|
Name |
Accession |
Description |
Interval |
E-value |
| PBP1_ABC_LIVBP-like |
cd06342 |
type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active ... |
31-367 |
1.88e-148 |
|
type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); This subgroup includes the type 1 periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine). This subgroup also includes a leucine-specific binding protein (or LivK), which is very similar in sequence and structure to leucine-isoleucine-valine binding protein (LIVBP). ABC-type active transport systems are transmembrane proteins that function in the transport of diverse sets of substrates across extra- and intracellular membranes, including carbohydrates, amino acids, inorganic ions, dipeptides and oligopeptides, metabolic products, lipids and sterols, and heme, to name a few.
Pssm-ID: 380565 [Multi-domain] Cd Length: 334 Bit Score: 423.09 E-value: 1.88e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlviGGKKVTLQLDAQDDAGDPRTATQVAQRLVDDKVIGVVGHHNSG 110
Cdd:cd06342 1 KIGVAGPLTGPNAALGQDIRNGAELAVDEINAKG---GGLGFKIELVAQDDACDPAQAVAAAQKLVADGVVAVIGHYNSG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 111 TSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEFEK 190
Cdd:cd06342 78 AAIAAAPIYAEAGIPMISPSATNPKLTEQGYKNFFRVVGTDDQQGPAAADYAAKTLKAKRVAVIHDGTAYGKGLADAFKK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 191 AAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLAGPA 270
Cdd:cd06342 158 ALKALGGTVVGREGITPGTTDFSALLTKIKAANPDAVYFGGYYPEAGLLLRQLREAGLKAPFMGGDGIVSPDFIKAAGDA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 271 SDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPATDYRGVIGETS 350
Cdd:cd06342 238 AEGVYATTPGAPPEKLPAAKAFLKAYKAKFGEPPGAYAAYAYDAAQVLLAAIEKAGSTDRAAVAAALRATDFDGVTGTIS 317
|
330
....*....|....*..
gi 979337434 351 FTSQGDLKHGAISVFTY 367
Cdd:cd06342 318 FDAKGDLTGPAFTVYQV 334
|
|
| PBP1_ABC_LivK_ligand_binding-like |
cd06347 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-356 |
2.34e-93 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380570 [Multi-domain] Cd Length: 334 Bit Score: 282.89 E-value: 2.34e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKVtlQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHNS 109
Cdd:cd06347 1 KIGVIGPLTGEAAAYGQPALNGAELAVDEINAAG-GILGKKI--ELIVYDNKSDPTEAANAAQKLIDeDKVVAIIGPVTS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGfKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVV-DDSTAYGQGLATEF 188
Cdd:cd06347 78 SIALAAAPIAQKAKIPMITPSATNPLVTKGG-DYIFRACFTDPFQGAALAKFAYEELGAKKAAVLyDVSSDYSKGLAKAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 189 EKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLAG 268
Cdd:cd06347 157 KEAFEKLGGEIVAEETYTSGDTDFSAQLTKIKAANPDVIFLPGYYEEAALIIKQARELGITAPILGGDGWDSPELLELGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 269 PASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPAT-DYRGVIG 347
Cdd:cd06347 237 DAVEGVYFTTHFSPDDPSPEVQEFVKAYKAKYGEPPNAFAALGYDAVMLLADAIKRAGSTDPEAIRDALAKTkDFEGVTG 316
|
....*....
gi 979337434 348 ETSFTSQGD 356
Cdd:cd06347 317 TITFDPNGN 325
|
|
| LivK |
COG0683 |
ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid ... |
27-372 |
2.36e-90 |
|
ABC-type branched-chain amino acid transport system, periplasmic component [Amino acid transport and metabolism];
Pssm-ID: 440447 [Multi-domain] Cd Length: 314 Bit Score: 274.50 E-value: 2.36e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 27 DEIVRIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLvIGGKKVtlQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVG 105
Cdd:COG0683 1 ADPIKIGVLLPLTGPYAALGQPIKNGAELAVEEINAAGG-VLGRKI--ELVVEDDASDPDTAVAAARKLIDqDKVDAIVG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 106 HHNSGTSIPASRVYRDGGVVQISQAATNPTYTQQ-GFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGL 184
Cdd:COG0683 78 PLSSGVALAVAPVAEEAGVPLISPSATAPALTGPeCSPYVFRTAPSDAQQAEALADYLAKKLGAKKVALLYDDYAYGQGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 185 ATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKIlagdgvcstdlp 264
Cdd:COG0683 158 AAAFKAALKAAGGEVVGEEYYPPGTTDFSAQLTKIKAAGPDAVFLAGYGGDAALFIKQAREAGLKGPL------------ 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 265 klagpasdnvvcseagialekmpgGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPATDYRG 344
Cdd:COG0683 226 ------------------------NKAFVKAYKAKYGREPSSYAAAGYDAALLLAEAIEKAGSTDREAVRDALEGLKFDG 281
|
330 340
....*....|....*....|....*...
gi 979337434 345 VIGETSFTSQGDLKHgAISVFTYKSGKK 372
Cdd:COG0683 282 VTGPITFDPDGQGVQ-PVYIVQVKADGK 308
|
|
| PBP1_ABC_HAAT-like |
cd06349 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-356 |
9.00e-84 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380572 [Multi-domain] Cd Length: 338 Bit Score: 258.27 E-value: 9.00e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLVIGGKkvtLQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd06349 1 KIGVSGPLTGDNAEYGQQFKNGVELAVDEINAAGGVNGRK---LELVVYDDQGDPKEAVNIAQKFVsDDKVVAVIGDFSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQqGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEFE 189
Cdd:cd06349 78 SCSMAAAPIYEEAGLVQISPTASHPDFTK-GGDYVFRNSPTQAVEAPFLADYAVKKLGAKKIAIIYLNTDWGVSAADAFK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 190 KAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLAGP 269
Cdd:cd06349 157 KAAKALGGEIVATEAYLPGTKDFSAQITKIKNANPDAIYLAAYYNDAALIAKQARQLGWDVQIFGSSSLYSPEFIELAGD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 270 ASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPATDYRGVIGET 349
Cdd:cd06349 237 AAEGVYLSSPFFPESPDPEVKEFVKAYKAKYGEDPDDFAARAYDAVNILAEAIEKAGTDREAIRDALANIKDFSGLTGTI 316
|
....*..
