|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
163-537 |
1.18e-151 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 448.83 E-value: 1.18e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 163 SFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVPaiRVLILTPT 242
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRAP--QALILAPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 243 RELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHL-RNSLSvgLEDLAVVILDEADRLL 321
Cdd:COG0513 81 RELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIeRGALD--LSGVETLVLDEADRML 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 322 ELGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRLEADPSLKRPATLTEEVVRIRRAREsnQEAVLLAL 401
Cdd:COG0513 159 DMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDK--LELLRRLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 402 CLKTFKRsVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQTVIN 481
Cdd:COG0513 237 RDEDPER-AIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVIN 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 226509858 482 FACPRDVKTYLHRVGRTARAGREGYAVTFVTDDDRSLLKAIAKKAGSQLKSRIVAE 537
Cdd:COG0513 316 YDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQKIEEEELPG 371
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
173-367 |
3.87e-123 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 366.58 E-value: 3.87e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVPAIRVLILTPTRELAAQVHSM 252
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKAATRVLVLVPTRELAMQCFSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 253 IEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLSVGLEDLAVVILDEADRLLELGFSAEIQEL 332
Cdd:cd17947 81 LQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRMLEEGFADELKEI 160
|
170 180 190
....*....|....*....|....*....|....*
gi 226509858 333 IRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRL 367
Cdd:cd17947 161 LRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
164-537 |
8.10e-100 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 315.34 E-value: 8.10e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 164 FLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVP-AIRVLILTPT 242
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRRKSgPPRILILTPT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 243 RELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSlSVGLEDLAVVILDEADRLLE 322
Cdd:PRK11192 83 RELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEE-NFDCRAVETLILDEADRMLD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 323 LGFSAEIQELIRMCPKRRQTMLFSATMteEIDELIKLS---LNKPVRLEADPSLKRPATLTEevvRIRRARESNQEAVLL 399
Cdd:PRK11192 162 MGFAQDIETIAAETRWRKQTLLFSATL--EGDAVQDFAerlLNDPVEVEAEPSRRERKKIHQ---WYYRADDLEHKTALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 400 ALCLKTF--KRSvIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQ 477
Cdd:PRK11192 237 CHLLKQPevTRS-IVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVS 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 478 TVINFACPRDVKTYLHRVGRTARAGREGYAVTFVTDDDRSLLKAIAKKAGSQLKSRIVAE 537
Cdd:PRK11192 316 HVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIERYIEEPLKARVIDE 375
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
161-522 |
3.06e-94 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 301.33 E-value: 3.06e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 161 ANSFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLlfRPKRvPAIRVLILT 240
Cdd:PRK11776 3 MTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKL--DVKR-FRVQALVLC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 241 PTRELAAQVHSMIEKLAQFTD-IRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHL-RNSLSvgLEDLAVVILDEAD 318
Cdd:PRK11776 80 PTRELADQVAKEIRRLARFIPnIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLrKGTLD--LDALNTLVLDEAD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 319 RLLELGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRLEADPslkrpatlTEEVVRIRRAR---ESNQE 395
Cdd:PRK11776 158 RMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVES--------THDLPAIEQRFyevSPDER 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 396 AVLLALCLKTFK-RSVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIV 474
Cdd:PRK11776 230 LPALQRLLLHHQpESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIK 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 226509858 475 GVQTVINFACPRDVKTYLHRVGRTARAGREGYAVTFVTDDDRSLLKAI 522
Cdd:PRK11776 310 ALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAI 357
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
173-368 |
4.68e-91 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 283.56 E-value: 4.68e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVP-AIRVLILTPTRELAAQVHS 251
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGrGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 252 MIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHL-RNSLSvgLEDLAVVILDEADRLLELGFSAEIQ 330
Cdd:cd00268 81 VARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIeRGKLD--LSNVKYLVLDEADRMLDMGFEEDVE 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 226509858 331 ELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRLE 368
Cdd:cd00268 159 KILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
164-510 |
6.17e-78 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 257.21 E-value: 6.17e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 164 FLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRP----KRVPAIRVLIL 239
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPapedRKVNQPRALIM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 240 TPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLsVGLEDLAVVILDEADR 319
Cdd:PRK04837 90 APTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNH-INLGAIQVVVLDEADR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 320 LLELGFSAEIQELIRMCP--KRRQTMLFSATMTEEIDELIKLSLNKPVRLEADPSLKRPATLTEEVVRirrarESNQE-- 395
Cdd:PRK04837 169 MFDLGFIKDIRWLFRRMPpaNQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFY-----PSNEEkm 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 396 AVLLALCLKTFKRSVIIFSGTKqsaHRLKIIFG-LS--GMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGID 472
Cdd:PRK04837 244 RLLQTLIEEEWPDRAIIFANTK---HRCEEIWGhLAadGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLH 320
|
330 340 350
....*....|....*....|....*....|....*...
gi 226509858 473 IVGVQTVINFACPRDVKTYLHRVGRTARAGREGYAVTF 510
Cdd:PRK04837 321 IPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
163-368 |
6.61e-78 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 249.16 E-value: 6.61e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 163 SFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVPAirvLILTPT 242
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFA---LVLAPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 243 RELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLSVGLEDLAVVILDEADRLLE 322
Cdd:cd17954 78 RELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFSLKSLKFLVMDEADRLLN 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 226509858 323 LGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRLE 368
Cdd:cd17954 158 MDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKIE 203
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
163-524 |
1.14e-77 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 257.81 E-value: 1.14e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 163 SFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPK----RVPaIRVLI 238
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPhakgRRP-VRALI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 239 LTPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDhLRNSLSVGLEDLAVVILDEAD 318
Cdd:PRK10590 81 LTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLD-LEHQNAVKLDQVEILVLDEAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 319 RLLELGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRLEadpsLKRPATLTEEV------VRIRRAREs 392
Cdd:PRK10590 160 RMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIE----VARRNTASEQVtqhvhfVDKKRKRE- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 393 nqeaVLLALCLKTFKRSVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGID 472
Cdd:PRK10590 235 ----LLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLD 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 226509858 473 IVGVQTVINFACPRDVKTYLHRVGRTARAGREGYAVTFVTDDDRSLLKAIAK 524
Cdd:PRK10590 311 IEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEK 362
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
163-524 |
7.19e-76 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 257.85 E-value: 7.19e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 163 SFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLlfrPKRVPAIRVLILTPT 242
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNL---DPELKAPQILVLAPT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 243 RELAAQVHSMIEKLA-QFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSlSVGLEDLAVVILDEADRLL 321
Cdd:PRK11634 84 RELAVQVAEAMTDFSkHMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRG-TLDLSKLSGLVLDEADEML 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 322 ELGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRLEADPSLKRPATLTEEVVRIRRARESnqEAVLLAL 401
Cdd:PRK11634 163 RMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRKN--EALVRFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 402 CLKTFKrSVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQTVIN 481
Cdd:PRK11634 241 EAEDFD-AAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVN 319
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 226509858 482 FACPRDVKTYLHRVGRTARAGREGYAVTFVTDDDRSLLKAIAK 524
Cdd:PRK11634 320 YDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIER 362
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
164-365 |
2.79e-74 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 239.82 E-value: 2.79e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 164 FLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVPAirvLILTPTR 243
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFA---LVLTPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 244 ELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNS--LSVGLEDLAVVILDEADRLL 321
Cdd:cd17955 78 ELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSddTTKVLSRVKFLVLDEADRLL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 226509858 322 ELGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPV 365
Cdd:cd17955 158 TGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
155-551 |
1.37e-72 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 244.82 E-value: 1.37e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 155 EGATfhanSFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRP----KR 230
Cdd:PRK01297 84 EGKT----RFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPppkeRY 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 231 VPAIRVLILTPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRS-MPDIVVATPGRIIDHLRNSlSVGLEDL 309
Cdd:PRK01297 160 MGEPRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEArFCDILVATPGRLLDFNQRG-EVHLDMV 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 310 AVVILDEADRLLELGFSAEIQELIRMCPKR--RQTMLFSATMTEEIDELIKLSLNKPVRLEADPSLKRPATLTEEVVRIR 387
Cdd:PRK01297 239 EVMVLDEADRMLDMGFIPQVRQIIRQTPRKeeRQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVA 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 388 RareSNQEAVLLALCLKTFKRSVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVA 467
Cdd:PRK01297 319 G---SDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVA 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 468 ARGIDIVGVQTVINFACPRDVKTYLHRVGRTARAGREGYAVTFVTDDDRSLLKAIAKKAGSQLKsrivAEKPVAECAQLI 547
Cdd:PRK01297 396 GRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLGRKIS----CEMPPAELLKPV 471
|
....
gi 226509858 548 EQLE 551
Cdd:PRK01297 472 PRKH 475
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
163-510 |
1.18e-70 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 242.16 E-value: 1.18e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 163 SFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRP---KRVPA-IRVLI 238
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPalaDRKPEdPRALI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 239 LTPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLSVGLEDLAVVILDEAD 318
Cdd:PRK04537 90 LAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICVLDEAD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 319 RLLELGFSAEIQELIRMCPKR--RQTMLFSATMTEEIDELIKLSLNKPVRLEADPSlkrpaTLTEEVVRIRRARESNQEA 396
Cdd:PRK04537 170 RMFDLGFIKDIRFLLRRMPERgtRQTLLFSATLSHRVLELAYEHMNEPEKLVVETE-----TITAARVRQRIYFPADEEK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 397 V--LLALCLKTFKRSVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIV 474
Cdd:PRK04537 245 QtlLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHID 324
|
330 340 350
....*....|....*....|....*....|....*.
