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Conserved domains on  [gi|1605041418|ref|NP_001155271|]
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microfibrillar-associated protein 2 isoform a precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAGP super family cl05196
Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian ...
 1-156 8.90e-41

Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils.


The actual alignment was detected with superfamily member pfam05507:

Pssm-ID: 461667  Cd Length: 137  Bit Score: 134.61  E-value: 8.90e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605041418   1 MRAACLFLLFMP-GLLAQGQYDLDPlppfpdhvqynhygdqiDNADYYDYQEVSPRTpeeqfqsqqqvqqevIPAPTPEP 79
Cdd:pfam05507   1 LLLGPKVLLFLTaLIIASDWTPLGV-----------------SGQRGDDVTQVTQET---------------FTDDPNLV 48

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605041418  80 AAAGDLET--EPTEPGPLD----------CREEQYPCTRLYSIHKPCKQCLNEVCFYSLRRVYVVNKEICVRTVCAHEEL 147
Cdd:pfam05507  49 NDPPTDETvlADIEPSTDDlassnnataeCREEQFPCTRLYSVHRPVKQCLHQLCFTSLRRMYIINKEICSRLVCKEHEA 128


                  ....*....
gi 1605041418 148 LRADLCRDK 156
Cdd:pfam05507 129 MKDELCRQM 137
 
Name Accession Description Interval E-value
MAGP pfam05507
Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian ...
 1-156 8.90e-41

Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils.


Pssm-ID: 461667  Cd Length: 137  Bit Score: 134.61  E-value: 8.90e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605041418   1 MRAACLFLLFMP-GLLAQGQYDLDPlppfpdhvqynhygdqiDNADYYDYQEVSPRTpeeqfqsqqqvqqevIPAPTPEP 79
Cdd:pfam05507   1 LLLGPKVLLFLTaLIIASDWTPLGV-----------------SGQRGDDVTQVTQET---------------FTDDPNLV 48

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605041418  80 AAAGDLET--EPTEPGPLD----------CREEQYPCTRLYSIHKPCKQCLNEVCFYSLRRVYVVNKEICVRTVCAHEEL 147
Cdd:pfam05507  49 NDPPTDETvlADIEPSTDDlassnnataeCREEQFPCTRLYSVHRPVKQCLHQLCFTSLRRMYIINKEICSRLVCKEHEA 128


                  ....*....
gi 1605041418 148 LRADLCRDK 156
Cdd:pfam05507 129 MKDELCRQM 137
 
Name Accession Description Interval E-value
MAGP pfam05507
Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian ...
 1-156 8.90e-41

Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils.


Pssm-ID: 461667  Cd Length: 137  Bit Score: 134.61  E-value: 8.90e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605041418   1 MRAACLFLLFMP-GLLAQGQYDLDPlppfpdhvqynhygdqiDNADYYDYQEVSPRTpeeqfqsqqqvqqevIPAPTPEP 79
Cdd:pfam05507   1 LLLGPKVLLFLTaLIIASDWTPLGV-----------------SGQRGDDVTQVTQET---------------FTDDPNLV 48

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1605041418  80 AAAGDLET--EPTEPGPLD----------CREEQYPCTRLYSIHKPCKQCLNEVCFYSLRRVYVVNKEICVRTVCAHEEL 147
Cdd:pfam05507  49 NDPPTDETvlADIEPSTDDlassnnataeCREEQFPCTRLYSVHRPVKQCLHQLCFTSLRRMYIINKEICSRLVCKEHEA 128


                  ....*....
gi 1605041418 148 LRADLCRDK 156
Cdd:pfam05507 129 MKDELCRQM 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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