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Conserved domains on  [gi|148224427|ref|NP_001091107|]
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galactoside alpha-(1,2)-fucosyltransferase 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_transf_11 pfam01531
Glycosyl transferase family 11; This family contains several fucosyl transferase enzymes.
21-334 6.84e-174

Glycosyl transferase family 11; This family contains several fucosyl transferase enzymes.


:

Pssm-ID: 250689  Cd Length: 298  Bit Score: 484.37  E-value: 6.84e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427   21 TVSTIFHVQQRLAKIQAMWELPVQIPvlastskalgpSQLRGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMH 100
Cdd:pfam01531   1 MVSVLFHGNLGNQLFQAAWALKPQHL-----------PSLIGMFTVNLNGRLGNQMGQYSTLIALAPLNGRLAFIPASMH 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427  101 STLAPiFRITLPVLHSATASRIPWQNYHLNDWMEEEYRHIPGEYVRFTGYPCSWTFYHH-LRQEILQEFTLHDHVREEAQ 179
Cdd:pfam01531  70 STLAP-FRITLPVLHSTTASRKPWQNYHLNDWMEEEYRHLRGEYVKFTGYPCSWTFYHHgLRQEILYEFTLHDHLREEIQ 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427  180 KFLRGLQVN-GSRPGTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHG 258
Cdd:pfam01531 149 NFLRGLQVNlGSRPSTFVGVHIRRGDYVDVMPKVWKGVVADINYLIQALDWFRARYSSPVFVVFSDDMEWCKKNIDTSCG 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148224427  259 DVVFAGDgieGSPAKDFALLTQCNHTIMTIGTFGIWAAYLTGGDTIYLANYTLPDSPFLkifKPEAAFLPEWTGIA 334
Cdd:pfam01531 229 DVYFAGD---GSPAEDFALLMQCNHTILSISTFSWWAAYLTGGDTIYLANFNLPDSEFL---KKEAAYLPEWVYIA 298
 
Name Accession Description Interval E-value
Glyco_transf_11 pfam01531
Glycosyl transferase family 11; This family contains several fucosyl transferase enzymes.
21-334 6.84e-174

Glycosyl transferase family 11; This family contains several fucosyl transferase enzymes.


Pssm-ID: 250689  Cd Length: 298  Bit Score: 484.37  E-value: 6.84e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427   21 TVSTIFHVQQRLAKIQAMWELPVQIPvlastskalgpSQLRGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMH 100
Cdd:pfam01531   1 MVSVLFHGNLGNQLFQAAWALKPQHL-----------PSLIGMFTVNLNGRLGNQMGQYSTLIALAPLNGRLAFIPASMH 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427  101 STLAPiFRITLPVLHSATASRIPWQNYHLNDWMEEEYRHIPGEYVRFTGYPCSWTFYHH-LRQEILQEFTLHDHVREEAQ 179
Cdd:pfam01531  70 STLAP-FRITLPVLHSTTASRKPWQNYHLNDWMEEEYRHLRGEYVKFTGYPCSWTFYHHgLRQEILYEFTLHDHLREEIQ 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427  180 KFLRGLQVN-GSRPGTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHG 258
Cdd:pfam01531 149 NFLRGLQVNlGSRPSTFVGVHIRRGDYVDVMPKVWKGVVADINYLIQALDWFRARYSSPVFVVFSDDMEWCKKNIDTSCG 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148224427  259 DVVFAGDgieGSPAKDFALLTQCNHTIMTIGTFGIWAAYLTGGDTIYLANYTLPDSPFLkifKPEAAFLPEWTGIA 334
Cdd:pfam01531 229 DVYFAGD---GSPAEDFALLMQCNHTILSISTFSWWAAYLTGGDTIYLANFNLPDSEFL---KKEAAYLPEWVYIA 298
Fut1_Fut2_like cd11301
Alpha-1,2-fucosyltransferase; Alpha-1,2-fucosyltransferases (Fut1, Fut2) catalyze the transfer ...
69-322 6.80e-67

