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Conserved domains on  [gi|78482611|ref|NP_001030603|]
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dyslexia-associated protein KIAA0319-like protein isoform 1 [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 20244047)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions; similar to Mus musculus dyslexia-associated protein KIAA0319-like protein

CATH:  2.10.25.10
Gene Ontology:  GO:0005515|GO:0005509
PubMed:  3282918|2288911|7606779
SCOP:  4003198

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
myxo_dep_M36 super family cl45606
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 404-786 2.57e-36

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


The actual alignment was detected with superfamily member NF038112:

Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 149.81  E-value: 2.57e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   404 NRPPVAVVSPQFQEisLPTTSTIIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 474
Cdd:NF038112 1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   475 SLTVvdSDGATNSTTASLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 553
Cdd:NF038112 1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   554 RTPALQLSAMQ---EGDYTYQLTVTDTAgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSTDDQRVVS 630
Cdd:NF038112 1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   631 YLWEQSRGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPVAKiAGNVVVTLPTS 707
Cdd:NF038112 1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   708 TAELDGSRSSDDKGIVSYLWTRDETSPAAgevLNHSDHHPVLFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 785
Cdd:NF038112 1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                  .
gi 78482611   786 R 786
Cdd:NF038112 1562 R 1562
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 890-910 9.29e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 9.29e-03
                           10        20
                   ....*....|....*....|.
gi 78482611    890 CSDHGHCDSFTKRCVCDPFWM 910
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQ 22
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 404-786 2.57e-36

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 149.81  E-value: 2.57e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   404 NRPPVAVVSPQFQEisLPTTSTIIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 474
Cdd:NF038112 1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   475 SLTVvdSDGATNSTTASLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 553
Cdd:NF038112 1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   554 RTPALQLSAMQ---EGDYTYQLTVTDTAgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSTDDQRVVS 630
Cdd:NF038112 1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   631 YLWEQSRGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPVAKiAGNVVVTLPTS 707
Cdd:NF038112 1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   708 TAELDGSRSSDDKGIVSYLWTRDETSPAAgevLNHSDHHPVLFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 785
Cdd:NF038112 1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                  .
gi 78482611   786 R 786
Cdd:NF038112 1562 R 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 282-692 1.45e-31

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 134.40  E-value: 1.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   282 PSYSYATPTP---QASSQSTSAPHPVVkelvvSAGKSVQItLPKNEVQLN--AFVLPEaepGETYTYDWqlithpTDYSG 356
Cdd:NF038112 1164 LKFTGITNTPftsLVAEPGVCNRRPVA-----NAGPDQTV-LERTTVTLNgsGSFDPD---GDPLTYAW------TQVSG 1228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   357 -EVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQNAHGEGYVNVTVKpepRKNRPPVAVVSPQfQEISLPTTSTIiDG 429
Cdd:NF038112 1229 pAVTLTGADTATPSFTAPEVTAdtvltFQLVVsDGTKTSAPDTVTVLVR---NVNRAPVAVAGAP-ATVDERSTVTL-DG 1303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   430 SQSTDDDKIVQYHWEELKGPLREEKiseDTAILKLSKLVP---GNYTFSLTVVDSDGaTNSTTASLTVN-KAVDYPPVAN 505
Cdd:NF038112 1304 SGTDADGDALTYAWTQTSGPAVTLT---GATTATATFTAPevtADTQLTFTLTVSDG-TASATDTVTVTvRNVNRAPVAN 1379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   506 AGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSA---MQEGDYTYQLTVTdtAGQQA 582
Cdd:NF038112 1380 AGADQTVD-ERSTVTLSGSATDPDGDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVS--ADGQA 1453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   583 TAQVTVIVQPEN-NKPPQADAGPDKELTlPVDSTTLDGSKSTDDQRVVSYLWEQSRGPdGVQLENANSSVATVTGLQVG- 660
Cdd:NF038112 1454 SADVTVTVTVRNvNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGP-SVTLTGADSAKLTFTAPEVSa 1531

                         410       420       430
                  ....*....|....*....|....*....|....
gi 78482611   661 --TYVFTLTVKDERNLQSQSSVNVIVKEEINKPP 692
Cdd:NF038112 1532 dtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 288-599 3.65e-18

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 90.87  E-value: 3.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   288 TPTPQASSQSTSAPHPVVKELVVSAG------KSVQITLPK---------------NE---VQLNAFVlpEAEPGETYTY 343
Cdd:NF038112 1238 TATPSFTAPEVTADTVLTFQLVVSDGtktsapDTVTVLVRNvnrapvavagapatvDErstVTLDGSG--TDADGDALTY 1315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   344 DWQLITHPTdysgeVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQnAHGEGYVNVTVKPeprKNRPPVAVVSPQfQE 417
Cdd:NF038112 1316 AWTQTSGPA-----VTLTGATTATATFTAPEVTAdtqltFTLTVsDGT-ASATDTVTVTVRN---VNRAPVANAGAD-QT 1385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   418 ISLPTTSTIiDGSQSTDDDKIVQYHWEELKGPlREEKISEDTAILKL---SKLVPGNYTFSLTVVDSDGATNSTTASLTV 494
Cdd:NF038112 1386 VDERSTVTL-SGSATDPDGDALTYAWTQTAGP-TVTLTGADTATASFtapEVAADTELTFQLTVSADGQASADVTVTVTV 1463

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   495 NKaVDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSAMQEG---DYTYQ 571
Cdd:NF038112 1464 RN-VNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT---QVAGPSVTLTGADSAKLTFTAPEVSadtTLTFS 1538

                         330       340
                  ....*....|....*....|....*...
gi 78482611   572 LTVTDTAGQQATAQVTVIVQPENNKPPQ 599
Cdd:NF038112 1539 LTVTDGSGSSGPVVVTVTVKNVNRAPDG 1566
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 689-779 2.03e-09

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 55.35  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    689 NKPPVAKIAGNVVVTlPTSTAELDGSRSSD-DKGIVSYLWTRDETSPAAGEVLNHSDHHPvlflsnlveGTYTFHLKVTD 767
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFGDGTTATGANVSHTYAAP---------GTYTVTLTVTD 70

                           90
                   ....*....|....*
gi 78482611    768 AKG---ESDTDRTTV 779
Cdd:pfam18911   71 DSGasnSTATDTVTV 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
472-774 2.24e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.54  E-value: 2.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  472 YTFSLTVVDSDGATN-STTASLTVNKAvdyPPVANAGPNQVITLPqNSITLfgN-QSTDDHGITSYEWSLSPSSKGKVVE 549
Cdd:COG3401  205 YYYRVAATDTGGESApSNEVSVTTPTT---PPSAPTGLTATADTP-GSVTL--SwDPVTESDATGYRVYRSNSGDGPFTK 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  550 MQGVRTPALQLSAMQEG-DYTYQLTVTDTAGQQATAQVTVIVQPENNkPPQADAGPDKELTLPvDSTTLDGSKSTDDQrV 628
Cdd:COG3401  279 VATVTTTSYTDTGLTNGtTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGLTATAVGS-SSITLSWTASSDAD-V 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  629 VSYLWEQSRGPDGVQ---LENANSSVATVTGLQVG-TYVFTLTVKDERNLQSQSSVNVIVKEEINKPPVAKIAGNVVVTL 704
Cdd:COG3401  356 TGYNVYRSTSGGGTYtkiAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPL 435

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  705 PTSTAELDGSRSSDDKGIVSYLWTRDETSPAAGEVLNHSDHHPVlflsNLVEGTYTFHLKVTDAKGESDT 774
Cdd:COG3401  436 TDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA----TTTDTTTANLSVTTGSLVGGSG 501
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 503-591 9.02e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.75  E-value: 9.02e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611     503 VANAGPNQVITLPQNSITlFGNQSTDDHGITSYEWSLS--PSSKGKVVEMQGVRtpalqlsamqEGDYTYQLTVTDTAGq 580
Cdd:smart00089    1 VADVSASPTVGVAGESVT-FTATSSDDGSIVSYTWDFGdgTSSTGPTVTHTYTK----------PGTYTVTLTVTNAVG- 68

