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Conserved domains on  [gi|148747275|ref|NP_001004203|]
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DNA replication licensing factor MCM7 [Rattus norvegicus]

Protein Classification

DNA replication licensing factor MCM( domain architecture ID 12168656)

DNA replication licensing factor MCM (minichromosome maintenance protein MCM) is one of the highly conserved MCM complex proteins; the complex may have helicase activity and is essential for the initiation of DNA replication

EC:  3.6.4.12
Gene Ontology:  GO:0042555|GO:0003678|GO:0006270|GO:0006271|GO:0016887|GO:0046872|GO:0003677|GO:0005524|GO:0032508
PubMed:  8332451|18208397|22841721|17506634

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
145-641 0e+00

minichromosome maintenance proteins;


:

Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 718.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   145 KPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSggRLYLQT 224
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTP--FSLNHE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   225 RgSKFIKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLrTGFQQMAQGLLSE--TYLEAHR 302
Cdd:smart00350  79 R-STFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVP-YGFKLNTVKGLPVfaTYIEANH 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   303 VVKMT---KSEDDVSGAGELSAEELKQIAE----EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PQGMKIRGN 374
Cdd:smart00350 157 VRKLDykrSFEDSSFSVQSLSDEEEEEIRKlskdPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNlPDGMKIRGD 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   375 IHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEAD 454
Cdd:smart00350 237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSD 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   455 RTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLA 534
Cdd:smart00350 317 RTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELA 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   535 QHITYVHQHSR-QPPAQFE-PLDMKLMRRYIAMCRER-QPTVPDSLADYITAAYVEMRREARASKDAT--YTSARTLLAI 609
Cdd:smart00350 397 KHVVDLHRYSHpEEDEAFEpPLSQEKLRKYIAYAREKiKPKLSEEAADKLVKAYVDLRKEDSQTESRSsiPITVRQLESI 476

                          490       500       510
                   ....*....|....*....|....*....|..
gi 148747275   610 LRLSTALARLRMVDIVEKEDVNEAIRLMEMSK 641
Cdd:smart00350 477 IRLSEAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
 10-103 2.92e-16

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


:

Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 74.64  E-value: 2.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   10 KEKVKKFLQEFYYDDelgKKQFKYGTQLVHLAHREQVALYVDLDDVAEDDPELVDSICENAKRYSRLFADVVQELLPEYK 89
Cdd:pfam14551   1 KRKFKDFLEEFREDG---DGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELS 77

                          90
                  ....*....|....
gi 148747275   90 EKEVVNKDVLDVYI 103
Cdd:pfam14551  78 EDPDYAEEEKEFQV 91
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
145-641 0e+00

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 718.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   145 KPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSggRLYLQT 224
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTP--FSLNHE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   225 RgSKFIKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLrTGFQQMAQGLLSE--TYLEAHR 302
Cdd:smart00350  79 R-STFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVP-YGFKLNTVKGLPVfaTYIEANH 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   303 VVKMT---KSEDDVSGAGELSAEELKQIAE----EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PQGMKIRGN 374
Cdd:smart00350 157 VRKLDykrSFEDSSFSVQSLSDEEEEEIRKlskdPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNlPDGMKIRGD 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   375 IHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEAD 454
Cdd:smart00350 237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSD 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   455 RTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLA 534
Cdd:smart00350 317 RTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELA 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   535 QHITYVHQHSR-QPPAQFE-PLDMKLMRRYIAMCRER-QPTVPDSLADYITAAYVEMRREARASKDAT--YTSARTLLAI 609
Cdd:smart00350 397 KHVVDLHRYSHpEEDEAFEpPLSQEKLRKYIAYAREKiKPKLSEEAADKLVKAYVDLRKEDSQTESRSsiPITVRQLESI 476

                          490       500       510
                   ....*....|....*....|....*....|..
gi 148747275   610 LRLSTALARLRMVDIVEKEDVNEAIRLMEMSK 641
Cdd:smart00350 477 IRLSEAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 335-640 0e+00

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 605.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 335 KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGL 414
Cdd:cd17758    1 KLAASIAPEIYGHEDVKKALLLLLVGGVDKRGDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 415 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGR 494
Cdd:cd17758   81 TAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 495 YNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMKLMRRYIAMCRERQPTVP 574
Cdd:cd17758  161 YNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVHQHNKQPDSDFEPLDPKLLRAYIALAKRKRPTVP 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148747275 575 DSLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMS 640
Cdd:cd17758  241 PALADYIVQAYVEMRQEAKRSKDFTFTTPRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 10-638 0e+00

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 547.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  10 KEKVKKFLQEFYYDDELGKKQFKYgtqlvhlahREQVALYVDLDDVAEDDPELVDSICENAKRYSRLFADVVQELLPEyk 89
Cdd:COG1241    6 VDKFEEFLRRYKYRDEILELAQEY---------PEKRSLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALREIDLE-- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  90 ekeVVNKDVLDVYIehrlmmeqrsRdpgaVRNPQNQYPselmrrfelyfqgpssskprvIREVRADSVGKLLTVRGIVTR 169
Cdd:COG1241   75 ---PYDVSLGDAHV----------R----ITNLPETVP---------------------IRDIRSDHIGKLISVEGIVRK 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 170 VSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQtnrsgGRLYLQTRGSKFIKFQEMKIQEHSDQVPVGNI 249
Cdd:COG1241  117 ATEVKPKITEAAFECPRCGTETYVPQTGEKLQEPHECPGCGRQ-----GPFKLLPEKSEFIDAQKIRIQEPPEDLPGGQQ 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 250 PRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAqgLLSETYLEAHRVVKMTKSEDDVsgagELSAEELKQIAE 329
Cdd:COG1241  192 PQSIDVILEDDLVGEVRPGDRVTVTGILRIEQRTSGRGKS--TIFDLYLEANSIEVEEKEFEEI----EITEEDEEKIKE 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 330 ----EDFYEKLAASIAPEIYGHEDVKKALLLllvggvdQ--------SPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRL 397
Cdd:COG1241  266 lskdPDIYEKIIASIAPSIYGYEEIKEAIAL-------QlfggvpkvLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARL 338

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 398 APRSQYTTGRGSSGVGLTAAVLRDSVS-GELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILT 476
Cdd:COG1241  339 APRGVYTSGKGSTAAGLTAAAVRDDFGtGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVA 418

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 477 TLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVH-------QHSRQPPA 549
Cdd:COG1241  419 TLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVHragelleQEIEEETE 498

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 550 QFEP-LDMKLMRRYIAMCRER-QPTVPDSLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEK 627
Cdd:COG1241  499 EVKPeIDPDLLRKYIAYARRNvFPVLTEEAKDLIEDFYVDMRKKGEDEDSPVPITARQLEALIRLAEASARMRLSDTVTE 578

                        650
                 ....*....|.
gi 148747275 628 EDVNEAIRLME 638
Cdd:COG1241  579 EDAERAIRLVD 589
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
10-638 4.66e-177

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 521.79  E-value: 4.66e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  10 KEKVKKFLQEFyyDDELGKkqFKYGTQLVHLAHREQVALYVDLDDVAEDDPELVDSICENAKRYSRLFADVVQELL---- 85
Cdd:NF040949   2 GEKFKEFIRTF--RDSFGN--EKYKERIFEMIAMRKRSLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALKEIVeeed 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  86 PEYKEKEvvnkdvldvyiehrlmmeqrsrdpgavrnpqnqypselmRRFELYFQGPssskPRV--IREVRADSVGKLLTV 163
Cdd:NF040949  78 PEYAEEV---------------------------------------AKFHVRFRNL----PRTvpLRDLRSEYIGKLIAV 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 164 RGIVTRVSEVKPRMVVATYTCDQCGAETYQPiQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFIKFQEMKIQEHSDQ 243
Cdd:NF040949 115 EGIVTRTTPVKPRIVKAVFRCRDCGCEFEWP-EEEEESYEIVEPPTVCPVCGKPGSFRLLQEKSKFIDWQKIVVQERPEE 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 244 VPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAQGLLSeTYLEAHRVVKMTKSEDDVsgagELSAEE 323
Cdd:NF040949 194 LPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGILRIKPDSSLKKGSRPIFK-NYIEANHIEVSQKELEEV----EITEED 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 324 LKQIAE----EDFYEKLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLA 398
Cdd:NF040949 269 EEKILElakdPWIREKIIASIAPSIYGHWEIKEAIALLLFGgVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLA 348

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 399 PRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTL 478
Cdd:NF040949 349 PRAVYTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATL 428

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 479 NARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSrqppAQFEP-LDMK 557
Cdd:NF040949 429 NARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGK----EKVKPeIDPD 504

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 558 LMRRYIAMCRER-QPTVPDSLADYITAAYVEMRREARASKD---ATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEA 633
Cdd:NF040949 505 LLKKYIAYARKYvRPKLTEEAKKLIEDFYVEMRKSSKSSEDpdsPIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERA 584


                 ....*
gi 148747275 634 IRLME 638
Cdd:NF040949 585 IRLML 589
MCM pfam00493
MCM P-loop domain;
322-541 1.64e-132

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 390.35  E-value: 1.64e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  322 EELKQIA-EEDFYEKLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAP 399
Cdd:pfam00493   3 EEIKELAkRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGgVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  400 RSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLN 479
Cdd:pfam00493  83 RAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLN 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148747275  480 ARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVH 541
Cdd:pfam00493 163 ARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 137-640 3.35e-83

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 282.65  E-value: 3.35e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 137 YFQGPSSSKPRVIREVRADSvgkLLTVRGIVTRVSEVKPRMVVATYTC---DQCGAETYQPIQSPTFMPLIMCPSQE--- 210
Cdd:PTZ00111 209 LMNKPVSDCVGNLEPSMADS---LVQFSGTVVRQTWIVPEITMACFRCrgqKKIGLNDYQPCTCEHYEYVIQGEVNEpll 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 211 CQTNRSGGRLYLQTRGSKFIKFQEMKIQEHSDQVPVGNIP--------------------RSITVVLEGENTRIAQPGDH 270
Cdd:PTZ00111 286 CNECNSKYTFELNHNMCVYSTKKIVKLLQSNSSLNNPDKDgldnsvdnsglngeiymkdnEVINLNLYDDLIDSVKTGDR 365

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 271 VSVTGIF--LPVlRTGFQQMAQGLLSETYLEA-HrvVKMTKSEDD---------VSGAGELSAEELKQIAE----EDFYE 334
Cdd:PTZ00111 366 VTVVGILkvTPI-RTSTTRRTLKSLYTYFVNViH--VKVINSTNAnqpekglkyLGNENDFSDLQVYKILElsrnPMIYR 442

