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Conserved domains on  [gi|923424571|ref|NP_001124318|]
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apoptosis-inducing factor 1, mitochondrial isoform AIFsh [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIF_C pfam14721
Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to ...
 126-255 1.49e-84

Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to be a dimerization domain of the mitochondrial apoptosis-inducing factor 1. protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerization and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.


:

Pssm-ID: 464279  Cd Length: 130  Bit Score: 248.72  E-value: 1.49e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  126 AGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIP 205
Cdd:pfam14721   1 AGENMTGAGKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATEKDTPKAVVEESGESIRSESEEEATASASAAP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 923424571  206 PSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKD 255
Cdd:pfam14721  81 SSEDVASEDPSPGEDYGKGVIFYLRDDKVVGIVLWNVFNRMPIARKIIKD 130
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 1-147 2.27e-25

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


:

Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 102.20  E-value: 2.27e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571   1 MGKILPEYlSNWTMEKVRREGVKVMPNAIVQSVgVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDfG 80
Cdd:COG0446  160 LGVLDPEM-AALLEEELREHGVELRLGETVVAI-DGDDKVAVTLTDGEEIPADLVVVAPGVRPNTELAKDAGLALGER-G 236

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 923424571  81 GFRVNAELQAR-SNIWVAGDAACFYDIKLGRR-RVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDL 147
Cdd:COG0446  237 WIKVDETLQTSdPDVYAAGDCAEVPHPVTGKTvYIPLASAANKQGRVAAENILGGPAPFPGLGTFISKV 305
 
Name Accession Description Interval E-value
AIF_C pfam14721
Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to ...
 126-255 1.49e-84

Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to be a dimerization domain of the mitochondrial apoptosis-inducing factor 1. protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerization and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.


Pssm-ID: 464279  Cd Length: 130  Bit Score: 248.72  E-value: 1.49e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  126 AGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIP 205
Cdd:pfam14721   1 AGENMTGAGKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATEKDTPKAVVEESGESIRSESEEEATASASAAP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 923424571  206 PSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKD 255
Cdd:pfam14721  81 SSEDVASEDPSPGEDYGKGVIFYLRDDKVVGIVLWNVFNRMPIARKIIKD 130
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
1-257 5.43e-29

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 113.31  E-value: 5.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571   1 MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDsdfG 80
Cdd:COG1251  178 LPRQLDEEAGALLQRLLEALGVEVRLGTGVTEIEGDDRVTGVRLADGEELPADLVVVAIGVRPNTELARAAGLAVD---R 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  81 GFRVNAELQA-RSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWH-QSMFWSDLgPDVGYEAIGL 158
Cdd:COG1251  255 GIVVDDYLRTsDPDIYAAGDCAEHPGPVYGRRVLELVAPAYEQARVAAANLAGGPAAYEGsVPSTKLKV-FGVDVASAGD 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571 159 VDsslptvgvfakataqdnpksATEQSgtgirseseteseaseitippstpavpqapVQGEDYGKGVI--FYLRDKVVVG 236
Cdd:COG1251  334 AE--------------------GDEEV------------------------------VVRGDPARGVYkkLVLRDGRLVG 363

                        250       260
                 ....*....|....*....|.
gi 923424571 237 IVLWNIFNRMPIARKIIKDGE 257
Cdd:COG1251  364 AVLVGDTSDAGALRQLIKNGR 384
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 1-147 2.27e-25

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 102.20  E-value: 2.27e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571   1 MGKILPEYlSNWTMEKVRREGVKVMPNAIVQSVgVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDfG 80
Cdd:COG0446  160 LGVLDPEM-AALLEEELREHGVELRLGETVVAI-DGDDKVAVTLTDGEEIPADLVVVAPGVRPNTELAKDAGLALGER-G 236

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 923424571  81 GFRVNAELQAR-SNIWVAGDAACFYDIKLGRR-RVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDL 147
Cdd:COG0446  237 WIKVDETLQTSdPDVYAAGDCAEVPHPVTGKTvYIPLASAANKQGRVAAENILGGPAPFPGLGTFISKV 305
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 1-123 1.45e-15

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 75.05  E-value: 1.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571    1 MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDfG 80
Cdd:pfam07992 187 LLRAFDEEISAALEKALEKNGVEVRLGTSVKEIIGDGDGVEVILKDGTEIDADLVVVAIGRRPNTELLEAAGLELDER-G 265

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 923424571   81 GFRVNAELQ-ARSNIWVAGDAacfydiklGRRRVEHHDHAVVSG 123
Cdd:pfam07992 266 GIVVDEYLRtSVPGIYAAGDC--------RVGGPELAQNAVAQG 301
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
1-101 1.17e-10

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 61.09  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571   1 MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSdfg 80
Cdd:PRK04965 177 LASLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDSGIRATLDSGRSIEVDAVIAAAGLRPNTALARRAGLAVNR--- 253

                         90       100
                 ....*....|....*....|..
gi 923424571  81 GFRVNAELQ-ARSNIWVAGDAA 101
Cdd:PRK04965 254 GIVVDSYLQtSAPDIYALGDCA 275
 
Name Accession Description Interval E-value
AIF_C pfam14721
Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to ...
 126-255 1.49e-84

Apoptosis-inducing factor, mitochondrion-associated, C-term; This C-terminal domain appears to be a dimerization domain of the mitochondrial apoptosis-inducing factor 1. protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerization and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.


Pssm-ID: 464279  Cd Length: 130  Bit Score: 248.72  E-value: 1.49e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  126 AGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTGIRSESETESEASEITIP 205
Cdd:pfam14721   1 AGENMTGAGKPYWHQSMFWSDLGPDVGYEAIGIVDSSLPTVGVFAKATEKDTPKAVVEESGESIRSESEEEATASASAAP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 923424571  206 PSTPAVPQAPVQGEDYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKD 255
Cdd:pfam14721  81 SSEDVASEDPSPGEDYGKGVIFYLRDDKVVGIVLWNVFNRMPIARKIIKD 130
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
1-257 5.43e-29

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 113.31  E-value: 5.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571   1 MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDsdfG 80
Cdd:COG1251  178 LPRQLDEEAGALLQRLLEALGVEVRLGTGVTEIEGDDRVTGVRLADGEELPADLVVVAIGVRPNTELARAAGLAVD---R 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  81 GFRVNAELQA-RSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWH-QSMFWSDLgPDVGYEAIGL 158
Cdd:COG1251  255 GIVVDDYLRTsDPDIYAAGDCAEHPGPVYGRRVLELVAPAYEQARVAAANLAGGPAAYEGsVPSTKLKV-FGVDVASAGD 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571 159 VDsslptvgvfakataqdnpksATEQSgtgirseseteseaseitippstpavpqapVQGEDYGKGVI--FYLRDKVVVG 236
Cdd:COG1251  334 AE--------------------GDEEV------------------------------VVRGDPARGVYkkLVLRDGRLVG 363

                        250       260
                 ....*....|....*....|.
gi 923424571 237 IVLWNIFNRMPIARKIIKDGE 257
Cdd:COG1251  364 AVLVGDTSDAGALRQLIKNGR 384
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 1-147 2.27e-25

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 102.20  E-value: 2.27e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571   1 MGKILPEYlSNWTMEKVRREGVKVMPNAIVQSVgVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDfG 80
Cdd:COG0446  160 LGVLDPEM-AALLEEELREHGVELRLGETVVAI-DGDDKVAVTLTDGEEIPADLVVVAPGVRPNTELAKDAGLALGER-G 236

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 923424571  81 GFRVNAELQAR-SNIWVAGDAACFYDIKLGRR-RVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDL 147
Cdd:COG0446  237 WIKVDETLQTSdPDVYAAGDCAEVPHPVTGKTvYIPLASAANKQGRVAAENILGGPAPFPGLGTFISKV 305
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 1-123 1.45e-15

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 75.05  E-value: 1.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571    1 MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDfG 80
Cdd:pfam07992 187 LLRAFDEEISAALEKALEKNGVEVRLGTSVKEIIGDGDGVEVILKDGTEIDADLVVVAIGRRPNTELLEAAGLELDER-G 265

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 923424571   81 GFRVNAELQ-ARSNIWVAGDAacfydiklGRRRVEHHDHAVVSG 123
Cdd:pfam07992 266 GIVVDEYLRtSVPGIYAAGDC--------RVGGPELAQNAVAQG 301
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
1-129 3.69e-11

