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Conserved domains on  [gi|386766143|ref|NP_001014642|]
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glial cell line-derived neurotrophic family receptor-like, isoform H [Drosophila melanogaster]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10492252)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF; similar to Mus musculus GDNF family receptor alpha-1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 573-654 5.75e-12

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 62.55  E-value: 5.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143   573 CHVVADSCKEDRECRLKLEYYEQACAVDSVTKKCAGRPSGCRTAM------IGILGTMLRTTCACQGTDPQHlYQCVGWR 646
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPARCLRAYrmtpnyVDNLGTSLLLWCTCKGSGNQD-EECEEFR 79


                   ....*...
gi 386766143   647 RLLWMNPC 654
Cdd:pfam02351   80 RNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 27-106 3.53e-10

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 57.54  E-value: 3.53e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143    27 CILARQLCFEDPSCSAILEIIPRVCGPIPVSCSTVT-VTKCQAALR-----TLQAFQFFRPTCLCKEPG-MDPDCNHFRD 99
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPnPARCLRAYRmtpnyVDNLGTSLLLWCTCKGSGnQDEECEEFRR 80


                   ....*..
gi 386766143   100 FLFDHPC 106
Cdd:pfam02351   81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 463-549 1.30e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 53.03  E-value: 1.30e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143    463 CHTALDTCREDPSCSSSLQPMLTHCE-----------LHRCNRNACMSSLQAFYkgphEDLNLDIAFCLCKktssqqngn 531
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSpspssscpgenSEACLRAYCGLALRPFY----DDNSSVLLFCTCA--------- 67

                            90
                    ....*....|....*....
gi 386766143    532 GNRHDMCMIAQEKLH-PVC 549
Cdd:smart00907   68 GNRDEECLEFRRLFHsNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 126-203 6.31e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 48.30  E-value: 6.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143   126 CNHALSVCQQERKCLKLFEDFKTHCKVRDNKCKM-ENRDACHDSWT-------NLRLSPMFGCICPNN-HMKKRCDRIFN 196
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGcPNPARCLRAYRmtpnyvdNLGTSLLLWCTCKGSgNQDEECEEFRR 80


                   ....*..
gi 386766143   197 IVNHNPC 203
Cdd:pfam02351   81 NFTVNSC 87
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 573-654 5.75e-12

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 62.55  E-value: 5.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143   573 CHVVADSCKEDRECRLKLEYYEQACAVDSVTKKCAGRPSGCRTAM------IGILGTMLRTTCACQGTDPQHlYQCVGWR 646
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPARCLRAYrmtpnyVDNLGTSLLLWCTCKGSGNQD-EECEEFR 79


                   ....*...
gi 386766143   647 RLLWMNPC 654
Cdd:pfam02351   80 RNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 27-106 3.53e-10

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 57.54  E-value: 3.53e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143    27 CILARQLCFEDPSCSAILEIIPRVCGPIPVSCSTVT-VTKCQAALR-----TLQAFQFFRPTCLCKEPG-MDPDCNHFRD 99
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPnPARCLRAYRmtpnyVDNLGTSLLLWCTCKGSGnQDEECEEFRR 80


                   ....*..
gi 386766143   100 FLFDHPC 106
Cdd:pfam02351   81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 573-654 3.25e-09

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 54.95  E-value: 3.25e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143    573 CHVVADSCKEDRECRLKLEYYEQACAVDSVTKKCAGRPSGCRTAMIG-------ILGTMLRTTCACQGtdpQHLYQCVGW 645
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAYCGlalrpfyDDNSSVLLFCTCAG---NRDEECLEF 77


                    ....*....
gi 386766143    646 RRLLWMNPC 654
Cdd:smart00907   78 RRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 463-549 1.30e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 53.03  E-value: 1.30e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143    463 CHTALDTCREDPSCSSSLQPMLTHCE-----------LHRCNRNACMSSLQAFYkgphEDLNLDIAFCLCKktssqqngn 531
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSpspssscpgenSEACLRAYCGLALRPFY----DDNSSVLLFCTCA--------- 67

                            90
                    ....*....|....*....
gi 386766143    532 GNRHDMCMIAQEKLH-PVC 549
Cdd:smart00907   68 GNRDEECLEFRRLFHsNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 126-203 6.31e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 48.30  E-value: 6.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143   126 CNHALSVCQQERKCLKLFEDFKTHCKVRDNKCKM-ENRDACHDSWT-------NLRLSPMFGCICPNN-HMKKRCDRIFN 196
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGcPNPARCLRAYRmtpnyvdNLGTSLLLWCTCKGSgNQDEECEEFRR 80


                   ....*..
gi 386766143   197 IVNHNPC 203
Cdd:pfam02351   81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 126-203 2.41e-05

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 43.78  E-value: 2.41e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143    126 CNHALSVCQQERKCLKLFEDFKTHCKVRD-NKCKMENRDACHDSWTNLRLSPMFG--------CICPNNHmKKRCDRIFN 196
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSPSPsSSCPGENSEACLRAYCGLALRPFYDdnssvllfCTCAGNR-DEECLEFRR 79


                    ....*..
gi 386766143    197 IVNHNPC 203
Cdd:smart00907   80 LFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 463-546 4.08e-04

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 40.21  E-value: 4.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143   463 CHTALDTCREDPSCSSSLQPMLTHC--ELHRCNRNACMSSLQAFYKGPHEDLNLDIA----FCLCKktssqqnGNGNRHD 536
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCqpSPESCSGCPNPARCLRAYRMTPNYVDNLGTslllWCTCK-------GSGNQDE 73

                           90
                   ....*....|
gi 386766143   537 MCMIAQEKLH 546
Cdd:pfam02351   74 ECEEFRRNFT 83
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 27-106 8.45e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 36.47  E-value: 8.45e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143     27 CILARQLCFEDPSCSAILEIIPRVCGP-IPVSCSTVTVTKCQAALRTLQAFQFF------RPTCLCKePGMDPDCNHFRD 99
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSPsPSSSCPGENSEACLRAYCGLALRPFYddnssvLLFCTCA-GNRDEECLEFRR 79


                    ....*..
gi 386766143    100 FLFDHPC 106
Cdd:smart00907   80 LFHSNPC 86
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 573-654 5.75e-12

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 62.55  E-value: 5.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143   573 CHVVADSCKEDRECRLKLEYYEQACAVDSVTKKCAGRPSGCRTAM------IGILGTMLRTTCACQGTDPQHlYQCVGWR 646
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPARCLRAYrmtpnyVDNLGTSLLLWCTCKGSGNQD-EECEEFR 79


                   ....*...
gi 386766143   647 RLLWMNPC 654
Cdd:pfam02351   80 RNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 27-106 3.53e-10

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 57.54  E-value: 3.53e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143    27 CILARQLCFEDPSCSAILEIIPRVCGPIPVSCSTVT-VTKCQAALR-----TLQAFQFFRPTCLCKEPG-MDPDCNHFRD 99
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPnPARCLRAYRmtpnyVDNLGTSLLLWCTCKGSGnQDEECEEFRR 80


                   ....*..
gi 386766143   100 FLFDHPC 106
Cdd:pfam02351   81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 573-654 3.25e-09

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 54.95  E-value: 3.25e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143    573 CHVVADSCKEDRECRLKLEYYEQACAVDSVTKKCAGRPSGCRTAMIG-------ILGTMLRTTCACQGtdpQHLYQCVGW 645
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAYCGlalrpfyDDNSSVLLFCTCAG---NRDEECLEF 77


                    ....*....
gi 386766143    646 RRLLWMNPC 654
Cdd:smart00907   78 RRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 463-549 1.30e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 53.03  E-value: 1.30e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143    463 CHTALDTCREDPSCSSSLQPMLTHCE-----------LHRCNRNACMSSLQAFYkgphEDLNLDIAFCLCKktssqqngn 531
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSpspssscpgenSEACLRAYCGLALRPFY----DDNSSVLLFCTCA--------- 67

                            90
                    ....*....|....*....
gi 386766143    532 GNRHDMCMIAQEKLH-PVC 549
Cdd:smart00907   68 GNRDEECLEFRRLFHsNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 126-203 6.31e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 48.30  E-value: 6.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143   126 CNHALSVCQQERKCLKLFEDFKTHCKVRDNKCKM-ENRDACHDSWT-------NLRLSPMFGCICPNN-HMKKRCDRIFN 196
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGcPNPARCLRAYRmtpnyvdNLGTSLLLWCTCKGSgNQDEECEEFRR 80


                   ....*..
gi 386766143   197 IVNHNPC 203
Cdd:pfam02351   81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 126-203 2.41e-05

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 43.78  E-value: 2.41e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143    126 CNHALSVCQQERKCLKLFEDFKTHCKVRD-NKCKMENRDACHDSWTNLRLSPMFG--------CICPNNHmKKRCDRIFN 196
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSPSPsSSCPGENSEACLRAYCGLALRPFYDdnssvllfCTCAGNR-DEECLEFRR 79


                    ....*..
gi 386766143    197 IVNHNPC 203
Cdd:smart00907   80 LFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 463-546 4.08e-04

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 40.21  E-value: 4.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143   463 CHTALDTCREDPSCSSSLQPMLTHC--ELHRCNRNACMSSLQAFYKGPHEDLNLDIA----FCLCKktssqqnGNGNRHD 536
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCqpSPESCSGCPNPARCLRAYRMTPNYVDNLGTslllWCTCK-------GSGNQDE 73

                           90
                   ....*....|
gi 386766143   537 MCMIAQEKLH 546
Cdd:pfam02351   74 ECEEFRRNFT 83
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 27-106 8.45e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 36.47  E-value: 8.45e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766143     27 CILARQLCFEDPSCSAILEIIPRVCGP-IPVSCSTVTVTKCQAALRTLQAFQFF------RPTCLCKePGMDPDCNHFRD 99
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSPsPSSSCPGENSEACLRAYCGLALRPFYddnssvLLFCTCA-GNRDEECLEFRR 79


                    ....*..
gi 386766143    100 FLFDHPC 106
Cdd:smart00907   80 LFHSNPC 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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