NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|72534716|ref|NP_001026883|]
View 

mitochondrial calcium uniporter regulator 1 [Homo sapiens]

Protein Classification

CCDC90 family protein( domain architecture ID 10544633)

coiled-coil domain-containing protein 90 (CCDC90) family protein similar to Homo sapiens mitochondrial calcium uniporter regulator 1 (MCUR1/CCDC90A) that is a key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CCDC90-like pfam07798
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 166-358 2.97e-77

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


:

Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 235.10  E-value: 2.97e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534716   166 FDTHALVCLLEDNGFATQQAEIIVSALVKILEANMDIVYKDMVTKMQQEITFQQVMSQIANVKKDMIILEKSEFSALRAE 245
Cdd:pfam07798   1 FDTHAFVRQLEEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKEDLENETYLQKADLAELRSELQILEKSEFAALRSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534716   246 NEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEKSRVKELYSlnekkllelrteivalhaQQDRALTQTDRKIETEVAGL 325
Cdd:pfam07798  81 NEKLRRELEKLKQRLREEITKLKADVRLDLNLEKGRIREELK------------------AQELKIQETNNKIDTEIANL 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 72534716   326 KTMLESHKLDNIKYLAGSIFTCLTVALGFYRLW 358
Cdd:pfam07798 143 RTQIESVKWDVIRYLIGVITGCLALVLAYLRLL 175
 
Name Accession Description Interval E-value
CCDC90-like pfam07798
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 166-358 2.97e-77

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 235.10  E-value: 2.97e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534716   166 FDTHALVCLLEDNGFATQQAEIIVSALVKILEANMDIVYKDMVTKMQQEITFQQVMSQIANVKKDMIILEKSEFSALRAE 245
Cdd:pfam07798   1 FDTHAFVRQLEEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKEDLENETYLQKADLAELRSELQILEKSEFAALRSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534716   246 NEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEKSRVKELYSlnekkllelrteivalhaQQDRALTQTDRKIETEVAGL 325
Cdd:pfam07798  81 NEKLRRELEKLKQRLREEITKLKADVRLDLNLEKGRIREELK------------------AQELKIQETNNKIDTEIANL 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 72534716   326 KTMLESHKLDNIKYLAGSIFTCLTVALGFYRLW 358
Cdd:pfam07798 143 RTQIESVKWDVIRYLIGVITGCLALVLAYLRLL 175
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 205-344 2.71e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 42.70  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534716   205 KDMVTKMQQEITfqqvMSQIANVKKDMIILEK-SEFSALRAENEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEkSRVK 283
Cdd:TIGR04523 341 NEQISQLKKELT----NSESENSEKQRELEEKqNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKD-EQIK 415

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 72534716   284 EL---YSLNEKKLLELRTEIVALHAQQDRaLTQTDRKIETEVAGLKTMLESHKlDNIKYLAGSI 344
Cdd:TIGR04523 416 KLqqeKELLEKEIERLKETIIKNNSEIKD-LTNQDSVKELIIKNLDNTRESLE-TQLKVLSRSI 477
 
Name Accession Description Interval E-value
CCDC90-like pfam07798
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 166-358 2.97e-77

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 235.10  E-value: 2.97e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534716   166 FDTHALVCLLEDNGFATQQAEIIVSALVKILEANMDIVYKDMVTKMQQEITFQQVMSQIANVKKDMIILEKSEFSALRAE 245
Cdd:pfam07798   1 FDTHAFVRQLEEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKEDLENETYLQKADLAELRSELQILEKSEFAALRSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534716   246 NEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEKSRVKELYSlnekkllelrteivalhaQQDRALTQTDRKIETEVAGL 325
Cdd:pfam07798  81 NEKLRRELEKLKQRLREEITKLKADVRLDLNLEKGRIREELK------------------AQELKIQETNNKIDTEIANL 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 72534716   326 KTMLESHKLDNIKYLAGSIFTCLTVALGFYRLW 358
Cdd:pfam07798 143 RTQIESVKWDVIRYLIGVITGCLALVLAYLRLL 175
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 205-344 2.71e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 42.70  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534716   205 KDMVTKMQQEITfqqvMSQIANVKKDMIILEK-SEFSALRAENEKIKLELHQLKQQVMDEVIKVRTDTKLDFNLEkSRVK 283
Cdd:TIGR04523 341 NEQISQLKKELT----NSESENSEKQRELEEKqNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKD-EQIK 415

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 72534716   284 EL---YSLNEKKLLELRTEIVALHAQQDRaLTQTDRKIETEVAGLKTMLESHKlDNIKYLAGSI 344
Cdd:TIGR04523 416 KLqqeKELLEKEIERLKETIIKNNSEIKD-LTNQDSVKELIIKNLDNTRESLE-TQLKVLSRSI 477
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 183-331 5.36e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.93  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534716   183 QQAEI-IVSALVKILEANMDIVYKDMVTKMQQEITFQQVMSQIANVKKDM---IILEKSEFSALRAENEKIKLELHQLKq 258
Cdd:TIGR04523 466 LETQLkVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLtkkISSLKEKIEKLESEKKEKESKISDLE- 544

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72534716   259 qvmDEVIKvrtdtkLDFNLEKSRVKELYSLNEKKLLELRTEIVALHAQQDRALTQTDRKiETEVAGLKTMLES 331
Cdd:TIGR04523 545 ---DELNK------DDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQK-EKEKKDLIKEIEE 607
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH