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Conserved domains on  [gi|1104469679|ref|NP_001150670|]
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polygalacturonase inhibitor 2 [Zea mays]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000136)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 72-401 1.72e-46

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 171.57  E-value: 1.72e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679  72 SECSAADR-DALLSIRAALSEEerqLGVFSTWAAGTDCCAgWYGVACDpTTGRVADLSLRGEAddavmapagrpasgvMS 150
Cdd:PLN00113   23 FSMLHAEElELLLSFKSSINDP---LKYLSNWNSSADVCL-WQGITCN-NSSRVVSIDLSGKN---------------IS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 151 GYVSDAVCRLDRLSTLVLADwKRISGPIPACVAT----------------------SLPYLRVLELPGNRLTGAVPPLGG 208
Cdd:PLN00113   83 GKISSAIFRLPYIQTINLSN-NQLSGPIPDDIFTtssslrylnlsnnnftgsiprgSIPNLETLDLSNNMLSGEIPNDIG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 209 GQSRLAVLNLAGNQLSGGIPASLTSLTELKHLDLAGNRLSGRVPPDLGRLRMLSRALLARNRLSGPIPASVASLPRLADL 288
Cdd:PLN00113  162 SFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 289 DLSENQLTGAIPEGLgagpGNSGVLTTLYLGGNRLSGGVPASLLRSGGLGMLNLSRNALGGGVPDAFTPRSYFMLLDLSR 368
Cdd:PLN00113  242 DLVYNNLTGPIPSSL----GNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFS 317

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1104469679 369 NRLTGGVPRSLASAAYVGHLDLSHNRLCGTIPA 401
Cdd:PLN00113  318 NNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPK 350
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-401 1.72e-46

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 171.57  E-value: 1.72e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679  72 SECSAADR-DALLSIRAALSEEerqLGVFSTWAAGTDCCAgWYGVACDpTTGRVADLSLRGEAddavmapagrpasgvMS 150
Cdd:PLN00113   23 FSMLHAEElELLLSFKSSINDP---LKYLSNWNSSADVCL-WQGITCN-NSSRVVSIDLSGKN---------------IS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 151 GYVSDAVCRLDRLSTLVLADwKRISGPIPACVAT----------------------SLPYLRVLELPGNRLTGAVPPLGG 208
Cdd:PLN00113   83 GKISSAIFRLPYIQTINLSN-NQLSGPIPDDIFTtssslrylnlsnnnftgsiprgSIPNLETLDLSNNMLSGEIPNDIG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 209 GQSRLAVLNLAGNQLSGGIPASLTSLTELKHLDLAGNRLSGRVPPDLGRLRMLSRALLARNRLSGPIPASVASLPRLADL 288
Cdd:PLN00113  162 SFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 289 DLSENQLTGAIPEGLgagpGNSGVLTTLYLGGNRLSGGVPASLLRSGGLGMLNLSRNALGGGVPDAFTPRSYFMLLDLSR 368
Cdd:PLN00113  242 DLVYNNLTGPIPSSL----GNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFS 317

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1104469679 369 NRLTGGVPRSLASAAYVGHLDLSHNRLCGTIPA 401
Cdd:PLN00113  318 NNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPK 350
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
159-373 2.44e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 2.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 159 RLDRLSTLVLADWKRISgpipacvatSLPYLRVLELPGNRLTgAVPPLGGGQSRLAVLNLAGNQLSGgIPASLTSLTELK 238
Cdd:COG4886    94 DLTNLTELDLSGNEELS---------NLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLTD-LPEPLGNLTNLK 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 239 HLDLAGNRLSGrVPPDLGRLRMLSRALLARNRLSgPIPASVASLPRLADLDLSENQLTgAIPEGLgagpGNSGVLTTLYL 318
Cdd:COG4886   163 SLDLSNNQLTD-LPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPL----ANLTNLETLDL 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1104469679 319 GGNRLSgGVPaSLLRSGGLGMLNLSRNALgGGVPDAFTPRSyfmL--LDLSRNRLTG 373
Cdd:COG4886   236 SNNQLT-DLP-ELGNLTNLEELDLSNNQL-TDLPPLANLTN---LktLDLSNNQLTD 286
LRR_8 pfam13855
Leucine rich repeat;
187-247 1.22e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.22e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104469679 187 PYLRVLELPGNRLTGAVPPLGGGQSRLAVLNLAGNQLSGGIPASLTSLTELKHLDLAGNRL 247
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 185-293 3.28e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 185 SLPYLRVLELPGNRLTgaVppLGG--GQSRLAVLNLAGNQLSGGI-----PASLTSLTE-LKHLDLAGNRLSGrvPPDLG 256
Cdd:cd21340    66 NLVNLKKLYLGGNRIS--V--VEGleNLTNLEELHIENQRLPPGEkltfdPRSLAALSNsLRVLNISGNNIDS--LEPLA 139

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1104469679 257 RLRMLSRALLARNRLS--GPIPASVASLPRLADLDLSEN 293
Cdd:cd21340   140 PLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-401 1.72e-46

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 171.57  E-value: 1.72e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679  72 SECSAADR-DALLSIRAALSEEerqLGVFSTWAAGTDCCAgWYGVACDpTTGRVADLSLRGEAddavmapagrpasgvMS 150
Cdd:PLN00113   23 FSMLHAEElELLLSFKSSINDP---LKYLSNWNSSADVCL-WQGITCN-NSSRVVSIDLSGKN---------------IS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 151 GYVSDAVCRLDRLSTLVLADwKRISGPIPACVAT----------------------SLPYLRVLELPGNRLTGAVPPLGG 208
Cdd:PLN00113   83 GKISSAIFRLPYIQTINLSN-NQLSGPIPDDIFTtssslrylnlsnnnftgsiprgSIPNLETLDLSNNMLSGEIPNDIG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 209 GQSRLAVLNLAGNQLSGGIPASLTSLTELKHLDLAGNRLSGRVPPDLGRLRMLSRALLARNRLSGPIPASVASLPRLADL 288
Cdd:PLN00113  162 SFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 289 DLSENQLTGAIPEGLgagpGNSGVLTTLYLGGNRLSGGVPASLLRSGGLGMLNLSRNALGGGVPDAFTPRSYFMLLDLSR 368
Cdd:PLN00113  242 DLVYNNLTGPIPSSL----GNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFS 317

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1104469679 369 NRLTGGVPRSLASAAYVGHLDLSHNRLCGTIPA 401
Cdd:PLN00113  318 NNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPK 350
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 149-402 6.71e-44

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 164.25  E-value: 6.71e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 149 MSGYVSDAVCRLDRLSTLVLADwKRISGPIPACVaTSLPYLRVLELPGNRLTGAVPPLGGGQSRLAVLNLAGNQLSGGIP 228
Cdd:PLN00113  296 LSGEIPELVIQLQNLEILHLFS-NNFTGKIPVAL-TSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIP 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 229 ASLTSLTELKHLDLAGNRLSGRVPPDLGRLRMLSRALLARNRLSGPIPASVASLPRLADLDLSENQLTGAIPEGLGAGPG 308
Cdd:PLN00113  374 EGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPS 453

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 309 nsgvLTTLYLGGNRLSGGVPASlLRSGGLGMLNLSRNALGGGVPDAFTPRSYFMLLDLSRNRLTGGVPRSLASAAYVGHL 388
Cdd:PLN00113  454 ----LQMLSLARNKFFGGLPDS-FGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSL 528

                         250
                  ....*....|....
gi 1104469679 389 DLSHNRLCGTIPAG 402
Cdd:PLN00113  529 DLSHNQLSGQIPAS 542
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 186-330 1.84e-24

