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Conserved domains on  [gi|194097401|ref|NP_001123492|]
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V-type proton ATPase 116 kDa subunit a 1 isoform 2 [Homo sapiens]

Protein Classification

V-type ATPase subunit a family protein( domain architecture ID 11119844)

V-type ATPase 116kDa subunit a family protein such as vertebrate V-type proton ATPase 116 kDa subunit a and plant/yeast V-type proton ATPase subunit a, an essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes

Gene Ontology:  GO:0042625|GO:0033176|GO:1902600
PubMed:  9210392|10224039
SCOP:  4001703

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
V_ATPase_I pfam01496
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-828 0e+00

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


:

Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 1285.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401   27 SELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIM---DTGENPEVPFPRDMIDLEANFEK 103
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLDIIPIkdtLDLETPEAPSPREIDELEEKLEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  104 IENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEAELHHQQMADPDLLEESSSLLEPSEMgrgtplRLGFVAGVIN 183
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDRASGEQEEIRAASSDQEEDNALLLDDV------ELGFVAGVIP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  184 RERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKE 263
Cdd:pfam01496 155 REKVPAFERILWRATRGNLFLRQAEIEEPLEDPVTGEEVEKNVFIIFFHGEQLLQKIKKICESFGATLYPCPEDAEERRE 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  264 MASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFA 343
Cdd:pfam01496 235 MLQEVNTRIEDLKTVLDQTEDHRRRELQAIASNLEEWKIFVRKEKAIYHTLNLFNYDVTRKCLIAEGWCPTSDLEEIQQA 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  344 LRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILM 423
Cdd:pfam01496 315 LRRATEESGSSVPSILNVIQTNKTPPTYFRTNKFTEGFQNIVDAYGIARYREVNPGLFTIITFPFLFAVMFGDIGHGLIL 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  424 TLFAVWMVLRESRILSQKNeNEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETlrg 503
Cdd:pfam01496 395 FLFALYLILNEKKLKKKKL-NEIFDMFFGGRYIILLMGLFSIYTGFIYNDFFSKSLNLFGSGWKWPEMKEGESIAKK--- 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  504 NPVLQLnpalpgvFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEI 583
Cdd:pfam01496 471 NGYLTL-------FGCPYPFGLDPAWHGAENELLFLNSYKMKLSIILGVIHMTFGICLSLFNHIYFKSKLDIFFEFIPQL 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  584 IFMTSLFGYLVILIFYKWTAYDAHTSeNAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPL 663
Cdd:pfam01496 544 LFLQSIFGYLVFLIIYKWCTDWADGS-PAPSLLNMLINMFLSPGTVPPEEPLYPGQATVQVILLLIALICVPWMLLPKPL 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  664 vlrrqYLRRKHlgtlnfggirvgngpteedaeiiqhdqlsthsedaDEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLW 743
Cdd:pfam01496 623 -----YLKRQH-----------------------------------KKFDFGEIFIHQVIHTIEFVLGCISNTASYLRLW 662
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  744 ALSLAHAQLSEVLWTMVIHI-GLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFK 822
Cdd:pfam01496 663 ALSLAHAQLSEVLWEMTLRNaGLGMGGILGVIMLFIGFAVWAVLTVAILLVMEGLSAFLHALRLHWVEFQSKFYKGDGYK 742

                  ....*.
gi 194097401  823 FLPFSF 828
Cdd:pfam01496 743 FEPFSF 748
 
Name Accession Description Interval E-value
V_ATPase_I pfam01496
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-828 0e+00