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 335 KLAASIAPEIYGHEDVKK----------ALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYT 404
Cdd:PTZ00111 443 ILLDSFAPSIKARNNVKIgllcqlfsgnKNSSDFNKSPDACYKVDNFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYT 522

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 405 TGRGSSGVGLTAAV-LRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCS 483
Cdd:PTZ00111 523 SGKSSSSVGLTASIkFNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETA 602

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 484 ILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHI-----------------TY------- 539
Cdd:PTZ00111 603 ILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIakdfllphmtgsgndedTYdrsntmh 682

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 540 VHQHSRQPPAQFEPLDMKLMRRYIAMCRER-QPTVPDSLADYITAAYVEMRR------------EARASKD--------- 597
Cdd:PTZ00111 683 VEDESLRSEKDYNKNDLDMLRMYIKFSKLHcFPKLSDEAKKVITREYVKMRQgnfqtsnldeleHAQEDDDddlyyqssg 762

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*
gi 148747275 598 --ATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMS 640
Cdd:PTZ00111 763 trMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
 10-103 2.92e-16

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 74.64  E-value: 2.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   10 KEKVKKFLQEFYYDDelgKKQFKYGTQLVHLAHREQVALYVDLDDVAEDDPELVDSICENAKRYSRLFADVVQELLPEYK 89
Cdd:pfam14551   1 KRKFKDFLEEFREDG---DGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELS 77

                          90
                  ....*....|....
gi 148747275   90 EKEVVNKDVLDVYI 103
Cdd:pfam14551  78 EDPDYAEEEKEFQV 91
 
Name Accession Description Interval E-value
MCM smart00350
minichromosome maintenance proteins;
145-641 0e+00

minichromosome maintenance proteins;


Pssm-ID: 214631 [Multi-domain]  Cd Length: 509  Bit Score: 718.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   145 KPRVIREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSggRLYLQT 224
Cdd:smart00350   1 KPSSIRELRADHLGKLVRISGIVTRTSGVRPKLKRASFTCEKCGATLGPEIQSGRETEPTVCPPRECQSPTP--FSLNHE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   225 RgSKFIKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLrTGFQQMAQGLLSE--TYLEAHR 302
Cdd:smart00350  79 R-STFIDFQKIKLQESPEEVPVGQLPRSVDVILDGDLVDKAKPGDRVEVTGIYRNVP-YGFKLNTVKGLPVfaTYIEANH 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   303 VVKMT---KSEDDVSGAGELSAEELKQIAE----EDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PQGMKIRGN 374
Cdd:smart00350 157 VRKLDykrSFEDSSFSVQSLSDEEEEEIRKlskdPDIYERLARSLAPSIYGHEDIKKAILLLLFGGVHKNlPDGMKIRGD 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   375 IHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEAD 454
Cdd:smart00350 237 INILLCGDPGTAKSQLLKYVEKTAPRAVYTTGKGSSAVGLTAAVTRDPETREFTLEAGALVLADNGVCCIDEFDKMDDSD 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   455 RTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLA 534
Cdd:smart00350 317 RTAIHEAMEQQTISIAKAGITTTLNARCSVLAAANPIGGRYDPKLTPEENIDLPAPILSRFDLLFVVLDEVDEERDRELA 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   535 QHITYVHQHSR-QPPAQFE-PLDMKLMRRYIAMCRER-QPTVPDSLADYITAAYVEMRREARASKDAT--YTSARTLLAI 609
Cdd:smart00350 397 KHVVDLHRYSHpEEDEAFEpPLSQEKLRKYIAYAREKiKPKLSEEAADKLVKAYVDLRKEDSQTESRSsiPITVRQLESI 476

                          490       500       510
                   ....*....|....*....|....*....|..
gi 148747275   610 LRLSTALARLRMVDIVEKEDVNEAIRLMEMSK 641
Cdd:smart00350 477 IRLSEAHAKMRLSDVVEEADVEEAIRLLRESI 508
MCM7 cd17758
DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in ...
 335-640 0e+00

DNA replication licensing factor Mcm7; Mcm7 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350664 [Multi-domain]  Cd Length: 306  Bit Score: 605.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 335 KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGL 414
Cdd:cd17758    1 KLAASIAPEIYGHEDVKKALLLLLVGGVDKRGDGMKIRGDINICLMGDPGVAKSQLLKYICRIAPRSVYTTGRGSSGVGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 415 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGR 494
Cdd:cd17758   81 TAAVMKDPVTGEMTLEGGALVLADQGICCIDEFDKMDESDRTAIHEVMEQQTISIAKAGITTTLNARTSILAAANPAYGR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 495 YNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMKLMRRYIAMCRERQPTVP 574
Cdd:cd17758  161 YNPRRSPEQNINLPAALLSRFDLLFLILDKPDRDNDLRLAEHVTYVHQHNKQPDSDFEPLDPKLLRAYIALAKRKRPTVP 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148747275 575 DSLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMS 640
Cdd:cd17758  241 PALADYIVQAYVEMRQEAKRSKDFTFTTPRTLLAILRLSQALARLRLSDSVEIDDVEEALRLMEMS 306
Mcm2 COG1241
DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and ...
 10-638 0e+00

DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair];


Pssm-ID: 440854 [Multi-domain]  Cd Length: 682  Bit Score: 547.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  10 KEKVKKFLQEFYYDDELGKKQFKYgtqlvhlahREQVALYVDLDDVAEDDPELVDSICENAKRYSRLFADVVQELLPEyk 89
Cdd:COG1241    6 VDKFEEFLRRYKYRDEILELAQEY---------PEKRSLVVDYNDLYSFDPDLADDLLENPDEVLEAAEEALREIDLE-- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  90 ekeVVNKDVLDVYIehrlmmeqrsRdpgaVRNPQNQYPselmrrfelyfqgpssskprvIREVRADSVGKLLTVRGIVTR 169
Cdd:COG1241   75 ---PYDVSLGDAHV----------R----ITNLPETVP---------------------IRDIRSDHIGKLISVEGIVRK 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 170 VSEVKPRMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQtnrsgGRLYLQTRGSKFIKFQEMKIQEHSDQVPVGNI 249
Cdd:COG1241  117 ATEVKPKITEAAFECPRCGTETYVPQTGEKLQEPHECPGCGRQ-----GPFKLLPEKSEFIDAQKIRIQEPPEDLPGGQQ 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 250 PRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAqgLLSETYLEAHRVVKMTKSEDDVsgagELSAEELKQIAE 329
Cdd:COG1241  192 PQSIDVILEDDLVGEVRPGDRVTVTGILRIEQRTSGRGKS--TIFDLYLEANSIEVEEKEFEEI----EITEEDEEKIKE 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 330 ----EDFYEKLAASIAPEIYGHEDVKKALLLllvggvdQ--------SPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRL 397
Cdd:COG1241  266 lskdPDIYEKIIASIAPSIYGYEEIKEAIAL-------QlfggvpkvLPDGSRIRGDIHILLVGDPGTAKSQLLRYAARL 338

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 398 APRSQYTTGRGSSGVGLTAAVLRDSVS-GELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILT 476
Cdd:COG1241  339 APRGVYTSGKGSTAAGLTAAAVRDDFGtGRWTLEAGALVLADGGLACIDELDKMREEDRSALHEAMEQQTISIAKAGIVA 418

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 477 TLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVH-------QHSRQPPA 549
Cdd:COG1241  419 TLNARCSVLAAANPKYGRFDPYEPIAEQIDLPPTLLSRFDLIFVLRDKPDEERDRELARHILKVHragelleQEIEEETE 498

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 550 QFEP-LDMKLMRRYIAMCRER-QPTVPDSLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEK 627
Cdd:COG1241  499 EVKPeIDPDLLRKYIAYARRNvFPVLTEEAKDLIEDFYVDMRKKGEDEDSPVPITARQLEALIRLAEASARMRLSDTVTE 578

                        650
                 ....*....|.
gi 148747275 628 EDVNEAIRLME 638
Cdd:COG1241  579 EDAERAIRLVD 589
minchrom_main_MCM NF040949
minichromosome maintenance protein MCM;
10-638 4.66e-177

minichromosome maintenance protein MCM;


Pssm-ID: 468880 [Multi-domain]  Cd Length: 681  Bit Score: 521.79  E-value: 4.66e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  10 KEKVKKFLQEFyyDDELGKkqFKYGTQLVHLAHREQVALYVDLDDVAEDDPELVDSICENAKRYSRLFADVVQELL---- 85
Cdd:NF040949   2 GEKFKEFIRTF--RDSFGN--EKYKERIFEMIAMRKRSLVVDFNDLYMFDPELADLLIEKPDEVLPAASKALKEIVeeed 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  86 PEYKEKEvvnkdvldvyiehrlmmeqrsrdpgavrnpqnqypselmRRFELYFQGPssskPRV--IREVRADSVGKLLTV 163
Cdd:NF040949  78 PEYAEEV---------------------------------------AKFHVRFRNL----PRTvpLRDLRSEYIGKLIAV 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 164 RGIVTRVSEVKPRMVVATYTCDQCGAETYQPiQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSKFIKFQEMKIQEHSDQ 243
Cdd:NF040949 115 EGIVTRTTPVKPRIVKAVFRCRDCGCEFEWP-EEEEESYEIVEPPTVCPVCGKPGSFRLLQEKSKFIDWQKIVVQERPEE 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 244 VPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPVLRTGFQQMAQGLLSeTYLEAHRVVKMTKSEDDVsgagELSAEE 323
Cdd:NF040949 194 LPPGQLPRSIEVVLEDDLVDTARPGDRVTVTGILRIKPDSSLKKGSRPIFK-NYIEANHIEVSQKELEEV----EITEED 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 324 LKQIAE----EDFYEKLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLA 398
Cdd:NF040949 269 EEKILElakdPWIREKIIASIAPSIYGHWEIKEAIALLLFGgVPKVLPDGTRIRGDIHVLIVGDPGTAKSQLLQYVARLA 348

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 399 PRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTL 478
Cdd:NF040949 349 PRAVYTSGKGSTAAGLTAAVVRDKLTGEYYLEAGALVLADGGVAVIDEIDKMREEDRSAIHEAMEQQTVSIAKAGIVATL 428

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 479 NARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSrqppAQFEP-LDMK 557
Cdd:NF040949 429 NARASVLAAGNPKFGRYDPNRSVAENIDLPPTILSRFDLIFVIRDKPNEERDRRLARHILDVHSGK----EKVKPeIDPD 504