                            90
                    ....*....|.
gi 78482611     581 QATAQVTVIVQ 591
Cdd:smart00089   69 SASATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 692-781 1.35e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.41  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  692 PVAKIAGNVVVTLPTStAELDGSRSSDDKgIVSYLWTRdetspaaGEVLNHSDHHPVLFLSNLVEGTYTFHLKVTDAKGE 771
Cdd:cd00146    1 PTASVSAPPVAELGAS-VTFSASDSSGGS-IVSYKWDF-------GDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGS 71

                         90
                 ....*....|
gi 78482611  772 SDTDRTTVEV 781
Cdd:cd00146   72 SSTKTTTVVV 81
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 890-910 9.29e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 9.29e-03
                           10        20
                   ....*....|....*....|.
gi 78482611    890 CSDHGHCDSFTKRCVCDPFWM 910
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQ 22
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 404-786 2.57e-36

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 149.81  E-value: 2.57e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   404 NRPPVAVVSPQFQEisLPTTSTIIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 474
Cdd:NF038112 1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   475 SLTVvdSDGATNSTTASLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 553
Cdd:NF038112 1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   554 RTPALQLSAMQ---EGDYTYQLTVTDTAgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSTDDQRVVS 630
Cdd:NF038112 1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   631 YLWEQSRGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPVAKiAGNVVVTLPTS 707
Cdd:NF038112 1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   708 TAELDGSRSSDDKGIVSYLWTRDETSPAAgevLNHSDHHPVLFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 785
Cdd:NF038112 1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                  .
gi 78482611   786 R 786
Cdd:NF038112 1562 R 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 282-692 1.45e-31

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 134.40  E-value: 1.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   282 PSYSYATPTP---QASSQSTSAPHPVVkelvvSAGKSVQItLPKNEVQLN--AFVLPEaepGETYTYDWqlithpTDYSG 356
Cdd:NF038112 1164 LKFTGITNTPftsLVAEPGVCNRRPVA-----NAGPDQTV-LERTTVTLNgsGSFDPD---GDPLTYAW------TQVSG 1228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   357 -EVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQNAHGEGYVNVTVKpepRKNRPPVAVVSPQfQEISLPTTSTIiDG 429
Cdd:NF038112 1229 pAVTLTGADTATPSFTAPEVTAdtvltFQLVVsDGTKTSAPDTVTVLVR---NVNRAPVAVAGAP-ATVDERSTVTL-DG 1303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   430 SQSTDDDKIVQYHWEELKGPLREEKiseDTAILKLSKLVP---GNYTFSLTVVDSDGaTNSTTASLTVN-KAVDYPPVAN 505
Cdd:NF038112 1304 SGTDADGDALTYAWTQTSGPAVTLT---GATTATATFTAPevtADTQLTFTLTVSDG-TASATDTVTVTvRNVNRAPVAN 1379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   506 AGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSA---MQEGDYTYQLTVTdtAGQQA 582
Cdd:NF038112 1380 AGADQTVD-ERSTVTLSGSATDPDGDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVS--ADGQA 1453

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   583 TAQVTVIVQPEN-NKPPQADAGPDKELTlPVDSTTLDGSKSTDDQRVVSYLWEQSRGPdGVQLENANSSVATVTGLQVG- 660
Cdd:NF038112 1454 SADVTVTVTVRNvNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGP-SVTLTGADSAKLTFTAPEVSa 1531

                         410       420       430
                  ....*....|....*....|....*....|....
gi 78482611   661 --TYVFTLTVKDERNLQSQSSVNVIVKEEINKPP 692
Cdd:NF038112 1532 dtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 288-599 3.65e-18

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 90.87  E-value: 3.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   288 TPTPQASSQSTSAPHPVVKELVVSAG------KSVQITLPK---------------NE---VQLNAFVlpEAEPGETYTY 343
Cdd:NF038112 1238 TATPSFTAPEVTADTVLTFQLVVSDGtktsapDTVTVLVRNvnrapvavagapatvDErstVTLDGSG--TDADGDALTY 1315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   344 DWQLITHPTdysgeVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQnAHGEGYVNVTVKPeprKNRPPVAVVSPQfQE 417
Cdd:NF038112 1316 AWTQTSGPA-----VTLTGATTATATFTAPEVTAdtqltFTLTVsDGT-ASATDTVTVTVRN---VNRAPVANAGAD-QT 1385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   418 ISLPTTSTIiDGSQSTDDDKIVQYHWEELKGPlREEKISEDTAILKL---SKLVPGNYTFSLTVVDSDGATNSTTASLTV 494
Cdd:NF038112 1386 VDERSTVTL-SGSATDPDGDALTYAWTQTAGP-TVTLTGADTATASFtapEVAADTELTFQLTVSADGQASADVTVTVTV 1463