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 106.47  E-value: 1.84e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 186 LPYLRVLELPGNRLTGAVPPLGGGqSRLAVLNLAGNQLSGGIPASLTSLTELKHLDLAGNRLSGRVPPDLGRLRMLSRAL 265
Cdd:PLN00113  451 MPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLD 529

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1104469679 266 LARNRLSGPIPASVASLPRLADLDLSENQLTGAIPEGLgagpGNSGVLTTLYLGGNRLSGGVPAS 330
Cdd:PLN00113  530 LSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNL----GNVESLVQVNISHNHLHGSLPST 590
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
159-373 2.44e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 2.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 159 RLDRLSTLVLADWKRISgpipacvatSLPYLRVLELPGNRLTgAVPPLGGGQSRLAVLNLAGNQLSGgIPASLTSLTELK 238
Cdd:COG4886    94 DLTNLTELDLSGNEELS---------NLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLTD-LPEPLGNLTNLK 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 239 HLDLAGNRLSGrVPPDLGRLRMLSRALLARNRLSgPIPASVASLPRLADLDLSENQLTgAIPEGLgagpGNSGVLTTLYL 318
Cdd:COG4886   163 SLDLSNNQLTD-LPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPL----ANLTNLETLDL 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1104469679 319 GGNRLSgGVPaSLLRSGGLGMLNLSRNALgGGVPDAFTPRSyfmL--LDLSRNRLTG 373
Cdd:COG4886   236 SNNQLT-DLP-ELGNLTNLEELDLSNNQL-TDLPPLANLTN---LktLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
155-349 4.15e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 4.15e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 155 DAVCRLDRLSTLVLADwKRISgPIPACVAtSLPYLRVLELPGNRLTGaVPPLGGGQSRLAVLNLAGNQLSGgIPASLTSL 234
Cdd:COG4886   130 EELANLTNLKELDLSN-NQLT-DLPEPLG-NLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITD-LPEPLGNL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 235 TELKHLDLAGNRLSgRVPPDLGRLRMLSRALLARNRLSgPIPaSVASLPRLADLDLSENQLTGaIPEGlgagpGNSGVLT 314
Cdd:COG4886   205 TNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DLP-ELGNLTNLEELDLSNNQLTD-LPPL-----ANLTNLK 275

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1104469679 315 TLYLGGNRLSGGVPASLLRSGGLGMLNLSRNALGG 349
Cdd:COG4886   276 TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
160-323 1.21e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 1.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 160 LDRLSTLVLADwKRISGpIPACVAtSLPYLRVLELPGNRLTGAVPPLGGGqSRLAVLNLAGNQLSGgIPASLTSLTELKH 239
Cdd:COG4886   158 LTNLKSLDLSN-NQLTD-LPEELG-NLTNLKELDLSNNQITDLPEPLGNL-TNLEELDLSGNQLTD-LPEPLANLTNLET 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 240 LDLAGNRLSgrVPPDLGRLRMLSRALLARNRLSGpIPASvASLPRLADLDLSENQLTGAIPEGLGAGPGNSGVLTTLYLG 319
Cdd:COG4886   233 LDLSNNQLT--DLPELGNLTNLEELDLSNNQLTD-LPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308


                  ....
gi 1104469679 320 GNRL 323
Cdd:COG4886   309 NLLE 312
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
212-395 2.69e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 2.69e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 212 RLAVLNLAGNQLSGGIPASLTSLTELKHLDLAGNRlsgrvppDLGRLRMLSRALLARNRLSGpIPASVASLPRLADLDLS 291
Cdd:COG4886    73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 292 ENQLTgAIPEGLGAGPGnsgvLTTLYLGGNRLSGgVPASLLRSGGLGMLNLSRNALGGgVPDAFTPRSYFMLLDLSRNRL 371
Cdd:COG4886   145 NNQLT-DLPEPLGNLTN----LKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQITD-LPEPLGNLTNLEELDLSGNQL 217