gi 226509858 475 GVQTVINFACPRDVKTYLHRVGRTARAGREGYAVTF 510
Cdd:PRK04537 325 GVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISF 360
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
163-365 |
4.92e-67 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 220.25 E-value: 4.92e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 163 SFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVpAIRVLILTPT 242
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTV-GARALILSPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 243 RELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIdHLRNSLSVGLEDLAVVILDEADRLLE 322
Cdd:cd17959 81 RELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLL-HLLVEMNLKLSSVEYVVFDEADRLFE 159
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 226509858 323 LGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPV 365
Cdd:cd17959 160 MGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPV 202
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
169-367 |
9.05e-65 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 214.37 E-value: 9.05e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 169 LSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRV---PAIRVLILTPTREL 245
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESgeeQGTRALILVPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 246 AAQVHSMIEKLAQFT--DIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLSVGLEDLAVVILDEADRLLEL 323
Cdd:cd17961 81 AQQVSKVLEQLTAYCrkDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVLSY 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 226509858 324 GFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRL 367
Cdd:cd17961 161 GYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAIL 204
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
163-524 |
2.58e-64 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 224.27 E-value: 2.58e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 163 SFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLP----VLERLLFRPKRVPAirVLI 238
Cdd:PTZ00110 131 SFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPaivhINAQPLLRYGDGPI--VLV 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 239 LTPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLSvGLEDLAVVILDEAD 318
Cdd:PTZ00110 209 LAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVT-NLRRVTYLVLDEAD 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 319 RLLELGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIK-LSLNKPVR-------LEADPSLKRPATLTEEVVRIRRAR 390
Cdd:PTZ00110 288 RMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARdLCKEEPVHvnvgsldLTACHNIKQEVFVVEEHEKRGKLK 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 391 EsnqeavLLALCLKTFKRsVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARG 470
Cdd:PTZ00110 368 M------LLQRIMRDGDK-ILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRG 440
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 226509858 471 IDIVGVQTVINFACPRDVKTYLHRVGRTARAGREGYAVTFVTDDDRSLLKAIAK 524
Cdd:PTZ00110 441 LDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPDKYRLARDLVK 494
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
162-531 |
2.65e-63 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 217.39 E-value: 2.65e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 162 NSFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRpkrVPAIRVLILTP 241
Cdd:PTZ00424 28 DSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYD---LNACQALILAP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 242 TRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLrNSLSVGLEDLAVVILDEADRLL 321
Cdd:PTZ00424 105 TRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMI-DKRHLRVDDLKLFILDEADEML 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 322 ELGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRLeadpsLKRPATLTEEVVRIRRARESNQEAVLLAL 401
Cdd:PTZ00424 184 SRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRI-----LVKKDELTLEGIRQFYVAVEKEEWKFDTL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 402 C----LKTFKRSvIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQ 477
Cdd:PTZ00424 259 CdlyeTLTITQA-IIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVS 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 226509858 478 TVINFACPRDVKTYLHRVGRTARAGREGYAVTFVTDDDRSLLKAIAKKAGSQLK 531
Cdd:PTZ00424 338 LVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIE 391
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
173-366 |
4.69e-61 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 204.35 E-value: 4.69e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRV--PAIRVLILTPTRELAAQVH 250
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANLkkGQVGALIISPTRELATQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 251 SMIEKLA--QFTDIRCCLIVGGLSTKVQEVAL-RSMPDIVVATPGRIIDHL-RNSLSVGLEDLAVVILDEADRLLELGFS 326
Cdd:cd17960 81 EVLQSFLehHLPKLKCQLLIGGTNVEEDVKKFkRNGPNILVGTPGRLEELLsRKADKVKVKSLEVLVLDEADRLLDLGFE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 226509858 327 AEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVR 366
Cdd:cd17960 161 ADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVR 200
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
163-541 |
1.72e-59 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 210.03 E-value: 1.72e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 163 SFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERL-LFRPKRVPAIR---VLI 238
Cdd:PLN00206 122 SFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCcTIRSGHPSEQRnplAMV 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 239 LTPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSlSVGLEDLAVVILDEAD 318
Cdd:PLN00206 202 LTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKH-DIELDNVSVLVLDEVD 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 319 RLLELGFSAEIQELIRMCPKRrQTMLFSATMTEEIdELIKLSLNKPVRLEADPSLKRPATLTEEVVRIRRARESNQEAVL 398
Cdd:PLN00206 281 CMLERGFRDQVMQIFQALSQP-QVLLFSATVSPEV-EKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLFD 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 399 LALCLKTFKRSVIIFSGTKQSAHRL-KIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQ 477
Cdd:PLN00206 359 ILKSKQHFKPPAVVFVSSRLGADLLaNAITVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVR 438
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226509858 478 TVINFACPRDVKTYLHRVGRTARAGREGYAVTFVTDDDRSLLK---AIAKKAGSQLKSRIVAEKPVA 541
Cdd:PLN00206 439 QVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPelvALLKSSGAAIPRELANSRYLG 505
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
175-365 |
2.97e-58 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 196.36 E-value: 2.97e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 175 RACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLlFRPKRVPA--IRVLILTPTRELAAQVHSM 252
Cdd:cd17941 3 KGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKL-YRERWTPEdgLGALIISPTRELAMQIFEV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 253 IEKLAQFTDIRCCLIVGGLSTKVQEVALRSMpDIVVATPGRIIDHLRNSLSVGLEDLAVVILDEADRLLELGFSAEIQEL 332
Cdd:cd17941 82 LRKVGKYHSFSAGLIIGGKDVKEEKERINRM-NILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDMGFKETLDAI 160
|
170 180 190
....*....|....*....|....*....|...
gi 226509858 333 IRMCPKRRQTMLFSATMTEEIDELIKLSLNKPV 365
Cdd:cd17941 161 VENLPKSRQTLLFSATQTKSVKDLARLSLKNPE 193
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
186-356 |
9.15e-58 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 194.00 E-value: 9.15e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 186 TPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPkrvPAIRVLILTPTRELAAQVHSMIEKLAQFTDIRCC 265
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLD---NGPQALVLAPTRELAEQIYEELKKLGKGLGLKVA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 266 LIVGGLSTKVQEVALRSmPDIVVATPGRIIDHLRNSlsVGLEDLAVVILDEADRLLELGFSAEIQELIRMCPKRRQTMLF 345
Cdd:pfam00270 78 SLLGGDSRKEQLEKLKG-PDILVGTPGRLLDLLQER--KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLL 154
|
170
....*....|.
gi 226509858 346 SATMTEEIDEL 356
Cdd:pfam00270 155 SATLPRNLEDL 165
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
174-364 |
2.09e-57 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 194.12 E-value: 2.09e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 174 VRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLE---RLLFRPKRVPAirVLILTPTRELAAQVH 250
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIEllyKLKFKPRNGTG--VIIISPTRELALQIY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 251 SMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLSVGLEDLAVVILDEADRLLELGFSAEIQ 330
Cdd:cd17942 80 GVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILEIGFEEEMR 159
|
170 180 190
....*....|....*....|....*....|....
gi 226509858 331 ELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKP 364
Cdd:cd17942 160 QIIKLLPKRRQTMLFSATQTRKVEDLARISLKKK 193
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
169-363 |
2.82e-57 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 194.34 E-value: 2.82e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 169 LSRPLVRACEALGYQKPTPIQAACIPLAL-TGRDICGSAITGSGKTAAFSLPVLERLL--FRPKRVPAIRVLILTPTREL 245
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPAIQSLLntKPAGRRSGVSALIISPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 246 AAQVHSMIEKLAQF-TDIRCCLIVGGLSTKVQEVALRSM-PDIVVATPGRIIDHLRNSLSVG-LEDLAVVILDEADRLLE 322
Cdd:cd17964 81 ALQIAAEAKKLLQGlRKLRVQSAVGGTSRRAELNRLRRGrPDILVATPGRLIDHLENPGVAKaFTDLDYLVLDEADRLLD 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 226509858 323 LGFSAEIQELIRMCPKR----RQTMLFSATMTEEIDELIKLSLNK 363
Cdd:cd17964 161 MGFRPDLEQILRHLPEKnadpRQTLLFSATVPDEVQQIARLTLKK 205
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
173-365 |
3.43e-56 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 191.76 E-value: 3.43e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVPAIR-----VLILTPTRELAA 247
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKddgpyALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 248 QVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLSVgLEDLAVVILDEADRLLELGFSA 327
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLV-LNQCTYVVLDEADRMIDMGFEP 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 226509858 328 EIQELIRMCP--------------------KRRQTMLFSATMTEEIDELIKLSLNKPV 365
Cdd:cd17945 160 QVTKILDAMPvsnkkpdteeaeklaasgkhRYRQTMMFTATMPPAVEKIAKGYLRRPV 217
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
173-363 |
3.80e-56 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 192.07 E-value: 3.80e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLALT-GRDICGSAITGSGKTAAFSLPVLERLL------FRPKRVPAIRVLILTPTREL 245
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILERLLsqkssnGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 246 AAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHL--RNSLSVGLEDLAVVILDEADRLLEL 323
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIqeGNEHLANLKSLRFLVLDEADRMLEK 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 226509858 324 GFSAEIQELIRMCP-------KRRQTMLFSATMTEEIDELIKLSLNK 363
Cdd:cd17946 161 GHFAELEKILELLNkdragkkRKRQTFVFSATLTLDHQLPLKLNSKK 207
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
163-356 |
3.83e-56 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 191.55 E-value: 3.83e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 163 SFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLL---------FRPKRVPa 233
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLedgppsvgrGRRKAYP- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 234 iRVLILTPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHL-RNSLSvgLEDLAVV 312
Cdd:cd17967 80 -SALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIeRGRIS--LSSIKFL 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 226509858 313 ILDEADRLLELGFSAEIQELIR---MCPKR-RQTMLFSATMTEEIDEL 356
Cdd:cd17967 157 VLDEADRMLDMGFEPQIRKIVEhpdMPPKGeRQTLMFSATFPREIQRL 204
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
173-367 |
7.67e-55 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 187.03 E-value: 7.67e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLfRPKRVPAIRVLILTPTRELAAQVHSM 252
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLG-KPRKKKGLRALILAPTRELASQIYRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 253 IEKLAQFTDIRCCLIvgglsTKVQEVALRSMP------DIVVATPGRIIDHLRNSlSVGLEDLAVVILDEADRLLELGFS 326
Cdd:cd17957 80 LLKLSKGTGLRIVLL-----SKSLEAKAKDGPksitkyDILVSTPLRLVFLLKQG-PIDLSSVEYLVLDEADKLFEPGFR 153
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 226509858 327 AEIQELIRMCP-KRRQTMLFSATMTEEIDELIKLSLNKPVRL 367
Cdd:cd17957 154 EQTDEILAACTnPNLQRSLFSATIPSEVEELARSVMKDPIRI 195
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
160-356 |
2.15e-51 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 180.16 E-value: 2.15e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 160 HANSFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLL--------FRPKRV 231
Cdd:cd18052 41 AILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMkegltassFSEVQE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 232 PAirVLILTPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLsVGLEDLAV 311
Cdd:cd18052 121 PQ--ALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGK-ISLSKLKY 197
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 226509858 312 VILDEADRLLELGFSAEIQELIR---MCPK-RRQTMLFSATMTEEIDEL 356
Cdd:cd18052 198 LILDEADRMLDMGFGPEIRKLVSepgMPSKeDRQTLMFSATFPEEIQRL 246
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
178-372 |
2.34e-51 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 177.68 E-value: 2.34e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 178 EALGYQKPTPIQAACIPLALTG-RDICGSAITGSGKTAAFSLPVLERLlfrpKRVPAIRVLILTPTRELAAQVHSMIEKL 256
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEAL----KRGKGGRVLVLVPTRELAEQWAEELKKL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 257 AQFTDIRCCLIVGGLSTKVQEVALRS-MPDIVVATPGRIIDHLRNSlSVGLEDLAVVILDEADRLLELGFSAEIQELIRM 335
Cdd:smart00487 78 GPSLGLKVVGLYGGDSKREQLRKLESgKTDILVTTPGRLLDLLEND-KLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKL 156
|
170 180 190
....*....|....*....|....*....|....*..
gi 226509858 336 CPKRRQTMLFSATMTEEIDELIKLSLNKPVRLEADPS 372
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFT 193
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
166-367 |
9.91e-51 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 175.98 E-value: 9.91e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 166 ELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRpkrVPAIRVLILTPTREL 245
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTT---VRETQALVLAPTREL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 246 AAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHL-RNSLSvgLEDLAVVILDEADRLLELG 324
Cdd:cd17939 78 AQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLqRRSLR--TDKIKMFVLDEADEMLSRG 155
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 226509858 325 FSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRL 367
Cdd:cd17939 156 FKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
169-367 |
1.11e-50 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 176.24 E-value: 1.11e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 169 LSRPLVracEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLL---FRPKRVPAIRVLILTPTREL 245
Cdd:cd17949 1 LVSHLK---SKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLslePRVDRSDGTLALVLVPTREL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 246 AAQVHSMIEKLAQ-FTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLSVGLEDLAVVILDEADRLLELG 324
Cdd:cd17949 78 ALQIYEVLEKLLKpFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMG 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 226509858 325 FSAEIQELIRM-------------CPKRRQTMLFSATMTEEIDELIKLSLNKPVRL 367
Cdd:cd17949 158 FEKDITKILELlddkrskaggeksKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
166-365 |
9.75e-49 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 171.41 E-value: 9.75e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 166 ELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVPA--IRVLILTPTR 243
Cdd:cd17953 16 QCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPVKPGegPIGLIMAPTR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 244 ELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHL--RNSLSVGLEDLAVVILDEADRLL 321
Cdd:cd17953 96 ELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILtaNNGRVTNLRRVTYVVLDEADRMF 175
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 226509858 322 ELGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPV 365
Cdd:cd17953 176 DMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
379-511 |
4.32e-48 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 166.14 E-value: 4.32e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 379 LTEEVVRIRRarESNQEAVLLALCLKTFKRSVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEV 458
Cdd:cd18787 1 IKQLYVVVEE--EEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKV 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 226509858 459 DFLIATDVAARGIDIVGVQTVINFACPRDVKTYLHRVGRTARAGREGYAVTFV 511
Cdd:cd18787 79 RVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
173-367 |
9.38e-48 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 167.59 E-value: 9.38e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVPA---IrVLILTPTRELAAQV 249
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRELEKGegpI-AVIVAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 250 HSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSlSVGLEDLAVVILDEADRLLELGFSAEI 329
Cdd:cd17952 80 YLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKK-ATNLQRVTYLVLDEADRMFDMGFEYQV 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 226509858 330 QELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRL 367
Cdd:cd17952 159 RSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
164-365 |
1.17e-47 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 167.47 E-value: 1.17e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 164 FLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLlfRPKRvPAIRVLILTPTR 243
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKI--DPKK-DVIQALILVPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 244 ELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLSVgLEDLAVVILDEADRLLEL 323
Cdd:cd17940 78 ELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVAD-LSHCKTLVLDEADKLLSQ 156
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 226509858 324 GFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPV 365
Cdd:cd17940 157 DFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPY 198
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
173-364 |
1.71e-47 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 168.19 E-value: 1.71e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLALTG---------RDICGSAITGSGKTAAFSLPVLERLLFRPkrVPAIRVLILTPTR 243
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSKRV--VPRLRALIVVPTK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 244 ELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALR--------SMPDIVVATPGRIIDHLRNSLSVGLEDLAVVILD 315
Cdd:cd17956 79 ELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLvdtsgrylSRVDILVATPGRLVDHLNSTPGFTLKHLRFLVID 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226509858 316 EADRLLELGF-------SAEIQELIRMC-------------PKRRQTMLFSATMTEEIDELIKLSLNKP 364
Cdd:cd17956 159 EADRLLNQSFqdwletvMKALGRPTAPDlgsfgdanllersVRPLQKLLFSATLTRDPEKLSSLKLHRP 227
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
173-365 |
5.90e-47 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 165.13 E-value: 5.90e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVpaiRVLILTPTRELAAQVHSM 252
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHP---QVLILAPTREIAVQIHDV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 253 IEKLAQ-FTDIRCCLIVGGLSTKVQEVALRSmPDIVVATPGRIIdHLRNSLSVGLEDLAVVILDEADRLLELGFSAEIQE 331
Cdd:cd17943 78 FKKIGKkLEGLKCEVFIGGTPVKEDKKKLKG-CHIAVGTPGRIK-QLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNW 155
|
170 180 190
....*....|....*....|....*....|....
gi 226509858 332 LIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPV 365
Cdd:cd17943 156 IFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPV 189
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
164-360 |
8.59e-47 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 165.19 E-value: 8.59e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 164 FLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLErllfrpkrvpAIRVLILTPTR 243
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQ----------IVVALILEPSR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 244 ELAAQVHSMIEKLAQFTD---IRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDhLRNSLSVGLEDLAVVILDEADRL 320
Cdd:cd17938 71 ELAEQTYNCIENFKKYLDnpkLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLED-LIKTGKLDLSSVRFFVLDEADRL 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 226509858 321 LELGFSAEIQELIRMCPK------RRQTMLFSATMTEeiDELIKLS 360
Cdd:cd17938 150 LSQGNLETINRIYNRIPKitsdgkRLQVIVCSATLHS--FEVKKLA 193
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
173-365 |
2.03e-45 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 161.35 E-value: 2.03e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVPAIR-----VLILTPTRELAA 247
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPFIKgegpyGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 248 QVHSMIEKLAQ------FTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLrNSLSVGLEDLAVVILDEADRLL 321
Cdd:cd17951 81 QTHEVIEYYCKalqeggYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDML-NKKKINLDICRYLCLDEADRMI 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 226509858 322 ELGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPV 365
Cdd:cd17951 160 DMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPV 203
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
179-367 |
4.46e-44 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 157.53 E-value: 4.46e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 179 ALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVPA--IRVLILTPTRELAAQVHSMIEKL 256
Cdd:cd17966 7 RQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLERGdgPIVLVLAPTRELAQQIQQEANKF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 257 AQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSlSVGLEDLAVVILDEADRLLELGFSAEIQELIRMC 336
Cdd:cd17966 87 GGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQG-KTNLRRVTYLVLDEADRMLDMGFEPQIRKIVDQI 165
|
170 180 190
....*....|....*....|....*....|.
gi 226509858 337 PKRRQTMLFSATMTEEIDELIKLSLNKPVRL 367
Cdd:cd17966 166 RPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
178-367 |
9.68e-44 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 156.55 E-value: 9.68e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 178 EALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRpKRVPAirVLILTPTRELAAQVHSMIEKLA 257
Cdd:cd17962 6 KKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTE-HRNPS--ALILTPTRELAVQIEDQAKELM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 258 Q-FTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSlSVGLEDLAVVILDEADRLLELGFSAEIQELIRMC 336
Cdd:cd17962 83 KgLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQS-SVELDNIKIVVVDEADTMLKMGFQQQVLDILENI 161
|
170 180 190
....*....|....*....|....*....|.
gi 226509858 337 PKRRQTMLFSATMTEEIDELIKLSLNKPVRL 367
Cdd:cd17962 162 SHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
164-367 |
1.93e-41 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 150.29 E-value: 1.93e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 164 FLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLlfrPKRVPAIRVLILTPTR 243
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQI---DTSLKATQALVLAPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 244 ELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHL-RNSLSVglEDLAVVILDEADRLLE 322
Cdd:cd18046 78 ELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMInRRYLRT--DYIKMFVLDEADEMLS 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 226509858 323 LGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRL 367
Cdd:cd18046 156 RGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
152-356 |
2.02e-40 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 149.03 E-value: 2.02e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 152 ASSEGATFHANSFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRV 231
Cdd:cd18051 11 ATGENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQGPGE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 232 PAIRV-------------LILTPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHL 298
Cdd:cd18051 91 SLPSEsgyygrrkqyplaLVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDML 170
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226509858 299 RNSlSVGLEDLAVVILDEADRLLELGFSAEIQELIR---MCPK-RRQTMLFSATMTEEIDEL 356
Cdd:cd18051 171 ERG-KIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEqdtMPPTgERQTLMFSATFPKEIQML 231
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
163-368 |
1.20e-39 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 145.57 E-value: 1.20e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 163 SFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLlfrpKRVPA-IRVLILTP 241
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQL----EPVDGqVSVLVICH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 242 TRELAAQVHSMIEKLAQF-TDIRCCLIVGGLSTKVQEVALRSM-PDIVVATPGRIIDHLRNSlSVGLEDLAVVILDEADR 319
Cdd:cd17950 79 TRELAFQISNEYERFSKYmPNVKTAVFFGGVPIKKDIEVLKNKcPHIVVGTPGRILALVREK-KLKLSHVKHFVLDECDK 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 226509858 320 LLE-LGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRLE 368
Cdd:cd17950 158 MLEqLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIF 207
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
169-358 |
3.01e-38 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 140.79 E-value: 3.01e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 169 LSRPLVRACEALGYQKPTPIQAACIPLALTG--RDICGSAITGSGKTAAFSLPVLERLlfrPKRVPAIRVLILTPTRELA 246
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRV---DPTLKSPQALCLAPTRELA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 247 AQVHSMIEKLAQFTDIRCCLIVGG----LSTKVQEvalrsmpDIVVATPGRIIDHLRnSLSVGLEDLAVVILDEADRLLE 322
Cdd:cd17963 78 RQIGEVVEKMGKFTGVKVALAVPGndvpRGKKITA-------QIVIGTPGTVLDWLK-KRQLDLKKIKILVLDEADVMLD 149
|
170 180 190
....*....|....*....|....*....|....*..
gi 226509858 323 L-GFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIK 358
Cdd:cd17963 150 TqGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAE 186
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
181-365 |
2.35e-37 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 138.37 E-value: 2.35e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 181 GYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRP---KRVPAIRVLILTPTRELAAQVHSMIEKLA 257
Cdd:cd17958 9 GFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPiprEQRNGPGVLVLTPTRELALQIEAECSKYS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 258 qFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDhLRNSLSVGLEDLAVVILDEADRLLELGFSAEIQELIRMCP 337
Cdd:cd17958 89 -YKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLND-LQMNNVINLKSITYLVLDEADRMLDMGFEPQIRKILLDIR 166
|
170 180
....*....|....*....|....*...
gi 226509858 338 KRRQTMLFSATMTEEIDELIKLSLNKPV 365
Cdd:cd17958 167 PDRQTIMTSATWPDGVRRLAQSYLKDPM 194
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
164-367 |
1.03e-35 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 134.13 E-value: 1.03e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 164 FLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLlfrPKRVPAIRVLILTPTR 243
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCL---DIQVRETQALILSPTR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 244 ELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHL-RNSLSVglEDLAVVILDEADRLLE 322
Cdd:cd18045 78 ELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIrRRSLRT--RHIKMLVLDEADEMLN 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 226509858 323 LGFSAEIQELIRMCPKRRQTMLFSATMTEEIDELIKLSLNKPVRL 367
Cdd:cd18045 156 KGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
164-356 |
1.09e-32 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 126.28 E-value: 1.09e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 164 FLELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRP--KRVPAIRVLILTP 241
Cdd:cd18049 26 FYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPflERGDGPICLVLAP 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 242 TRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSlSVGLEDLAVVILDEADRLL 321
Cdd:cd18049 106 TRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAG-KTNLRRCTYLVLDEADRML 184
|
170 180 190
....*....|....*....|....*....|....*
gi 226509858 322 ELGFSAEIQELIRMCPKRRQTMLFSATMTEEIDEL 356
Cdd:cd18049 185 DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQL 219
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
182-356 |
3.62e-32 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 126.28 E-value: 3.62e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 182 YQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRP--KRVPAIRVLILTPTRELAAQVHSMIEKLAQF 259
Cdd:cd18050 82 FKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPylERGDGPICLVLAPTRELAQQVQQVADDYGKS 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 260 TDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSlSVGLEDLAVVILDEADRLLELGFSAEIQELIRMCPKR 339
Cdd:cd18050 162 SRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAG-KTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPD 240
|
170
....*....|....*..
gi 226509858 340 RQTMLFSATMTEEIDEL 356
Cdd:cd18050 241 RQTLMWSATWPKEVRQL 257
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
173-357 |
3.91e-32 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 124.79 E-value: 3.91e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRP----KRVPAIRVLILTPTRELAAQ 248
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKllaeGPFNAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 249 VHSMIEKLAQFTDIRCCLIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSLsVGLEDLAVVILDEADRLLELGFSAE 328
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRI-YSLEQLRHLVLDEADTLLDDSFNEK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 226509858 329 IQELIRMCP--KRR-----------QTMLFSATMTEEIDELI 357
Cdd:cd17948 160 LSHFLRRFPlaSRRsentdgldpgtQLVLVSATMPSGVGEVL 201
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
396-502 |
2.06e-30 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 115.39 E-value: 2.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 396 AVLLALCLKTFKRSVIIFSGTKQSAHrLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVG 475
Cdd:pfam00271 4 EALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPD 82
|
90 100
....*....|....*....|....*..
gi 226509858 476 VQTVINFACPRDVKTYLHRVGRTARAG 502
Cdd:pfam00271 83 VDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
187-348 |
4.44e-30 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 118.03 E-value: 4.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 187 PIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERL---LFRPKRVPAIRVLILTPTRELAAQVHSMIEKLAQFTDIR 263
Cdd:cd17944 15 PIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLqedQQPRKRGRAPKVLVLAPTRELANQVTKDFKDITRKLSVA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 264 CclIVGGLSTKVQEVALRSMPDIVVATPGRIIDHLRNSlSVGLEDLAVVILDEADRLLELGFSAEIQELIRMCPKRR--- 340
Cdd:cd17944 95 C--FYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNG-RLDLTKLKHVVLDEVDQMLDMGFAEQVEEILSVSYKKDsed 171
|
170
....*....|
gi 226509858 341 --QTMLFSAT 348
Cdd:cd17944 172 npQTLLFSAT 181
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
431-502 |
2.87e-24 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 96.90 E-value: 2.87e-24
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226509858 431 GMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQTVINFACPRDVKTYLHRVGRTARAG 502
Cdd:smart00490 11 GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
159-353 |
4.71e-22 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 95.47 E-value: 4.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 159 FHANSFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTG--RDICGSAITGSGKTAAFSLPVLERLLFRpKRVPaiRV 236
Cdd:cd18048 15 FSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDAL-KLYP--QC 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 237 LILTPTRELAAQVHSMIEKLAQF-TDIRCCLIVGG----LSTKVQEvalrsmpDIVVATPGRIIDHLRNSLSVGLEDLAV 311
Cdd:cd18048 92 LCLSPTFELALQTGKVVEEMGKFcVGIQVIYAIRGnrpgKGTDIEA-------QIVIGTPGTVLDWCFKLRLIDVTNISV 164
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 226509858 312 VILDEADRLLEL-GFSAEIQELIRMCPKRRQTMLFSATMTEEI 353
Cdd:cd18048 165 FVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSV 207
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
208-660 |
5.37e-21 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 97.79 E-value: 5.37e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 208 TGSGKT--AAFslpVLERLLFRPkrvpaiRVLILTPTRELAAQVHsmiEKLAQFTDIRcclIVGGLSTKVQEvalrsmpD 285
Cdd:COG1061 109 TGTGKTvlALA---LAAELLRGK------RVLVLVPRRELLEQWA---EELRRFLGDP---LAGGGKKDSDA-------P 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 286 IVVATPGRIIDHLRNSLSVGLEDLavVILDEADRLlelgFSAEIQELIRMCPKRRqTMLFSAT------MTEEIDELIKL 359
Cdd:COG1061 167 ITVATYQSLARRAHLDELGDRFGL--VIIDEAHHA----GAPSYRRILEAFPAAY-RLGLTATpfrsdgREILLFLFDGI 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 360 SLNKPVR-LEADPSLKRP------ATLTEEVVRIRRARE-------SNQEAVLLAL----CLKTFKRSVIIFSGTKQSAH 421
Cdd:COG1061 240 VYEYSLKeAIEDGYLAPPeyygirVDLTDERAEYDALSErlrealaADAERKDKILrellREHPDDRKTLVFCSSVDHAE 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 422 RLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQTVInFACPRDVKT-YLHRVGRTAR 500
Cdd:COG1061 320 ALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAI-LLRPTGSPReFIQRLGRGLR 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 501 AGREGYAVTF--VTDDDRSLLKAIAKKAGSQLKSRIVAEKPVAECAQLIEQLEDQISIIIREERVEREARKAEMEIAKAE 578
Cdd:COG1061 399 PAPGKEDALVydFVGNDVPVLEELAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEELLEELELLEDALLL 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 579 NMIAHKDEIYSRPKRTWFATEREKKLLVAAAKESLGQGKSTSGVISAKQAEDLRLKEKKRREHEKDLPRKKRRRLEAQRE 658
Cdd:COG1061 479 VLAELLLLELLALALELLELAKAEGKAEEEEEEKELLLLLALAKLLKLLLLLLLLLLLELLELLAALLRLEELAALLLKE 558
|
..
gi 226509858 659 ML 660
Cdd:COG1061 559 LL 560
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
206-348 |
2.37e-18 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 82.45 E-value: 2.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 206 AITGSGKTAAFSLPVLERLLFRPKRVpairvLILTPTRELAAQVHSMIEKLAQfTDIRCCLIVGGLSTKVQEVALRSMPD 285
Cdd:cd00046 8 APTGSGKTLAALLAALLLLLKKGKKV-----LVLVPTKALALQTAERLRELFG-PGIRVAVLVGGSSAEEREKNKLGDAD 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 226509858 286 IVVATPGRIIDHLRNSLSVGLEDLAVVILDEADRLLELGFSAEIqELIRMCPKRR---QTMLFSAT 348
Cdd:cd00046 82 IIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALI-LDLAVRKAGLknaQVILLSAT 146
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
180-354 |
4.41e-18 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 84.74 E-value: 4.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 180 LGYQKPTPIQAACIPlALTGRDICG-----------------SAITGSGKTAAFSLPVLERL-------------LFRPK 229
Cdd:cd17965 26 DEEIKPSPIQTLAIK-KLLKTLMRKvtkqtsneepklevfllAAETGSGKTLAYLAPLLDYLkrqeqepfeeaeeEYESA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 230 RVPA-IRVLILTPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTKVQEVAL--RSMPDIVVATPGRIIDhLRNSLSVGL 306
Cdd:cd17965 105 KDTGrPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFGPSYQRLQLafKGRIDILVTTPGKLAS-LAKSRPKIL 183
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 226509858 307 EDLAVVILDEADRLLELGFSAEIQELIRMCPKRRQTMLFSATMTEEID 354
Cdd:cd17965 184 SRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFD 231
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
165-515 |
5.99e-18 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 88.74 E-value: 5.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 165 LELNLSRPLVRACEALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLfrpkRVPAIRVLILTPTRE 244
Cdd:COG1205 37 WPDWLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALL----EDPGATALYLYPTKA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 245 LAA-QVHSmIEKLAQFT--DIRCCLIVGglSTKVQE-VALRSMPDIVVATPgriiD--H---LRNSLSVG--LEDLAVVI 313
Cdd:COG1205 113 LARdQLRR-LRELAEALglGVRVATYDG--DTPPEErRWIREHPDIVLTNP----DmlHyglLPHHTRWArfFRNLRYVV 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 314 LDEA---------------DRLLelgfsaeiqeliRMCPKRRQTMLF---SATM---TEEIDELIklslNKPVRL-EADP 371
Cdd:COG1205 186 IDEAhtyrgvfgshvanvlRRLR------------RICRHYGSDPQFilaSATIgnpAEHAERLT----GRPVTVvDEDG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 372 SLKRPAT--LTEEVVRIRRARES-NQEAV-LLALCLKTfKRSVIIFSGTKQSAHRLKIIF------GLSGMKAAELHGNL 441
Cdd:COG1205 250 SPRGERTfvLWNPPLVDDGIRRSaLAEAArLLADLVRE-GLRTLVFTRSRRGAELLARYArralrePDLADRVAAYRAGY 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226509858 442 TQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQTVINFACPRDVKTYLHRVGRTARAGREGYAVtFVTDDD 515
Cdd:COG1205 329 LPEERREIERGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVV-LVAGDD 401
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
163-353 |
6.73e-17 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 80.15 E-value: 6.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 163 SFLELNLSRPLVRACEALGYQKPTPIQAACIPLALTG--RDICGSAITGSGKTAAFSLPVLERLlfrpkrVPAIR---VL 237
Cdd:cd18047 2 SFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQV------EPANKypqCL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 238 ILTPTRELAAQVHSMIEKLAQF-TDIRCCLIVGGlstKVQEVALRSMPDIVVATPGRIIDHLRNSLSVGLEDLAVVILDE 316
Cdd:cd18047 76 CLSPTYELALQTGKVIEQMGKFyPELKLAYAVRG---NKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDE 152
|
170 180 190
....*....|....*....|....*....|....*...
gi 226509858 317 ADRLLEL-GFSAEIQELIRMCPKRRQTMLFSATMTEEI 353
Cdd:cd18047 153 ADVMIATqGHQDQSIRIQRMLPRNCQMLLFSATFEDSV 190
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
182-497 |
2.52e-14 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 77.06 E-value: 2.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 182 YQKPTPIQAACIPLALTGRDICGSAITGSGKT-AAFsLPVLERLLFRP---KRVPAIRVLILTPTRELAAQVH-SMIEKL 256
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAF-LPALDELARRPrpgELPDGLRVLYISPLKALANDIErNLRAPL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 257 AQFTDIRcclivgGLSTKVQEVALRS--------------MPDIVVATPgriidhlrNSLSV---------GLEDLAVVI 313
Cdd:COG1201 101 EEIGEAA------GLPLPEIRVGVRTgdtpaserqrqrrrPPHILITTP--------ESLALlltspdareLLRGVRTVI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 314 LDE----AD--R--LLELGfsaeIQELIRMCPKRRQTMLFSATMtEEIDE----LIKLSLNKPVRLeADPSLKRPATL-- 379
Cdd:COG1201 167 VDEihalAGskRgvHLALS----LERLRALAPRPLQRIGLSATV-GPLEEvarfLVGYEDPRPVTI-VDAGAGKKPDLev 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 380 ----TEEVVRIRRARESNQEAV--LLALCLKtfKRSVIIF----SGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEA 449
Cdd:COG1201 241 lvpvEDLIERFPWAGHLWPHLYprVLDLIEA--HRTTLVFtntrSQAERLFQRLNELNPEDALPIAAHHGSLSREQRLEV 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 226509858 450 LELFRKQEVDFLIAT---DVaarGIDIVGVQTVINFACPRDVKTYLHRVGR 497
Cdd:COG1201 319 EEALKAGELRAVVATsslEL---GIDIGDVDLVIQVGSPKSVARLLQRIGR 366
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
173-525 |
2.80e-13 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 73.01 E-value: 2.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 173 LVRACEALGYQKPTPIQAACIPLAL-TGRDICGSAITGSGKTAAFSLPVLERLLFRPKrvpairVLILTPTRELAAQVHS 251
Cdd:COG1204 11 VIEFLKERGIEELYPPQAEALEAGLlEGKNLVVSAPTASGKTLIAELAILKALLNGGK------ALYIVPLRALASEKYR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 252 MIEKLAQFTDIRccliVGGLSTKVQEVALRSM-PDIVVATPGRIIDHLRNSLSVgLEDLAVVILDEA------DR--LLE 322
Cdd:COG1204 85 EFKRDFEELGIK----VGVSTGDYDSDDEWLGrYDILVATPEKLDSLLRNGPSW-LRDVDLVVVDEAhliddeSRgpTLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 323 LgfsaEIQELIRMCPkRRQTMLFSATM--TEEIDELiklslnkpvrLEADP--SLKRPATLTEEVV---RIRRARESNQE 395
Cdd:COG1204 160 V----LLARLRRLNP-EAQIVALSATIgnAEEIAEW----------LDAELvkSDWRPVPLNEGVLydgVLRFDDGSRRS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 396 A-VLLALCLKTFK--RSVIIFSGTKQSAHRL------KIIFGLSGMKAAEL----------------------------- 437
Cdd:COG1204 225 KdPTLALALDLLEegGQVLVFVSSRRDAESLakkladELKRRLTPEEREELeelaeellevseethtnekladclekgva 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 438 --HGNLTQAQRLEALELFRKQEVDFLIATD-VAArgidivGV----QTVI------NFACPRDVKTYLHRVGRTARAGRE 504
Cdd:COG1204 305 fhHAGLPSELRRLVEDAFREGLIKVLVATPtLAA------GVnlpaRRVIirdtkrGGMVPIPVLEFKQMAGRAGRPGYD 378
|
410 420
....*....|....*....|...
gi 226509858 505 --GYAVtfVTDDDRSLLKAIAKK 525
Cdd:COG1204 379 pyGEAI--LVAKSSDEADELFER 399
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
189-317 |
2.73e-12 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 66.07 E-value: 2.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 189 QAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLfrpkRVPAIRVLILTPTRELAA-QVHSMIEKLAQF-TDIRCCL 266
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALL----RDPGSRALYLYPTKALAQdQLRSLRELLEQLgLGIRVAT 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 226509858 267 IVGGLSTKVQEVALRSMPDIVVATPgRIIDH--LRNSLSVG--LEDLAVVILDEA 317
Cdd:cd17923 81 YDGDTPREERRAIIRNPPRILLTNP-DMLHYalLPHHDRWArfLRNLRYVVLDEA 134
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
206-497 |
3.43e-10 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 63.79 E-value: 3.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 206 AITGSGKTAAFSLPVLERLlFR--------PKRVPAIRVLILTPTRELAAQV--------HSMIEKLAQFTDIRCCLIVG 269
Cdd:PRK09751 3 APTGSGKTLAAFLYALDRL-FReggedtreAHKRKTSRILYISPIKALGTDVqrnlqiplKGIADERRRRGETEVNLRVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 270 GLS--TKVQEVA--LRSMPDIVVATPGRIIDHLRNSLSVGLEDLAVVILDE------ADRLLELGFSAEiqELIRMCPKR 339
Cdd:PRK09751 82 IRTgdTPAQERSklTRNPPDILITTPESLYLMLTSRARETLRGVETVIIDEvhavagSKRGAHLALSLE--RLDALLHTS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 340 RQTMLFSATMTEEIDELIKLSLNKPVRLEADPSLKR---------------PATLTEEVVRIRRARESN----QEAVLLA 400
Cdd:PRK09751 160 AQRIGLSATVRSASDVAAFLGGDRPVTVVNPPAMRHpqirivvpvanmddvSSVASGTGEDSHAGREGSiwpyIETGILD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 401 LCLKtfKRSVIIFSGTKQSAHRLKIifGLSGMKAAEL-----------------------------------HGNLTQAQ 445
Cdd:PRK09751 240 EVLR--HRSTIVFTNSRGLAEKLTA--RLNELYAARLqrspsiavdaahfestsgatsnrvqssdvfiarshHGSVSKEQ 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 226509858 446 RLEALELFRKQEVDFLIATDVAARGIDIVGVQTVINFACPRDVKTYLHRVGR 497
Cdd:PRK09751 316 RAITEQALKSGELRCVVATSSLELGIDMGAVDLVIQVATPLSVASGLQRIGR 367
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
411-501 |
1.39e-09 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 57.22 E-value: 1.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 411 IIFSGTKQSAHRLKIIF-----GLSGMKAAELHGN----------LTQAQRLEALELFRKQEVDFLIATDVAARGIDIVG 475
Cdd:cd18802 29 IIFVERRATAVVLSRLLkehpsTLAFIRCGFLIGRgnssqrkrslMTQRKQKETLDKFRDGELNLLIATSVLEEGIDVPA 108
|
90 100
....*....|....*....|....*.