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611   495 NKaVDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSAMQEG---DYTYQ 571
Cdd:NF038112 1464 RN-VNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT---QVAGPSVTLTGADSAKLTFTAPEVSadtTLTFS 1538

                         330       340
                  ....*....|....*....|....*...
gi 78482611   572 LTVTDTAGQQATAQVTVIVQPENNKPPQ 599
Cdd:NF038112 1539 LTVTDGSGSSGPVVVTVTVKNVNRAPDG 1566
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 689-779 2.03e-09

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 55.35  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    689 NKPPVAKIAGNVVVTlPTSTAELDGSRSSD-DKGIVSYLWTRDETSPAAGEVLNHSDHHPvlflsnlveGTYTFHLKVTD 767
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFGDGTTATGANVSHTYAAP---------GTYTVTLTVTD 70

                           90
                   ....*....|....*
gi 78482611    768 AKG---ESDTDRTTV 779
Cdd:pfam18911   71 DSGasnSTATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 501-588 3.85e-07

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 48.81  E-value: 3.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    501 PPVANAGPNQVITLPQnSITLFGNQSTD-DHGITSYEWSLS--PSSKGKVVemqgVRTpalqlsAMQEGDYTYQLTVTDT 577
Cdd:pfam18911    3 APVADAGGDRIVAEGE-TVTFDASASDDpDGDILSYRWDFGdgTTATGANV----SHT------YAAPGTYTVTLTVTDD 71

                           90
                   ....*....|....
gi 78482611    578 AGQQ---ATAQVTV 588
Cdd:pfam18911   72 SGASnstATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 595-684 9.57e-07

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 47.65  E-value: 9.57e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    595 NKPPQADAGPDKELTlPVDSTTLDGSKSTD-DQRVVSYLWEQSrgpDGvqlenanssvATVTGLQV-------GTYVFTL 666
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFG---DG----------TTATGANVshtyaapGTYTVTL 66

                           90
                   ....*....|....*...
gi 78482611    667 TVKDERNLQSQSSVNVIV 684
Cdd:pfam18911   67 TVTDDSGASNSTATDTVT 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
472-774 2.24e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.54  E-value: 2.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  472 YTFSLTVVDSDGATN-STTASLTVNKAvdyPPVANAGPNQVITLPqNSITLfgN-QSTDDHGITSYEWSLSPSSKGKVVE 549
Cdd:COG3401  205 YYYRVAATDTGGESApSNEVSVTTPTT---PPSAPTGLTATADTP-GSVTL--SwDPVTESDATGYRVYRSNSGDGPFTK 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  550 MQGVRTPALQLSAMQEG-DYTYQLTVTDTAGQQATAQVTVIVQPENNkPPQADAGPDKELTLPvDSTTLDGSKSTDDQrV 628
Cdd:COG3401  279 VATVTTTSYTDTGLTNGtTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGLTATAVGS-SSITLSWTASSDAD-V 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  629 VSYLWEQSRGPDGVQ---LENANSSVATVTGLQVG-TYVFTLTVKDERNLQSQSSVNVIVKEEINKPPVAKIAGNVVVTL 704
Cdd:COG3401  356 TGYNVYRSTSGGGTYtkiAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPL 435

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  705 PTSTAELDGSRSSDDKGIVSYLWTRDETSPAAGEVLNHSDHHPVlflsNLVEGTYTFHLKVTDAKGESDT 774
Cdd:COG3401  436 TDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA----TTTDTTTANLSVTTGSLVGGSG 501
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 503-591 9.02e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.75  E-value: 9.02e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611     503 VANAGPNQVITLPQNSITlFGNQSTDDHGITSYEWSLS--PSSKGKVVEMQGVRtpalqlsamqEGDYTYQLTVTDTAGq 580
Cdd:smart00089    1 VADVSASPTVGVAGESVT-FTATSSDDGSIVSYTWDFGdgTSSTGPTVTHTYTK----------PGTYTVTLTVTNAVG- 68