gi 979337434 350 SFTSQGD 356
Cdd:cd06349 317 TFDENGD 323
|
|
| PBP1_ABC_ligand_binding-like |
cd19980 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-356 |
1.69e-82 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380635 [Multi-domain] Cd Length: 334 Bit Score: 254.84 E-value: 1.69e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKVtlQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd19980 1 KIGVIAPLSGPVAALGQQVLNGAKLAVEEINAKG-GVLGRKL--ELVVEDDKCPPAEGVAAAKKLItDDKVPAIIGAWCS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEFE 189
Cdd:cd19980 78 SVTLAVMPVAERAKVPLVVEISSAPKITEGGNPYVFRLNPTNSMLAKAFAKYLADKGKPKKVAFLAENDDYGRGAAEAFK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 190 KAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLAGP 269
Cdd:cd19980 158 KALKAKGVKVVATEYFDQGQTDFTTQLTKLKAANPDAIFVVAETEDGALILKQARELGLKQQLVGTGGTTSPDLIKLAGD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 270 ASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVL-AAMPATDYRGVIGE 348
Cdd:cd19980 238 AAEGVYGASIYAPTADNPANKAFVAAYKKKYGEPPDKFAALGYDAVMVIAEAIKKAGSTDPEKIRaAALKKVDYKGPGGT 317
|
....*...
gi 979337434 349 TSFTSQGD 356
Cdd:cd19980 318 IKFDEKGQ 325
|
|
| PBP1_ABC_HAAT-like |
cd06344 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
51-362 |
5.79e-81 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380567 [Multi-domain] Cd Length: 332 Bit Score: 250.99 E-value: 5.79e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 51 NGARLAVEEINAKGLViGGKKVTLQLdaQDDAGDPRTATQVAQRLVDDK-VIGVVGHHNSGTSIPASRVYRDGGVVQISQ 129
Cdd:cd06344 19 EGVELAVEEINAAGGV-LGRKIRLVE--YDDEASVDKGLAIAQRFADNPdVVAVIGHRSSYVAIPASIIYERAGLLMLSP 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 130 AATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNmGIRTVAVVDDSTAYGQGLATEFEKAAKAAGMKVVSRDATNDKA 209
Cdd:cd06344 96 GATAPKLTQHGFKYIFRNIPSDEDIARQLARYAARQ-GYKRIVIYYDDDSYGKGLANAFEEEARELGITIVDRRSYSSDE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 210 IDFRAILTKIKGTNP-DAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLAGPASDNVVCSEAGIALEKMPG 288
Cdd:cd06344 175 EDFRRLLSKWKALDFfDAIFLAGSMPEGAEFIKQARELGIKVPIIGGDGLDSPELIEIAGKAAEGVVVATVFDPDDPRPE 254
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 979337434 289 GAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPAT-DYRGVIGETSFTSQGDLKHGAI 362
Cdd:cd06344 255 VRAFVEAFRKKYGREPDVWAAQGYDAVKLLAEAIEKAGSTVPAKIASALRFLeNWEGVTGTYSFDANGDVVGKAI 329
|
|
| PBP1_ABC_transporter_LIVBP-like |
cd06268 |
periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the ... |
31-324 |
7.42e-79 |
|
periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily; Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. They are mostly present in archaea and eubacteria, and are primarily involved in scavenging solutes from the environment. ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes, including amino acids, peptides, lipids and sterols, and various drugs. These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. These PBPs bind their substrates selectively and with high affinity. Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP), which are homologous to the aliphatic amidase transcriptional repressor, AmiC, of Pseudomonas aeruginosa. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.
Pssm-ID: 380492 [Multi-domain] Cd Length: 298 Bit Score: 244.54 E-value: 7.42e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLvIGGKKvtLQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd06268 1 KIGVVVPLTGPYADYGEEILRGVALAVEEINAAGG-INGRK--LELVIADDQGDPETAVAVARKLVdDDKVLAVVGHYSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEFE 189
Cdd:cd06268 78 SVTLAAAPIYQEAGIPLISPGSTAPELTEGGGPYVFRTVPSDAMQAAALADYLAKKLKGKKVAILYDDYDYGKSLADAFK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 190 KAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLAGP 269
Cdd:cd06268 158 KALKALGGEIVAEEDFPLGTTDFSAQLTKIKAAGPDVLFLAGYGADAANALKQARELGLKLPILGGDGLYSPELLKLGGE 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 979337434 270 ASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKR 324
Cdd:cd06268 238 AAEGVVVAVPWHPDSPDPPKQAFVKAYKKKYGGPPSWRAATAYDATQALAGDRVQ 292
|
|
| PRK15404 |
PRK15404 |
high-affinity branched-chain amino acid ABC transporter substrate-binding protein; |
1-372 |
2.26e-75 |
|
high-affinity branched-chain amino acid ABC transporter substrate-binding protein;
Pssm-ID: 237959 [Multi-domain] Cd Length: 369 Bit Score: 238.00 E-value: 2.26e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 1 MNRHHKTVLASAAALTCALSAWpahADEIvRIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKvtLQLDAQD 80
Cdd:PRK15404 1 MKSKGKTLLAGCIALALSHAAL---ADDI-KIAIVGPMSGPVAQYGDMEFTGARQAIEDINAKG-GIKGDK--LEGVEYD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 81 DAGDPRTATQVAQRLVDDKVIGVVGHHNSGTSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVATDAQQGPALAM 160
Cdd:PRK15404 74 DACDPKQAVAVANKVVNDGIKYVIGHLCSSSTQPASDIYEDEGILMITPAATAPELTARGYQLIFRTIGLDSDQGPTAAK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 161 YAAKNMGIRTVAVVDDSTAYGQGLATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLA 240
Cdd:PRK15404 154 YILEKVKPKRIAVLHDKQQYGEGLARSVKDGLKKAGANVVFFEGITAGDKDFSALIAKLKKENVDFVYYGGYHPEMGQIL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 241 KQARQLGMRAKILAGDGVCSTDLPKLAGPASDNVVCSEAGiALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVD 320
Cdd:PRK15404 234 RQAREAGLKTQFMGPEGVGNKSLSNIAGPASEGMLVTLPK-RYDQDPANKAIVDAFKAKKQDPSGPFVWTTYAAVQSLAA 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 979337434 321 AMKRANSTDPAKVLAAMPATDYRGVIGETSFTSQGDLKHGAISVFTY-KSGKK 372
Cdd:PRK15404 313 GINRAGSDDPAKVAKYLKANTFDTVIGPLSWDEKGDLKGFEFGVFEWhADGTK 365
|
|
| PBP1_ABC_ligand_binding-like |
cd19984 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-319 |
2.82e-71 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380639 [Multi-domain] Cd Length: 296 Bit Score: 224.79 E-value: 2.82e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLvIGGKKVtlQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHNS 109
Cdd:cd19984 1 KIGVILPLTGDAASYGEDMKNGIELAVEEINAAGG-INGKKI--ELIYEDSKCDPKKAVSAANKLINvDKVKAIIGGVCS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGfKTTYRVVATDAQQGPALAMYAAKNmGIRTVAVVDDSTAYGQGLATEFE 189
Cdd:cd19984 78 SETLAIAPIAEQNKVVLISPGASSPEITKAG-DYIFRNYPSDAYQGKVLAEFAYNK-LYKKVAILYENNDYGVGLKDVFK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 190 KAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLAGP 269
Cdd:cd19984 156 KEFEELGGKIVASESFEQGETDFRTQLTKIKAANPDAIFLPGYPKEGGLILKQAKELGIKAPILGSDGFEDPELLEIAGE 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 979337434 270 ASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIV 319
Cdd:cd19984 236 AAEGVIFTYPAFDDSSEKKQKFFFYRYKEKYGKEPDIYAALAYDAVMILA 285
|
|
| PBP1_ABC_HAAT-like |
cd19988 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-319 |
3.96e-70 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380643 [Multi-domain] Cd Length: 302 Bit Score: 222.15 E-value: 3.96e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLVIGGKkvtLQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHNS 109
Cdd:cd19988 1 KIGVFGPLSGDAAPYGQAMLQGAELAVEEINAAGGILGIP---IELVVEDDEGLPAASVSAAKKLIYqDKVWAIIGSINS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEFE 189
Cdd:cd19988 78 SCTLAAIRVALKAGVPQINPGSSAPTITESGNPWVFRCTPDDRQQAYALVDYAFEKLKVTKIAVLYVNDDYGRGGIDAFK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 190 KAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAI-MYGgmDATGGPL-AKQARQLGMRAKILAGDGVCSTDLPKLA 267
Cdd:cd19988 158 DAAKKYGIEVVVEESYNRGDKDFSPQLEKIKDSGAQAIvMWG--QYTEGALiAKQARELGLKQPLFGSDGLVTPKFIELA 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 979337434 268 GPASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIV 319
Cdd:cd19988 236 GDAAEGAIATTPFLPDSDDPKVSAFVEKYKKRYGEEPDVFAAQAYDAMNILA 287
|
|
| PBP1_ABC_ligand_binding-like |
cd06335 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
31-364 |
1.22e-65 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380558 [Multi-domain] Cd Length: 348 Bit Score: 212.08 E-value: 1.22e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKvtLQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHNS 109
Cdd:cd06335 1 KIGVIGPLTGPSAELGESARRGVELAVEEINAAG-GILGRK--IELVERDDEANPTKAVQNAQELIDkEKVVAIIGPTNS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQG---FKTTYRVVATDAQQGPALAMYAAKNmGIRTVAVVDDSTAYGQGLAT 186
Cdd:cd06335 78 GVALATIPILQEAKIPLIIPVATGTAITKPPakpRNYIFRVAASDTLQADFLVDYAVKK-GFKKIAILHDTTGYGQGGLK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 187 EFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKL 266
Cdd:cd06335 157 DVEAALKKRGITPVATESFKIGDTDMTPQLLKAKDAGADVILVYGLGPDLAQILKAMEKLGWKVPLVGSWGLSMPNFIEL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 267 AGPASDNVVCSEAGIALEKMPGGAAFAKRYEARY---HQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPATD-Y 342
Cdd:cd06335 237 AGPLAEGTIMTQTFIEDYLTPRAKKFIDAYKKKYgtdRIPSPVSAAQGYDAVYLLAAAIKQAGSTDGKKIRAALENLKgY 316
|
330 340
....*....|....*....|....
gi 979337434 343 RGVIG--ETSFTSQgdlKHGAISV 364
Cdd:cd06335 317 VGGVKtyNKPFSKT---DHEALDV 337
|
|
| PBP1_ABC_RPA1789-like |
cd06333 |
type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, ... |
31-354 |
2.01e-64 |
|
type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, RPA1791-1793), involved in active transport of lignin-derived aromatic substrates, and its close homologs; This group includes RPA1789 (CouP) from Rhodopseudomonas palustris and its close homologs in other bacteria. RPA1789 (CouP) is the periplasmic binding-protein component of an ABC system (CouPSTU; RPA1789, RPA1791-1793) that is involved in the active transport of lignin-derived aromatic substrates. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).
Pssm-ID: 380556 [Multi-domain] Cd Length: 342 Bit Score: 208.56 E-value: 2.01e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKVtlQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd06333 1 KIGAILSLTGPAASLGIPERNAVELLVEQINAAG-GINGRKL--ELIVYDDESDPTKAVTNARKLIeEDKVDAIIGPSTT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTyTQQGFKTTYRVVATDAQQGPALAMYAAKNmGIRTVAVVDDSTAYGQGLATEFE 189
Cdd:cd06333 78 GESLAVAPIAEEAKVPLISLAGAAAI-VEPVRKWVFKTPQSDSLVAEAILDYMKKK-GIKKVALLGDSDAYGQSGRAALK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 190 KAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLAGP 269
Cdd:cd06333 156 KLAPEYGIEIVADERFARTDTDMTAQLTKIRAAKPDAVLVWASGPPAALVAKNLRQLGYKGPIYQSHGAANQDFIKLAGK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 270 ASDNVVCSeAGIAL--EKMPGG-------AAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPAT 340
Cdd:cd06333 236 AAEGVILP-AGKLLvaDQLPDSdpqkkvlLEFVKAYEAKYGEGPSTFAGHAYDALLLLVEAIEPAGGTDRAALRDALENT 314
|
330
....*....|....*
gi 979337434 341 -DYRGVIGETSFTSQ 354
Cdd:cd06333 315 kGLVGVTGVYNFSPT 329
|
|
| PBP1_ABC_ligand_binding-like |
cd06340 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
31-336 |
3.23e-64 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380563 [Multi-domain] Cd Length: 352 Bit Score: 208.57 E-value: 3.23e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLV--IGGKKVTLQL-DAQddaGDPRTATQVAQRLV-DDKVIGVVGH 106
Cdd:cd06340 1 KIGVLYPLSGPLALIGQEAKRGAELAVDEINAAGGIksLGGAKIELVVaDTQ---SDPEVAASEAERLItQEGVVAIIGA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 107 HNSGTSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVATDAQQGPALAMY-----AAKNMGIRTVAVVDDSTAYG 181
Cdd:cd06340 78 YSSSVTLAASQVAERYGVPFVTASAVADEITERGFKYVFRTAPTASQFAEDAVDFlkelaKKKGKKIKKVAIIYEDSAFG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 182 QGLATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGG--MDATGgpLAKQARQLGMRAKIL--AGDG 257
Cdd:cd06340 158 TSVAKGLKKAAKKAGLEVVLDEPYPAGATDLSSEVLKLKAAKPDVVFATSytNDAIL--LLRTMKELGFKPKAIigVGGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 258 VCSTDLPKLAGPASDNVVCSE--AGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLA 335
Cdd:cd06340 236 YSDPEFLKALGKDAEGVFSVVpwSPDLAKKKPGAKEVNERYKKKYGEDMTGHAARAYTAAWVLADALERAGSTDPEAIRA 315
|
.
gi 979337434 336 A 336
Cdd:cd06340 316 A 316
|
|
| PBP1_ABC_HAAT-like |
cd06348 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-359 |
5.47e-63 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380571 [Multi-domain] Cd Length: 342 Bit Score: 205.16 E-value: 5.47e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLVIGGKkvtLQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd06348 1 KIGVALSLTGPGALYGQSQKNGAQLAVEEINAAGGVGGVK---IELIVEDTAGDPEQAINAFQKLInQDKVLAILGPTLS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGfKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVV----DDSTAYGqglA 185
Cdd:cd06348 78 SEAFAADPIAQQAKVPVVGISNTAPGITDIG-PYIFRNSLPEDKVIPPTVKAAKKKYGIKKVAVLydqdDAFTVSG---T 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 186 TEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPK 265
Cdd:cd06348 154 KVFPAALKKNGVEVLDTETFQTGDTDFSAQLTKIKALNPDAIVISALAQEGALIVKQARELGLKGPIVGGNGFNSPDLIK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 266 LAGPASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANST-DPAKVLAAM----PAT 340
Cdd:cd06348 234 LAGKAAEGVIVGSAWSPDNPDPKNQAFVAAYKEKYGKEPDQFAAQAYDAAYILAEAIKKAGSTtDRADLRDALarilIAK 313
|
330
....*....|....*....
gi 979337434 341 DYRGVIGETSFTSQGDLKH 359
Cdd:cd06348 314 DFEGPLGPFSFDADRDGIQ 332
|
|
| PBP1_ABC_ligand_binding-like |
cd06336 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
31-341 |
8.53e-62 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380559 [Multi-domain] Cd Length: 345 Bit Score: 202.08 E-value: 8.53e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKG-LVIGGKKVTLQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHN 108
Cdd:cd06336 1 KIGFLGPLSGPAAAWGLPMLRGLELAADEINAAGgIKVGGKKYKVEVVSYDDKYTPAEAVAAARRLVSqDGVKFIFGPGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 109 SGTSIPASRVYRDGGVVQISQAATNPtYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEF 188
Cdd:cd06336 81 SAIAAAVQPVTERNKVLLLTAAFSDP-ILGPDNPLLFRIPPTPYEYAPPFIKWLKKNGPIKTVALIAPNDATGKDWAAAF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 189 EKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMD-ATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLA 267
Cdd:cd06336 160 VAAWKAAGGEVVAEEFYDRGTTDFYPVLTKILALKPDALDLGGSSpGPAGLIIKQARELGFKGPFVSEGGAKADEILKEV 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 979337434 268 GP-ASDNVVCSEAGIALEKM-PGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPATD 341
Cdd:cd06336 240 GGeAAEGFIGVLPADDDPIAsPGAKAFVERYKKKYGEPPNSESALFYDAAYILVKAMEKAGTVDDTKKIRAALAML 315
|
|
| PBP1_ABC_ligand_binding-like |
cd06345 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-370 |
9.20e-62 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380568 [Multi-domain] Cd Length: 356 Bit Score: 202.11 E-value: 9.20e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTgaiAHLGKDSENGARLAVEEINAKGlVIGGKKVtlQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd06345 1 KIGVLGPLS---APAGEAMERGAELAVEEINAAG-GILGRKV--ELVVADTQGKPEDGVAAAERLItEDKVDAIVGGFRS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQ------GFKTTYRVVATDAQQGPALAMYAAKNM----GIRTVAVVDDSTA 179
Cdd:cd06345 75 EVVLAAMEVAAEYKVPFIVTGAASPAITKKvkkdyeKYKYVFRVGPNNSYLGATVAEFLKDLLveklGFKKVAILAEDAA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 180 YGQGLATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAkILAGDGVC 259
Cdd:cd06345 155 WGRGIAEALKKLLPEAGLEVVGVERFPTGTTDFTPILSKIKASGADVIVTIFSGPGGILLVKQWAELGVPA-PLVGINVP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 260 STDLP--KLAGPASDNVVCSEAGIALEKM-PGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAA 336
Cdd:cd06345 234 AQDPEfwENTGGAGEYEITLAFAAPKAKVtPKTKPFVDAYKKKYGEAPNYTAYTAYDAIYILAEAIERAGSTDPDALVKA 313
|
330 340 350
....*....|....*....|....*....|....
gi 979337434 337 MPATDYRGVIGETSFTSQGDLKHGAISVFTYKSG 370
Cdd:cd06345 314 LEKTDYEGVRGRIKFDKKDEYPHDVKYGPGYVTG 347
|
|
| PBP1_ABC_HAAT-like |
cd19986 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-318 |
1.36e-60 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380641 [Multi-domain] Cd Length: 297 Bit Score: 197.46 E-value: 1.36e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKvtLQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd19986 1 KIGVVAPLTGPAALNGEYQKNGAQLALEEINAAG-GVLGRP--LELVVEDDQGTNTGAVNAVNKLIsDDKVVAVIGPHYS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISqAATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEFE 189
Cdd:cd19986 78 TQVLAVSPLVKEAKIPVIT-GGTSPKLTEQGNPYMFRIRPSDSVSAKALAKYAVEELGAKKIAILYDNDDFGTGGADVVT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 190 KAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLAGP 269
Cdd:cd19986 157 AALKALGLEPVAVESYNTGDKDFTAQLLKLKNSGADVIIAWGHDAEAALIARQIRQLGLDVPVIGSSSFATPTVLLLAGE 236
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 979337434 270 ASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHII 318
Cdd:cd19986 237 ALEGIYSVTDFVPSDPDPKVQAFVKKYKAKYGEDPDLYSAWYYDAMYLL 285
|
|
| PBP1_ABC_HAAT-like |
cd19981 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-323 |
1.48e-60 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380636 [Multi-domain] Cd Length: 297 Bit Score: 197.13 E-value: 1.48e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKVtlQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHNS 109
Cdd:cd19981 1 KIGFFAPLTGPAAADGKSALHGAELAVEQINAAG-GINGKKV--ELVVYDDQASPKQAVNIAQKLIEqDKVVAVVSGSYS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGfKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEFE 189
Cdd:cd19981 78 GPTRAAAPIFQEAKVPMVSAYAVHPDITKAG-DYVFRVAFLGPVQGRAGAEYAVKDLGAKKVAILTIDNDFGKSLAAGFK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 190 KAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLAGP 269
Cdd:cd19981 157 EEAKKLGAEIVSEYAYALGDRDFRPILTKIKSANPDAIYASGYYAEAAPIVKQARELGIKVPIIGQEGYDSPKFIEIAGS 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 979337434 270 ASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIV-DAMK 323
Cdd:cd19981 237 AAEGVIITTSLNRDSDRPITQKFIKEYRKRYGIDPDMVAASTYDAVMVLAgEVQK 291
|
|
| Peripla_BP_6 |
pfam13458 |
Periplasmic binding protein; This family includes a diverse range of periplasmic binding ... |
30-372 |
7.40e-60 |
|
Periplasmic binding protein; This family includes a diverse range of periplasmic binding proteins.