gi 226509858 476 VQTVINFACPRDVKTYLHRVGRtARA 501
Cdd:cd18802 109 CNLVIRFDLPKTLRSYIQSRGR-ARA 133
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
186-348 |
1.66e-09 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 57.66 E-value: 1.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 186 TPIQAACI-PLALTGRDICGSAITGSGKTAAFSLpVLERLLFRPKRvpaiRVLILTPTRELAAQVHSMIEKLAQFTDIRC 264
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLIAEL-AILRALATSGG----KAVYIAPTRALVNQKEADLRERFGPLGKNV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 265 CLIVGGLSTKVQEVALrsmPDIVVATPGRIIDHLRNSLSVGLEDLAVVILDEA------DR--LLELGfsaeIQELIRMC 336
Cdd:cd17921 78 GLLTGDPSVNKLLLAE---ADILVATPEKLDLLLRNGGERLIQDVRLVVVDEAhligdgERgvVLELL----LSRLLRIN 150
|
170
....*....|..
gi 226509858 337 PKRRQTMLfSAT 348
Cdd:cd17921 151 KNARFVGL-SAT 161
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
208-348 |
3.07e-08 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 53.46 E-value: 3.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 208 TGSGKTA-AFSLPVLerllfrpkrVPAIRVLILTPTRELAAQvhsMIEKLAQFTDIRCCLIVGGLSTKVQEVAlrsmpDI 286
Cdd:cd17926 27 TGSGKTLtALALIAY---------LKELRTLIVVPTDALLDQ---WKERFEDFLGDSSIGLIGGGKKKDFDDA-----NV 89
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226509858 287 VVATPgRIIDHLRNSLSVGLEDLAVVILDEADRLLELGFSAEIQELIRMCpkrrqTMLFSAT 348
Cdd:cd17926 90 VVATY-QSLSNLAEEEKDLFDQFGLLIVDEAHHLPAKTFSEILKELNAKY-----RLGLTAT 145
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
460-511 |
6.75e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.40 E-value: 6.75e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 226509858 460 FLIATDVAARGIDIVGVQTVINFACPRDVKTYLHRVGRTARAG-REGYAVTFV 511
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGkDEGEVILFV 77
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
397-482 |
9.32e-08 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 51.71 E-value: 9.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 397 VLLALCLKTFKRS--VIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRK--QEVDFLIATDVAARGID 472
Cdd:cd18793 15 ALLELLEELREPGekVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEdpDIRVFLLSTKAGGVGLN 94
|
90
....*....|
gi 226509858 473 IVGVQTVINF 482
Cdd:cd18793 95 LTAANRVILY 104
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
441-728 |
1.08e-07 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 55.51 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 441 LTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQTVINF-ACPRDVKtYLHRVGRTARaGREGYAVTFVTDDDR--- 516
Cdd:COG1111 395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYePVPSEIR-SIQRKGRTGR-KREGRVVVLIAKGTRdea 472
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 517 ----SLLKaiAKKAGSQLK--SRIVAEKPVAECAQLIE-QLEDQISiiIREERVEREARKAEMEIAKAENmIAHKDEIYS 589
Cdd:COG1111 473 yywsSRRK--EKKMKSILKklKKLLDKQEKEKLKESAQaTLDEFES--IKELAEDEINEKDLDEIESSEN-GAHVDWREP 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 590 RPKRTWFATEREKKLLVAAAKESLGQGKSTSGVISAKQAEDLRLKEKKRREHEKDLPRKKRRRLEAQREMLEDEDEDDEE 669
Cdd:COG1111 548 VLLQVIVSTLAESLELRELGEKVDDEVNLILEIDRVDVVDDGSVLRVSRLLVEIGELDGKTRVIIASYGDEYFDAILRLT 627
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 226509858 670 AKESDRGKKLKKGQSLVDAAYRKAKSLKAASKRGPGASKGKKEKNARQYSEKTPNRHEE 728
Cdd:COG1111 628 SKIKLPSLVSDISVDIPDLPIVEIVGEAVLCKKEDGSREARFIKKERDLKGIRLAEGET 686
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
410-508 |
3.21e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 50.43 E-value: 3.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 410 VIIFSGTKQSAhrLKIIFGLS----GMKAAELHGN--------LTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQ 477
Cdd:cd18801 33 VIIFSEFRDSA--EEIVNFLSkirpGIRATRFIGQasgksskgMSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVD 110
|
90 100 110
....*....|....*....|....*....|..
gi 226509858 478 TVINF-ACPRDVKTyLHRVGRTARaGREGYAV 508
Cdd:cd18801 111 LIICYdASPSPIRM-IQRMGRTGR-KRQGRVV 140
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
329-520 |
7.95e-07 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 52.45 E-value: 7.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 329 IQELIRMCPkRRQTMLFSATMTEE-IDELIK-LSLNKPVRLEAdpSLKRPaTLTeevVRIRRARESNQEAVLLALCLKTF 406
Cdd:COG0514 157 LGELRERLP-NVPVLALTATATPRvRADIAEqLGLEDPRVFVG--SFDRP-NLR---LEVVPKPPDDKLAQLLDFLKEHP 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 407 KRSVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATdVA-ARGIDIVGVQTVINFACP 485
Cdd:COG0514 230 GGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-IAfGMGIDKPDVRFVIHYDLP 308
|
170 180 190
....*....|....*....|....*....|....*
gi 226509858 486 RDVKTYLHRVGRTARAGREGYAVTFVTDDDRSLLK 520
Cdd:COG0514 309 KSIEAYYQEIGRAGRDGLPAEALLLYGPEDVAIQR 343
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
208-317 |
1.51e-06 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 49.57 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 208 TGSGKTAaFSLPVLERL--LFRPKRVPAIRVLILTPTRELAAQVHSMIEklaQFTDIRCCLIVG--GLSTKVQEVALRSM 283
Cdd:cd18034 25 TGSGKTL-IAVMLIKEMgeLNRKEKNPKKRAVFLVPTVPLVAQQAEAIR---SHTDLKVGEYSGemGVDKWTKERWKEEL 100
|
90 100 110
....*....|....*....|....*....|....*.
gi 226509858 284 --PDIVVATPGRIIDHLRNSLsVGLEDLAVVILDEA 317
Cdd:cd18034 101 ekYDVLVMTAQILLDALRHGF-LSLSDINLLIFDEC 135
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
178-362 |
2.55e-06 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 48.68 E-value: 2.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 178 EALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLP--VLERLlfrpkrvpairVLILTPtreLAAQVHSMIEK 255
Cdd:cd17920 6 EVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPalLLDGV-----------TLVVSP---LISLMQDQVDR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 256 LAQfTDIRCCLIVGGLSTKVQEVALRSMP----DIVVATP-----GRIIDHLRNSLSVGLedLAVVILDEADRLLELGFS 326
Cdd:cd17920 72 LQQ-LGIRAAALNSTLSPEEKREVLLRIKngqyKLLYVTPerllsPDFLELLQRLPERKR--LALIVVDEAHCVSQWGHD 148
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 226509858 327 -----AEIQELIRMCPkRRQTMLFSATMTEEIDELIKLSLN 362
Cdd:cd17920 149 frpdyLRLGRLRRALP-GVPILALTATATPEVREDILKRLG 188
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
199-316 |
3.03e-06 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 47.96 E-value: 3.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 199 GRDICGSAITGSGKTAAFSLPVLERLLFRPKrvPAIRVLILTPTRELAAQVHSMIEKLAQ--FTDIRCCLIVGGLSTKVQ 276
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPE--KGVQVLYISPLKALINDQERRLEEPLDeiDLEIPVAVRHGDTSQSEK 78
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 226509858 277 EVALRSMPDIVVATPGRIIDHL-RNSLSVGLEDLAVVILDE 316
Cdd:cd17922 79 AKQLKNPPGILITTPESLELLLvNKKLRELFAGLRYVVVDE 119
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
401-505 |
3.31e-06 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 47.20 E-value: 3.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 401 LCLKTFKR-----SVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVG 475
Cdd:cd18794 19 DLLKRIKVehlggSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPD 98
|
90 100 110
....*....|....*....|....*....|
gi 226509858 476 VQTVINFACPRDVKTYLHRVGrtaRAGREG 505
Cdd:cd18794 99 VRFVIHYSLPKSMESYYQESG---RAGRDG 125
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
441-516 |
6.14e-06 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 49.87 E-value: 6.14e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226509858 441 LTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQTVINF-ACPRDVKTyLHRVGRTARaGREGYAVTFVTDDDR 516
Cdd:PRK13766 407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYePVPSEIRS-IQRKGRTGR-QEEGRVVVLIAKGTR 481
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
408-504 |
1.42e-05 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 45.72 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 408 RSVIIFSGTKQSA----HRLKIIFGLSGM--KAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQTVIN 481
Cdd:cd18796 39 KSTLVFTNTRSQAerlaQRLRELCPDRVPpdFIALHHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQ 118
|
90 100
....*....|....*....|...
