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Conserved domains on  [gi|88758615|ref|NP_000410|]
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integrin alpha-IIb preproprotein [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192641)

integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 482-921 7.91e-179

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 528.43  E-value: 7.91e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    482 QPVVKASVQLLVQ-DSLNPAVKSCVLpqTKTPVSCFNIQMCVGATGHNIP-QKLSLNAELQLDRQ-KPRQGRRVLLLGSQ 558
Cdd:pfam08441    1 RPVVSVSASLQVEpNSINPEKKNCTL--TGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQkKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    559 QAGTTLNLDLGGKHSPICHTTMAFLRDEadFRDKLSPIVLSLNVSLPPTEA------GMAPAVVLHGDTHVQEQTRIVLD 632
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLRVDPRapsdlpGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    633 CGEDDVCVPQLQLTASVT----GSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNvEGFERLICNQK 708
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRRE-GSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    709 KENETRVVLCELGNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPA 788
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    789 SLV---VAAEEGEREQnSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPS-DLLYILDIQPQGGLQCFPQPPVN 864
Cdd:pfam08441  316 QVVggsVKGESAMKPR-SEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGkWLLYLLDVQGQGKGECSPQNEIN 394

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 88758615    865 PLKVDWGLPIPSPSPIHPAHHKRDRRQiflPEPEQPSRLQDPVLVSCDS-APCTVVQC 921
Cdd:pfam08441  395 PLNLTQSLESSKPLRTSRVHHVVKRRD---VLKSEKATQTASVLLSCDSgARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 384-438 4.30e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 64.70  E-value: 4.30e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 88758615     384 YGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGR-GQVLVFLGQSEGLRSRPSQVL 438
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 316-367 5.67e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.67e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 88758615     316 MASYFGHSVA-VTDVNGDGRHDLLVGAPLYMESradrklAEVGRVYLFLQPRG 367
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSG 47
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 445-485 3.53e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.84  E-value: 3.53e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 88758615     445 GSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVV 485
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVY 42
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 46-102 1.61e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.91  E-value: 1.61e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 88758615      46 NGSQFGFSLDFHKDSH--GRVAIVVGAPRtlGPSQEETGGVFLCPWRAEGGQCPSLLFD 102
Cdd:smart00191    1 PGSYFGYSVAGVGDVNgdGYPDLLVGAPR--ANDAGETGAVYVYFGSSGGGNSIPLQNL 57
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1020-1034 1.12e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


:

Pssm-ID: 459778  Cd Length: 15  Bit Score: 37.09  E-value: 1.12e-03
                           10
                   ....*....|....*
gi 88758615   1020 KVGFFKRNRPPLEED 1034
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 262-302 7.02e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.81  E-value: 7.02e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 88758615     262 FDGYWGYSVA-VGEFDGDlNTTEYVVGAPTWSWT--LGAVEILD 302
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGD-GYPDLLVGAPRANDAgeTGAVYVYF 43
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 482-921 7.91e-179

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 528.43  E-value: 7.91e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    482 QPVVKASVQLLVQ-DSLNPAVKSCVLpqTKTPVSCFNIQMCVGATGHNIP-QKLSLNAELQLDRQ-KPRQGRRVLLLGSQ 558
Cdd:pfam08441    1 RPVVSVSASLQVEpNSINPEKKNCTL--TGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQkKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    559 QAGTTLNLDLGGKHSPICHTTMAFLRDEadFRDKLSPIVLSLNVSLPPTEA------GMAPAVVLHGDTHVQEQTRIVLD 632
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLRVDPRapsdlpGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    633 CGEDDVCVPQLQLTASVT----GSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNvEGFERLICNQK 708
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRRE-GSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    709 KENETRVVLCELGNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPA 788
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    789 SLV---VAAEEGEREQnSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPS-DLLYILDIQPQGGLQCFPQPPVN 864
Cdd:pfam08441  316 QVVggsVKGESAMKPR-SEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGkWLLYLLDVQGQGKGECSPQNEIN 394

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 88758615    865 PLKVDWGLPIPSPSPIHPAHHKRDRRQiflPEPEQPSRLQDPVLVSCDS-APCTVVQC 921
Cdd:pfam08441  395 PLNLTQSLESSKPLRTSRVHHVVKRRD---VLKSEKATQTASVLLSCDSgARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 384-438 4.30e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 64.70  E-value: 4.30e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 88758615     384 YGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGR-GQVLVFLGQSEGLRSRPSQVL 438
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 316-367 5.67e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.67e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 88758615     316 MASYFGHSVA-VTDVNGDGRHDLLVGAPLYMESradrklAEVGRVYLFLQPRG 367
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSG 47
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 320-362 6.44e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.13  E-value: 6.44e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 88758615    320 FGHSVAVTDVNGDGRHDLLVGAPLYMESRAdrklaevGRVYLF 362
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGA-------GAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 387-423 1.19e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 88758615    387 FGSAIApLGDLDRDGYNDIAVAAPYGGPSGRGQVLVF 423
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 445-485 3.53e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.84  E-value: 3.53e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 88758615     445 GSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVV 485
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVY 42
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 46-102 1.61e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.91  E-value: 1.61e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 88758615      46 NGSQFGFSLDFHKDSH--GRVAIVVGAPRtlGPSQEETGGVFLCPWRAEGGQCPSLLFD 102
Cdd:smart00191    1 PGSYFGYSVAGVGDVNgdGYPDLLVGAPR--ANDAGETGAVYVYFGSSGGGNSIPLQNL 57
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1020-1034 1.12e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 37.09  E-value: 1.12e-03
                           10
                   ....*....|....*
gi 88758615   1020 KVGFFKRNRPPLEED 1034
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 448-479 5.09e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 35.56  E-value: 5.09e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 88758615    448 FGFSLrGAVDIDDNGYPDLIVGAYGANQV---AVY 479
Cdd:pfam01839    1 FGYSV-AVGDLNGDGYADLAVGAPGEGGAgagAVY 34
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 262-302 7.02e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.81  E-value: 7.02e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 88758615     262 FDGYWGYSVA-VGEFDGDlNTTEYVVGAPTWSWT--LGAVEILD 302
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGD-GYPDLLVGAPRANDAgeTGAVYVYF 43
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 482-921 7.91e-179