Pssm-ID: 433225 [Multi-domain] Cd Length: 342 Bit Score: 196.73 E-value: 7.40e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 30 VRIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLVIGgkkVTLQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHN 108
Cdd:pfam13458 2 IKIGVLTPLSGPYASSGKSSRAGARAAIEEINAAGGVNG---RKIELVVADDQGDPDVAAAAARRLVDqDGVDAIVGGVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 109 SGTSIPASRVYRDGGVVQISQAATNPTytqQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEF 188
Cdd:pfam13458 79 SAVALAVAEVLAKKGVPVIGPAALTGE---KCSPYVFSLGPTYSAQATALGRYLAKELGGKKVALIGADYAFGRALAAAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 189 EKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAK--ILAGDGVCSTDLPKL 266
Cdd:pfam13458 156 KAAAKAAGGEVVGEVRYPLGTTDFSSQVLQIKASGADAVLLANAGADTVNLLKQAREAGLDAKgiKLVGLGGDEPDLKAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 267 AGPASDNVVCSEAGIALEKMPGGAAFAKRYEARY-HQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPATDYRGV 345
Cdd:pfam13458 236 GGDAAEGVYATVPFFPDLDNPATRAFVAAFAAKYgEAPPTQFAAGGYIAADLLLAALEAAGSPTREAVIAALRALPYDGP 315
|
330 340
....*....|....*....|....*..
gi 979337434 346 IGETSFTSQGDLKHGAISVFTYKSGKK 372
Cdd:pfam13458 316 FGPVGFRAEDHQAVHCMYLVQVKADGK 342
|
|
| PBP1_ABC_ligand_binding-like |
cd06346 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-367 |
7.34e-59 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380569 [Multi-domain] Cd Length: 314 Bit Score: 193.55 E-value: 7.34e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKVtlQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHNS 109
Cdd:cd06346 1 KIGALLPLTGPLASLGPPMLAAAELAVEEINAAG-GVLGKKV--ELVVEDSQTDPTAAVDAARKLVDvEGVPAIVGAASS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTY-RVVATDAQQGPALAMYAAKNmGIRTVAVVDDSTAYGQGLATEF 188
Cdd:cd06346 78 GVTLAVASVAVPNGVVQISPSSTSPALTTLEDKGYVfRTAPSDALQGVVLAQLAAER-GFKKVAVIYVNNDYGQGLADAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 189 EKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRA-KILAGDGVCSTDLPKLA 267
Cdd:cd06346 157 KKAFEALGGTVTASVPYEPGQTSYRAELAQAAAGGPDALVLIGYPEDGATILREALELGLDFtPWIGTDGLKSDDLVEAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 268 GP-ASDNVVCSEAGIALEkmPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIvdamkranstdpakVLAampatdYRGVI 346
Cdd:cd06346 237 GAeALEGMLGTAPGSPGS--PAYEAFAAAYKAEYGDDPGPFAANAYDAVMLL--------------ALA------YEGAS 294
|
330 340
....*....|....*....|.
gi 979337434 347 GETSFTSQGDLKhGAISVFTY 367
Cdd:cd06346 295 GPIDFDENGDVA-GPYEIWKV 314
|
|
| PBP1_ABC_ligand_binding-like |
cd06338 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
31-359 |
4.67e-58 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380561 [Multi-domain] Cd Length: 347 Bit Score: 192.41 E-value: 4.67e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLV-IGGKKVTLQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHN 108
Cdd:cd06338 1 KIGASLSLTGPFAGEGKAQKRGYELWVEDVNAAGGVkGGGKKRPVELVYYDDQSDPATAVRLYEKLItEDKVDLLLGPYS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 109 SGTSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVAT-DAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATE 187
Cdd:cd06338 81 SGLTLAAAPVAEKYGIPMIAGGAASDSIFERGYKYVFGVLPPaSDYAKGLLDLLAELGPKPKTVAIVYEDDPFGKEVAEG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 188 FEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILA-GDGVCSTDLPKL 266
Cdd:cd06338 161 AREAAKKAGLEVVYDESYPPGTTDFSPLLTKVKAANPDILLVGGYPPDAITLVRQMKELGYNPKAFFlTVGPAFPAFREA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 267 AGPASDNVVCS---EAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPATDYR 343
Cdd:cd06338 241 LGKDAEGVLGPsqwEPSLPYKVFPGAKEFVKAYKEKFGEEPSYHAAAAYAAGQVLQQAIEKAGSLDPEKVRDALASLDFD 320
|
330
....*....|....*.
gi 979337434 344 GVIGETSFTSQGDLKH 359
Cdd:cd06338 321 TVYGPIKFDETGLQIG 336
|
|
| PBP1_ABC_HAAT-like |
cd19985 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-319 |
6.90e-52 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380640 [Multi-domain] Cd Length: 321 Bit Score: 175.54 E-value: 6.90e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKVtlQLDAQDDAGDPRTATQVAQRLVDDKVIGVVGHHNSG 110
Cdd:cd19985 1 HIAVVGPMSGKSASKGKSMLRGAELYIDQINAAG-GINGKKV--KLDVFDDQNDPDAARKAAQIIVSDKALAVIGHYYSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 111 TSIPASRVYRDGGVVQISQAATNPTYTQQGfKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEFEK 190
Cdd:cd19985 78 ASIAAGKIYKKAGIPAITPSATADAVTRDN-PWYFRVIFNDSLQGRFLANYAKKVLKKDKVSIIYEEDSYGKSLASVFEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 191 AAKAAGMKVVSRDATNDKAIDFRA----ILTKIK--GTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCS---- 260
Cdd:cd19985 157 TARALGLKVLKKWSFDTDSSQLDQnldqIVDELKkaPDEPGVIFLATHADEGAKLIKKLRDAGLKAPIIGPDSLASesfa 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 979337434 261 ---TDLPK---LAGPASDNVVCSEA---GIALEKmpgGAAFAKRYEARYHQPMQVYAPFSYDAVHIIV 319
Cdd:cd19985 237 qgfAEYPEekeEPGYYTDGIYATSPfifDIANEK---AQKFRDTYQKRYGEEPSWIAAFAYDAAMLAI 301
|
|
| PBP1_ABC_ligand_binding-like |
cd19982 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
31-308 |
8.94e-50 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.