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 1285.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401   27 SELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIM---DTGENPEVPFPRDMIDLEANFEK 103
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLDIIPIkdtLDLETPEAPSPREIDELEEKLEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  104 IENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEAELHHQQMADPDLLEESSSLLEPSEMgrgtplRLGFVAGVIN 183
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDRASGEQEEIRAASSDQEEDNALLLDDV------ELGFVAGVIP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  184 RERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKE 263
Cdd:pfam01496 155 REKVPAFERILWRATRGNLFLRQAEIEEPLEDPVTGEEVEKNVFIIFFHGEQLLQKIKKICESFGATLYPCPEDAEERRE 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  264 MASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFA 343
Cdd:pfam01496 235 MLQEVNTRIEDLKTVLDQTEDHRRRELQAIASNLEEWKIFVRKEKAIYHTLNLFNYDVTRKCLIAEGWCPTSDLEEIQQA 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  344 LRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILM 423
Cdd:pfam01496 315 LRRATEESGSSVPSILNVIQTNKTPPTYFRTNKFTEGFQNIVDAYGIARYREVNPGLFTIITFPFLFAVMFGDIGHGLIL 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  424 TLFAVWMVLRESRILSQKNeNEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETlrg 503
Cdd:pfam01496 395 FLFALYLILNEKKLKKKKL-NEIFDMFFGGRYIILLMGLFSIYTGFIYNDFFSKSLNLFGSGWKWPEMKEGESIAKK--- 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  504 NPVLQLnpalpgvFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEI 583
Cdd:pfam01496 471 NGYLTL-------FGCPYPFGLDPAWHGAENELLFLNSYKMKLSIILGVIHMTFGICLSLFNHIYFKSKLDIFFEFIPQL 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  584 IFMTSLFGYLVILIFYKWTAYDAHTSeNAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPL 663
Cdd:pfam01496 544 LFLQSIFGYLVFLIIYKWCTDWADGS-PAPSLLNMLINMFLSPGTVPPEEPLYPGQATVQVILLLIALICVPWMLLPKPL 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  664 vlrrqYLRRKHlgtlnfggirvgngpteedaeiiqhdqlsthsedaDEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLW 743
Cdd:pfam01496 623 -----YLKRQH-----------------------------------KKFDFGEIFIHQVIHTIEFVLGCISNTASYLRLW 662
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  744 ALSLAHAQLSEVLWTMVIHI-GLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFK 822
Cdd:pfam01496 663 ALSLAHAQLSEVLWEMTLRNaGLGMGGILGVIMLFIGFAVWAVLTVAILLVMEGLSAFLHALRLHWVEFQSKFYKGDGYK 742

                  ....*.
gi 194097401  823 FLPFSF 828
Cdd:pfam01496 743 FEPFSF 748
NtpI COG1269
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal ...
26-829 5.31e-49

Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 440880 [Multi-domain]  Cd Length: 645  Bit Score: 183.95  E-value: 5.31e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  26 VSELGELGKVQFRDLNP---DVNVFQR-KFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANF 101
Cdd:COG1269   22 LEALQELGVVHIEDLDEeleEEEGLKPgEPDEELEELSELLSRLRSALSILGPYLEEKGGLKPKKEVTLEELEEELEEEL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 102 EKIENELKEINTNQEALKRNFLELTELKFILRKTQQF-FDEAELHHQQmadpdlleesssllepsemgrgtplRLGFVAG 180
Cdd:COG1269  102 EEIEEEVNELEERLEELEEELEELEELIEALEPWGDLdIDLEELRGTK-------------------------YLSVRVG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 181 VINRERIPTFERMLwrvcrgnvflrqAEIENPLEdPVTGDYVHKSVFIIFFQGDQlKNRVKKICEGFRASLYPCPETPQE 260
Cdd:COG1269  157 TVPKENLEKLKKAL------------EILADYVE-VVSSDKEDEVYVVVIVPKED-EEEVEEVLRSLGFERLEIPELEGT 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 261 RKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNlcNIDVTQKCLIAEVWCPVTDLDSI 340
Cdd:COG1269  223 PSEALEELEEEIEELEKEIEELEKELEELAEKYREDLLALYEYLEIEKEKAEAPL--KLATTENLFVLEGWVPEEEVEEL 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 341 QFALRRgtEHSGSTVPSILNRMqTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHG 420
Cdd:COG1269  301 EKALEK--ATGGRVYVEEEDPE-EDDEPPTLLKNPKFVKPFELLVEMYGLPKYGEIDPTPFFALFFPLFFGMMFGDAGYG 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 421 ILMTLFAVWMVLresrilsqKNENEMFSTVFsgrYIILLMGVFSMYTGLIYNdcfskslnifgsswsvrpmftynwteet 500
Cdd:COG1269  378 LLLLLAGLLLLK--------KFLSKGLKKLG---KLLLYLGISTIIFGLLYG---------------------------- 418
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 501 lrgnpvlqlnpalpGVFGGPYPFGIDPIWNIATnkLTFLNSFkMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFI 580
Cdd:COG1269  419 --------------SFFGFELLAGLLPALWLDP--LEDPNTM-LVLSLAIGVIHLLLGLILGIYNLLKRGDYKDALLDQG 481
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 581 PEIIFMTSLFGYLVILIFYKWTaydahtsenaPSLLIHFInmflfsypesgysmlysgqkgiqCFLVVVALLCVPWMLLF 660
Cdd:COG1269  482 GWLLLLLGLLLLVLGLVLGGPL----------PLTTIGLV-----------------------LLIIGLVLLLLFGGRSG 528
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 661 KPlvlrrqylrrkhlgtlnfGGIRVGNGPTEedaeiiqhdqlsthsedadefdfgdtmvhqaihTIEYcLGCISNTASYL 740
Cdd:COG1269  529 KN------------------IGGRLGEGLFG---------------------------------LYEI-TGYLSDVLSYI 556
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 741 RLWALSLAHAQLSEVLWTMVIHIGLS-VKSLAGGLVlfffftafatltVAIL-----LIMEGLSAFLHALRLHWVEFQNK 814
Cdd:COG1269  557 RLFALGLASAGLAMVVNTLAGMVGGGpIVGIIGGIL------------ILILghllnIALEGLGAFVHSLRLQYVEFFGK 624
                        810
                 ....*....|....*
gi 194097401 815 FYSGTGFKFLPFSFE 829
Cdd:COG1269  625 FYEGGGKPFKPFKLK 639
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
26-826 2.21e-37

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 149.31  E-value: 2.21e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  26 VSELGELGKVQFRDLNPDVNVFQrkfVNEVRR-CEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKI 104
Cdd:PRK05771  22 LEALHELGVVHIEDLKEELSNER---LRKLRSlLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDVEEELEKI 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 105 ENELKEINTNQEALKRNFLELTELKFILRKTQQF-FDEAELHHQQmadpdlleesssllepsemgrgtplRLGFVAGVIN 183
Cdd:PRK05771  99 EKEIKELEEEISELENEIKELEQEIERLEPWGNFdLDLSLLLGFK-------------------------YVSVFVGTVP 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 184 REriptfermlwrvcrgnVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICE-GFRASLYPCPETPQERk 262
Cdd:PRK05771 154 ED----------------KLEELKLESDVENVEYISTDKGYVYVVVVVLKELSDEVEEELKKlGFERLELEEEGTPSEL- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 263 emASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWF----IKVRKMKAiyhtlnLCNIDVTQKCLIAEVWCPVTDLD 338
Cdd:PRK05771 217 --IREIKEELEEIEKERESLLEELKELAKKYLEELLALYeyleIELERAEA------LSKFLKTDKTFAIEGWVPEDRVK 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 339 SIQFALRRGTEhsGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFG 418
Cdd:PRK05771 289 KLKELIDKATG--GSAYVEFVEPDEEEEEVPTKLKNPKFIKPFESLTEMYSLPKYNEIDPTPFLAIFFPLFFGMMLGDAG 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 419 HGILMTLFAVWMVLResriLSQKNENemfSTVFSgrYIILLMGVFSMYTGLIYNDCfskslniFGSSWSVRPMFtynwte 498
Cdd:PRK05771 367 YGLLLLLIGLLLSFK----LKKKSEG---LKRLL--KILIYLGISTIIWGLLTGSF-------FGFSLPIFLPG------ 424
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 499 etlrgnPVLQLNPALPGVFGGPYPFGIdpiwniatnkltflnsfkMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFG 578
Cdd:PRK05771 425 ------GYLELPEGYPSLSTENDVMTI------------------LIISLLIGVIHLFLGLLLGFINNVRKGDYKDAFLA 480
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 579 FIPEIIFMTSLFGYLVILIfykwtaydahtsenaPSLLIHFINMFLfsypesGYSMLYSGqkgiqcfLVVVALLCVPwml 658
Cdd:PRK05771 481 QLGWLLILLGILLIVLGGF---------------GLVVGLGPLGLI------GKYLIIGG-------VVLIILGEGI--- 529
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 659 lfkplvlrrqylrrkhlgtlnFGGIRVGNGPTEEDAEIIqhdqlsthsedadefdfgdtmvhqaihtieyclGCISNTAS 738
Cdd:PRK05771 530 ---------------------DGKSLGGALGGLGLYEIT---------------------------------GYLGDVLS 555
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 739 YLRLWALSLAHA-------QLSEVLWTMVIHIGLSVkslagGLVlfffftafatltvaILLI-------MEGLSAFLHAL 804
Cdd:PRK05771 556 YARLMALGLAGAgiamafnLMAGLLPPSIGVIGIIV-----GII--------------IFIFghllniaLSILGAFVHGL 616
                        810       820
                 ....*....|....*....|..
gi 194097401 805 RLHWVEFQNKFYSGTGFKFLPF 826
Cdd:PRK05771 617 RLHYVEFFGKFYEGGGKKFNPF 638
 
