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Conserved domains on  [gi|214831364|ref|NP_001135777|]
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zinc finger protein 771 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
62-221 1.77e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 1.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 214831364  62 PHACPDCGRAFARRSTLAKHART--HTGE--RPFGCTE--CGRRFSQKSALTKHGRTHTGERPYECP--ECDKRFSAASN 133
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 214831364 134 -----LRQHRRRHTGEKPYACAH--CGRRFAQSSNYAQHLRVHTGEKPYAC--PDCGRAFGGSSCLARHRRTHTGERPYA 204
Cdd:COG5048  369 neppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*..
gi 214831364 205 CADCGtRFAQSSALAKH 221
Cdd:COG5048  449 CSILK-SFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-268 1.53e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 214831364  245 NLAEHARTHTGERPYPCAECGRRF 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-240 3.36e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|....
gi 214831364  217 ALAKHRRVHTGEKPHRCAVCGRRF 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
62-221 1.77e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 1.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 214831364  62 PHACPDCGRAFARRSTLAKHART--HTGE--RPFGCTE--CGRRFSQKSALTKHGRTHTGERPYECP--ECDKRFSAASN 133
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 214831364 134 -----LRQHRRRHTGEKPYACAH--CGRRFAQSSNYAQHLRVHTGEKPYAC--PDCGRAFGGSSCLARHRRTHTGERPYA 204
Cdd:COG5048  369 neppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*..
gi 214831364 205 CADCGtRFAQSSALAKH 221
Cdd:COG5048  449 CSILK-SFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
133-158 1.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 214831364  133 NLRQHRRRHTGEKPYACAHCGRRFAQ 158
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-268 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 214831364  245 NLAEHARTHTGERPYPCAECGRRF 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-240 3.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|....
gi 214831364  217 ALAKHRRVHTGEKPHRCAVCGRRF 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
62-221 1.77e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 1.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 214831364  62 PHACPDCGRAFARRSTLAKHART--HTGE--RPFGCTE--CGRRFSQKSALTKHGRTHTGERPYECP--ECDKRFSAASN 133
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 214831364 134 -----LRQHRRRHTGEKPYACAH--CGRRFAQSSNYAQHLRVHTGEKPYAC--PDCGRAFGGSSCLARHRRTHTGERPYA 204
Cdd:COG5048  369 neppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*..
gi 214831364 205 CADCGtRFAQSSALAKH 221
Cdd:COG5048  449 CSILK-SFRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 148-254 1.00e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 214831364 148 ACAHCGRRFAQSSnyAQHLRVhTGEKPYACP--DCGRAFGGSSCLARHRRThtgerpyacADCGTRFAQSSALAKHRRVH 225
Cdd:COG5189  326 KLAHGGERNIDTP--SRMLKV-KDGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFS 393

                         90       100
                 ....*....|....*....|....*....
gi 214831364 226 TGEKPHRCAVCGRRFGHRSNLAEHaRTHT 254
Cdd:COG5189  394 AKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 115-198 4.69e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 4.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 214831364 115 GERPYECP--ECDKRFSAASNLRQHRRRhtgekpyacAHCGRRFAQSSNYAQHLRVHTGEKPYACPDCGRAFGGSSCLAR 192
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 214831364 193 HrRTHT 198
Cdd:COG5189  417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
53-162 6.41e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 6.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 214831364  53 PAPSADPaRPHACPDCGRAFARRSTLAKHARTHTGERPFGCTECGrrfsqksaltkhgrthtgerpyecpeCDKRFSAAS 132
Cdd:COG5048   25 KSLSNAP-RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPL 77

                         90       100       110
                 ....*....|....*....|....*....|
gi 214831364 133 NLRQHRRRHTGEKPYACAHCGRRFAQSSNY 162
Cdd:COG5048   78 ELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-209 7.86e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 7.86e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 214831364 145 KPYACAHCGRRFAQSSNYAQHLRVHTGEKPYACPDCGRA--FGGSSCLARHRRTHTGERPYACADCG 209
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNSKSL 98
zf-H2C2_2 pfam13465
Zinc-finger double domain;
133-158 1.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 214831364  133 NLRQHRRRHTGEKPYACAHCGRRFAQ 158
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
173-253 5.19e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 5.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 214831364 173 KPYACPDCGRAFGGSSCLARHRRTHTGERPYACADCGTRFAQS--SALAKHRRVHTGEKPHRCA--VCGRRFGHRSNLAE 248
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSksLPLSNSKASSSSLS 111


                 ....*
gi 214831364 249 HARTH 253
Cdd:COG5048  112 SSSSN 116
zf-H2C2_2 pfam13465
Zinc-finger double domain;
105-129 1.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|....*
gi 214831364  105 ALTKHGRTHTGERPYECPECDKRFS 129
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
161-184 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....
gi 214831364  161 NYAQHLRVHTGEKPYACPDCGRAF 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-268 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 214831364  245 NLAEHARTHTGERPYPCAECGRRF 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-240 3.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|....
gi 214831364  217 ALAKHRRVHTGEKPHRCAVCGRRF 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 119-141 3.63e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 3.63e-03
                          10        20
                  ....*....|....*....|...
gi 214831364  119 YECPECDKRFSAASNLRQHRRRH 141
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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