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Conserved domains on  [gi|56549677|ref|NP_001008487|]
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solute carrier family 41 member 3 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
80-214 1.57e-15

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 72.86  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677    80 VPPLVGLKGNLEMTLASRLSTAANTGQIDdPQEQHRVISSNLALIQVQATVVGLLAAVAALLLgvvsreeVDVAKVELLC 159
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW-------FGGLLLGLVV 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 56549677   160 ASSVLTAFLAAFALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 214
Cdd:pfam01769  73 GLALLLAVLIALLLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
293-421 3.44e-14

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 69.01  E-value: 3.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677   293 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLveg 372
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 56549677   373 qsvinsqtFVVLYLLAGLI-QVTILLYLAEVMVRLTWHQALDPDNHCIPY 421
Cdd:pfam01769  67 --------LLGLVVGLALLlAVLIALLLGTLLPLLLWRLGLDPDNASGPL 108
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
80-214 1.57e-15

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 72.86  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677    80 VPPLVGLKGNLEMTLASRLSTAANTGQIDdPQEQHRVISSNLALIQVQATVVGLLAAVAALLLgvvsreeVDVAKVELLC 159
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW-------FGGLLLGLVV 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 56549677   160 ASSVLTAFLAAFALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 214
Cdd:pfam01769  73 GLALLLAVLIALLLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
293-421 3.44e-14

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 69.01  E-value: 3.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677   293 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLveg 372
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 56549677   373 qsvinsqtFVVLYLLAGLI-QVTILLYLAEVMVRLTWHQALDPDNHCIPY 421
Cdd:pfam01769  67 --------LLGLVVGLALLlAVLIALLLGTLLPLLLWRLGLDPDNASGPL 108
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
34-218 1.62e-10

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 60.26  E-value: 1.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677  34 ESFFTIMCQVVVPILLSGLCMMTAGLVMNTIQhwPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQID-DPQE 112
Cdd:COG1824   5 WTVRRIVRESLPVLLVLAVGGIIAGLVLEGME--ELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHLGLLEpRLRP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677 113 QHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCassVLTAFLAAFALGVLMVCIVIGARKLGVNPD 192
Cdd:COG1824  83 DRRLLNNILATLILALLISPLIGVLAWLVAVLLGRGSLGLLTLVGIA---LLAGLLLALLLIVVTYYVAIASYRFGLDPD 159
                       170       180
                ....*....|....*....|....*.
gi 56549677 193 NIATPIAASLGDLITLSILALVSSFF 218
Cdd:COG1824 160 NVVIPVVTTLGDVFGVLFLILVARLV 185
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
252-420 2.09e-07

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 51.02  E-value: 2.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677 252 IVKILKFGWFPIILAMVISSFGGLIL-SKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMwsapGVLPlqmKK 330
Cdd:COG1824   7 VRRIVRESLPVLLVLAVGGIIAGLVLeGMEELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLE---PR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677 331 FWPNP--CSTFCTSEINSMSARVLLLLVVpghliffYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTW 408
Cdd:COG1824  80 LRPDRrlLNNILATLILALLISPLIGVLA-------WLVAVLLGRGSLGLLTLVGIALLAGLLLALLLIVVTYYVAIASY 152
                       170
                ....*....|..
gi 56549677 409 HQALDPDNHCIP 420
Cdd:COG1824 153 RFGLDPDNVVIP 164
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
80-214 1.57e-15

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 72.86  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677    80 VPPLVGLKGNLEMTLASRLSTAANTGQIDdPQEQHRVISSNLALIQVQATVVGLLAAVAALLLgvvsreeVDVAKVELLC 159
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW-------FGGLLLGLVV 72
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 56549677   160 ASSVLTAFLAAFALGVLMVcivIGARKLGVNPDNIATPIAASLGDLITLSILALV 214
Cdd:pfam01769  73 GLALLLAVLIALLLGTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
293-421 3.44e-14

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 69.01  E-value: 3.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677   293 TPVICGVGGNLVAIQTSRISTYLHMWSapgvlplqmkkFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLveg 372
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGE-----------IEPRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 56549677   373 qsvinsqtFVVLYLLAGLI-QVTILLYLAEVMVRLTWHQALDPDNHCIPY 421
Cdd:pfam01769  67 --------LLGLVVGLALLlAVLIALLLGTLLPLLLWRLGLDPDNASGPL 108
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
34-218 1.62e-10

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 60.26  E-value: 1.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677  34 ESFFTIMCQVVVPILLSGLCMMTAGLVMNTIQhwPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQID-DPQE 112
Cdd:COG1824   5 WTVRRIVRESLPVLLVLAVGGIIAGLVLEGME--ELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHLGLLEpRLRP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677 113 QHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCassVLTAFLAAFALGVLMVCIVIGARKLGVNPD 192
Cdd:COG1824  83 DRRLLNNILATLILALLISPLIGVLAWLVAVLLGRGSLGLLTLVGIA---LLAGLLLALLLIVVTYYVAIASYRFGLDPD 159
                       170       180
                ....*....|....*....|....*.
gi 56549677 193 NIATPIAASLGDLITLSILALVSSFF 218
Cdd:COG1824 160 NVVIPVVTTLGDVFGVLFLILVARLV 185
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
252-420 2.09e-07

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 51.02  E-value: 2.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677 252 IVKILKFGWFPIILAMVISSFGGLIL-SKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMwsapGVLPlqmKK 330
Cdd:COG1824   7 VRRIVRESLPVLLVLAVGGIIAGLVLeGMEELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLE---PR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549677 331 FWPNP--CSTFCTSEINSMSARVLLLLVVpghliffYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTW 408
Cdd:COG1824  80 LRPDRrlLNNILATLILALLISPLIGVLA-------WLVAVLLGRGSLGLLTLVGIALLAGLLLALLLIVVTYYVAIASY 152
                       170
                ....*....|..
gi 56549677 409 HQALDPDNHCIP 420
Cdd:COG1824 153 RFGLDPDNVVIP 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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