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Conserved domains on  [gi|608601807|ref|NP_001034450|]
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PRAME family member 10 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
219-410 3.92e-03

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601807 219 NKTGKFAPYLSQMSNLRELFLAFGYerelyvsvqwpcIPDLDSPFLCLYYPQMLYIK--KISNIKEHLEHL--LRYLknp 294
Cdd:COG4886  123 NQLTDLPEELANLTNLKELDLSNNQ------------LTDLPEPLGNLTNLKSLDLSnnQLTDLPEELGNLtnLKEL--- 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601807 295 lgafIFSDAYLTDRDMEcLSQypsLSQLKELRLIHilmwtTNLEPLGVLLEKVAAtLKTLVLKDCRIQDpqlrvlLPALS 374
Cdd:COG4886  188 ----DLSNNQITDLPEP-LGN---LTNLEELDLSG-----NQLTDLPEPLANLTN-LETLDLSNNQLTD------LPELG 247

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 608601807 375 HCSQLTTFNFHGN-------ETSMNALKDLLRHTRGLSKLGLE 410
Cdd:COG4886  248 NLTNLEELDLSNNqltdlppLANLTNLKTLDLSNNQLTDLKLK 290
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
219-410 3.92e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601807 219 NKTGKFAPYLSQMSNLRELFLAFGYerelyvsvqwpcIPDLDSPFLCLYYPQMLYIK--KISNIKEHLEHL--LRYLknp 294
Cdd:COG4886  123 NQLTDLPEELANLTNLKELDLSNNQ------------LTDLPEPLGNLTNLKSLDLSnnQLTDLPEELGNLtnLKEL--- 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601807 295 lgafIFSDAYLTDRDMEcLSQypsLSQLKELRLIHilmwtTNLEPLGVLLEKVAAtLKTLVLKDCRIQDpqlrvlLPALS 374
Cdd:COG4886  188 ----DLSNNQITDLPEP-LGN---LTNLEELDLSG-----NQLTDLPEPLANLTN-LETLDLSNNQLTD------LPELG 247

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 608601807 375 HCSQLTTFNFHGN-------ETSMNALKDLLRHTRGLSKLGLE 410
Cdd:COG4886  248 NLTNLEELDLSNNqltdlppLANLTNLKTLDLSNNQLTDLKLK 290
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
219-410 3.92e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601807 219 NKTGKFAPYLSQMSNLRELFLAFGYerelyvsvqwpcIPDLDSPFLCLYYPQMLYIK--KISNIKEHLEHL--LRYLknp 294
Cdd:COG4886  123 NQLTDLPEELANLTNLKELDLSNNQ------------LTDLPEPLGNLTNLKSLDLSnnQLTDLPEELGNLtnLKEL--- 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601807 295 lgafIFSDAYLTDRDMEcLSQypsLSQLKELRLIHilmwtTNLEPLGVLLEKVAAtLKTLVLKDCRIQDpqlrvlLPALS 374
Cdd:COG4886  188 ----DLSNNQITDLPEP-LGN---LTNLEELDLSG-----NQLTDLPEPLANLTN-LETLDLSNNQLTD------LPELG 247

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 608601807 375 HCSQLTTFNFHGN-------ETSMNALKDLLRHTRGLSKLGLE 410
Cdd:COG4886  248 NLTNLEELDLSNNqltdlppLANLTNLKTLDLSNNQLTDLKLK 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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