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Conserved domains on  [gi|2329591297|ref|NP_001104515|]
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cyclin-A1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 132-294 2.84e-111

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410263  Cd Length: 163  Bit Score: 323.72  E-value: 2.84e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 132 LLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVG 211
Cdd:cd20560     1 LLDLSSASPMLVDTSLQSQSEDDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 212 EEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVL 291
Cdd:cd20560    81 EEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160


                  ...
gi 2329591297 292 AFD 294
Cdd:cd20560   161 AFD 163
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 298-420 7.53e-80

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410266  Cd Length: 123  Bit Score: 242.02  E-value: 7.53e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVP 377
Cdd:cd20563     1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDPFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFTGYSLSEIVP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2329591297 378 CLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLL 420
Cdd:cd20563    81 CLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEPPAVLPL 123
Cyclin_N2 pfam16500
Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found ...
 88-146 7.80e-07

Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found upstream of the family Cyclin_N, pfam00134. This region controls the stability of the region by recruiting the APC/C. This region includes the ABBA motif.


:

Pssm-ID: 465146  Cd Length: 72  Bit Score: 46.26  E-value: 7.80e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2329591297  88 KQGFDIYMDELEQGDRDSCSV-------REGMAF--------EDVYEVDtgtlksdlhfLLDFNTVSPMLVDSS 146
Cdd:pfam16500   9 TNAFTIHVDEPEQEERPSEPVsketeeeSEELALnpavtlerQPLAELD----------LLDLSTDSPMLVDTS 72
 
Name Accession Description Interval E-value
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 132-294 2.84e-111

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 323.72  E-value: 2.84e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 132 LLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVG 211
Cdd:cd20560     1 LLDLSSASPMLVDTSLQSQSEDDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 212 EEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVL 291
Cdd:cd20560    81 EEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160


                  ...
gi 2329591297 292 AFD 294
Cdd:cd20560   161 AFD 163
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 298-420 7.53e-80

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 242.02  E-value: 7.53e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVP 377
Cdd:cd20563     1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDPFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFTGYSLSEIVP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2329591297 378 CLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLL 420
Cdd:cd20563    81 CLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEPPAVLPL 123
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 170-296 5.04e-66

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 206.60  E-value: 5.04e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 170 EIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAA 249
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2329591297 250 MLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLT 296
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
143-410 1.67e-53

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 184.21  E-value: 1.67e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 143 VDSSLLSQSEDISSLGtDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLY 222
Cdd:COG5024   157 KRESQSWQDLDATDQE-DPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLF 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 223 LAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQ 302
Cdd:COG5024   236 LAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMS 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 303 FLLQYLRRQGVCVRTENLAKYVAELSLLEaDPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTG-YSLSEIVPCLSE 381
Cdd:COG5024   316 FLRRISKASDYDIFSRTPAKFSSEISPVD-YKFIQISPSWCAAAAMYLSRKILSQNQWDRTLIHYSGnYTNPDLKPLNES 394

                         250       260
                  ....*....|....*....|....*....
gi 2329591297 382 LHKaYLDIPHRPQQAIREKYKASKYLCVS 410
Cdd:COG5024   395 NKE-NLQNPSVHHDAIFPKYPSPTFGKAS 422
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 298-415 2.78e-38

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 134.29  E-value: 2.78e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQYLRRQGV--CVRTENLAKYVAELSLLEADpFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEI 375
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYD-FLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2329591297 376 VPCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPP 415
Cdd:pfam02984  80 KPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 205-289 3.26e-23

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 92.66  E-value: 3.26e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297  205 DWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDdtYTKRQLLKME 284
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 2329591297  285 HLLLK 289
Cdd:smart00385  79 RLLLE 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 302-384 5.64e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 75.32  E-value: 5.64e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297  302 QFLLQYLRRQGVCVRTENLAKYVAELSLLEaDPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGY-SLSEIVPCLS 380
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSD-YKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYfTEEEILRMER 79


                   ....
gi 2329591297  381 ELHK 384
Cdd:smart00385  80 LLLE 83
Cyclin_N2 pfam16500
Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found ...
 88-146 7.80e-07

Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found upstream of the family Cyclin_N, pfam00134. This region controls the stability of the region by recruiting the APC/C. This region includes the ABBA motif.