                         170       180
                  ....*....|....*....|....
gi 1104469679 372 TGgVPRSLASAAYVGHLDLSHNRL 395
Cdd:COG4886   218 TD-LPEPLANLTNLETLDLSNNQL 240
PLN03150 PLN03150
hypothetical protein; Provisional
 186-264 1.01e-13

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 72.93  E-value: 1.01e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1104469679 186 LPYLRVLELPGNRLTGAVPPLGGGQSRLAVLNLAGNQLSGGIPASLTSLTELKHLDLAGNRLSGRVPPDLGRlRMLSRA 264
Cdd:PLN03150  441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGG-RLLHRA 518
PLN03150 PLN03150
hypothetical protein; Provisional
 213-300 2.33e-13

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 71.77  E-value: 2.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 213 LAVLNLAGNQLSGGIPASLTSLTELKHLDLAGNRLSGRVPPDLGRLRMLSRALLARNRLSGPIPASVASLP-RLADLDLS 291
Cdd:PLN03150  444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRLlHRASFNFT 523


                  ....*....
gi 1104469679 292 ENQLTGAIP 300
Cdd:PLN03150  524 DNAGLCGIP 532
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
153-371 1.13e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 1.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 153 VSDAVCRLDRLSTLVLAD--WKRISGPIpacvaTSLPYLRVLELPGNRLTGAVPPLGGgQSRLAVLNLAGNQLSGgIPaS 230
Cdd:COG4886   174 LPEELGNLTNLKELDLSNnqITDLPEPL-----GNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQLTD-LP-E 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 231 LTSLTELKHLDLAGNRLSGrvPPDLGRLRMLSRALLARNRLSGPIPASVASLPRLADLDLSENQLTGAIPEGLGAGPGNS 310
Cdd:COG4886   246 LGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104469679 311 GVLTTLYLGGNRLSGGVPASLLRSGGLGMLNLSRNALGGGVPDAFTPRSYFMLLDLSRNRL 371
Cdd:COG4886   324 LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
PLN03150 PLN03150
hypothetical protein; Provisional
 216-307 1.12e-11

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 66.76  E-value: 1.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 216 LNLAGNQLSGGIPASLTSLTELKHLDLAGNRLSGRVPPDLGRLRMLSRALLARNRLSGPIPASVASLPRLADLDLSENQL 295
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502

                          90
                  ....*....|..
gi 1104469679 296 TGAIPEGLGAGP 307
Cdd:PLN03150  503 SGRVPAALGGRL 514
PLN03150 PLN03150
hypothetical protein; Provisional
 271-358 1.33e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 60.21  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 271 LSGPIPASVASLPRLADLDLSENQLTGAIPEGLGAGPGnsgvLTTLYLGGNRLSGGVPASLLRSGGLGMLNLSRNALGGG 350
Cdd:PLN03150  430 LRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITS----LEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGR 505


                  ....*...
gi 1104469679 351 VPDAFTPR 358
Cdd:PLN03150  506 VPAALGGR 513
PLN03150 PLN03150
hypothetical protein; Provisional
 312-423 7.36e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.90  E-value: 7.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 312 VLTTLYLGGNRLSGGVPASLLRSGGLGMLNLSRNALGGGVPDAFTPRSYFMLLDLSRNRLTGGVPRSLASAAYVGHLDLS 391
Cdd:PLN03150  419 FIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLN 498

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1104469679 392 HNRLCGTIPA---GPPFDRlGAESFVGNSCLCGGP 423
Cdd:PLN03150  499 GNSLSGRVPAalgGRLLHR-ASFNFTDNAGLCGIP 532
PLN03150 PLN03150
hypothetical protein; Provisional
 77-231 1.48e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 53.67  E-value: 1.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679  77 ADRDALLSIRAALSEEERQLGVFSTWAAGTDCCAG----WYGVAC--DPTTGR--VADLSLRGEAddavmapagrpasgv 148
Cdd:PLN03150  365 AESKTLLEEVSALQTLKSSLGLPLRFGWNGDPCVPqqhpWSGADCqfDSTKGKwfIDGLGLDNQG--------------- 429