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 528.43  E-value: 7.91e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    482 QPVVKASVQLLVQ-DSLNPAVKSCVLpqTKTPVSCFNIQMCVGATGHNIP-QKLSLNAELQLDRQ-KPRQGRRVLLLGSQ 558
Cdd:pfam08441    1 RPVVSVSASLQVEpNSINPEKKNCTL--TGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQkKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    559 QAGTTLNLDLGGKHSPICHTTMAFLRDEadFRDKLSPIVLSLNVSLPPTEA------GMAPAVVLHGDTHVQEQTRIVLD 632
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLRVDPRapsdlpGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    633 CGEDDVCVPQLQLTASVT----GSPLLVGADNVLELQMDAANEGEGAYEAELAVHLPQGAHYMRALSNvEGFERLICNQK 708
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRRE-GSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    709 KENETRVVLCELGNPMKKNAQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPA 788
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    789 SLV---VAAEEGEREQnSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPS-DLLYILDIQPQGGLQCFPQPPVN 864
Cdd:pfam08441  316 QVVggsVKGESAMKPR-SEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGkWLLYLLDVQGQGKGECSPQNEIN 394

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 88758615    865 PLKVDWGLPIPSPSPIHPAHHKRDRRQiflPEPEQPSRLQDPVLVSCDS-APCTVVQC 921
Cdd:pfam08441  395 PLNLTQSLESSKPLRTSRVHHVVKRRD---VLKSEKATQTASVLLSCDSgARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 384-438 4.30e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 64.70  E-value: 4.30e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 88758615     384 YGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGR-GQVLVFLGQSEGLRSRPSQVL 438
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 316-367 5.67e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.67e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 88758615     316 MASYFGHSVA-VTDVNGDGRHDLLVGAPLYMESradrklAEVGRVYLFLQPRG 367
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSG 47
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 320-362 6.44e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.13  E-value: 6.44e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 88758615    320 FGHSVAVTDVNGDGRHDLLVGAPLYMESRAdrklaevGRVYLF 362
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGA-------GAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 387-423 1.19e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 88758615    387 FGSAIApLGDLDRDGYNDIAVAAPYGGPSGRGQVLVF 423
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 445-485 3.53e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.84  E-value: 3.53e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 88758615     445 GSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVV 485
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVY 42
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 46-102 1.61e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.91  E-value: 1.61e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 88758615      46 NGSQFGFSLDFHKDSH--GRVAIVVGAPRtlGPSQEETGGVFLCPWRAEGGQCPSLLFD 102
Cdd:smart00191    1 PGSYFGYSVAGVGDVNgdGYPDLLVGAPR--ANDAGETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 396-468 4.58e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 44.91  E-value: 4.58e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 88758615    396 DLDRDGYNDIAVAapyggpsGRGQVLVFLGQSEGLRSRPSQVLdspfPTGSAFGFSLRgAVDIDDNGYPDLIV 468
Cdd:pfam13517    1 DLDGDGKLDLVVA-------NDGGLRLYLNNGDGTFTFITSVS----LGGGGGGLSVA-VGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 328-407 3.46e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.60  E-value: 3.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88758615    328 DVNGDGRHDLLVGAPlymesradrklaevGRVYLFLQprgphaLGAPSLLLTGTQLYGRFGSAIAP-LGDLDRDGYNDIA 406
Cdd:pfam13517    1 DLDGDGKLDLVVAND--------------GGLRLYLN------NGDGTFTFITSVSLGGGGGGLSVaVGDLDGDGRLDLL 60


                   .
gi 88758615    407 V 407
Cdd:pfam13517   61 V 61
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1020-1034 1.12e-03

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 37.09  E-value: 1.12e-03
                           10
                   ....*....|....*
gi 88758615   1020 KVGFFKRNRPPLEED 1034
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 448-479 5.09e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 35.56  E-value: 5.09e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 88758615    448 FGFSLrGAVDIDDNGYPDLIVGAYGANQV---AVY 479
Cdd:pfam01839    1 FGYSV-AVGDLNGDGYADLAVGAPGEGGAgagAVY 34
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 262-302 7.02e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.81  E-value: 7.02e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 88758615     262 FDGYWGYSVA-VGEFDGDlNTTEYVVGAPTWSWT--LGAVEILD 302
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGD-GYPDLLVGAPRANDAgeTGAVYVYF 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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