Name Accession Description Interval E-value
V_ATPase_I pfam01496
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-828 0e+00

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 1285.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401   27 SELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIM---DTGENPEVPFPRDMIDLEANFEK 103
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLDIIPIkdtLDLETPEAPSPREIDELEEKLEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  104 IENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEAELHHQQMADPDLLEESSSLLEPSEMgrgtplRLGFVAGVIN 183
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDRASGEQEEIRAASSDQEEDNALLLDDV------ELGFVAGVIP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  184 RERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKE 263
Cdd:pfam01496 155 REKVPAFERILWRATRGNLFLRQAEIEEPLEDPVTGEEVEKNVFIIFFHGEQLLQKIKKICESFGATLYPCPEDAEERRE 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  264 MASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFA 343
Cdd:pfam01496 235 MLQEVNTRIEDLKTVLDQTEDHRRRELQAIASNLEEWKIFVRKEKAIYHTLNLFNYDVTRKCLIAEGWCPTSDLEEIQQA 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  344 LRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILM 423
Cdd:pfam01496 315 LRRATEESGSSVPSILNVIQTNKTPPTYFRTNKFTEGFQNIVDAYGIARYREVNPGLFTIITFPFLFAVMFGDIGHGLIL 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  424 TLFAVWMVLRESRILSQKNeNEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETlrg 503
Cdd:pfam01496 395 FLFALYLILNEKKLKKKKL-NEIFDMFFGGRYIILLMGLFSIYTGFIYNDFFSKSLNLFGSGWKWPEMKEGESIAKK--- 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  504 NPVLQLnpalpgvFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEI 583
Cdd:pfam01496 471 NGYLTL-------FGCPYPFGLDPAWHGAENELLFLNSYKMKLSIILGVIHMTFGICLSLFNHIYFKSKLDIFFEFIPQL 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  584 IFMTSLFGYLVILIFYKWTAYDAHTSeNAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPL 663
Cdd:pfam01496 544 LFLQSIFGYLVFLIIYKWCTDWADGS-PAPSLLNMLINMFLSPGTVPPEEPLYPGQATVQVILLLIALICVPWMLLPKPL 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  664 vlrrqYLRRKHlgtlnfggirvgngpteedaeiiqhdqlsthsedaDEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLW 743
Cdd:pfam01496 623 -----YLKRQH-----------------------------------KKFDFGEIFIHQVIHTIEFVLGCISNTASYLRLW 662
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  744 ALSLAHAQLSEVLWTMVIHI-GLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFK 822
Cdd:pfam01496 663 ALSLAHAQLSEVLWEMTLRNaGLGMGGILGVIMLFIGFAVWAVLTVAILLVMEGLSAFLHALRLHWVEFQSKFYKGDGYK 742