Pssm-ID: 465146  Cd Length: 72  Bit Score: 46.26  E-value: 7.80e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2329591297  88 KQGFDIYMDELEQGDRDSCSV-------REGMAF--------EDVYEVDtgtlksdlhfLLDFNTVSPMLVDSS 146
Cdd:pfam16500   9 TNAFTIHVDEPEQEERPSEPVsketeeeSEELALnpavtlerQPLAELD----------LLDLSTDSPMLVDTS 72
 
Name Accession Description Interval E-value
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 132-294 2.84e-111

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 323.72  E-value: 2.84e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 132 LLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVG 211
Cdd:cd20560     1 LLDLSSASPMLVDTSLQSQSEDDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 212 EEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVL 291
Cdd:cd20560    81 EEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160


                  ...
gi 2329591297 292 AFD 294
Cdd:cd20560   161 AFD 163
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 166-293 2.48e-91

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 271.43  E-value: 2.48e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 166 EYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLV 245
Cdd:cd20504     1 EYADDIYEYLRESELKHRPKPDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2329591297 246 GTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAF 293
Cdd:cd20504    81 GTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 164-294 2.10e-82

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 248.82  E-value: 2.10e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 164 VTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQ 243
Cdd:cd20561     1 VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2329591297 244 LVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFD 294
Cdd:cd20561    81 LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 298-420 7.53e-80

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 242.02  E-value: 7.53e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVP 377
Cdd:cd20563     1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDPFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFTGYSLSEIVP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2329591297 378 CLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLL 420
Cdd:cd20563    81 CLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEPPAVLPL 123
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 164-293 4.39e-68

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 212.00  E-value: 4.39e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 164 VTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQ 243
Cdd:cd20507     1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2329591297 244 LVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAF 293
Cdd:cd20507    81 LVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 170-296 5.04e-66

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 206.60  E-value: 5.04e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 170 EIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAA 249
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2329591297 250 MLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLT 296
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 298-406 6.79e-58

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 185.19  E-value: 6.79e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVP 377
Cdd:cd20505     1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDADPYLKYLPSVIAAAAVCLANHTLGNEVWPQKLARSTGYSLEDLLP 80

                          90       100
                  ....*....|....*....|....*....
gi 2329591297 378 CLSELHKAYLDIPHRPQQAIREKYKASKY 406
Cdd:cd20505    81 CLRDLHRTFLNAPSSPQQAIREKYKSSKY 109
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 167-294 1.81e-57

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 184.92  E-value: 1.81e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 167 YAEEIYQYLREAEIRHRPKAHYMKK-QPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLV 245
Cdd:cd20562     8 YATDIYLNLRVAELKRRPLPDYMEKiQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLL 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2329591297 246 GTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFD 294
Cdd:cd20562    88 GVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 164-293 2.17e-57

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 185.24  E-value: 2.17e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 164 VTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQ 243
Cdd:cd20567    18 AVEYVEDIYSFYRKVEPESCVPPYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKELQ 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2329591297 244 LVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAF 293
Cdd:cd20567    98 LVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 159-294 5.47e-55

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 178.60  E-value: 5.47e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 159 TDVINVTEYAEEIYQYLREAEIRHRPKAhYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVL 238
Cdd:cd20508     8 DDPFQVSEYAKDIFDYMKEREEKFVVPD-YLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVK 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2329591297 239 RGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFD 294
Cdd:cd20508    87 KEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
143-410 1.67e-53

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 184.21  E-value: 1.67e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 143 VDSSLLSQSEDISSLGtDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLY 222
Cdd:COG5024   157 KRESQSWQDLDATDQE-DPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLF 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 223 LAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQ 302
Cdd:COG5024   236 LAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMS 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 303 FLLQYLRRQGVCVRTENLAKYVAELSLLEaDPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTG-YSLSEIVPCLSE 381
Cdd:COG5024   316 FLRRISKASDYDIFSRTPAKFSSEISPVD-YKFIQISPSWCAAAAMYLSRKILSQNQWDRTLIHYSGnYTNPDLKPLNES 394