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 558 LMRRYIAMCRER-QPTVPDSLADYITAAYVEMRREARASKD---ATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEA 633
Cdd:NF040949 505 LLKKYIAYARKYvRPKLTEEAKKLIEDFYVEMRKSSKSSEDpdsPIPITARQLEALIRLSEAHAKMRLKDEVTAEDAERA 584


                 ....*
gi 148747275 634 IRLME 638
Cdd:NF040949 585 IRLML 589
MCM cd17706
MCM helicase family; MCM helicases are a family of helicases that play an important role in ...
 335-640 7.46e-137

MCM helicase family; MCM helicases are a family of helicases that play an important role in replication and homologous recombination repair. The heterohexameric ring-shaped Mcm2-7 complex is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases. Mcm8 and Mcm9, form a complex required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350658 [Multi-domain]  Cd Length: 311  Bit Score: 404.80  E-value: 7.46e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 335 KLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 413
Cdd:cd17706    1 ILADSIAPSIYGHEDVKKAVLLQLFGGVQKIlEDGTRIRGDIHILLVGDPGTAKSQILKYVLKIAPRGVYTSGKGSSGAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 414 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 493
Cdd:cd17706   81 LTAAVVRDSETGEWYLEAGALVLADGGVCCIDEFDKMKELDRTALHEAMEQQTISIAKAGIVTTLNARCSILAAANPKGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 494 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHS-----RQPPAQFEPLDMKLMRRYIAMCRE 568
Cdd:cd17706  161 RYNPKLSPIENINLPSPLLSRFDLIFVIRDDPDEERDEELAEHIIDLHRGSdpeeqVKPEEDGIPIDIELLRKYILYARQ 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148747275 569 RQPTVPDSLADYITAAYVEMRREArASKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMS 640
Cdd:cd17706  241 IHPKISEEAREKLVRWYVELRKES-ERRSTIPITARQLESVIRLAEAHAKMRLSEVVTEEDVEEAIRLVRHS 311
MCM pfam00493
MCM P-loop domain;
322-541 1.64e-132

MCM P-loop domain;


Pssm-ID: 459830 [Multi-domain]  Cd Length: 224  Bit Score: 390.35  E-value: 1.64e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  322 EELKQIA-EEDFYEKLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAP 399
Cdd:pfam00493   3 EEIKELAkRPDIYDKLADSIAPSIYGHEDVKKAILLQLFGgVKKILPDGTRLRGDINVLLVGDPGTAKSQLLKYVEKIAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  400 RSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLN 479
Cdd:pfam00493  83 RAVYTSGKGSSAAGLTAAVVRDPVTGEFVLEAGALVLADGGVCCIDEFDKMNDEDRVALHEAMEQQTISIAKAGIVATLN 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148747275  480 ARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVH 541
Cdd:pfam00493 163 ARCSILAAANPIFGRYDPKKSIAENINLPPPLLSRFDLIFVLLDKPDEEKDERLAKHIVDLH 224
MCM4 cd17755
DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in ...
 335-637 4.79e-121

DNA replication licensing factor Mcm4; Mcm4 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350661 [Multi-domain]  Cd Length: 309  Bit Score: 364.45  E-value: 4.79e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 335 KLAASIAPEIYGHEDVKKALLLLL--VGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGV 412
Cdd:cd17755    1 RLARSIAPSIYELEDVKKGILLQLfgGTRKDFTKTGGKYRGDINILLCGDPGTSKSQLLQYVHKISPRGVYTSGKGSSAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 413 GLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAY 492
Cdd:cd17755   81 GLTAYVTRDPDTKQLVLESGALVLSDGGICCIDEFDKMSDSTRSVLHEVMEQQTLSIAKAGIITTLNARTSILASANPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 493 GRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPAQFEPLDMKLMRRYIAMCRER-QP 571
Cdd:cd17755  161 SRYNPKLTVVENIDLPPTLLSRFDLIYLVLDKVDEKYDRRLAKHLVSLYLEDTPEHIQDEVLDVEVLTDYISYAREHiHP 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148747275 572 TVPDSLADYITAAYVEMRReARASKDATYTSA-RTLLAILRLSTALARLRMVDIVEKEDVNEAIRLM 637
Cdd:cd17755  241 KLSEEAAQELVQAYVDMRK-MGSDARKRITATpRQLESLIRLAEAHAKMRLSNVVEAEDVEEAVRLI 306
MCM5 cd17756
DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in ...
 335-640 5.70e-120

DNA replication licensing factor Mcm5; Mcm5 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350662 [Multi-domain]  Cd Length: 317  Bit Score: 361.70  E-value: 5.70e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 335 KLAASIAPEIYGHEDVKKALLLLLVGGVDQS-PQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 413
Cdd:cd17756    1 IISKSIAPSIYGNEDIKKAIACLLFGGSRKRlPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIGVYTSGKGSSAAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 414 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 493
Cdd:cd17756   81 LTASVMRDPSTREFYLEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRTSVLAAANPVFG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 494 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSR--QPPAQFEP-LDMKLMRRYIAMCRER- 569
Cdd:cd17756  161 RYDDLKTPGDNIDFQTTILSRFDMIFIVKDKHDEERDITIAKHVINIHASARkaSQSQENEGeIPISKLKRYIAYCRAKc 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148747275 570 QPTVPDSLADYITAAYVEMRREARASKDATYTSA------RTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMS 640
Cdd:cd17756  241 APRLSEEAAEKLSNHYVTIRKDVRQNELESDNRSsipitvRQLEAIIRISESLAKMELSPIATEKHVEEAIRLFQVS 317
MCM_arch cd17761
archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the ...
 334-637 4.30e-119

archaeal MCM protein; archaeal MCM proteins form a homohexameric ring homologous to the eukaryotic Mcm2-7 helicase and also function as the replicative helicase at the replication fork


