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Conserved domains on  [gi|56605758|ref|NP_001008341|]
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THAP domain-containing protein 1 [Rattus norvegicus]

Protein Classification

THAP domain-containing protein( domain architecture ID 10659521)

THAP domain-containing protein may act as a DNA-binding transcription regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-82 1.01e-27

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


:

Pssm-ID: 214951  Cd Length: 80  Bit Score: 100.20  E-value: 1.01e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605758      4 SCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKQWEAAVRRKNF---KPTKYSSICSEHFTPDCFKRecNNKLLKENAVPTI 80
Cdd:smart00980   1 KCCVPGCGNRSKKNPGLSFFRFPKEDPELRKKWLENLGLPDDpnrKPKKRSRICSRHFEPDDFDN--SGRRLKPGAVPTL 78


                   ..
gi 56605758     81 FL 82
Cdd:smart00980  79 FL 80
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-82 1.01e-27

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 100.20  E-value: 1.01e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605758      4 SCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKQWEAAVRRKNF---KPTKYSSICSEHFTPDCFKRecNNKLLKENAVPTI 80
Cdd:smart00980   1 KCCVPGCGNRSKKNPGLSFFRFPKEDPELRKKWLENLGLPDDpnrKPKKRSRICSRHFEPDDFDN--SGRRLKPGAVPTL 78


                   ..
gi 56605758     81 FL 82
Cdd:smart00980  79 FL 80
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-81 4.11e-27

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 98.37  E-value: 4.11e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56605758     5 CSAYGCKNRYDKDKPVSFHKFPLtRPSLCKQWEAAVRRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIF 81
Cdd:pfam05485   1 CSVPGCTNRKKKNPRTSFHKFPK-DPERRKKWLNACKRKDLPPPSNSYVCSLHFEENDFEKSGGKRKLKPGAIPTLF 76
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 4-82 1.01e-27

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 100.20  E-value: 1.01e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605758      4 SCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKQWEAAVRRKNF---KPTKYSSICSEHFTPDCFKRecNNKLLKENAVPTI 80
Cdd:smart00980   1 KCCVPGCGNRSKKNPGLSFFRFPKEDPELRKKWLENLGLPDDpnrKPKKRSRICSRHFEPDDFDN--SGRRLKPGAVPTL 78


                   ..
gi 56605758     81 FL 82
Cdd:smart00980  79 FL 80
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-81 4.11e-27

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 98.37  E-value: 4.11e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56605758     5 CSAYGCKNRYDKDKPVSFHKFPLtRPSLCKQWEAAVRRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIF 81
Cdd:pfam05485   1 CSVPGCTNRKKKNPRTSFHKFPK-DPERRKKWLNACKRKDLPPPSNSYVCSLHFEENDFEKSGGKRKLKPGAIPTLF 76
DM3 smart00692
Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;
22-82 2.49e-14

Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;


Pssm-ID: 128933  Cd Length: 59  Bit Score: 64.64  E-value: 2.49e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56605758     22 FHKFPlTRPSLCKQWEAAVR-RKNFKPTKYSSICSEHFTPDCFkreCNNKLLKENAVPTIFL 82
Cdd:smart00692   1 LFRFP-KDPELLKKWEHNLRlSPDEKKLKNSRICSRHFEPECF---GKRRRLKPGAVPTLEL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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