                         250       260
                  ....*....|....*....|....*....
gi 2329591297 382 LHKaYLDIPHRPQQAIREKYKASKYLCVS 410
Cdd:COG5024   395 NKE-NLQNPSVHHDAIFPKYPSPTFGKAS 422
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 160-293 4.51e-51

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 168.24  E-value: 4.51e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 160 DVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLR 239
Cdd:cd20568     1 DPLMVAEYVPEIFEYLRELELKTLPNPNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2329591297 240 GKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAF 293
Cdd:cd20568    81 NKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 298-406 4.33e-47

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 157.29  E-value: 4.33e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVP 377
Cdd:cd20564     1 PTINQFLTQYFLHQQANCKVESLSMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLESLKP 80

                          90       100
                  ....*....|....*....|....*....
gi 2329591297 378 CLSELHKAYLDIPHRPQQAIREKYKASKY 406
Cdd:cd20564    81 CLMDLHQTYLKAPQHAQQSIREKYKNSKY 109
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 165-293 1.46e-44

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 151.17  E-value: 1.46e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 165 TEYAEEIYQYLREAEIRHRPKAHYMKKQpDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQL 244
Cdd:cd20566     6 SDYVKDIYQYLRQLEVQQSIRPHYLDGK-EINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2329591297 245 VGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAF 293
Cdd:cd20566    85 VGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 169-291 2.52e-43

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 147.84  E-value: 2.52e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 169 EEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMS-VLRGKLQLVGT 247
Cdd:cd20519     6 EEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTnVPKTQLQLIGI 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2329591297 248 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVL 291
Cdd:cd20519    86 TCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKAL 129
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 165-293 1.08e-41

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 143.87  E-value: 1.08e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 165 TEYAEEIYQYLREAEIRHRPKAHYMKKQpDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQL 244
Cdd:cd20565     2 SEYVKDIYAYLRQLEEEQAVRPKYLEGQ-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2329591297 245 VGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAF 293
Cdd:cd20565    81 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 298-415 2.78e-38

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 134.29  E-value: 2.78e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQYLRRQGV--CVRTENLAKYVAELSLLEADpFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEI 375
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYD-FLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2329591297 376 VPCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPP 415
Cdd:pfam02984  80 KPCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 298-406 2.00e-37

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 131.60  E-value: 2.00e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQYLRRQGVCV---RTENLAKYVAELSLLEaDPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSE 374
Cdd:cd20506     1 PTIKTFLRRFLRAAQASVpdlKLEFLANYLAELSLLD-YEFLKYLPSLIAASAVFLARHTLNPHPWNPTLEHYTGYKAAD 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2329591297 375 IVPCLSELHKAYLDIPHRPQQAIREKYKASKY 406
Cdd:cd20506    80 LKPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 200-295 5.89e-32

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 116.65  E-value: 5.89e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 200 RTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQ 279
Cdd:cd20542     1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                          90
                  ....*....|....*.
gi 2329591297 280 LLKMEHLLLKVLAFDL 295
Cdd:cd20542    81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 175-291 3.94e-31

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 116.13  E-value: 3.94e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 175 LREAEIRHRPKaHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCM-SVLRGKLQLVGTAAMLLA 253
Cdd:cd20579    19 LNKDKTYLRDK-NFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQeNVVKTRLQLIGISSLFIA 97

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2329591297 254 SKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVL 291
Cdd:cd20579    98 AKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKAL 135
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 199-291 9.18e-31

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 113.58  E-value: 9.18e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 199 MRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKR 278
Cdd:cd20536     1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                          90
                  ....*....|...
gi 2329591297 279 QLLKMEHLLLKVL 291
Cdd:cd20536    81 QICNLECIILTKL 93
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 168-291 6.02e-30

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 112.63  E-value: 6.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 168 AEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRF-LSCMSVLRGKLQLVG 246
Cdd:cd20580    11 SKDVWLNMLKKESKYVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIG 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2329591297 247 TAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVL 291
Cdd:cd20580    91 ITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKAL 135
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 173-294 4.95e-28

