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Conserved domains on  [gi|115430099|ref|NP_000540|]
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thyrotropin subunit beta isoform 1 precursor [Homo sapiens]

Protein Classification

GHB_like domain-containing protein( domain architecture ID 11251631)

GHB_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 18-126 1.15e-48

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


:

Pssm-ID: 214502  Cd Length: 107  Bit Score: 151.67  E-value: 1.15e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430099    18 AMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPkyALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSY 97
Cdd:smart00068   1 LRPGCRPTNATIAVEKEECPVCITINTTICAGYCYTRDPVYKSPLP--PLPQRVCTYRELRYETVRLPGCPPGVDPVVTY 78

                           90       100
                   ....*....|....*....|....*....
gi 115430099    98 PVALSCKCGKCNTDYSDCIHEAIKTNYCT 126
Cdd:smart00068  79 PVALSCHCGKCNTDTTDCTVESLGPDSCS 107
 
Name Accession Description Interval E-value
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 18-126 1.15e-48

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


Pssm-ID: 214502  Cd Length: 107  Bit Score: 151.67  E-value: 1.15e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430099    18 AMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPkyALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSY 97
Cdd:smart00068   1 LRPGCRPTNATIAVEKEECPVCITINTTICAGYCYTRDPVYKSPLP--PLPQRVCTYRELRYETVRLPGCPPGVDPVVTY 78

                           90       100
                   ....*....|....*....|....*....
gi 115430099    98 PVALSCKCGKCNTDYSDCIHEAIKTNYCT 126
Cdd:smart00068  79 PVALSCHCGKCNTDTTDCTVESLGPDSCS 107
GHB_like cd00069
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 22-118 5.44e-43

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


Pssm-ID: 200450  Cd Length: 96  Bit Score: 137.03  E-value: 5.44e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430099  22 CIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKyALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVAL 101
Cdd:cd00069    1 CHPRNYTIAVEKEGCGVCLAINTTICAGRCDTRDPVYKSPPYK-PSHQPVCTYDEWRYETVRLPGCPPGVDPTYTYPVAL 79

                         90
                 ....*....|....*..
gi 115430099 102 SCKCGKCNTDYSDCIHE 118
Cdd:cd00069   80 SCRCGLCNTDTTDCTRL 96
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 19-125 1.60e-41

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 133.30  E-value: 1.60e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430099   19 MSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDinGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYP 98
Cdd:pfam00007   1 RKKCIPTNYTISVEKEGCTSCKTINTTICAGYCYTRD--PVYKDGRRAVSQRVCTYRDVTYETVVLPGCPPGVDPTVTYP 78

                          90       100
                  ....*....|....*....|....*..
gi 115430099   99 VALSCKCGKCNTDYSDCIHEAIKTNYC 125
Cdd:pfam00007  79 VALSCHCGNCPTDNSDCTRLSLQPDSC 105
 
Name Accession Description Interval E-value
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 18-126 1.15e-48

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


Pssm-ID: 214502  Cd Length: 107  Bit Score: 151.67  E-value: 1.15e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430099    18 AMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPkyALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSY 97
Cdd:smart00068   1 LRPGCRPTNATIAVEKEECPVCITINTTICAGYCYTRDPVYKSPLP--PLPQRVCTYRELRYETVRLPGCPPGVDPVVTY 78

                           90       100
                   ....*....|....*....|....*....
gi 115430099    98 PVALSCKCGKCNTDYSDCIHEAIKTNYCT 126
Cdd:smart00068  79 PVALSCHCGKCNTDTTDCTVESLGPDSCS 107
GHB_like cd00069
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 22-118 5.44e-43

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


Pssm-ID: 200450  Cd Length: 96  Bit Score: 137.03  E-value: 5.44e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430099  22 CIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKyALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVAL 101
Cdd:cd00069    1 CHPRNYTIAVEKEGCGVCLAINTTICAGRCDTRDPVYKSPPYK-PSHQPVCTYDEWRYETVRLPGCPPGVDPTYTYPVAL 79

                         90
                 ....*....|....*..
gi 115430099 102 SCKCGKCNTDYSDCIHE 118
Cdd:cd00069   80 SCRCGLCNTDTTDCTRL 96
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 19-125 1.60e-41

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 133.30  E-value: 1.60e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430099   19 MSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDinGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYP 98
Cdd:pfam00007   1 RKKCIPTNYTISVEKEGCTSCKTINTTICAGYCYTRD--PVYKDGRRAVSQRVCTYRDVTYETVVLPGCPPGVDPTVTYP 78

                          90       100
                  ....*....|....*....|....*..
gi 115430099   99 VALSCKCGKCNTDYSDCIHEAIKTNYC 125
Cdd:pfam00007  79 VALSCHCGNCPTDNSDCTRLSLQPDSC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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