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 149 MSGYVSDAVCRLDRLSTLVLADwKRISGPIPACVATsLPYLRVLELPGNRLTGAVPPLGGGQSRLAVLNLAGNQLSGGIP 228
Cdd:PLN03150  430 LRGFIPNDISKLRHLQSINLSG-NSIRGNIPPSLGS-ITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVP 507


                  ...
gi 1104469679 229 ASL 231
Cdd:PLN03150  508 AAL 510
LRR_8 pfam13855
Leucine rich repeat;
187-247 1.22e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.22e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104469679 187 PYLRVLELPGNRLTGAVPPLGGGQSRLAVLNLAGNQLSGGIPASLTSLTELKHLDLAGNRL 247
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 185-293 3.28e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 185 SLPYLRVLELPGNRLTgaVppLGG--GQSRLAVLNLAGNQLSGGI-----PASLTSLTE-LKHLDLAGNRLSGrvPPDLG 256
Cdd:cd21340    66 NLVNLKKLYLGGNRIS--V--VEGleNLTNLEELHIENQRLPPGEkltfdPRSLAALSNsLRVLNISGNNIDS--LEPLA 139

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1104469679 257 RLRMLSRALLARNRLS--GPIPASVASLPRLADLDLSEN 293
Cdd:cd21340   140 PLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 150-278 1.02e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 150 SGYVSDAVCRLDRLSTLVLADwKRISGPIPACVaTSLPYLRVLELPGNRLTGAVPPLGGGQSRLAVLNLAGNQLSGGIPA 229
Cdd:PLN00113  488 SGAVPRKLGSLSELMQLKLSE-NKLSGEIPDEL-SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPK 565

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1104469679 230 SLTSLTELKHLDLAGNRLSGRVPPDLGRLRMLSRALLARNRLSGPIPAS 278
Cdd:PLN00113  566 NLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAGNIDLCGGDTTS 614
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 210-356 1.78e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.71  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 210 QSRLAVLNLAGNQLSG----GIPASLTSLTELKHLDLAGNRLSGR----VPPDLGRLRMLSRALLARNRLSG----PIPA 277
Cdd:COG5238   263 NTTVETLYLSGNQIGAegaiALAKALQGNTTLTSLDLSVNRIGDEgaiaLAEGLQGNKTLHTLNLAYNGIGAqgaiALAK 342

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 278 SVASLPRLADLDLSENQLTGAIPEGLGAGPGNSGVLTTLYLGGNRLSG-GVPA--SLLRSGGLGMLNLSRNALGGGVPDA 354
Cdd:COG5238   343 ALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKqGAEAliDALQTNRLHTLILDGNLIGAEAQQR 422


                  ..
gi 1104469679 355 FT 356
Cdd:COG5238   423 LE 424
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 75-118 2.62e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 41.13  E-value: 2.62e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1104469679  75 SAADRDALLSIRAALSEEerqLGVFSTW-AAGTDCCaGWYGVACD 118
Cdd:pfam08263   1 LNDDGQALLAFKSSLNDP---PGALSSWnSSSSDPC-SWTGVTCD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 179-248 2.83e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 2.83e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1104469679 179 PACVATSLPYLRVLELPGNRLTGAVP--PLgggqSRLAVLNLAGNQLSGG--IPASLTSLTELKHLDLAGNRLS 248
Cdd:cd21340   112 PRSLAALSNSLRVLNISGNNIDSLEPlaPL----RNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGNPVC 181
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 231-396 7.17e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 7.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 231 LTSLTelkHLDLAGNRLsgRVPPDLGRLRMLSRALLARNRLSGpIPaSVASLPRLADLDLSENQLTgAIpEGLGagpgNS 310
Cdd:cd21340     1 LKRIT---HLYLNDKNI--TKIDNLSLCKNLKVLYLYDNKITK-IE-NLEFLTNLTHLYLQNNQIE-KI-ENLE----NL 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 311 GVLTTLYLGGNRLSggVPASLLRSGGLGMLNLSRNALGGGVPDAFTPRSYFML------LDLSRNRLTGgvPRSLASAAY 384
Cdd:cd21340    68 VNLKKLYLGGNRIS--VVEGLENLTNLEELHIENQRLPPGEKLTFDPRSLAALsnslrvLNISGNNIDS--LEPLAPLRN 143