gi 226509858 482 FACPRDVKTYLHRVGRTARAGRE 504
Cdd:cd18796 119 IGSPKSVARLLQRLGRSGHRPGA 141
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
206-515 |
1.58e-05 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 47.81 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 206 AITGSGKT-AAFSLpvlerLLFRPKRVPAIRVLILTPTRELAAQVHSMIEKLAQFTDIRCCLIVGGLSTK-------VQE 277
Cdd:cd09639 6 APTGYGKTeAALLW-----ALHSLKSQKADRVIIALPTRATINAMYRRAKEAFGETGLYHSSILSSRIKEmgdseefEHL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 278 VALRSMP-DIVVATPGRI--IDHLRNSLSVGLED---------LAVVILDEADRLLE--LGFSAEIQELIRmcPKRRQTM 343
Cdd:cd09639 81 FPLYIHSnDTLFLDPITVctIDQVLKSVFGEFGHyeftlasiaNSLLIFDEVHFYDEytLALILAVLEVLK--DNDVPIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 344 LFSATMTEEIDELIKLSLN---------KPVRLEadPSLKRPATLTEEVVRIRRARESNQEAVLLALCLKTFKRSVIIFS 414
Cdd:cd09639 159 LMSATLPKFLKEYAEKIGYveenepldlKPNERA--PFIKIESDKVGEISSLERLLEFIKKGGSVAIIVNTVDRAQEFYQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 415 GTKQSAHRLKIIFglsgmkaaeLHGNLTQAQRL----EALELFRKQEVDFLIATDVAARGIDIvGVQTVINFACPRDvkT 490
Cdd:cd09639 237 QLKEKGPEEEIML---------IHSRFTEKDRAkkeaELLLEFKKSEKFVIVATQVIEASLDI-SVDVMITELAPID--S 304
|
330 340
....*....|....*....|....*....
gi 226509858 491 YLHRVGRTARAGR----EGYAVTFVTDDD 515
Cdd:cd09639 305 LIQRLGRLHRYGEkngeEVYIITDAPDGK 333
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
184-348 |
3.55e-05 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 45.10 E-value: 3.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 184 KPTPIQAACI---------PLALTgRDICGSaiTGSGKTAAFSLPVLErLLFRPKRVpairvLILTPTRELAAQVHSMIE 254
Cdd:cd17918 15 SLTKDQAQAIkdiekdlhsPEPMD-RLLSGD--VGSGKTLVALGAALL-AYKNGKQV-----AILVPTEILAHQHYEEAR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 255 KLaqFTDIRCCLIVGGLSTKVQevalrSMPDIVVATPGRIidhlrnSLSVGLEDLAVVILDEADRllelgFSAEIQELIR 334
Cdd:cd17918 86 KF--LPFINVELVTGGTKAQIL-----SGISLLVGTHALL------HLDVKFKNLDLVIVDEQHR-----FGVAQREALY 147
|
170
....*....|....
gi 226509858 335 MCpKRRQTMLFSAT 348
Cdd:cd17918 148 NL-GATHFLEATAT 160
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
196-319 |
3.77e-05 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 45.50 E-value: 3.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 196 ALTGRDICGSAITGSGKTAAfSLPVLERLLFRPKRVPAIRVLILTPTRELAAQvhsMIEKLAQFTDiRCCLIVGGLS--- 272
Cdd:cd17927 14 ALKGKNTIICLPTGSGKTFV-AVLICEHHLKKFPAGRKGKVVFLANKVPLVEQ---QKEVFRKHFE-RPGYKVTGLSgdt 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 226509858 273 ---TKVQEVALRSmpDIVVATPGRIIDHLRNSLSVGLEDLAVVILDEADR 319
Cdd:cd17927 89 senVSVEQIVESS--DVIIVTPQILVNDLKSGTIVSLSDFSLLVFDECHN 136
|
|
| SF2_C_reverse_gyrase |
cd18798 |
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological ... |
398-525 |
5.92e-05 |
|
C-terminal helicase domain of the reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350185 [Multi-domain] Cd Length: 174 Bit Score: 44.22 E-value: 5.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 398 LLALcLKTFKRSVIIFSGT---KQSAHRLKIIFGLSGMKAAELHgnltqAQRLEALELFRKQEVDFLIAT----DVAARG 470
Cdd:cd18798 16 LLEL-VKKLGDGGLIFVSIdygKEYAEELKEFLERHGIKAELAL-----SSTEKNLEKFEEGEIDVLIGVasyyGVLVRG 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 226509858 471 IDIVG-VQTVINFACPrdVKTYLHRVGRTAR--AGREGYAVTFVTDDDRSLLKAIAKK 525
Cdd:cd18798 90 IDLPErIKYAIFYGVP--VTTYIQASGRTSRlyAGGLTKGLSVVLVDDPELFEALKKR 145
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
178-548 |
9.69e-05 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 45.86 E-value: 9.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 178 EALGYQKPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERllfrpkrvPAIrVLILTPtreLAAQVHSMIEKLA 257
Cdd:PRK11057 19 ETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVL--------DGL-TLVVSP---LISLMKDQVDQLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 258 QFTDIRCCLIvgglSTKVQEVALRSMPD-------IVVATPGRI-----IDHLRNSlsvgleDLAVVILDEADRLLELG- 324
Cdd:PRK11057 87 ANGVAAACLN----STQTREQQLEVMAGcrtgqikLLYIAPERLmmdnfLEHLAHW------NPALLAVDEAHCISQWGh 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 325 -FSAEIQELIRMcpKRR----QTMLFSATM--TEEIDELIKLSLNKPvrLEADPSLKRPA---TLTE------EVVRIRR 388
Cdd:PRK11057 157 dFRPEYAALGQL--RQRfptlPFMALTATAddTTRQDIVRLLGLNDP--LIQISSFDRPNiryTLVEkfkpldQLMRYVQ 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 389 ARESNqeavllalclktfkrSVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAA 468
Cdd:PRK11057 233 EQRGK---------------SGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFG 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 469 RGIDIVGVQTVINFACPRDVKTYLHRVGRTARAGREGYAVTFVTDDDRSLLKaiakkagsqlksRIVAEKPVAEcAQLIE 548
Cdd:PRK11057 298 MGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPADMAWLR------------RCLEEKPAGQ-QQDIE 364
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
178-321 |
2.55e-04 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 42.70 E-value: 2.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 178 EALGYqKPTPIQAACIPLALTGRDICGSAITGSGKTaafSLPVLERLLFRPKRVpaiRVLILTPTRELAAQVHSMIEKLA 257
Cdd:cd17924 12 KKTGF-PPWGAQRTWAKRLLRGKSFAIIAPTGVGKT---TFGLATSLYLASKGK---RSYLIFPTKSLVKQAYERLSKYA 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 258 QFTDIRCCLIV--GGLSTKVQEVALRSMP----DIVVATPGRIIDHlRNSLSVGLEDLAVVilDEADRLL 321
Cdd:cd17924 85 EKAGVEVKILVyhSRLKKKEKEELLEKIEkgdfDILVTTNQFLSKN-FDLLSNKKFDFVFV--DDVDAVL 151
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
569-769 |
2.78e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 44.75 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 569 KAEMEIAKAENMIAHKDEIYSRPKRTWFATEREKKLLVAAAKESLGQGKSTSGVISAKQAEDLRLKEKKRREHEKDLPRK 648
Cdd:PTZ00121 1316 KADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADE 1395
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 649 KRRRLEAQREMLEDEDEDDEEAKESDRGKKLKKGQSLVDAAYRKAKSLKAASKRGPGASKGKKEKNARQYSEKTpNRHEE 728
Cdd:PTZ00121 1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEA-KKADE 1474
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 226509858 729 MRElfqnDMSEWKQGRSSKKNNNFAHKKSKAFNSKARYKRR 769
Cdd:PTZ00121 1475 AKK----KAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKK 1511
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
433-524 |
2.86e-04 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 42.25 E-value: 2.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 433 KAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQTVINFACPRDVKTYLHRV-GRTARAGREGYAVtFV 511
Cdd:cd18792 62 RVALLHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIEDADRFGLSQLHQLrGRVGRGKHQSYCY-LL 140
|
90 100
....*....|....*....|
gi 226509858 512 TDDDRSL-------LKAIAK 524
Cdd:cd18792 141 YPDPKKLtetakkrLRAIAE 160
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
187-505 |
3.48e-04 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 44.12 E-value: 3.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 187 PIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLerllfrpkRVPAIrVLILTPtreLAAQVHSMIEKLAQfTDIRCCL 266
Cdd:PLN03137 463 PNQREIINATMSGYDVFVLMPTGGGKSLTYQLPAL--------ICPGI-TLVISP---LVSLIQDQIMNLLQ-ANIPAAS 529
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 267 IVGGLSTKVQEVALRSMPD------IVVATPGRI------IDHLRNSLSVGLedLAVVILDEADRLLELG--FSAEIQEL 332
Cdd:PLN03137 530 LSAGMEWAEQLEILQELSSeyskykLLYVTPEKVaksdslLRHLENLNSRGL--LARFVIDEAHCVSQWGhdFRPDYQGL 607
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 333 IRMCPKRRQT--MLFSATMTEEIDELIKLSLNKPVRLEADPSLKRPATLTEEVVRIRRARESNQEAVLLalclKTFKRSV 410
Cdd:PLN03137 608 GILKQKFPNIpvLALTATATASVKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPKTKKCLEDIDKFIKE----NHFDECG 683
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 411 IIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQTVINFACPRDVKT 490
Cdd:PLN03137 684 IIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEG 763
|
330
....*....|....*
gi 226509858 491 YLHRVGrtaRAGREG 505
Cdd:PLN03137 764 YHQECG---RAGRDG 775
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
410-505 |
4.78e-04 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 41.47 E-value: 4.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 410 VIIFSGTKQSAHRLKIIFGLSGmkaaeLHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDI----VGVQTVINFACP 485
Cdd:cd18789 52 IIVFTDNVEALYRYAKRLLKPF-----ITGETPQSEREEILQNFREGEYNTLVVSKVGDEGIDLpeanVAIQISGHGGSR 126
|
90 100
....*....|....*....|
gi 226509858 486 RDvktYLHRVGRTARAGREG 505
Cdd:cd18789 127 RQ---EAQRLGRILRPKKGG 143
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
184-316 |
8.58e-04 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 41.31 E-value: 8.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 184 KPTPIQAACIPLALTGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVPAIRVLILTPTRELAAQvhsmiEKLAQFTDIR 263
Cdd:cd18036 2 ELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKRRSAGEKGRVVVLVNKVPLVEQ-----QLEKFFKYFR 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226509858 264 CCLIVGGLS------TKVQEVALRSmpDIVVATPGRIIDHLRN---SLSVGLEDLAVVILDE 316
Cdd:cd18036 77 KGYKVTGLSgdsshkVSFGQIVKAS--DVIICTPQILINNLLSgreEERVYLSDFSLLIFDE 136
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
408-482 |
9.10e-04 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 42.90 E-value: 9.10e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226509858 408 RSVIIFSGTKQSAHRLKIIFGLSGMKAAELHGNLTQAQRLEALELFRKQE--VDFLIATDVAARGIDIVGVQTVINF 482
Cdd:COG0553 550 EKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPeaPVFLISLKAGGEGLNLTAADHVIHY 626
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
208-319 |
9.85e-04 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 40.96 E-value: 9.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 208 TGSGKTAAFSLPVLERLLFRPKRVpairvLILTPTRELAAQVHSMIEKLAQFTDiRCCLIVGGLSTKVQEVALRSmPDIV 287
Cdd:cd18035 25 TGLGKTIIAILVAADRLTKKGGKV-----LILAPSRPLVEQHAENLKRVLNIPD-KITSLTGEVKPEERAERWDA-SKII 97
|
90 100 110
....*....|....*....|....*....|..
