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Conserved domains on  [gi|145580619|ref|NP_001078826|]
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B- and T-lymphocyte attenuator isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgI_BTLA cd20928
Extracellular Immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA); member ...
 34-134 3.63e-63

Extracellular Immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA); member of the I-set Ig superfamily domains; The members here are composed of the extracellular immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA; also known as CD270). BTLA is a type I transmembrane glycoprotein that is structurally similar to the CD28 family of T cell co-stimulatory or coinhibitory molecules. BTLA is a coinhibitory molecule expressed on T cells, B cells, macrophages, dendritic and natural killer (NK) cells. Unlike CD28 family members, BTLA interacts with the tumor necrosis factor receptor superfamily member HVEM (herpes virus entry mediator) rather than with B7 family ligands. In addition, BTLA does not form a homodimer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. In contrast to CD28 family members, the structure of the BTLA extracellular Ig domain lacks a C" strand and thus is better described as a member of the I-set of Ig domains. I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM).


:

Pssm-ID: 409522  Cd Length: 101  Bit Score: 192.23  E-value: 3.63e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145580619  34 CDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSY 113
Cdd:cd20928    1 CDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSY 80

                         90       100
                 ....*....|....*....|.
gi 145580619 114 RCSANFQSNLIESHSTTLYVT 134
Cdd:cd20928   81 RCSANFQSNLIESHSTTLYVT 101
 
Name Accession Description Interval E-value
IgI_BTLA cd20928
Extracellular Immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA); member ...
 34-134 3.63e-63

Extracellular Immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA); member of the I-set Ig superfamily domains; The members here are composed of the extracellular immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA; also known as CD270). BTLA is a type I transmembrane glycoprotein that is structurally similar to the CD28 family of T cell co-stimulatory or coinhibitory molecules. BTLA is a coinhibitory molecule expressed on T cells, B cells, macrophages, dendritic and natural killer (NK) cells. Unlike CD28 family members, BTLA interacts with the tumor necrosis factor receptor superfamily member HVEM (herpes virus entry mediator) rather than with B7 family ligands. In addition, BTLA does not form a homodimer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. In contrast to CD28 family members, the structure of the BTLA extracellular Ig domain lacks a C" strand and thus is better described as a member of the I-set of Ig domains. I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM).


Pssm-ID: 409522  Cd Length: 101  Bit Score: 192.23  E-value: 3.63e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145580619  34 CDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSY 113
Cdd:cd20928    1 CDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSY 80

                         90       100
                 ....*....|....*....|.
gi 145580619 114 RCSANFQSNLIESHSTTLYVT 134
Cdd:cd20928   81 RCSANFQSNLIESHSTTLYVT 101
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 43-133 6.35e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.04  E-value: 6.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145580619    43 QSEHSILAGDPFELECPVKYCANrPHVTWCKlNGTTCVKLEDRqtsWKEEKNISFFILHFEPVLPNDNGSYRCSANFQSN 122
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP-PEVTWYK-QGGKLLAESGR---FSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSG 75

                           90
                   ....*....|.
gi 145580619   123 LIEShSTTLYV 133
Cdd:smart00410  76 SASS-GTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 43-134 1.33e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.83  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145580619   43 QSEHSILA--GDPFELECPVKYCANRPH--VTWCKL---NGTTCV----------KLEDRQTSWKEEKNISFFILHFEPV 105
Cdd:pfam07686   1 QTPREVTValGGSVTLPCTYSSSMSEAStsVYWYRQppgKGPTFLiayysngseeGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*....
gi 145580619  106 LPNDNGSYRCSANFQSNLIESHSTTLYVT 134
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
 
Name Accession Description Interval E-value
IgI_BTLA cd20928
Extracellular Immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA); member ...
 34-134 3.63e-63

Extracellular Immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA); member of the I-set Ig superfamily domains; The members here are composed of the extracellular immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA; also known as CD270). BTLA is a type I transmembrane glycoprotein that is structurally similar to the CD28 family of T cell co-stimulatory or coinhibitory molecules. BTLA is a coinhibitory molecule expressed on T cells, B cells, macrophages, dendritic and natural killer (NK) cells. Unlike CD28 family members, BTLA interacts with the tumor necrosis factor receptor superfamily member HVEM (herpes virus entry mediator) rather than with B7 family ligands. In addition, BTLA does not form a homodimer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. In contrast to CD28 family members, the structure of the BTLA extracellular Ig domain lacks a C" strand and thus is better described as a member of the I-set of Ig domains. I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM).