                         170
                  ....*....|..
gi 1104469679 385 VGHLDLSHNRLC 396
Cdd:cd21340   144 LEQLDASNNQIS 155
LRR_8 pfam13855
Leucine rich repeat;
211-271 1.61e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.61e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1104469679 211 SRLAVLNLAGNQLSGGIPASLTSLTELKHLDLAGNRLSgRVPP----DLGRLRMLsraLLARNRL 271
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-TLSPgafsGLPSLRYL---DLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 283-383 1.80e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 283 PRLADLDLSENQlTGAIPEGLGA---GPGNSGVLTTLYLGGNRLSGGVPA---SLLRSGGLGMLNLSRNALGGGvPDAFT 356
Cdd:cd00116    51 PSLKELCLSLNE-TGRIPRGLQSllqGLTKGCGLQELDLSDNALGPDGCGvleSLLRSSSLQELKLNNNGLGDR-GLRLL 128

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1104469679 357 PRSYFML------LDLSRNRLTGGVPRSLASAA 383
Cdd:cd00116   129 AKGLKDLppalekLVLGRNRLEGASCEALAKAL 161
LRR_8 pfam13855
Leucine rich repeat;
257-323 1.10e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1104469679 257 RLRMLSralLARNRLSGPIPASVASLPRLADLDLSENQLTGaIPEGLGAGPGNsgvLTTLYLGGNRL 323
Cdd:pfam13855   2 NLRSLD---LSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSGLPS---LRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
340-395 1.31e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1104469679 340 LNLSRNALGGGVPDAFTPRSYFMLLDLSRNRLTGGVPRSLASAAYVGHLDLSHNRL 395
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 309-402 1.39e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 309 NSGVLTTLYLGGNRLSGGVPASLLRSGGLGMLNLSRNALGGGVPDAFTPRSYFMLldlsrnrltggvprslasaayvgHL 388
Cdd:PLN00113   67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLR-----------------------YL 123

                          90
                  ....*....|....
gi 1104469679 389 DLSHNRLCGTIPAG 402
Cdd:PLN00113  124 NLSNNNFTGSIPRG 137
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 212-253 3.89e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 3.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1104469679 212 RLAVLNLAGNQLSGgIPAsLTSLTELKHLDLAGNRLSGRVPP 253
Cdd:pfam12799   2 NLEVLDLSNNQITD-IPP-LAKLPNLETLDLSGNNKITDLSD 41
LRR_8 pfam13855
Leucine rich repeat;
283-347 4.18e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1104469679 283 PRLADLDLSENQLTGaIPEGLGAGPGNsgvLTTLYLGGNRLSGGVPASLLRSGGLGMLNLSRNAL 347
Cdd:pfam13855   1 PNLRSLDLSNNRLTS-LDDGAFKGLSN---LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 216-348 6.97e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469679 216 LNLAGNQL----SGGIPASLTSLTELKHLDLAGNRLSGRVPPDLGRL----RMLSRALLARNRLSGPIPASVASL----P 283
Cdd:COG5238   213 LWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNQIGAEGAIALAKAlqgnT 292

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1104469679 284 RLADLDLSENQLTGAIPEGLGAGPGNSGVLTTLYLGGNRLSG----GVPASLLRSGGLGMLNLSRNALG 348
Cdd:COG5238   293 TLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAqgaiALAKALQENTTLHSLDLSDNQIG 361
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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