Pssm-ID: 380637 [Multi-domain] Cd Length: 302 Bit Score: 169.38 E-value: 8.94e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKvtLQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd19982 1 KIGAILSLTGPFAPFGEMFKNGYEMALEEINAAG-GIKGKK--LELVIEDDQSKPQTALAAAEKLVsQDKVPLIVGGYSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEFE 189
Cdd:cd19982 78 GITLPVAAVAERQKIPLLVPTAADDDITKPGYKYVFRLNPPASIYAKALFDFFKELVKPKTIAILYENTAFGTSVAKAAR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 190 KAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCST--DLPKLA 267
Cdd:cd19982 158 RFAKKRGIEVVADESYDKGATDFKPLLNKVKAANPDVVYMVSYLNDAILLMRQAKELGLNPKLFAGGGAGFTipEFLKQA 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 979337434 268 GPASDNVVCSEAGIALEKMPGGAAFAKRYEARY-HQP----MQVYA 308
Cdd:cd19982 238 GPLAEYVVTATLWSPDVKYPGAKEFYEKYKAKYgVEPsyheAEAYA 283
|
|
| PBP1_As_SBP-like |
cd06330 |
periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
31-351 |
1.95e-45 |
|
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea that is predicted to be involved in the efflux of toxic compounds. Members of this subgroup include proteins from Herminiimonas arsenicoxydans, which is resistant to arsenic (As) and various heavy metals such as cadmium and zinc. Moreover, they show significant sequence similarity to the cluster of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa.
Pssm-ID: 380553 [Multi-domain] Cd Length: 342 Bit Score: 159.26 E-value: 1.95e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLvIGGKKVtlQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd06330 1 KIGVITPLSGAAAVYGEPARNGAELAVEEINAAGG-ILGRKI--ELVVRDDKGKPDEAVRAARELVlQEGVDFLIGTISS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGF-KTTYRVVATDAQQGPALAMYAAKNM-GIRTVAVVDDSTAYGQGLATE 187
Cdd:cd06330 78 GVALAVAPVAEELKVLFIATDAATDRLTEENFnPYVFRTSPNTYMDAVAAALYAAKKPpDVKRWAGIGPDYEYGRDSWAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 188 FEKAAKAAG--MKVVSRDATNDKAIDFRAILTKIKGTNPDAI---MYGGmDATGgpLAKQARQLGM--RAKILAGDGVCS 260
Cdd:cd06330 158 FKAALKKLKpdVEVVGELWPKLGATDYTAYITALLAAKPDGVfssLWGG-DLVT--FVKQAKPYGLfdKTKVVSGLGGGS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 261 TDLPKLAGPASDNVVCSEAGI-ALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPA 339
Cdd:cd06330 235 EVLQALGKEMPEGLIGGGRYPfGWPDTPLNKAFVEAYRAKYGEYPTYWAYEAYAAVMALKAAIEKAGSTDTDKVIAALEG 314
|
330
....*....|..
gi 979337434 340 TDYRGVIGETSF 351
Cdd:cd06330 315 LTFDTPGGKITI 326
|
|
| PBP1_ABC_HAAT-like |
cd19983 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type ... |
31-319 |
4.52e-44 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of hydrophobic amino acids or peptides; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of hydrophobic amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.
Pssm-ID: 380638 [Multi-domain] Cd Length: 303 Bit Score: 154.66 E-value: 4.52e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKVtlQLDAQDDAGDPRTATQVAQRLVDDKVIGVVGHHNSG 110
Cdd:cd19983 1 RIGFVGGLTGRYSDLGVQGRNGAQLAVEEINAAG-GINGRPV--ELIIRDDQQDPEAAKAADRELIAGGVVAIIGHMTSA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 111 TSIPASRVYRDGGVVQISQAATNPTYTQQ--GFkttYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDST--AYGQGLAT 186
Cdd:cd19983 78 MTVAVLPVINEAKVLMISPTVSTPELSGKddYF---FRVTPTTRESAQALARYAYNRGGLRRVAVIYDLSnrAYSESWLD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 187 EFEKAAKAAGMKVVSRDATNDKA-IDFRAILTKIKGTNPDAI--MYGGMDATggPLAKQARQLGMRAKILAGDGVCSTDL 263
Cdd:cd19983 155 NFRSEFEALGGRIVAEIPFSSGAdVDFSDLARRLLASKPDGLllVASAVDTA--MLAQQIRKLGSKIPLFSSAWAATEEL 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 979337434 264 PKLAGPASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIV 319
Cdd:cd19983 233 LELGGKAVEGMLFSQAYDRNSSNPRYLAFKEAYEERFGREPSFAAAYAYEAAMVLA 288
|
|
| PBP1_ABC_ligand_binding-like |
cd06343 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
26-337 |
5.06e-43 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however its ligand specificity has not been determined experimentally.
Pssm-ID: 380566 [Multi-domain] Cd Length: 355 Bit Score: 153.11 E-value: 5.06e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 26 ADEIvRIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLvIGGKKVTLQldAQDDAGDPRTATQVAQRLVD-DKVIGVV 104
Cdd:cd06343 4 DDEI-KIGTSLPLSGPAAAYGKPVRAGAAAYFDEVNAAGG-INGRKIELI--VEDDGYDPARAVAAVRKLVEqDKVFAIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 105 GHHNSGTSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGL 184
Cdd:cd06343 80 GGLGTPTNLAVRPYLNEAGVPQLFPATGASALSPPPKPYTFGVQPSYEDEGRILADYIVETLPAAKVAVLYQNDDFGKDG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 185 ATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTD-L 263
Cdd:cd06343 160 LEGLKEALKAYGLEVVAEETYEPGDTDFSSQVLKLKAAGADVVVLGTLPKEAAAALKEAAKLGWKPTFLGSSVSADPTtL 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 979337434 264 PKLAGPASDNVVCSEAG--IALEKMPGGAAFAKRYEARYHQ-PMQVYAPFSYDAVHIIVDAMKRA-NSTDPAKVLAAM 337
Cdd:cd06343 240 AKAGGDAAEGVYSASYLkdPTDADDPAVKEFREAYKKYFPDdPPNAYALYGYAAAQVFVEALKRAgKDLTREGLIKAL 317
|
|
| PBP1_SBP-like |
cd19989 |
periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
31-319 |
2.20e-38 |
|
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380644 [Multi-domain] Cd Length: 299 Bit Score: 139.33 E-value: 2.20e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKVtlQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd19989 1 KIGVLTPLSGPYAALGEEARRGAQLAVEEINAAG-GILGRPV--ELVVEDTEGKPATAVQKARKLVeQDGVDFLTGAVSS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQI-SQAATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDsTAYGQGLATEF 188
Cdd:cd19989 78 AVALAVAPKAAELKVPYLvTVAADDELTGENCNRYTFRVNTSDRMIARALAPWLAENGGKKWYIVYAD-YAWGQSSAEAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 189 EKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDA---IMYGGmDATGgpLAKQARQLGMRAKILAGDGVCSTD--L 263
Cdd:cd19989 157 KEAIEELGGEVVGTLFAPLGTTDFSSYITQISDSGADGlllALAGS-DAVN--FLKQAGQFGLGKKYKIVGGILSIEplA 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 979337434 264 PKLAGPASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIV 319
Cdd:cd19989 234 LPALGDAAEGVYGGVRYPPTLDTPANRAFVEAYEKEYGEAPDNFAGEAYEAMQALA 289
|
|
| PBP1_AmiC-like |
cd06331 |
type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system ... |
31-351 |
4.62e-38 |
|
type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); This group includes the type 1 periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF), found in bacteria and Archaea. AmiC controls expression of the amidase operon by a ligand-triggered conformational switch. In the absence of ligand or presence of butyramide (repressor), AmiC (the ligand sensor and negative regulator) adopts an open conformation and inhibits the transcription antitermination function of AmiR by direct protein-protein interaction. In the presence of inducing ligands such as acetamide, AmiC adopts a closed conformation which disrupts a silencing AmiC-AmiR complex and the expression of amidase and other genes of the operon is induced. FmdDEF is predicted to be an ATP-dependent transporter and closely resembles the periplasmic binding protein and the two transmembrane proteins present in various hydrophobic amino acid-binding transport systems.