                  ....*.
gi 194097401  823 FLPFSF 828
Cdd:pfam01496 743 FEPFSF 748
NtpI COG1269
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal ...
26-829 5.31e-49

Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 440880 [Multi-domain]  Cd Length: 645  Bit Score: 183.95  E-value: 5.31e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  26 VSELGELGKVQFRDLNP---DVNVFQR-KFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANF 101
Cdd:COG1269   22 LEALQELGVVHIEDLDEeleEEEGLKPgEPDEELEELSELLSRLRSALSILGPYLEEKGGLKPKKEVTLEELEEELEEEL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 102 EKIENELKEINTNQEALKRNFLELTELKFILRKTQQF-FDEAELHHQQmadpdlleesssllepsemgrgtplRLGFVAG 180
Cdd:COG1269  102 EEIEEEVNELEERLEELEEELEELEELIEALEPWGDLdIDLEELRGTK-------------------------YLSVRVG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 181 VINRERIPTFERMLwrvcrgnvflrqAEIENPLEdPVTGDYVHKSVFIIFFQGDQlKNRVKKICEGFRASLYPCPETPQE 260
Cdd:COG1269  157 TVPKENLEKLKKAL------------EILADYVE-VVSSDKEDEVYVVVIVPKED-EEEVEEVLRSLGFERLEIPELEGT 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 261 RKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNlcNIDVTQKCLIAEVWCPVTDLDSI 340
Cdd:COG1269  223 PSEALEELEEEIEELEKEIEELEKELEELAEKYREDLLALYEYLEIEKEKAEAPL--KLATTENLFVLEGWVPEEEVEEL 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 341 QFALRRgtEHSGSTVPSILNRMqTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHG 420
Cdd:COG1269  301 EKALEK--ATGGRVYVEEEDPE-EDDEPPTLLKNPKFVKPFELLVEMYGLPKYGEIDPTPFFALFFPLFFGMMFGDAGYG 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 421 ILMTLFAVWMVLresrilsqKNENEMFSTVFsgrYIILLMGVFSMYTGLIYNdcfskslnifgsswsvrpmftynwteet 500
Cdd:COG1269  378 LLLLLAGLLLLK--------KFLSKGLKKLG---KLLLYLGISTIIFGLLYG---------------------------- 418
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 501 lrgnpvlqlnpalpGVFGGPYPFGIDPIWNIATnkLTFLNSFkMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFI 580
Cdd:COG1269  419 --------------SFFGFELLAGLLPALWLDP--LEDPNTM-LVLSLAIGVIHLLLGLILGIYNLLKRGDYKDALLDQG 481
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 581 PEIIFMTSLFGYLVILIFYKWTaydahtsenaPSLLIHFInmflfsypesgysmlysgqkgiqCFLVVVALLCVPWMLLF 660
Cdd:COG1269  482 GWLLLLLGLLLLVLGLVLGGPL----------PLTTIGLV-----------------------LLIIGLVLLLLFGGRSG 528
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 661 KPlvlrrqylrrkhlgtlnfGGIRVGNGPTEedaeiiqhdqlsthsedadefdfgdtmvhqaihTIEYcLGCISNTASYL 740
Cdd:COG1269  529 KN------------------IGGRLGEGLFG---------------------------------LYEI-TGYLSDVLSYI 556
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 741 RLWALSLAHAQLSEVLWTMVIHIGLS-VKSLAGGLVlfffftafatltVAIL-----LIMEGLSAFLHALRLHWVEFQNK 814
Cdd:COG1269  557 RLFALGLASAGLAMVVNTLAGMVGGGpIVGIIGGIL------------ILILghllnIALEGLGAFVHSLRLQYVEFFGK 624
                        810
                 ....*....|....*
gi 194097401 815 FYSGTGFKFLPFSFE 829
Cdd:COG1269  625 FYEGGGKPFKPFKLK 639
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
26-826 2.21e-37