gi 226509858 288 VATPGRIIDHLRNSlSVGLEDLAVVILDEADR 319
Cdd:cd18035 98 VATPQVIENDLLAG-RITLDDVSLLIFDEAHH 128
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
188-316 |
1.04e-03 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 41.19 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 188 IQAACIPLAL-TGRDICGSAITGSGKTAAFSLPVLERLLFRPKRVP-AIRVLILTPTRELAAqvhsmiEKLAQFT----- 260
Cdd:cd18023 5 IQSEVFPDLLySDKNFVVSAPTGSGKTVLFELAILRLLKERNPLPWgNRKVVYIAPIKALCS------EKYDDWKekfgp 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226509858 261 -DIRCCLIVGGLSTKvqevALRSMP--DIVVATPGR---IIDHLRNSLSVgLEDLAVVILDE 316
Cdd:cd18023 79 lGLSCAELTGDTEMD----DTFEIQdaDIILTTPEKwdsMTRRWRDNGNL-VQLVALVLIDE 135
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
375-506 |
1.47e-03 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 39.84 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 375 RPATLTEEVVRI----------RRARESNQEAVLLALCLKTFKRSVIIFSGTKQSAHRL-KIIFGlsgmkAAELHGNLTQ 443
Cdd:cd18795 1 RPVPLEEYVLGFnglgiklrvdVMNKFDSDIIVLLKIETVSEGKPVLVFCSSRKECEKTaKDLAG-----IAFHHAGLTR 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 226509858 444 AQRlEALE-LFRKQEVDFLIATDVAARGID------IVGVQTVINFACPRDVK--TYLHRVGrtaRAGREGY 506
Cdd:cd18795 76 EDR-ELVEeLFREGLIKVLVATSTLAAGVNlpartvIIKGTQRYDGKGYRELSplEYLQMIG---RAGRPGF 143
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
208-348 |
1.97e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 39.58 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 208 TGSGKTA-AFSLPvleRLLFrpKRVPAIRVLILTPTRELAAQvhsMIEKLAQFTDirCCLIVGGLS---TKVQEVALRsm 283
Cdd:pfam04851 32 TGSGKTLtAAKLI---ARLF--KKGPIKKVLFLVPRKDLLEQ---ALEEFKKFLP--NYVEIGEIIsgdKKDESVDDN-- 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226509858 284 pDIVVATP---GRIIDHLRNSLSVGLEDlaVVILDEADRLLELGFsaeiQELIRMCPKrrQTML-FSAT 348
Cdd:pfam04851 100 -KIVVTTIqslYKALELASLELLPDFFD--VIIIDEAHRSGASSY----RNILEYFKP--AFLLgLTAT 159
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
208-319 |
2.36e-03 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 41.40 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 208 TGSGKTAAFSLPVLERLLFRPKRVpairvLILTPTRELAAQvHsmIEKLAQFTDIRCCLIV---GGLSTKvQEVALRSMP 284
Cdd:PRK13766 38 TGLGKTAIALLVIAERLHKKGGKV-----LILAPTKPLVEQ-H--AEFFRKFLNIPEEKIVvftGEVSPE-KRAELWEKA 108
|
90 100 110
....*....|....*....|....*....|....*...
gi 226509858 285 DIVVATPGRIidhlRNSLSVG---LEDLAVVILDEADR 319
Cdd:PRK13766 109 KVIVATPQVI----ENDLIAGrisLEDVSLLIFDEAHR 142
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
433-524 |
2.46e-03 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 39.25 E-value: 2.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 433 KAAELHGNLTQAQRLEALELFRKQEVDFLIATDVAARGIDIVGVQTVINFACPRDVKTYLHRV-GRTARAGREGYAVtFV 511
Cdd:cd18810 53 RIAIAHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIIERADKFGLAQLYQLrGRVGRSKERAYAY-FL 131
|
90 100
....*....|....*....|
gi 226509858 512 TDDDRSL-------LKAIAK 524
Cdd:cd18810 132 YPDQKKLtedalkrLEAIQE 151
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
524-770 |
6.62e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 40.12 E-value: 6.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 524 KKAGSQLKSRIVAEKPVAECAQLIEQLE--DQISIIIREERVEREARKAEMEIAKAENMIAHK------DEIYSRPKRTW 595
Cdd:PTZ00121 1404 KKKADELKKAAAAKKKADEAKKKAEEKKkaDEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAeeakkaDEAKKKAEEAK 1483
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 596 FATEREKKLLVAAAKESLGQGKSTSgvisAKQAEDLRLKEKKRREHEKDLPRKKRRRLEAQREMLEDEDEDDEEAKESDR 675
Cdd:PTZ00121 1484 KADEAKKKAEEAKKKADEAKKAAEA----KKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKK 1559
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 676 GKKLKKGQSLVDA------AYRKAKSLKAASK-------------RGPGASKGKKEKNARQYSEKTPNRHEEMRELFQND 736
Cdd:PTZ00121 1560 AEEKKKAEEAKKAeedknmALRKAEEAKKAEEarieevmklyeeeKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLK 1639
|
250 260 270
....*....|....*....|....*....|....*..
gi 226509858 737 MSEWKQGRSS---KKNNNFAHKKSKAFNSKARYKRRK 770
Cdd:PTZ00121 1640 KKEAEEKKKAeelKKAEEENKIKAAEEAKKAEEDKKK 1676
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
285-473 |
8.09e-03 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 39.68 E-value: 8.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 285 DIVVATpgriIDHL-------RNSLSVGLEDLA--VVILDEADrLLELGFSAEIQELIRMCpKRRQT--MLFSATMTeei 353
Cdd:COG1203 240 PVVVTT----IDQLfeslfsnRKGQERRLHNLAnsVIILDEVQ-AYPPYMLALLLRLLEWL-KNLGGsvILMTATLP--- 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 354 dELIKLSLNKPVRL---EADPSLKRPATLTEEVVRIRRARESNQEAVLLAL-CLKTFKRSVIIFSgTKQSAHRLKIIfgL 429
Cdd:COG1203 311 -PLLREELLEAYELipdEPEELPEYFRAFVRKRVELKEGPLSDEELAELILeALHKGKSVLVIVN-TVKDAQELYEA--L 386
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 226509858 430 SGMKAAE----LHGNLTQAQRLE----ALELFRKQEVDFLIATDVAARGIDI 473
Cdd:COG1203 387 KEKLPDEevylLHSRFCPADRSEiekeIKERLERGKPCILVSTQVVEAGVDI 438
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
625-769 |
8.18e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 39.74 E-value: 8.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226509858 625 AKQAEDLRLKEKKRREHEKDLPRKKRRRLEAQREMLEDEDEDDEEAKESDRGKKL-----------KKGQSLVDAAYRKA 693
Cdd:PTZ00121 1277 ARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKAdaakkkaeeakKAAEAAKAEAEAAA 1356
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 226509858 694 KSLKAASKRGPGASKGKKEknARQYSEKTPNRHEEMR--ELFQNDMSEWKQGRSSKKNNNFAHKKSKAFNSKARYKRR 769
Cdd:PTZ00121 1357 DEAEAAEEKAEAAEKKKEE--AKKKADAAKKKAEEKKkaDEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKK 1432
|
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| |