Pssm-ID: 350667 [Multi-domain]  Cd Length: 308  Bit Score: 359.07  E-value: 4.30e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 334 EKLAASIAPEIYGHEDVKKALLLLL-VGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGV 412
Cdd:cd17761    1 EKIISSIAPSIYGHEDVKEAIALQLfGGVPKVLPDGTRIRGDIHILLVGDPGTAKSQLLKYVSKVAPRAVYTTGKGSTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 413 GLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAY 492
Cdd:cd17761   81 GLTAAVVRDEGTGEWYLEAGALVLADKGIAVVDEIDKMRKEDRSALHEAMEQQTISIAKAGIVATLNARAAVLAAANPKF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 493 GRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRqpPAQFEP-LDMKLMRRYIAMCRER-Q 570
Cdd:cd17761  161 GRFDSYRPVAEQIDLPPTLLSRFDLIFVLKDTPNEEKDRRLANHILDTHSGGE--MREIKPeIDPDLLRKYIAYARKNvR 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148747275 571 PTVPDSLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLM 637
Cdd:cd17761  239 PVLTEEAKQLIKDFYVEMRKSGQETPSPVPITARQLEALVRLSEASARMRLSQEVTLEDAERAIRIM 305
MCM6 cd17757
DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in ...
 335-640 4.33e-116

DNA replication licensing factor Mcm6; Mcm6 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350663 [Multi-domain]  Cd Length: 307  Bit Score: 351.29  E-value: 4.33e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 335 KLAASIAPEIYGHEDVKKALLLLLVG-GVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 413
Cdd:cd17757    1 NLVRSIAPSIYGHEEVKKGILLMLLGgVHKITREGISLRGDINVCIVGDPSTAKSQFLKYVEEFSPRAVYTSGKASSAAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 414 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 493
Cdd:cd17757   81 LTAAVVRDEETGDFVIEAGALMLADNGICCIDEFDKMDIKDQVAIHEAMEQQTISITKAGIQATLNARTSILAAANPVGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 494 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHItyVHQHSRQPPAQFEPLDMKLMRRYIAMCRERQPTV 573
Cdd:cd17757  161 RYDRSKSLKQNINISAPIMSRFDLFFVLLDECNEVTDYAIASHI--VDLHSKREEAIEPPFTAEQLKRYIAYARTFKPKL 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148747275 574 PDSLADYITAAYVEMR-REARASKDATY-TSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMS 640
Cdd:cd17757  239 TKEAKDELVEQYKELRqDDASGSTRSSYrITVRQLESLIRLSEAIARLHCSDEVTPEHVEEAARLLKKS 307
MCM2 cd17753
DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in ...
 335-637 1.62e-114

DNA replication licensing factor Mcm2; Mcm2 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350659 [Multi-domain]  Cd Length: 325  Bit Score: 347.90  E-value: 1.62e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 335 KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPQGM-KIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVG 413
Cdd:cd17753    1 RIINSIAPSIYGHDDIKTAIALALFGGVAKNPGGKhRIRGDINVLLLGDPGTAKSQFLKYVEKTAHRAVFTTGQGASAVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 414 LTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYG 493
Cdd:cd17753   81 LTASVRKDPVTKEWTLEGGALVLADKGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 494 RYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHItyVHQHSRQPPA--------------------QFEP 553
Cdd:cd17753  161 RYNPTLTFAQNVNLTEPILSRFDILCVVRDTVDPEEDERLAKFV--VGSHVRSHPEndedregeeeknqrqrpketKVEP 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 554 LDMKLMRRYIAMCRER-QPTVPDSLADYITAAYVEMRREARASKDATYTsARTLLAILRLSTALARLRMVDIVEKEDVNE 632
Cdd:cd17753  239 IPQELLRKYIHYAREKvRPKLNQMDMDKVSRVYADLRKESMATGSLPIT-VRHLESIIRISEAHAKMHLREYVSEEDVDM 317


                 ....*
gi 148747275 633 AIRLM 637
Cdd:cd17753  318 AIRVM 322
MCM3 cd17754
DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in ...
 336-637 3.28e-113

DNA replication licensing factor Mcm3; Mcm3 is a helicase that play an important role in replication. It is part of the heterohexameric ring-shaped Mcm2-7 complex, which is part of the replicative helicase that unwinds parental double-stranded DNA at a replication fork to provide single-stranded DNA templates for the replicative polymerases.