Pssm-ID: 380554 [Multi-domain] Cd Length: 333 Bit Score: 139.28 E-value: 4.62e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKVTLQLdaQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd06331 1 KIGLLTPLSGPASVYGRAIANGAELAVEEINAAG-GVLGRPVELVV--EDDASDPATAVAAARRLIqQDKVDAIVGPITS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQIsqaatNPTYTQQGFKTTYRVV--ATDAQQGPALAMYAAKNMGiRTVAVVDDSTAYGQGLATE 187
Cdd:cd06331 78 ATRNAVAPVAERAKVPLL-----YPTFYEGGECSPYLFCfgEVPNQQLDPLIPWLMEEYG-KKFYLIGSDYVWPRTMNDA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 188 FEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKI-LAGDGVCSTDLPKL 266
Cdd:cd06331 152 ARRVIEAHGGEVVGEEYLPLGTTDFSSVIEKIKASGADVVLSTLVGADAVTFLKQFAAAGLRRKVrIAALLFDENTLAGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 267 AGPASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQ---PMQVYAPFSYDAVHIIVDAMKRANSTDPAKVLAAMPATDYR 343
Cdd:cd06331 232 GAEAAEGIYSVLSYFQSLDTPENKAFVAAYRKKFGEdapPITSLSEAAYEAVHLYAAAVEKAGSTDPEAVIAALPGVSFD 311
|
....*...
gi 979337434 344 GVIGETSF 351
Cdd:cd06331 312 GPQGPVTM 319
|
|
| PBP1_aromatic_compounds-like |
cd06332 |
type 1 periplasmic binding proteins of active transport systems predicted to be involved in ... |
31-356 |
4.90e-35 |
|
type 1 periplasmic binding proteins of active transport systems predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; This group includes the type 1 periplasmic binding proteins of active transport systems that are predicted to be involved in transport of aromatic compounds such as 2-nitrobenzoic acid and alkylbenzenes; their substrate specificities are not well characterized, however. Members also exhibit close similarity to active transport systems for short chain amides and/or urea found in bacteria and archaea.
Pssm-ID: 380555 [Multi-domain] Cd Length: 336 Bit Score: 131.18 E-value: 4.90e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKglvIGGKKVTLQLdaQDDAGDPRTATQVAQRLVD-DKVIGVVGHHNS 109
Cdd:cd06332 1 KIGLLAPLTGPFAALGEDMVRGFELALEEVGGE---VAGRKVELVV--EDDAGDPDTAVTKARKLVEqDKVDVLIGPLSG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQG-FKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATEF 188
Cdd:cd06332 76 DEGLAVAPYAKEPGVPFINPVAGADDLTQRAkAPNFFRTSFTGSQWSAPLGDYAYKELGYKKVATIGSDYAFGYEQAAGF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 189 EKAAKAAGMKVVSR--DATNDKaiDFRAILTKIKGTNpDAIMYGGMDATGGPLAKQARQLGMRAKI-LAGDGvCSTDLPK 265
Cdd:cd06332 156 KRGFEAAGGEVVQEiwVPLGTT--DFSPYIAQIPSAD-DAVFAFLGGADAVRFLKQYREFGLKDKIpLIGGG-TTVDESV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 266 LA--GPASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRAN--STDPAKVLAAMPATD 341
Cdd:cd06332 232 LPamGDAALGIISASHYAEGLDNPENKKFVAAYKKKFGKLPSLYAAGGYDGAQAILEALEAVGgdVSDKQALAAALRKVK 311
|
330
....*....|....*
gi 979337434 342 YRGVIGETSFTSQGD 356
Cdd:cd06332 312 FDSPRGPFSFDENRN 326
|
|
| PBP1_RPA0668_benzoate-like |
cd20014 |
type 1 periplasmic binding-protein component of an ABC system (RPA0668), involved in in the ... |
31-337 |
1.30e-34 |
|
type 1 periplasmic binding-protein component of an ABC system (RPA0668), involved in in the active transport of lignin-derived benzoate derivative compounds, and its close homologs; This group includes RPA0668 from Rhodopseudomonas palustris and its close homologs in other bacteria. Rpa0668 is the periplasmic binding-protein component of an ABC system that is involved in the active transport of lignin-derived benzoate derivative compounds. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).
Pssm-ID: 380667 [Multi-domain] Cd Length: 346 Bit Score: 130.43 E-value: 1.30e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKglvIGGKKVtlQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd20014 1 KIGLLLPYSGVYAALGEDIRNGFQLYLDEHGGK---LGGRPI--ELVKEDDEADPDVALQKARKLIeQDKVDVLVGPVSS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGV-VQISQAATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAyGQGLATEF 188
Cdd:cd20014 76 GVALAIRDVVEQAKVpLIVANAGANALTRAACSPYIFRTSFSNWQLGYALGKYAAENVGKTVVTIASDYAA-GREVVAGF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 189 EKAAKAAGMKVVSRDATN-DKAIDFRAILTKIKGTNPDAI--MYGGMDATggPLAKQARQLGMRAKI-LAGDGVCsTDLP 264
Cdd:cd20014 155 KEGFEAAGGKVVGEIWTPlGTTTDFSPYLTQIAASGPDAVyaFFAGADAV--RFVKQYAEFGLKGKIpLYGPGFL-TDED 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 265 KLA--GPASDNVVcseagIALEKMPG-----GAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANS--TDPAKVLA 335
Cdd:cd20014 232 VLPalGEAAEGII-----TVLHYAPTldnpaNRAFVAAYQAKYGRLPDVYAVQGYDAAQVIDAALEAVGGdtSDKDILAA 306
|
..