Alpha-1,2-fucosyltransferase; Alpha-1,2-fucosyltransferases (Fut1, Fut2) catalyze the transfer of alpha-L-fucose to the terminal beta-D-galactose residue of glycoconjugates via an alpha-1,2-linkage, generating carbohydrate structures that exhibit H-antigenicity for blood-group carbohydrates. These structures also act as ligands for morphogenesis, the adhesion of microbes, and metastasizing cancer cells. Fut1 is responsible for producing the H antigen on red blood cells. Fut2 is expressed in epithelia of secretory tissues, and individuals termed "secretors" have at least one functional copy of the gene; they secrete H antigen which is further processed into A and/or B antigens depending on the ABO genotype. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


Pssm-ID: 211387  Cd Length: 265  Bit Score: 211.17  E-value: 6.80e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427  69 IGRLGNQMGEYATLYALAKMNG-RPAFIPAQMHST-----LAPIFRITLPVLHSATASRIPWQ-----NYHLNDWMEEEY 137
Cdd:cd11301    8 AGGLGNQLFQYAFLRALAKKLGrRKLFLDTSGYFErnllkLLEFFNISLPILSRKEILLLKNLrllneDPVLKKLLRENY 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427 138 RHIPGEYVRFtgypcsWTFYHHLRQEILQEFTLHDHVREEAQKFLRGLQVNGSRPgTFVGVHVRRGDYVHVMPKVWKGVV 217
Cdd:cd11301   88 RHYLGRYYQF------WKYFYSIKGEIRQEFKFFEDLEEENNKILKKLKEELKNT-NSVSVHIRRGDYLTNGNAKGYHGI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427 218 ADRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHGDVVFAGDGIEgSPAKDFALLTQCNHTIMTIGTFGIWAAY 297
Cdd:cd11301  161 CDLEYYKKAIEYIKEKVKNPVFFVFSDDIEWVKENLALTSKENVYFVDGNN-SSYEDLYLMSLCKHVIISNSTFSWWGAY 239
                        250       260
                 ....*....|....*....|....*
gi 148224427 298 LTGGDTIYLANYTLPDSPFLKIFKP 322
Cdd:cd11301  240 LNKNPDKIVIIAPNPWFVKKKLFPP 264
 
Name Accession Description Interval E-value
Glyco_transf_11 pfam01531
Glycosyl transferase family 11; This family contains several fucosyl transferase enzymes.
21-334 6.84e-174

Glycosyl transferase family 11; This family contains several fucosyl transferase enzymes.


Pssm-ID: 250689  Cd Length: 298  Bit Score: 484.37  E-value: 6.84e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427   21 TVSTIFHVQQRLAKIQAMWELPVQIPvlastskalgpSQLRGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMH 100
Cdd:pfam01531   1 MVSVLFHGNLGNQLFQAAWALKPQHL-----------PSLIGMFTVNLNGRLGNQMGQYSTLIALAPLNGRLAFIPASMH 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427  101 STLAPiFRITLPVLHSATASRIPWQNYHLNDWMEEEYRHIPGEYVRFTGYPCSWTFYHH-LRQEILQEFTLHDHVREEAQ 179
Cdd:pfam01531  70 STLAP-FRITLPVLHSTTASRKPWQNYHLNDWMEEEYRHLRGEYVKFTGYPCSWTFYHHgLRQEILYEFTLHDHLREEIQ 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427  180 KFLRGLQVN-GSRPGTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHG 258
Cdd:pfam01531 149 NFLRGLQVNlGSRPSTFVGVHIRRGDYVDVMPKVWKGVVADINYLIQALDWFRARYSSPVFVVFSDDMEWCKKNIDTSCG 228
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148224427  259 DVVFAGDgieGSPAKDFALLTQCNHTIMTIGTFGIWAAYLTGGDTIYLANYTLPDSPFLkifKPEAAFLPEWTGIA 334
Cdd:pfam01531 229 DVYFAGD---GSPAEDFALLMQCNHTILSISTFSWWAAYLTGGDTIYLANFNLPDSEFL---KKEAAYLPEWVYIA 298
Fut1_Fut2_like cd11301
Alpha-1,2-fucosyltransferase; Alpha-1,2-fucosyltransferases (Fut1, Fut2) catalyze the transfer ...
69-322 6.80e-67