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 62.46  E-value: 3.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571   1 MGKILPEY---LSNWTMEKVRREGVKVMPNAIVQSvgVSSGKllIKLKDGRKVETDHIVAAVGLEPNvELAKTGGLEIDS 77
Cdd:COG1252  194 GPRILPGLgekLSEAAEKELEKRGVEVHTGTRVTE--VDADG--VTLEDGEEIPADTVIWAAGVKAP-PLLADLGLPTDR 268

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  78 DfGGFRVNAELQARS--NIWVAGDAACFYDI------KLGRrrvehhdHAVVSGRLAGEN 129
Cdd:COG1252  269 R-GRVLVDPTLQVPGhpNVFAIGDCAAVPDPdgkpvpKTAQ-------AAVQQAKVLAKN 320
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
1-101 1.17e-10

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 61.09  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571   1 MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSdfg 80
Cdd:PRK04965 177 LASLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDSGIRATLDSGRSIEVDAVIAAAGLRPNTALARRAGLAVNR--- 253

                         90       100
                 ....*....|....*....|..
gi 923424571  81 GFRVNAELQ-ARSNIWVAGDAA 101
Cdd:PRK04965 254 GIVVDSYLQtSAPDIYALGDCA 275
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 18-132 4.36e-10

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 59.72  E-value: 4.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  18 RREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVET---DHIVAAVGLEPNVE---LAKTgGLEIDSDfGGFRVNAELQ-A 90
Cdd:COG1249  220 EKEGIDILTGAKVTSVEKTGDGVTVTLEDGGGEEAveaDKVLVATGRRPNTDglgLEAA-GVELDER-GGIKVDEYLRtS 297

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 923424571  91 RSNIWVAGDAAcfydiklGRRRVEHhdHAVVSGRLAGENMTG 132
Cdd:COG1249  298 VPGIYAIGDVT-------GGPQLAH--VASAEGRVAAENILG 330
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 1-146 4.63e-08

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 53.39  E-value: 4.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571   1 MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVgVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDsdfG 80
Cdd:PRK09754 180 MGRNAPPPVQRYLLQRHQQAGVRILLNNAIEHV-VDGEKVELTLQSGETLQADVVIYGIGISANDQLAREANLDTA---N 255

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 923424571  81 GFRVNAELQ-ARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSD 146
Cdd:PRK09754 256 GIVIDEACRtCDPAIFAGGDVAITRLDNGALHRCESWENANNQAQIAAAAMLGLPLPLLPPPWFWSD 322
PRK06370 PRK06370
FAD-containing oxidoreductase;
14-99 5.70e-08

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 53.28  E-value: 5.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  14 MEKVRREGVKVMPNAIVQSVGVSSGKLLIKLK---DGRKVETDHIVAAVGLEPNVE---LAKTgGLEIDSDfGGFRVNAE 87
Cdd:PRK06370 219 REILEREGIDVRLNAECIRVERDGDGIAVGLDcngGAPEITGSHILVAVGRVPNTDdlgLEAA-GVETDAR-GYIKVDDQ 296

                         90
                 ....*....|...
gi 923424571  88 LQAR-SNIWVAGD 99
Cdd:PRK06370 297 LRTTnPGIYAAGD 309
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 15-137 9.59e-07

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 49.27  E-value: 9.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  15 EKVRREGVKVMPNAIVQSVgVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDfGGFRVNAELQAR-SN 93
Cdd:PRK09564 199 EELRENGVELHLNEFVKSL-IGEDKVEGVVTDKGEYEADVVIVATGVKPNTEFLEDTGLKTLKN-GAIIVDEYGETSiEN 276

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 923424571  94 IWVAGDAACFYDIKLGRRR-VEHHDHAVVSGRLAGENMTGAAKPY 137
Cdd:PRK09564 277 IYAAGDCATIYNIVSNKNVyVPLATTANKLGRMVGENLAGRHVSF 321
PRK07845 PRK07845
flavoprotein disulfide reductase; Reviewed
 15-99 2.15e-05

flavoprotein disulfide reductase; Reviewed


Pssm-ID: 236112 [Multi-domain]  Cd Length: 466  Bit Score: 45.24  E-value: 2.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  15 EKV-RREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPN----------VELAKTGGLEIDsdfggfR 83
Cdd:PRK07845 225 EEVfARRGMTVLKRSRAESVERTGDGVVVTLTDGRTVEGSHALMAVGSVPNtaglgleeagVELTPSGHITVD------R 298

                         90
                 ....*....|....*....
gi 923424571  84 VnaelqARSN---IWVAGD 99
Cdd:PRK07845 299 V-----SRTSvpgIYAAGD 312
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
13-101 2.76e-05

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 44.73  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  13 TMEKVRR-EGVKVMPNAIVQSV----GVSSgkllIKLKDG-----RKVETDHIVAAVGLEPNVELAKTGGLEIDSDfGGF 82
Cdd:COG0492  182 LVERLRAnPKIEVLWNTEVTEIegdgRVEG----VTLKNVktgeeKELEVDGVFVAIGLKPNTELLKGLGLELDED-GYI 256

                         90       100
                 ....*....|....*....|
gi 923424571  83 RVNAELQ-ARSNIWVAGDAA 101
Cdd:COG0492  257 VVDEDMEtSVPGVFAAGDVR 276
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 22-137 6.20e-05

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 44.01  E-value: 6.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  22 VKVMPNAIVQSVGVSSGKLLIKLKDGRKVET---DHIVAAVGLEPNVE---LAKTgGLEIDSDfgGF-RVNAEL-QARSN 93
Cdd:PRK06292 224 FKIKLGAKVTSVEKSGDEKVEELEKGGKTETieaDYVLVATGRRPNTDglgLENT-GIELDER--GRpVVDEHTqTSVPG 300

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 923424571  94 IWVAGDAAcfydiklGRRRVEHhdHAVVSGRLAGENMTGAAKPY 137
Cdd:PRK06292 301 IYAAGDVN-------GKPPLLH--EAADEGRIAAENAAGDVAGG 335
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
18-135 1.12e-04

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 43.22  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571  18 RREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLEPNVE---LAKTgGLEIDSDfGGFRVNAELQ-ARSN 93
Cdd:PRK05249 227 RDSGVTIRHNEEVEKVEGGDDGVIVHLKSGKKIKADCLLYANGRTGNTDglnLENA-GLEADSR-GQLKVNENYQtAVPH 304

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 923424571  94 IWVAGD-------AACFYDiklgrrrvehhdhavvSGRLAGENMTGAAK 135
Cdd:PRK05249 305 IYAVGDvigfpslASASMD----------------QGRIAAQHAVGEAT 337
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
9-78 3.83e-04

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 41.06  E-value: 3.83e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 923424571    9 LSNWT----MEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHI-VAAVGLEPNVELAKTGGLEIDSD 78
Cdd:pfam13738 201 LSPDTlnrlEELVKNGKIKAHFNAEVKEITEVDVSYKVHTEDGRKVTSNDDpILATGYHPDLSFLKKGLFELDED 275
PTZ00058 PTZ00058
glutathione reductase; Provisional
 7-100 1.46e-03

glutathione reductase; Provisional


Pssm-ID: 185420 [Multi-domain]  Cd Length: 561  Bit Score: 39.60  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923424571   7 EYLSNWTMEKVRREGVKVMPNAIVQSV-GVSSGKLLIKLKDGRKVET-DHIVAAVGLEPNVELAKTGGLEIDSDFGGFRV 84
Cdd:PTZ00058 278 ETIINELENDMKKNNINIITHANVEEIeKVKEKNLTIYLSDGRKYEHfDYVIYCVGRSPNTEDLNLKALNIKTPKGYIKV 357

                         90
                 ....*....|....*..
gi 923424571  85 NA-ELQARSNIWVAGDA 100
Cdd:PTZ00058 358 DDnQRTSVKHIYAVGDC 374
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 1-47 3.57e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 35.64  E-value: 3.57e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 923424571    1 MGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDG 47
Cdd:pfam00070  34 LLPGFDPEIAKILQEKLEKNGIEFLLNTTVEAIEGNGDGVVVVLTDG 80
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
15-82 4.63e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 38.30  E-value: 4.63e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 923424571  15 EKVRREGVKV---MPNAIVQSVGvssGKLLIKLKD---GRKVE--TDHIVAAVGLEPNV---ELAKTGGLEIDSDfgGF 82
Cdd:COG1148  358 RRAREDGVRFirgRVAEIEEDEG---GKLVVTVEDtllGEPVEieADLVVLATGMVPSEdneELAKLLKLPLDQD--GF 431
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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