Pssm-ID: 350660 [Multi-domain]  Cd Length: 299  Bit Score: 343.68  E-value: 3.28e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 336 LAASIAPEIYGHEDVKKALLLLLVGGVDQS-PQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGL 414
Cdd:cd17754    2 LSKSLAPSIYGHEYIKKAILLMLLGGVEKNlENGSHLRGDINILLVGDPSVAKSQLLRYVLNTAPLAIATTGRGSSGVGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 415 TAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGR 494
Cdd:cd17754   82 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHASLNARCSVLAAANPVYGR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 495 YNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHsrqppaqfepldMKLMRRYIAMCRER-QPTV 573
Cdd:cd17754  162 YDVYKTPMENIGLPDSLLSRFDLLFIVLDDIDEERDRSISEHVLRMHRY------------IKFLRKYIHYAKERiKPKL 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148747275 574 PDSLADYITAAYVEMRREARASKDATYTS---ARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLM 637
Cdd:cd17754  230 TQEAAEYIAEEYADLRNDDNTKTDKARTSpitARTLETLIRLATAHAKARLSKTVDKVDAEVALNLL 296
MCM9 cd17760
DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a ...
 336-640 1.74e-83

DNA helicase Mcm9; Mcm9 plays an important role homologous recombination repair. It forms a complex with Mcm8 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350666 [Multi-domain]  Cd Length: 299  Bit Score: 266.33  E-value: 1.74e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 336 LAASIAPEIYGHEDVKKALLLLLV---GGVDQSpqGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGV 412
Cdd:cd17760    2 ILASLCPQVFGLYNVKLAVAMVLAggvQRIDAS--GTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTAGIGSTSA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 413 GLTAAVLRDSvsGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAy 492
Cdd:cd17760   80 GLTVTAVKDG--GEWNLEAGALVLADGGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPK- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 493 GRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITyvhqHSRQPPAQFEPL-DMKLMRRYIAMCRERQP 571
Cdd:cd17760  157 GQYDPNESISVNIALASPLLSRFDLVLVLLDTKNEDWDRIISSFIL----ENKGEPSKSSKLwSMEKMRTYFCLIKNLRP 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148747275 572 TVPDSlADYITAAYVEMRREArASKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMS 640
Cdd:cd17760  233 VLSDE-ANAILLRYYQLQRQS-DCRNAARTTIRMLESLIRLAEAHARLMFRETVTEEDAITVVSVMESS 299
PTZ00111 PTZ00111
DNA replication licensing factor MCM4; Provisional
 137-640 3.35e-83

DNA replication licensing factor MCM4; Provisional


Pssm-ID: 173403 [Multi-domain]  Cd Length: 915  Bit Score: 282.65  E-value: 3.35e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 137 YFQGPSSSKPRVIREVRADSvgkLLTVRGIVTRVSEVKPRMVVATYTC---DQCGAETYQPIQSPTFMPLIMCPSQE--- 210
Cdd:PTZ00111 209 LMNKPVSDCVGNLEPSMADS---LVQFSGTVVRQTWIVPEITMACFRCrgqKKIGLNDYQPCTCEHYEYVIQGEVNEpll 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 211 CQTNRSGGRLYLQTRGSKFIKFQEMKIQEHSDQVPVGNIP--------------------RSITVVLEGENTRIAQPGDH 270
Cdd:PTZ00111 286 CNECNSKYTFELNHNMCVYSTKKIVKLLQSNSSLNNPDKDgldnsvdnsglngeiymkdnEVINLNLYDDLIDSVKTGDR 365

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 271 VSVTGIF--LPVlRTGFQQMAQGLLSETYLEA-HrvVKMTKSEDD---------VSGAGELSAEELKQIAE----EDFYE 334
Cdd:PTZ00111 366 VTVVGILkvTPI-RTSTTRRTLKSLYTYFVNViH--VKVINSTNAnqpekglkyLGNENDFSDLQVYKILElsrnPMIYR 442

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 335 KLAASIAPEIYGHEDVKK----------ALLLLLVGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYT 404
Cdd:PTZ00111 443 ILLDSFAPSIKARNNVKIgllcqlfsgnKNSSDFNKSPDACYKVDNFRGIINVLLCGDPGTAKSQLLHYTHLLSPRSIYT 522

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 405 TGRGSSGVGLTAAV-LRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCS 483
Cdd:PTZ00111 523 SGKSSSSVGLTASIkFNESDNGRAMIQPGAVVLANGGVCCIDELDKCHNESRLSLYEVMEQQTVTIAKAGIVATLKAETA 602

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 484 ILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHI-----------------TY------- 539
Cdd:PTZ00111 603 ILASCNPINSRYNKNKAVIENINISPSLFTRFDLIYLVLDHIDQDTDQLISLSIakdfllphmtgsgndedTYdrsntmh 682

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 540 VHQHSRQPPAQFEPLDMKLMRRYIAMCRER-QPTVPDSLADYITAAYVEMRR------------EARASKD--------- 597
Cdd:PTZ00111 683 VEDESLRSEKDYNKNDLDMLRMYIKFSKLHcFPKLSDEAKKVITREYVKMRQgnfqtsnldeleHAQEDDDddlyyqssg 762

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|....*
gi 148747275 598 --ATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMS 640
Cdd:PTZ00111 763 trMIYVSSRMISSIIRISVSLARMRLSTVVTPADALQAVQIVKSS 807
MCM8 cd17759
DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a ...
 336-640 4.38e-73

DNA helicase Mcm8; Mcm8 plays an important role homologous recombination repair. It forms a complex with Mcm9 that is required for homologous recombination (HR) repair induced by DNA interstrand crosslinks (ICLs).