Pssm-ID: 409522  Cd Length: 101  Bit Score: 192.23  E-value: 3.63e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145580619  34 CDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSY 113
Cdd:cd20928    1 CDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSY 80

                         90       100
                 ....*....|....*....|.
gi 145580619 114 RCSANFQSNLIESHSTTLYVT 134
Cdd:cd20928   81 RCSANFQSNLIESHSTTLYVT 101
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 43-133 6.35e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 49.04  E-value: 6.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145580619    43 QSEHSILAGDPFELECPVKYCANrPHVTWCKlNGTTCVKLEDRqtsWKEEKNISFFILHFEPVLPNDNGSYRCSANFQSN 122
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP-PEVTWYK-QGGKLLAESGR---FSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSG 75

                           90
                   ....*....|.
gi 145580619   123 LIEShSTTLYV 133
Cdd:smart00410  76 SASS-GTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 43-134 1.33e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.83  E-value: 1.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145580619   43 QSEHSILA--GDPFELECPVKYCANRPH--VTWCKL---NGTTCV----------KLEDRQTSWKEEKNISFFILHFEPV 105
Cdd:pfam07686   1 QTPREVTValGGSVTLPCTYSSSMSEAStsVYWYRQppgKGPTFLiayysngseeGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*....
gi 145580619  106 LPNDNGSYRCSANFQSNLIESHSTTLYVT 134
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 41-119 4.28e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 41.03  E-value: 4.28e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145580619   41 KRQSEHSILAGDPFELECPVKYCANRPHVTWcKLNGTTcvkLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANF 119
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTW-SKEGGT---LIESLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNN 75
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 43-118 2.67e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 38.70  E-value: 2.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145580619   43 QSEHSILAGDPFELECPVKYcANRPHVTWCKlNGTTCVKLEDRqtswKEEKNISFFILHFEPVLPNDNGSYRCSAN 118
Cdd:pfam13927   8 PSSVTVREGETVTLTCEATG-SPPPTITWYK-NGEPISSGSTR----SRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 54-129 3.91e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 38.08  E-value: 3.91e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145580619  54 FELECPVKYcANRPHVTWCKLNgttcvKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANFQSNLIESHST 129
Cdd:cd00096    1 VTLTCSASG-NPPPTITWYKNG-----KPLPPSSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSASASV 70
Ig3_L1-CAM_like cd05731
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar ...
 43-134 5.06e-04

Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains; The members here are composed of the third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, and spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM and human neurofascin.


Pssm-ID: 409394 [Multi-domain]  Cd Length: 83  Bit Score: 37.77  E-value: 5.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145580619  43 QSEHSILAGDPFELEC-----PVkycanrPHVTWCKLNGTTcvkLEDRQTSWKEEKnisffILHFEPVLPNDNGSYRCSA 117
Cdd:cd05731    2 ESSTMVLRGGVLLLECiaeglPT------PDIRWIKLGGEL---PKGRTKFENFNK-----TLKIENVSEADSGEYQCTA 67

                         90
                 ....*....|....*..
gi 145580619 118 nfqSNLIESHSTTLYVT 134
Cdd:cd05731   68 ---SNTMGSARHTISVT 81
IgC2_CD160 cd21392
Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed ...
 69-138 7.25e-04

Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed at the cell surface as a tightly disulfide-linked multimer and is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. Structurally similar to The B and T lymphocyte attenuator (BTLA), which appears to act as a negative regulator of T cell activation and growth. CD160 is a ligand for HVEM (herpes virus entry mediator), and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti-PD-1 antibodies. CD160 has also been proposed as a potential target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.


Pssm-ID: 409621  Cd Length: 119  Bit Score: 38.16  E-value: 7.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145580619  69 VTWCKLNGTTCVKledrQTSWKEEK------------NISFFILHFEPVLPNDNGSYRCSANFQSNLI--ESHSTTLYVT 134
Cdd:cd21392   33 VFWCKDRSNDCSP----ETSLKQLRlkrdpesdgvteRSSQLVFTINQVTPSDSGTYQCCARSQKPEIhlQGHFISVLVT 108


                 ....
gi 145580619 135 GKQN 138
Cdd:cd21392  109 ETGN 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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