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Conserved domains on  [gi|85702266|ref|NP_001030075|]
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MANSC domain-containing protein 4 precursor [Mus musculus]

Protein Classification

MANEC domain-containing protein( domain architecture ID 10654847)

MANEC domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 24-113 1.18e-24

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


:

Pssm-ID: 129004  Cd Length: 93  Bit Score: 95.59  E-value: 1.18e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702266     24 VFYRDCWIR--RFPGMLLDLEESQRLGAQFLKY-YSENTGQKCGRSCCLRKDvsCNVAVFFHDPVHDNVNCLHVHC--PT 98
Cdd:smart00765   1 SPGEDCLGRfrVLENAIIRTEESLSAGARFLKSpIAVNTWEDCVRACCSTPN--CNLAVFELRREDAEGNCYLFNCtyPG 78

                           90
                   ....*....|....*
gi 85702266     99 LESCILEPGASAILY 113
Cdd:smart00765  79 KEVCKFKPHEGYTSY 93
 
Name Accession Description Interval E-value
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 24-113 1.18e-24

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 95.59  E-value: 1.18e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702266     24 VFYRDCWIR--RFPGMLLDLEESQRLGAQFLKY-YSENTGQKCGRSCCLRKDvsCNVAVFFHDPVHDNVNCLHVHC--PT 98
Cdd:smart00765   1 SPGEDCLGRfrVLENAIIRTEESLSAGARFLKSpIAVNTWEDCVRACCSTPN--CNLAVFELRREDAEGNCYLFNCtyPG 78

                           90
                   ....*....|....*
gi 85702266     99 LESCILEPGASAILY 113
Cdd:smart00765  79 KEVCKFKPHEGYTSY 93
MANEC pfam07502
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 35-80 3.26e-04

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


Pssm-ID: 462186  Cd Length: 90  Bit Score: 39.22  E-value: 3.26e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 85702266    35 PGMLLDLEESQRLGAQFLKYYSENTGQKCGRSCClrKDVSCNVAVF 80
Cdd:pfam07502  11 EDFIIDTEDSVKNGATFLSSPEVSSARDCVRACC--STPRCNLAVF 54
 
Name Accession Description Interval E-value
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 24-113 1.18e-24

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 95.59  E-value: 1.18e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702266     24 VFYRDCWIR--RFPGMLLDLEESQRLGAQFLKY-YSENTGQKCGRSCCLRKDvsCNVAVFFHDPVHDNVNCLHVHC--PT 98
Cdd:smart00765   1 SPGEDCLGRfrVLENAIIRTEESLSAGARFLKSpIAVNTWEDCVRACCSTPN--CNLAVFELRREDAEGNCYLFNCtyPG 78

                           90
                   ....*....|....*
gi 85702266     99 LESCILEPGASAILY 113
Cdd:smart00765  79 KEVCKFKPHEGYTSY 93
MANEC pfam07502
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 35-80 3.26e-04

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


Pssm-ID: 462186  Cd Length: 90  Bit Score: 39.22  E-value: 3.26e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 85702266    35 PGMLLDLEESQRLGAQFLKYYSENTGQKCGRSCClrKDVSCNVAVF 80
Cdd:pfam07502  11 EDFIIDTEDSVKNGATFLSSPEVSSARDCVRACC--STPRCNLAVF 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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