Alpha-1,2-fucosyltransferase; Alpha-1,2-fucosyltransferases (Fut1, Fut2) catalyze the transfer of alpha-L-fucose to the terminal beta-D-galactose residue of glycoconjugates via an alpha-1,2-linkage, generating carbohydrate structures that exhibit H-antigenicity for blood-group carbohydrates. These structures also act as ligands for morphogenesis, the adhesion of microbes, and metastasizing cancer cells. Fut1 is responsible for producing the H antigen on red blood cells. Fut2 is expressed in epithelia of secretory tissues, and individuals termed "secretors" have at least one functional copy of the gene; they secrete H antigen which is further processed into A and/or B antigens depending on the ABO genotype. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


Pssm-ID: 211387  Cd Length: 265  Bit Score: 211.17  E-value: 6.80e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427  69 IGRLGNQMGEYATLYALAKMNG-RPAFIPAQMHST-----LAPIFRITLPVLHSATASRIPWQ-----NYHLNDWMEEEY 137
Cdd:cd11301    8 AGGLGNQLFQYAFLRALAKKLGrRKLFLDTSGYFErnllkLLEFFNISLPILSRKEILLLKNLrllneDPVLKKLLRENY 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427 138 RHIPGEYVRFtgypcsWTFYHHLRQEILQEFTLHDHVREEAQKFLRGLQVNGSRPgTFVGVHVRRGDYVHVMPKVWKGVV 217
Cdd:cd11301   88 RHYLGRYYQF------WKYFYSIKGEIRQEFKFFEDLEEENNKILKKLKEELKNT-NSVSVHIRRGDYLTNGNAKGYHGI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427 218 ADRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHGDVVFAGDGIEgSPAKDFALLTQCNHTIMTIGTFGIWAAY 297
Cdd:cd11301  161 CDLEYYKKAIEYIKEKVKNPVFFVFSDDIEWVKENLALTSKENVYFVDGNN-SSYEDLYLMSLCKHVIISNSTFSWWGAY 239
                        250       260
                 ....*....|....*....|....*
gi 148224427 298 LTGGDTIYLANYTLPDSPFLKIFKP 322
Cdd:cd11301  240 LNKNPDKIVIIAPNPWFVKKKLFPP 264
O-FucT_like cd11296
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like ...
160-298 3.55e-11

GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


Pssm-ID: 211383  Cd Length: 206  Bit Score: 61.66  E-value: 3.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427 160 LRQEILQEFTLHDHVREEAQKFLRGLQVNGSRPgtFVGVHVRRGDYVHVMPKVWKGVVADRR--------YLQQALDWFR 231
Cdd:cd11296   41 PIRLVGKHLRFSPEIRKLADRFVRKLLGLPGGP--YLAVHLRRGDFEVECCHLAKWMGEYLEecllsaeeIAEKIKELMA 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427 232 ARYSSLIFVVTSNGM-AWCRENIDTSHGDVVFAGDGIEGS-------------PAKDFALLTQCNHTIMTIG-TFGIWAA 296
Cdd:cd11296  119 ERKLKVVYVATDEADrEELREELRKAGIRVVTKDDLLEDAellelekldnyllSLVDQEICSRADVFIGTGFsTFSSNVA 198

                 ..
gi 148224427 297 YL 298
Cdd:cd11296  199 LL 200
O-FucT pfam10250
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
70-206 2.21e-03

GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.


Pssm-ID: 463023 [Multi-domain]  Cd Length: 247  Bit Score: 39.20  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148224427   70 GRLGNQMGEYATLYALAKMngrpafipaqMHSTLA-PIFrITLPVLHSATASRIPWQNYhLNDWMEEEYRHIPGEYVRFt 148
Cdd:pfam10250   9 GGFNQQRDHICDAVAFARL----------LNATLVlPPW-DQLYHWRDPSTDQIPFSDI-FDEFIESLCRSKQGNFGPF- 75
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 148224427  149 gypcsWTFYHHLRqeilqeFTlhDHVREEAQKFLRGLqvngsRPGTFVGVHVRRG-DYV 206
Cdd:pfam10250  76 -----WVNFHALR------FS--PEIEELGDKLVDRL-----LKGPYLALHLRREkDML 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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