NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|87578394|ref|NP_001034627|]
View 

microtubule-associated protein 2 isoform 5 [Homo sapiens]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 393-422 2.55e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 63.97  E-value: 2.55e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 87578394   393 VRILNKKIDFSKVQSRCGSKDNIKHSAGGG 422
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 424-453 8.89e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.35  E-value: 8.89e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 87578394   424 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 453
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 455-485 3.07e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 57.81  E-value: 3.07e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 87578394   455 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 485
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 362-391 3.52e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 3.52e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 87578394   362 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 391
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 175-389 2.12e-06

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.84  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87578394  175 TLSKIPALQGSTKSPRYSSAcPSTTKRatfsdslliqPTSAGSTDRLPYSKSGNKDGVTKSPEKRSSLPRPSSILPPRRG 254
Cdd:PTZ00449 574 TLSKKPEFPKDPKHPKDPEE-PKKPKR----------PRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRP 642

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87578394  255 VSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTP 315
Cdd:PTZ00449 643 SSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTTVVLDESFESILKETLPETPGTPFTTPRPLP 722

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87578394  316 gtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLINQPLPDL-------KNVKSKIGSTDNIKYQ 387
Cdd:PTZ00449 723 --PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPADTPLPDIlaeefkeEDIHAETGEPDEAMKR 795


                 ..
gi 87578394  388 PK 389
Cdd:PTZ00449 796 PD 797
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 393-422 2.55e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 63.97  E-value: 2.55e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 87578394   393 VRILNKKIDFSKVQSRCGSKDNIKHSAGGG 422
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 424-453 8.89e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.35  E-value: 8.89e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 87578394   424 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 453
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 455-485 3.07e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 57.81  E-value: 3.07e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 87578394   455 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 485
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 362-391 3.52e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 3.52e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 87578394   362 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 391
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 175-389 2.12e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.84  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87578394  175 TLSKIPALQGSTKSPRYSSAcPSTTKRatfsdslliqPTSAGSTDRLPYSKSGNKDGVTKSPEKRSSLPRPSSILPPRRG 254
Cdd:PTZ00449 574 TLSKKPEFPKDPKHPKDPEE-PKKPKR----------PRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRP 642

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87578394  255 VSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTP 315
Cdd:PTZ00449 643 SSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTTVVLDESFESILKETLPETPGTPFTTPRPLP 722

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87578394  316 gtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLINQPLPDL-------KNVKSKIGSTDNIKYQ 387
Cdd:PTZ00449 723 --PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPADTPLPDIlaeefkeEDIHAETGEPDEAMKR 795


                 ..
gi 87578394  388 PK 389
Cdd:PTZ00449 796 PD 797
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 393-422 2.55e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 63.97  E-value: 2.55e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 87578394   393 VRILNKKIDFSKVQSRCGSKDNIKHSAGGG 422
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 424-453 8.89e-12

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 59.35  E-value: 8.89e-12
                          10        20        30
                  ....*....|....*....|....*....|
gi 87578394   424 VQIVTKKIDLSHVTSKCGSLKNIRHRPGGG 453
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 455-485 3.07e-11

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 57.81  E-value: 3.07e-11
                          10        20        30
                  ....*....|....*....|....*....|.
gi 87578394   455 VKIESVKLDFKeKAQAKVGSLDNAHHVPGGG 485
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 362-391 3.52e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 3.52e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 87578394   362 RLINQPLpDLKNVKSKIGSTDNIKYQPKGG 391
Cdd:pfam00418   2 KIESKKL-DFSKVQSKCGSKDNIKHKPGGG 30
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 175-389 2.12e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.84  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87578394  175 TLSKIPALQGSTKSPRYSSAcPSTTKRatfsdslliqPTSAGSTDRLPYSKSGNKDGVTKSPEKRSSLPRPSSILPPRRG 254
Cdd:PTZ00449 574 TLSKKPEFPKDPKHPKDPEE-PKKPKR----------PRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPPQRP 642

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87578394  255 VSGDRDENSFSLNSSISSSA------------------RRTTRS-EPIRRAGKSGTSTPTTPGSTAITPGTPPSYSSRTP 315
Cdd:PTZ00449 643 SSPERPEGPKIIKSPKPPKSpkppfdpkfkekfyddylDAAAKSkETKTTVVLDESFESILKETLPETPGTPFTTPRPLP 722

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87578394  316 gtPGTPSYPRTPHTP-GTPKSAILVPSEkkvaiIRTPPKSPATPKQLRLINQPLPDL-------KNVKSKIGSTDNIKYQ 387
Cdd:PTZ00449 723 --PKLPRDEEFPFEPiGDPDAEQPDDIE-----FFTPPEEERTFFHETPADTPLPDIlaeefkeEDIHAETGEPDEAMKR 795


                 ..
gi 87578394  388 PK 389
Cdd:PTZ00449 796 PD 797
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH