam05672  81 AEEeaeereqreqEEQERLQKQKEEAEAKAREEAERQRQEREKIMQQEEQERLERKKRIEEIMKRTRKSDQA 152
DUF4639 pfam15479
Domain of unknown function (DUF4639); This family of proteins is found in eukaryotes. Proteins ...
368-451 5.92e-04

Domain of unknown function (DUF4639); This family of proteins is found in eukaryotes. Proteins in this family are typically between 161 and 601 amino acids in length.


Pssm-ID: 464739  Cd Length: 580  Bit Score: 43.26  E-value: 5.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291084570  368 PEASLEAPPEVSL----EALPEVSVEAAPEGSLEAPPKGSAEVApkeSVKGSPKESMEASPEAMVKASPKTSLEASMEAS 443
Cdd:pfam15479 171 QMESWEPSPELRVtpgpPPTPELFQEAGPGGPLEEPDGQARSHL---SSAGSLNASFQPSVEVAPAGSPHPSLELSQVAS 247

                  ....*...
gi 291084570  444 PKAKARDA 451
Cdd:pfam15479 248 PQASAERA 255
PRK11633 PRK11633
cell division protein DedD; Provisional
348-473 3.47e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.99  E-value: 3.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291084570 348 IEALPKVD--LETVPKVSIVASPEASLEAPPEVslealpEVSVEAAPEGSLEAPPKGSAEVAPKESVKGSPKESMEASPE 425
Cdd:PRK11633  53 PDMMPAATqaLPTQPPEGAAEAVRAGDAAAPSL------DPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVE 126
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 291084570 426 AMVKASPKTSLEASMEASPKAKA--------RDAPKKSEMdkqalipIAKKRLSSY 473
Cdd:PRK11633 127 APPAPKPEPKPVVEEKAAPTGKAyvvqlgalKNADKVNEI-------VAKLRLSGY 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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