Pssm-ID: 350665 [Multi-domain]  Cd Length: 289  Bit Score: 238.59  E-value: 4.38e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 336 LAASIAPEIYGHEDVKKALLLLL---VGGVDQSPQGMKIRGNIHICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGV 412
Cdd:cd17759    2 IVNSLCPAIYGHELVKAGLLLSLfggKQKYADDKNRIPIRGDPHVLIVGDPGLGKSQMLQAACNIAPRGVYVCGNTTTTS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 413 GLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEaDRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAY 492
Cdd:cd17759   82 GLTVTLTKDGRSGDFALEAGALVLGDQGICGIDEFDKMGS-QHQALLEAMEQQSVSLAKAGVVCSLPARTSVIAAANPVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 493 GRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHityvhqhsrqppaqfepldMKLMRRYIAMCR-ERQP 571
Cdd:cd17759  161 GHYNKGKTVSENLKMGPALLSRFDLVFILLDTPSEEHDHLLSEH-------------------HQLLRKYISYARqYVNP 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148747275 572 TVPDSLADYITAAYVEMRREARaSKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRLMEMS 640
Cdd:cd17759  222 VLSKDASEALQEFYLELRKQNQ-LADSSPITTRQLESLIRLTEARARLELREEATKEDAEDVIEIMKES 289
MCM_OB pfam17207
MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains ...
 149-280 7.62e-52

MCM OB domain; This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif.


Pssm-ID: 465381 [Multi-domain]  Cd Length: 126  Bit Score: 175.75  E-value: 7.62e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  149 IREVRADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQCGAETYQPIQSPTfmpliMCPSQECQtnrSGGRLYLQTRGSK 228
Cdd:pfam17207   2 IRDLRSEHIGKLVSVSGIVTRTSEVRPKLKKATFTCRKCGHTVGVKITEPT-----KCPNPECG---NKDPFKLVHEKSK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148747275  229 FIKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVSVTGIFLPV 280
Cdd:pfam17207  74 FVDFQKIKIQESPEEVPAGELPRSLDVILDDDLVDRVKPGDRVTVTGIYRVV 125
MCM_lid pfam17855
MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.
 558-641 4.42e-27

MCM AAA-lid domain; This entry represents the AAA-lid domain found in MCM proteins.


Pssm-ID: 465534 [Multi-domain]  Cd Length: 86  Bit Score: 104.93  E-value: 4.42e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  558 LMRRYIAMCRER-QPTVPDSLADYITAAYVEMRREARASKDATYTSARTLLAILRLSTALARLRMVDIVEKEDVNEAIRL 636
Cdd:pfam17855   2 LLRKYIAYAREKiKPKLSEEAREKLVDAYVELRKESTGSGSSIPITVRQLESLIRLSEAHAKMRLSEIVTEEDVEEAIRL 81


                  ....*
gi 148747275  637 MEMSK 641
Cdd:pfam17855  82 LKESL 86
MCM_N pfam14551
MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.
 10-103 2.92e-16

MCM N-terminal domain; This family contains the N-terminal domain of MCM proteins.


Pssm-ID: 464206 [Multi-domain]  Cd Length: 95  Bit Score: 74.64  E-value: 2.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275   10 KEKVKKFLQEFYYDDelgKKQFKYGTQLVHLAHREQVALYVDLDDVAEDDPELVDSICENAKRYSRLFADVVQELLPEYK 89
Cdd:pfam14551   1 KRKFKDFLEEFREDG---DGEFKYRDQLREMIEREQRSLEVDLDDLREFDPDLAEALLENPYEYLPLFEEALKEVVKELS 77

                          90
                  ....*....|....
gi 148747275   90 EKEVVNKDVLDVYI 103
Cdd:pfam14551  78 EDPDYAEEEKEFQV 91
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 376-515 3.61e-06

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 46.90  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275  376 HICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSgvGLTAAVLRDSVS---GELTLEGGALVLADQ--GVCCIDEFDKm 450
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNRPVFYVQLTR--DTTEEDLFGRRNidpGGASWVDGPLVRAARegEIAVLDEINR- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148747275  451 AEADRTAI-HEVMEQQTISIAKAGILTTLNARC-SILAAANPAYGRYNPrrsleqniqLPAALLSRF 515
Cdd:pfam07728  78 ANPDVLNSlLSLLDERRLLLPDGGELVKAAPDGfRLIATMNPLDRGLNE---------LSPALRSRF 135
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 376-630 3.69e-06

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 49.40  E-value: 3.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 376 HICLMGDPGVAKSQL---------LSYIdrlapRSQYTTG-RGSSGVGLTAAVLRDsvsGELTLEGGALVladQGVCCID 445
Cdd:COG0714   33 HLLLEGVPGVGKTTLakalaralgLPFI-----RIQFTPDlLPSDILGTYIYDQQT---GEFEFRPGPLF---ANVLLAD 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 446 EFDKmaeAD-RT--AIHEVMEQQTISIAKAGIltTLNARCSILAAANP--AYGRYnprrsleqniQLPAALLSRFDL-LW 519
Cdd:COG0714  102 EINR---APpKTqsALLEAMEERQVTIPGGTY--KLPEPFLVIATQNPieQEGTY----------PLPEAQLDRFLLkLY 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148747275 520 LiqDRPDRDNDLRLaqhityVHQHSRQPPAQFEPLdmkLMRRYIAMCRE--RQPTVPDSLADYITAAYVEMRREARASKD 597
Cdd:COG0714  167 I--GYPDAEEEREI------LRRHTGRHLAEVEPV---LSPEELLALQElvRQVHVSEAVLDYIVDLVRATREHPDLRKG 235

                        250       260       270
                 ....*....|....*....|....*....|...
gi 148747275 598 AtytSARTLLAILRLSTALARLRMVDIVEKEDV 630
Cdd:COG0714  236 P---SPRASIALLRAARALALLDGRDYVTPDDV 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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