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Conserved domains on  [gi|71043842|ref|NP_001020844|]
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centromere protein U [Rattus norvegicus]

Protein Classification

CENP-U and Mplasa_alph_rch domain-containing protein( domain architecture ID 10586794)

CENP-U and Mplasa_alph_rch domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 137-312 8.07e-58

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


:

Pssm-ID: 463785  Cd Length: 180  Bit Score: 187.22  E-value: 8.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043842   137 EDNVRRSV-SIERPRARKPPAAPAAASSSSSPSERPAEQVTPRKTS--FPQPSAVEETPAA-QSQLKTQKKVRPSPGRRK 212
Cdd:pfam13097   1 ESDVRRKVqSAEKISTQQREAVPATASASSELSEKPAESVTPRKTGplSASSSVEKETLAWtQSQLKTQKKVKMSHGKRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043842   213 RPRRGSTHSDASESMHILCLEGKRQSDVMELDVVLSAFERTFLDYKQRVESESCNQAISKFYFKIKGELIRMLKEVQMLK 292
Cdd:pfam13097  81 KSRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLK 160

                         170       180
                  ....*....|....*....|
gi 71043842   293 ALKRKNTKIISNMEKKRQRL 312
Cdd:pfam13097 161 NLKRKNAKVISDIEKKRQRL 180
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 276-355 2.44e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 40.00  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043842   276 KIKGELIRMLKEVQMLKALKRKNTKIISNMEKKRQR----LIDVQDELIRLEPQLKQLQTKYDDLKKRKSALKNSKHFLS 351
Cdd:TIGR04523 100 KLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKEnkknIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLE 179


                  ....
gi 71043842   352 NLKQ 355
Cdd:TIGR04523 180 KEKL 183
 
Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 137-312 8.07e-58

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


Pssm-ID: 463785  Cd Length: 180  Bit Score: 187.22  E-value: 8.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043842   137 EDNVRRSV-SIERPRARKPPAAPAAASSSSSPSERPAEQVTPRKTS--FPQPSAVEETPAA-QSQLKTQKKVRPSPGRRK 212
Cdd:pfam13097   1 ESDVRRKVqSAEKISTQQREAVPATASASSELSEKPAESVTPRKTGplSASSSVEKETLAWtQSQLKTQKKVKMSHGKRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043842   213 RPRRGSTHSDASESMHILCLEGKRQSDVMELDVVLSAFERTFLDYKQRVESESCNQAISKFYFKIKGELIRMLKEVQMLK 292
Cdd:pfam13097  81 KSRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLK 160

                         170       180
                  ....*....|....*....|
gi 71043842   293 ALKRKNTKIISNMEKKRQRL 312
Cdd:pfam13097 161 NLKRKNAKVISDIEKKRQRL 180
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 276-355 2.44e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 40.00  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043842   276 KIKGELIRMLKEVQMLKALKRKNTKIISNMEKKRQR----LIDVQDELIRLEPQLKQLQTKYDDLKKRKSALKNSKHFLS 351
Cdd:TIGR04523 100 KLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKEnkknIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLE 179


                  ....
gi 71043842   352 NLKQ 355
Cdd:TIGR04523 180 KEKL 183
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 261-363 4.64e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 39.14  E-value: 4.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043842  261 VESESCNQAISKFYF-KIKGELIRMLKEVQMLKALKRKNTKIISNMEKKR------------QRLIDVQDELIRLEPQLK 327
Cdd:PRK05771  31 VHIEDLKEELSNERLrKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSvksleelikdveEELEKIEKEIKELEEEIS 110

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 71043842  328 QLQTKYDDLKKRKSALKNSKHFLSNLKQLYqDYSNV 363
Cdd:PRK05771 111 ELENEIKELEQEIERLEPWGNFDLDLSLLL-GFKYV 145
 
Name Accession Description Interval E-value
CENP-U pfam13097
CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that ...
 137-312 8.07e-58

CENP-A nucleosome associated complex (NAC) subunit; CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.


Pssm-ID: 463785  Cd Length: 180  Bit Score: 187.22  E-value: 8.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043842   137 EDNVRRSV-SIERPRARKPPAAPAAASSSSSPSERPAEQVTPRKTS--FPQPSAVEETPAA-QSQLKTQKKVRPSPGRRK 212
Cdd:pfam13097   1 ESDVRRKVqSAEKISTQQREAVPATASASSELSEKPAESVTPRKTGplSASSSVEKETLAWtQSQLKTQKKVKMSHGKRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043842   213 RPRRGSTHSDASESMHILCLEGKRQSDVMELDVVLSAFERTFLDYKQRVESESCNQAISKFYFKIKGELIRMLKEVQMLK 292
Cdd:pfam13097  81 KSRSKATDSDSSDSVHIWCLKGKKRSDIMELDVVLSAFEKTCLEYKQRIESKICREAINKFHSNIKEELIKMIKEVQMLK 160

                         170       180
                  ....*....|....*....|
gi 71043842   293 ALKRKNTKIISNMEKKRQRL 312
Cdd:pfam13097 161 NLKRKNAKVISDIEKKRQRL 180
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 276-355 2.44e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 40.00  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043842   276 KIKGELIRMLKEVQMLKALKRKNTKIISNMEKKRQR----LIDVQDELIRLEPQLKQLQTKYDDLKKRKSALKNSKHFLS 351
Cdd:TIGR04523 100 KLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKEnkknIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLE 179


                  ....
gi 71043842   352 NLKQ 355
Cdd:TIGR04523 180 KEKL 183
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 261-363 4.64e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 39.14  E-value: 4.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71043842  261 VESESCNQAISKFYF-KIKGELIRMLKEVQMLKALKRKNTKIISNMEKKR------------QRLIDVQDELIRLEPQLK 327
Cdd:PRK05771  31 VHIEDLKEELSNERLrKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSvksleelikdveEELEKIEKEIKELEEEIS 110

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 71043842  328 QLQTKYDDLKKRKSALKNSKHFLSNLKQLYqDYSNV 363
Cdd:PRK05771 111 ELENEIKELEQEIERLEPWGNFDLDLSLLL-GFKYV 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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