                            90
                    ....*....|.
gi 78482611     581 QATAQVTVIVQ 591
Cdd:smart00089   69 SASATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 692-781 1.35e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.41  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  692 PVAKIAGNVVVTLPTStAELDGSRSSDDKgIVSYLWTRdetspaaGEVLNHSDHHPVLFLSNLVEGTYTFHLKVTDAKGE 771
Cdd:cd00146    1 PTASVSAPPVAELGAS-VTFSASDSSGGS-IVSYKWDF-------GDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGS 71

                         90
                 ....*....|
gi 78482611  772 SDTDRTTVEV 781
Cdd:cd00146   72 SSTKTTTVVV 81
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 459-692 2.32e-05

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 48.27  E-value: 2.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    459 TAILKLSKLVPGNYTFSLTVVDSDGATNSTTASLTVN-KAVDYPPVANAGPNQVITLpQNSITLFGNQSTD------DHG 531
Cdd:pfam02010   42 QLTIPSGTLPYGTYVFTLTVSLSSTPSLAGTDIITVTvQPSPLVAVIDGGSSRVVGY-NQDLTLDGSESYDpdvdpgSSS 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    532 ITSYEWS---------LSPSSKGKVVE------MQGVRTPALQLSA-MQEGDYTYQ--LTVTDTAGQQATAQVTVIVQPE 593
Cdd:pfam02010  121 GLTYLWScrrsssgdnPLLNNDPVCFSdqnegtLLQSTSSSLTIPAsTLQANVTYTfkLTVSKGSRNSASTTQTILVVDG 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    594 NnkPPQAD---AGPDKELTLPVDSTTLDGSKSTDDQRV---VSYLWE-QSRGPDGVQLENANSSVATVTG---------- 656
Cdd:pfam02010  201 N--PPIIIlscISNCNRKNNPVDRLVLLASTCLNCSSDlsdVTYRWLsLGSENTSLVLDQLNSQTSTGRSgpylvikagv 278

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 78482611    657 LQVGT-YVFTLTVKDeRNLQSQSSVNVIVKeeINKPP 692
Cdd:pfam02010  279 LQSGVsYRFTLIVTV-YPGLVSGLASISFI--TNAPP 312
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 693-782 2.87e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 43.21  E-value: 2.87e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611     693 VAKIAGNVVVTLPTSTAELDGSrSSDDKGIVSYLWTRDETSPAAGEVLNHSdhhpvlFLSnlvEGTYTFHLKVTDAKGeS 772
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDFGDGTSSTGPTVTHT------YTK---PGTYTVTLTVTNAVG-S 69

                            90
                    ....*....|
gi 78482611     773 DTDRTTVEVK 782
Cdd:smart00089   70 ASATVTVVVQ 79
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 408-494 3.01e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 43.21  E-value: 3.01e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611     408 VAVVSPQFQEISLPTTSTIIDgsQSTDDDKIVQYHWEELKGPLREEKisedTAILKLSKlvPGNYTFSLTVVDSDGaTNS 487
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTGP----TVTHTYTK--PGTYTVTLTVTNAVG-SAS 71


                    ....*..
gi 78482611     488 TTASLTV 494
Cdd:smart00089   72 ATVTVVV 78
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
469-734 4.88e-05

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 46.97  E-value: 4.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  469 PGNYTFSLTVVDSDGATNSTTASLTVNKAVDYPPVA--NAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGK 546
Cdd:COG3291   49 PGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVttSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGG 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  547 VVEMQGVRTPALQLSAMQEGDYTYQLTVTDTAGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSTDDQ 626
Cdd:COG3291  129 GTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTA 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  627 RVVSYlWEQSRGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPVAKIAGNVVVTLPT 706
Cdd:COG3291  209 GVTTG-ATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGG 287

                        250       260
                 ....*....|....*....|....*...
gi 78482611  707 STAELDGSRSSDDKGIVSYLWTRDETSP 734
Cdd:COG3291  288 LGTTTAITPGNVSTTADVTGGTATLAVS 315
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 365-711 6.09e-05

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 46.73  E-value: 6.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    365 SLQLSKLTPGLYEFKVTV---DGQNAHGEGYVNVTVKPEPRknrppVAVVSPQfQEISLPTTSTII-DGSQSTDDDK--- 437
Cdd:pfam02010   44 TIPSGTLPYGTYVFTLTVslsSTPSLAGTDIITVTVQPSPL-----VAVIDGG-SSRVVGYNQDLTlDGSESYDPDVdpg 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    438 ---IVQYHWEELKGPLREEKISEDTA-----------------ILKL--SKLVPG-NYTFSLTVVDSDGATNSTTASLTV 494
Cdd:pfam02010  118 sssGLTYLWSCRRSSSGDNPLLNNDPvcfsdqnegtllqstssSLTIpaSTLQANvTYTFKLTVSKGSRNSASTTQTILV 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    495 nkaVDYPP-------VANAGPnqvITLPQNSITLFGNQSTDDHGITS---YEWSLSPSSKGKVVE-------MQGVRTPA 557
Cdd:pfam02010  198 ---VDGNPpiiilscISNCNR---KNNPVDRLVLLASTCLNCSSDLSdvtYRWLSLGSENTSLVLdqlnsqtSTGRSGPY 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    558 LQLSA--MQEG-DYTYQLTVTDTAGQ-QATAQVTVIvqpeNNKPPQ---ADAGPDKELTLpVDSTTLDGSKSTDDQRVVS 630
Cdd:pfam02010  272 LVIKAgvLQSGvSYRFTLIVTVYPGLvSGLASISFI----TNAPPTggtCSVTPTEGTAL-ETKFTVTCQGWTDDDLPLT 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    631 Y----LWEQSRGPDGVQLENANSSVATVTGLQVGT----YVFTL--TVKDerNLQSQSSVNVIVKeeinkppvakiagnv 700
Cdd:pfam02010  347 YqfgdISFREASEEWFLLYEGSSQISISTFLPPGLpandYQVTVvvVVYD--SLGAATSVSLTIT--------------- 409

                          410
                   ....*....|.
gi 78482611    701 vVTLPTSTAEL 711
Cdd:pfam02010  410 -VTPPSSSDEL 419
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 502-590 2.47e-04

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 40.94  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  502 PVANAGPNQVITLPQnSITLFGNqSTDDHGITSYEWSLSpsskGKVVEMQGVRTPalQLSAMQEGDYTYQLTVTDTAGQQ 581
Cdd:cd00146    1 PTASVSAPPVAELGA-SVTFSAS-DSSGGSIVSYKWDFG----DGEVSSSGEPTV--THTYTKPGTYTVTLTVTNAVGSS 72


                 ....*....
gi 78482611  582 ATAQVTVIV 590
Cdd:cd00146   73 STKTTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 600-685 4.63e-04

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 39.74  E-value: 4.63e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611     600 ADAGPDKELTLPVDSTTLDGSkSTDDQRVVSYLWEQsrgPDGVQLENANssvATVTGLQVGTYVFTLTVKDErNLQSQSS 679
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDF---GDGTSSTGPT---VTHTYTKPGTYTVTLTVTNA-VGSASAT 73


                    ....*.
gi 78482611     680 VNVIVK 685
Cdd:smart00089   74 VTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 622-684 8.41e-04

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 39.40  E-value: 8.41e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 78482611  622 STDDQRVVSYLWeqSRGPDGVQLENAnsSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIV 684
Cdd:cd00146   23 DSSGGSIVSYKW--DFGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
Big_13 pfam19077
Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in ...
 478-588 2.81e-03

Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in bacterial cell surface proteins.


Pssm-ID: 465968 [Multi-domain]  Cd Length: 102  Bit Score: 38.40  E-value: 2.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611    478 VVDSDGATNSTTASLTVnKAVDyppvanagpNQVITLpqnSITLFGNQST-----DDHGItsyeWSLSPSSkgkvvemqg 552
Cdd:pfam19077   17 VSDSDNITNDTTPTFTG-TNED---------GDVVTV---TVSIDGNGVTgtataGADGN----WSFTPPA--------- 70

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 78482611    553 vrtpalqlsAMQEGDYTYQLTVTDTAGQQATA---QVTV 588
Cdd:pfam19077   71 ---------ALADGTYTLTVTVTDIAGNTATSsplSFTI 100
ClfA COG4932
Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing ...
 463-785 4.82e-03

Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443959 [Multi-domain]  Cd Length: 689  Bit Score: 41.11  E-value: 4.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  463 KLSKLVPGNYTFSLTV-----VDSDGATNSTTASLTVNKAvdypPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEW 537
Cdd:COG4932  207 TFTDLPPGTYTLTETKapegyVLDTKDPTGATITVTVNAG----GTVTVTLKNTPKYTKGSVTVTKTDADTGEPLAGATF 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  538 SLSPSSKGKVVEMQGVRTPA---LQLSAMQEGDYTYQLTVTDTAGQQATAQVTVIVQPENNKPPQADAGPDKELTLPV-- 612
Cdd:COG4932  283 TLTDADGNTVVTTTVTVTDAdgsYTFTDLPPGTYTVTETKAPAGYDLDGEAVKVTITAGQTTTVTVTNGNNEVKTGSVtl 362

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  613 -------DSTTLDGSKST---DDQRVVSYLWEQSRGpdgvqlenanssVATVTGLQVGTYVFTLTVKDERNLQSQSSVNV 682
Cdd:COG4932  363 tkvdaddGEAPLAGAEFTltdADGTVVATITTDADG------------TASFKGLAPGTYTLTETKAPEGYTLDSTPITV 430

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  683 IVKEEINKPPV----AKIAGNVVVT-----LPTSTAELDgsrssDDKGIVSYLWTRDETSPA----AGEVLNHSDHHPVL 749
Cdd:COG4932  431 TVTDGGTGAIDtitnERKKGSVQVTkvdapLAGATFTLT-----DADGTVVTLTTDADLAGAtfeaDGKVVTTTDASGKY 505

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 78482611  750 FLSNLVEGTYTFHLKVTDAKGESDTDRTTVEVKPDP 785
Cdd:COG4932  506 TFKNLPPGTYTDAGGSATVITDDTDGTVGDEATGTD 541
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
522-781 5.38e-03

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 40.42  E-value: 5.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  522 FGNQSTDDhgITSYEWSLSPSSKGkvVEMQGVRTPAlqlsamQEGDYTYQLTVTDTAGQQATAQVTVIVQPENNKPPQAD 601
Cdd:COG3291   16 FTDTSSGN--ATSYEWDFGDGTTS--TEANPSHTYT------TPGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  602 AGPDKELTLPVDSTTLDGSKSTDDQRVVSYLWEQSRGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVN 681
Cdd:COG3291   86 TSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVT 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  682 VIVKEEINKPPVAKIAGNVVVTLPTSTAELDGSRSSDDKGIVSYLWTRDETSPAAGEVLNHSDHHPVLFLSNLVEGTYTF 761
Cdd:COG3291  166 SDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGT 245

                        250       260
                 ....*....|....*....|
gi 78482611  762 HLKVTDAKGESDTDRTTVEV 781
Cdd:COG3291  246 PGTNTVTTSGANTAGTSTIT 265
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 406-494 8.76e-03

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 36.32  E-value: 8.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78482611  406 PPVAVVSPQFQEISLPTTSTIidgsQSTDDDKIVQYHWEELKGPLreekISEDTAILKLSKLVPGNYTFSLTVVDSDGAT 485
Cdd:cd00146    1 PTASVSAPPVAELGASVTFSA----SDSSGGSIVSYKWDFGDGEV----SSSGEPTVTHTYTKPGTYTVTLTVTNAVGSS 72


                 ....*....
gi 78482611  486 NSTTASLTV 494
Cdd:cd00146   73 STKTTTVVV 81
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 890-910 9.29e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 9.29e-03
                           10        20
                   ....*....|....*....|.
gi 78482611    890 CSDHGHCDSFTKRCVCDPFWM 910
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQ 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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