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 108.16  E-value: 4.95e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 173 QYLREAEIRHRPKAHYMKK-QPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAML 251
Cdd:cd20515    28 QNLLSLEERYLPSASYFKCvQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLF 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2329591297 252 LASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFD 294
Cdd:cd20515   108 LASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 169-294 1.98e-24

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 98.14  E-value: 1.98e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 169 EEIYQYLREAEIRHRPKAHYMK-KQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGT 247
Cdd:cd20575    24 QRVLQNLLRLEERYVPRVSYFQcVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGA 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2329591297 248 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFD 294
Cdd:cd20575   104 VCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 205-289 3.26e-23

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 92.66  E-value: 3.26e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297  205 DWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDdtYTKRQLLKME 284
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 2329591297  285 HLLLK 289
Cdd:smart00385  79 RLLLE 83
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 305-409 5.43e-23

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 93.06  E-value: 5.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 305 LQYLRR----QGVCVRTENLAKYVAELSLLEADpFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLS 380
Cdd:cd20509     4 LHFLRRfskaGGADAQKHTLAKYLMELTLLDYD-MVHYKPSEIAAAALCLSRKILDEPEWTPTLEHYSTYSEEDLLPIVQ 82

                          90       100
                  ....*....|....*....|....*....
gi 2329591297 381 ELHKAYLDIPHRPQQAIREKYKASKYLCV 409
Cdd:cd20509    83 KMAKLVVKSQTSKYQAVKNKYSSSKFMRI 111
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 169-294 2.70e-20

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 86.96  E-value: 2.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 169 EEIYQYLREAEIRHRPKAHYMK-KQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGT 247
Cdd:cd20573    23 DRVLQTMLKAEETCLPSVSYFKcVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGA 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2329591297 248 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFD 294
Cdd:cd20573   103 TCMFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 298-386 2.97e-20

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 84.67  E-value: 2.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADpFLKYLPSLIAAAAFCLANYTVNKHFW-PETLAAFTGYSLSEIV 376
Cdd:cd20537     1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYE-FLKYRPSLIAAAALYLARKILGEPPPsPQLLQLVTGYSENDLQ 79

                          90
                  ....*....|
gi 2329591297 377 PCLSELHKAY 386
Cdd:cd20537    80 ECAKELLELL 89
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 199-283 7.63e-20

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 83.90  E-value: 7.63e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 199 MRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKR 278
Cdd:cd20521     3 MRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYKYE 82


                  ....*
gi 2329591297 279 QLLKM 283
Cdd:cd20521    83 DVVRM 87
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 167-294 2.08e-19

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 84.27  E-value: 2.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 167 YAEEIYQYLREAEIRHRPKAHYMK-KQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLV 245
Cdd:cd20574    22 YDDRVLQNLLTIEERYLPQCSYFKcVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLL 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2329591297 246 GTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFD 294
Cdd:cd20574   102 GAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWN 150
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 305-411 2.60e-17

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 77.27  E-value: 2.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 305 LQYLRR----QGVCVRTENLAKYVAELSLLEADpFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLS 380
Cdd:cd20512     3 MNFLRRiskaDDYDIQTRTLAKYLLEITILDHR-FLGYPPSLLAAAAMYLARKMLGRGDWNDNLVHYSGYTESQLIPCAD 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2329591297 381 ELHKaYLDIPHRPQQAIREKYKASKYLCVSL 411
Cdd:cd20512    82 IMLE-YLVKPIKHHDAFFKKYSSKKFLKASI 111
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 302-384 5.64e-17

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 75.32  E-value: 5.64e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297  302 QFLLQYLRRQGVCVRTENLAKYVAELSLLEaDPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGY-SLSEIVPCLS 380
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSD-YKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYfTEEEILRMER 79


                   ....
gi 2329591297  381 ELHK 384
Cdd:smart00385  80 LLLE 83
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 298-414 2.48e-16