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 149.31  E-value: 2.21e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401  26 VSELGELGKVQFRDLNPDVNVFQrkfVNEVRR-CEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKI 104
Cdd:PRK05771  22 LEALHELGVVHIEDLKEELSNER---LRKLRSlLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDVEEELEKI 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 105 ENELKEINTNQEALKRNFLELTELKFILRKTQQF-FDEAELHHQQmadpdlleesssllepsemgrgtplRLGFVAGVIN 183
Cdd:PRK05771  99 EKEIKELEEEISELENEIKELEQEIERLEPWGNFdLDLSLLLGFK-------------------------YVSVFVGTVP 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 184 REriptfermlwrvcrgnVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICE-GFRASLYPCPETPQERk 262
Cdd:PRK05771 154 ED----------------KLEELKLESDVENVEYISTDKGYVYVVVVVLKELSDEVEEELKKlGFERLELEEEGTPSEL- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 263 emASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWF----IKVRKMKAiyhtlnLCNIDVTQKCLIAEVWCPVTDLD 338
Cdd:PRK05771 217 --IREIKEELEEIEKERESLLEELKELAKKYLEELLALYeyleIELERAEA------LSKFLKTDKTFAIEGWVPEDRVK 288
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 339 SIQFALRRGTEhsGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFG 418
Cdd:PRK05771 289 KLKELIDKATG--GSAYVEFVEPDEEEEEVPTKLKNPKFIKPFESLTEMYSLPKYNEIDPTPFLAIFFPLFFGMMLGDAG 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 419 HGILMTLFAVWMVLResriLSQKNENemfSTVFSgrYIILLMGVFSMYTGLIYNDCfskslniFGSSWSVRPMFtynwte 498
Cdd:PRK05771 367 YGLLLLLIGLLLSFK----LKKKSEG---LKRLL--KILIYLGISTIIWGLLTGSF-------FGFSLPIFLPG------ 424
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 499 etlrgnPVLQLNPALPGVFGGPYPFGIdpiwniatnkltflnsfkMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFG 578
Cdd:PRK05771 425 ------GYLELPEGYPSLSTENDVMTI------------------LIISLLIGVIHLFLGLLLGFINNVRKGDYKDAFLA 480
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 579 FIPEIIFMTSLFGYLVILIfykwtaydahtsenaPSLLIHFINMFLfsypesGYSMLYSGqkgiqcfLVVVALLCVPwml 658
Cdd:PRK05771 481 QLGWLLILLGILLIVLGGF---------------GLVVGLGPLGLI------GKYLIIGG-------VVLIILGEGI--- 529
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 659 lfkplvlrrqylrrkhlgtlnFGGIRVGNGPTEEDAEIIqhdqlsthsedadefdfgdtmvhqaihtieyclGCISNTAS 738
Cdd:PRK05771 530 ---------------------DGKSLGGALGGLGLYEIT---------------------------------GYLGDVLS 555
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194097401 739 YLRLWALSLAHA-------QLSEVLWTMVIHIGLSVkslagGLVlfffftafatltvaILLI-------MEGLSAFLHAL 804
Cdd:PRK05771 556 YARLMALGLAGAgiamafnLMAGLLPPSIGVIGIIV-----GII--------------IFIFghllniaLSILGAFVHGL 616
                        810       820
                 ....*....|....*....|..
gi 194097401 805 RLHWVEFQNKFYSGTGFKFLPF 826
Cdd:PRK05771 617 RLHYVEFFGKFYEGGGKKFNPF 638
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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