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 74.65  E-value: 2.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADpFLKYLPSLIAAAAFCLANYTVNKH-FWPETLAAFTGYSLSEIV 376
Cdd:cd20511     1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYE-MLKYSPSMLAASAVYTARCTLNKTpEWTSTLEFHTGYSESQLM 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2329591297 377 PC---LSELHKAyldIPHRPQQAIREKYKASKYLCVSLMEP 414
Cdd:cd20511    80 ECarlMVRLHSK---AGTGKLTAVYKKYSSSKFGAVALLPP 117
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 307-401 4.91e-16

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 73.86  E-value: 4.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 307 YLRRQGVCVR----TENLAKYVAELSLLEADpFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSEL 382
Cdd:cd20510     6 FLRRYAKCARasmeTLTLARYILELSLMEYQ-FVQERASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPLVRKL 84

                          90
                  ....*....|....*....
gi 2329591297 383 HKAYLDIPHRPQQAIREKY 401
Cdd:cd20510    85 NAMLTKPPNKKLKTVRSKY 103
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 203-284 6.15e-14

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 66.67  E-value: 6.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 203 LVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIyPPEVDEFVYITDdtYTKRQLLK 282
Cdd:cd00043     2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEEL-PRTLKEIAKVSG--VSEKELRK 78


                  ..
gi 2329591297 283 ME 284
Cdd:cd00043    79 AE 80
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 198-293 6.71e-14

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 67.24  E-value: 6.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 198 GMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYP--PEVDEFVYITD-DT 274
Cdd:cd20528     5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLNRYLCnSV 84

                          90
                  ....*....|....*....
gi 2329591297 275 YTKRQLLKMEHLLLKVLAF 293
Cdd:cd20528    85 YSKQEYLQMELLILEFFQW 103
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 200-291 9.48e-14

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 66.96  E-value: 9.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 200 RTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGK---LQLVGTAAMLLASKYEEI-YPPEVDEFVYITDDTY 275
Cdd:cd20543     2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKMEETdVPLLVDLQVEEPKYVF 81

                          90
                  ....*....|....*.
gi 2329591297 276 TKRQLLKMEHLLLKVL 291
Cdd:cd20543    82 EAKTIQRMELLVLSTL 97
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 319-415 1.53e-13

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 66.49  E-value: 1.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 319 NLAKYVAELSLLEADpFLKYLPSLIAAAAFCLANYTVNKHF-WPETLAAFTGYSLSEIVPCLSELHKAYL------DIPH 391
Cdd:cd20522     1 CLASYICELSLLHTE-LGRYSPAVIAASCLLLARVLLNQALpWPSQLEEFTGFSLEDLLSCVLHLHKKCFhedspkDYRN 79

                          90       100
                  ....*....|....*....|....
gi 2329591297 392 RPQQAIREKYKASKYLCVSLMEPP 415
Cdd:cd20522    80 VSLTAVKQRYEDERFLSISKIKVM 103
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 203-294 4.65e-13

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 64.71  E-value: 4.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 203 LVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYP--PEVDEFVYITDDTYTKRQL 280
Cdd:cd20559     2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELF 81

                          90
                  ....*....|....
gi 2329591297 281 LKMEHLLLKVLAFD 294
Cdd:cd20559    82 IQMEMHILNTLNWD 95
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 195-293 5.89e-12

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 61.81  E-value: 5.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 195 ITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDT 274
Cdd:cd20517     1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80

                          90
                  ....*....|....*....
gi 2329591297 275 YTKRQLLKMEHLLLKVLAF 293
Cdd:cd20517    81 FTNLELINQEKDILEALKW 99
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 305-410 3.09e-11

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 60.29  E-value: 3.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 305 LQYLRRQG----VCVRTENLAKYVAELSLLEADpFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLS 380
Cdd:cd20569     4 LHFLRRASkigeVDVEQHTLAKYLMELTMVDYD-MVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYMSYTEESLLPVMQ 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2329591297 381 ELHKAYLDIPH--RPQQAIREKYKASKYLCVS 410
Cdd:cd20569    83 HMAKNVVKVNQglTKHMTVKNKYASSKQMKIS 114
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 321-382 5.34e-10

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 56.22  E-value: 5.34e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2329591297 321 AKYVAELSLLEaDPFLKYLPSLIAAAAFCLANYTVN-KHFWPETLAAFTGYSLSEIVPCLSEL 382
Cdd:cd20529    40 ADFFLDLSLQD-YAFLNYKPSLLAAACIAAARKALGlSPTWPEELEKLTGYSEDELEPCVELL 101
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 305-412 9.79e-10

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 56.04  E-value: 9.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 305 LQYLRRQG----VCVRTENLAKYVAELSLLEADpFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLS 380
Cdd:cd20570     4 LHFLRRASkagsADVEKHTLAKYLMELTLIDYD-MVHYHPSEIAAAALCLSQKVLDGGKWSLTQQYYTGYTEDDLKPIMQ 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2329591297 381 ELHKAYLDIPHRPQQ--AIREKYKASKYLCVSLM 412
Cdd:cd20570    83 HMAKNVVKVNEGLTKhvAVKNKYASSKLMKISTI 116
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 164-385 1.08e-08

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 56.28  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 164 VTEYAEEIY-------QYLREAEIRHRPKAHYMKKQpditEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMS 236
Cdd:COG5333     6 ESNLVSSRPllsfdssQNAIELDLLVLEPELTLEKE----LNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 237 VLRGKLQLVGTAAMLLASKYEeiyppevDEFVYITDDTYTKRQL------------LKMEHLLLKVLAFDLTVPTTNQFL 304
Cdd:COG5333    82 VEEISLYSVVTTCVYLACKVE-------DTPRDISIESFEARDLwseepkssreriLEYEFELLEALDFDLHVHHPYKYL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 305 LQYLRrqgVCV-----RTENLAKYVAELSLLEaDPFLKYLPSLIAAAAFCLANYTVNKHFWPET-LAAFTgySLSEIVPC 378
Cdd:COG5333   155 EGFLK---DLQekdkyKLLQIAWKIINDALRT-DLCLLYPPHIIALAALLIACEVLGMPIIKLLdFVSYE--TKEEVIAL 228


                  ....*..
gi 2329591297 379 LSELHKA 385
Cdd:COG5333   229 NYKSIVK 235
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 214-291 8.18e-08

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 49.66  E-value: 8.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 214 YKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKY--EEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVL 291
Cdd:cd20523    15 YGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLMRMEGIILEKL 94
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 204-295 8.61e-08

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 50.00  E-value: 8.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 204 VDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEE----IypPEVDEFVYITDDTYTKRQ 279
Cdd:cd20526     6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEedevI--PSTKDLVRVSKCGCSVAE 83

                          90
                  ....*....|....*.
gi 2329591297 280 LLKMEHLLLKVLAFDL 295
Cdd:cd20526    84 VLRMERIILDKLHWDL 99
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 298-388 7.68e-07

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 47.12  E-value: 7.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQYLRR------QGVCVRT-ENLAKYVAELSLLEaDPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGY 370
Cdd:cd20721     1 PTILTFLRMYIERlslesgAAHASRPlERLAMFLAEISLLH-YSFLQFRPSTVAAACLVLAEIMHNRPAAWAAEALSAEL 79

                          90       100
                  ....*....|....*....|....*
gi 2329591297 371 -------SLSEIVPCLSELHKAYLD 388
Cdd:cd20721    80 aavlvhtRAPEVLRCVQALHQLVGQ 104
Cyclin_N2 pfam16500
Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found ...
 88-146 7.80e-07

Cyclin-A N-terminal APC/C binding region; This entry represents a disorder region found upstream of the family Cyclin_N, pfam00134. This region controls the stability of the region by recruiting the APC/C. This region includes the ABBA motif.


Pssm-ID: 465146  Cd Length: 72  Bit Score: 46.26  E-value: 7.80e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2329591297  88 KQGFDIYMDELEQGDRDSCSV-------REGMAF--------EDVYEVDtgtlksdlhfLLDFNTVSPMLVDSS 146
Cdd:pfam16500   9 TNAFTIHVDEPEQEERPSEPVsketeeeSEELALnpavtlerQPLAELD----------LLDLSTDSPMLVDTS 72
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 298-382 1.37e-06

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 46.19  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 298 PTTNQFLLQY-----LRRQGVCV----RTENLAKYVAELSLLEADpFLKYLPSLIAAAAFCLANYTVNKHfwPETLAAFT 368
Cdd:cd20722     1 PTLQFFLEHFsslrlENRELSCAeearKARALARYLAELSLADYA-FNQYPPSLLAICSLELADRMLQHR--SPITERLS 77

                          90
                  ....*....|....
gi 2329591297 369 GYSLSEIVPCLSEL 382
Cdd:cd20722    78 GYPQSALEDCVGKL 91
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 199-291 3.11e-06

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 45.58  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 199 MRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKY--EEIYPPEVDEFVYITDDTYT 276
Cdd:cd20583     1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFT 80

                          90
                  ....*....|....*
gi 2329591297 277 KRQLLKMEHLLLKVL 291
Cdd:cd20583    81 VSDMMRMEKIILEKL 95
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 219-287 6.69e-05

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 41.76  E-value: 6.69e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2329591297 219 ETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKY--EEIYPPEVDEFVYITDDTYTKRQLLKMEHLL 287
Cdd:cd20584    21 ETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRMEKII 91
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 302-378 7.40e-05

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 40.86  E-value: 7.40e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2329591297 302 QFLLQYLRRQGVCVRTENLAKYVAELsLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPC 378
Cdd:cd00043     4 DFIRRLCSKLGLPEEVLELAIELLDR-FLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSGVSEKELRKA 79
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 297-386 5.71e-04

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 39.19  E-value: 5.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 297 VPTTNQFL---LQYLRRQGVCVRTENLAK--------YVAELSLLEADPF----LKYLPSLIAAAAFClanytvnkHFWP 361
Cdd:cd20520     1 PPTPNSWLnlyLQLAQLNPPPKENDSAFLlpqysldrFVRAAQLLDLCILdigsLQFSYSVLAASALY--------LVSP 72

                          90       100
                  ....*....|....*....|....*..
gi 2329591297 362 ETLAAF--TGYSLSEIVPCLSELHKAY 386
Cdd:cd20520    73 DDEAIEqvTGYSWEQLAPCVEWMTPFA 99
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 177-294 1.56e-03

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 37.98  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 177 EAEIRHRpkahymkkqpdiTEGMRTILvdwlvEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKY 256
Cdd:cd20530     5 ETEARYR------------REGARFIQ-----DVGTKLGLPYDTIATGIVYFHRFYMFHSFKDFDRYVTAACCLFLAGKV 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2329591297 257 EEIYPPEVD-----EFVYITDDTYT-----KRQLLKMEHLLLKVLAFD 294
Cdd:cd20530    68 EETPKKCKDiiktaRSLLNDKQFAQfgddpKEEVMVLERILLQTIKFD 115
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 169-295 1.62e-03

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 38.73  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 169 EEIYQYLREAEIRHRPKAHYmkkqpdITEGMRTILVDW----LVEVGEEYKLRAETLYLAVNFLDRF-LSCmSVLRGKLQ 243
Cdd:cd20524    26 EKAREKLKESLKEEDAEPKF------LTPEEELLLVRYyekkLLEFCRAFKLPDSVLATALTYFKRFyLKN-SVMEYHPK 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2329591297 244 LVGTAAMLLASKYEEIYPPeVDEFV-YITDDTYTKRQLLKMEHLLLKVLAFDL 295
Cdd:cd20524    99 EIMLTCLYLACKVEEFNIS-IDQFVgNIKESEKTAEIILEYELLLLQGLNFHL 150
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 209-291 2.81e-03

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 37.19  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2329591297 209 EVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEE--------------IYPPEVDEFvyitddT 274
Cdd:cd20513    11 ALGERLKLRQRVIATAIVYFKRFYARNSFKDIDPRLVAPTCLYLASKVEEcpsharlivaeakvLKTKFSYEF------P 84

                          90
                  ....*....|....*..
gi 2329591297 275 YTKRQLLKMEHLLLKVL 291
Cdd:cd20513    85 YRVNDILECEFYLLEAL 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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