gi 979337434 336 AM 337
Cdd:cd20014 307 AL 308
|
|
| PBP1_ABC_transporter_GPCR_C-like |
cd04509 |
Family C of G-protein coupled receptors and their close homologs, the type 1 ... |
52-264 |
7.89e-31 |
|
Family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems; This CD includes members of the family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems. The family C GPCR includes glutamate/glycine-gated ion channels such as the NMDA receptor, G-protein-coupled receptors, metabotropic glutamate, GABA-B, calcium sensing, pheromone receptors, and atrial natriuretic peptide-guanylate cyclase receptors. The glutamate receptors that form cation-selective ion channels, iGluR, can be classified into three different subgroups according to their binding-affinity for the agonists NMDA (N-methyl-D-asparate), AMPA (alpha-amino-3-dihydro-5-methyl-3-oxo-4-isoxazolepropionic acid), and kainate. L-glutamate is a major neurotransmitter in the brain of vertebrates and acts through either mGluRs or iGluRs. mGluRs subunits possess seven transmembrane segments and a large N-terminal extracellular domain. ABC-type leucine-isoleucine-valine binding protein (LIVBP) is a bacterial periplasmic binding protein that has homology with the amino-terminal domain of the glutamate-receptor ion channels (iGluRs). The extracellular regions of iGluRs are made of two PBP-like domains in tandem, a LIVBP-like domain that constitutes the N terminus (included in this model) followed by a domain related to lysine-arginine-ornithine-binding protein (LAOBP) that belongs to the type 2 periplasmic binding fold protein superfamily. The uncharacterized periplasmic components of various ABC-type transport systems are also included in this family.
Pssm-ID: 380490 Cd Length: 306 Bit Score: 119.33 E-value: 7.89e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 52 GARLAVEEINAKGLVIggKKVTLQLDAQDDAGDPRTATQVAQRLVDD-----------------------KVIGVVGHHN 108
Cdd:cd04509 32 AMEQALDDINADPNLL--PNNTLGIVIYDDCCDPKQALEQSNKFVNDliqkdtsdvrctngeppvfvkpeGIKGVIGHLC 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 109 SGTSIPASRVYRDGGVVQISQAATNPTYT-QQGFKTTYRVVATDAQQGPALAMYaAKNMGIRTVAVVDDSTAYGQGLATE 187
Cdd:cd04509 110 SSVTIPVSNILELFGIPQITYAATAPELSdDRGYQLFLRVVPLDSDQAPAMADI-VKEKVWQYVSIVHDEGQYGEGGARA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 188 FEKAAKAAGMKVVSRDA--TNDKAIDFRAILTKIKGTNP-DAIMYGGMDATGGPLAKQARQLGMRAKIL--AGDGVCSTD 262
Cdd:cd04509 189 FQDGLKKGGLCIAFSDGitAGEKTKDFDRLVARLKKENNiRFVVYFGYHPEMGQILRAARRAGLVGKFQfmGSDGWANVS 268
|
..
gi 979337434 263 LP 264
Cdd:cd04509 269 LS 270
|
|
| PBP1_alkylbenzenes-like |
cd06360 |
type 1 periplasmic binding component of active transport systems predicted be involved in ... |
31-351 |
2.82e-29 |
|
type 1 periplasmic binding component of active transport systems predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; This group includes the type 1 periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; their substrate specificity is not well characterized, however.
Pssm-ID: 380583 [Multi-domain] Cd Length: 357 Bit Score: 116.24 E-value: 2.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKglvIGGKKVtlQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHNS 109
Cdd:cd06360 1 KIGVLLPLTGPLAVNGEDVRDGFELYFDEIGNQ---VAGRKI--ELIVEDDEGKPDVGLTKARKLVErDKVHVLAGIVSS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIpASRVYRDGGVVQ--ISQAATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQGLATE 187
Cdd:cd06360 76 AVAY-AVRDYVVEQKIPlvISNAGAAPLTQELASPYIFRTSFSNGQYDAPFGQYAYEKLGYRRIAVMASDYAAGHEQAGA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 188 FEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAK---ILAGDGVCSTDLP 264
Cdd:cd06360 155 FARTFKQAGGKVVQEIYPPLGTADFAPYLARIQQDAADAVWAFFAGADAIRFVKQYDEYGLKGKlplVGIGGLVDDAILP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 265 KLaGPASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMK--RANSTDPAKVLAAMPATDY 342
Cdd:cd06360 235 EQ-GDAALGIVSYLHYSAALDTPENKAFVQAYRKKYGRDPGLYAEGGYVAARAIAEALEavKGNVEDKEAFLEALRKVRF 313
|
....*....
gi 979337434 343 RGVIGETSF 351
Cdd:cd06360 314 EAPRGPFRF 322
|
|
| PBP1_ABC_ligand_binding-like |
cd06326 |
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to ... |
30-337 |
3.29e-27 |
|
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in uptake of amino acids, peptides, or inorganic ions; This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally, however.
Pssm-ID: 380549 [Multi-domain] Cd Length: 339 Bit Score: 109.94 E-value: 3.29e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 30 VRIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLvIGGKKvtLQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHN 108
Cdd:cd06326 1 IVIGQSAPLSGPLAELGREYLAGAKAYFDQVNAAGG-INGRK--IRLVTLDDGYDPARTVENTRQLIEqDKVVALFGYVG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 109 SGTSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVATDAQQGPALAMYAAkNMGIRTVAVVDDSTAYGQGLATEF 188
Cdd:cd06326 78 TANVEAVLPLLEEAGVPLVGPLTGADSLREPGNPYVFHVRASYADEVEKIVRHLA-TLGLKRIAVVYQDDPFGKEGLAAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 189 EKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDLPKLAG 268
Cdd:cd06326 157 EAALAARGLEPVATAAVARNAADVAAAAAALAAAKPQAVVLIAAGKAAAAFIKALRAAGGAAQFYGLSVVGAAALAKALG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 269 PASDNVVCSEAgialekMP----GGAAFAKRYEARyhqpMQVYAP--FSYD------AVHIIVDAMKRANST-DPAKVLA 335
Cdd:cd06326 237 DAARGVVVSQV------VPnpwsTTLPLVREYQAA----MKAAGPkePSYAslegyiAARVLVEALRRAGRNpTRESLVA 306
|
..
gi 979337434 336 AM 337
Cdd:cd06326 307 AL 308
|
|
| PBP1_SBP-like |
cd06328 |
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins ... |
31-337 |
1.03e-26 |
|
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins or SBPs); Periplasmic substrate-binding domain of active transport proteins found in gram-negative and gram-positive bacteria. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380551 [Multi-domain] Cd Length: 336 Bit Score: 108.54 E-value: 1.03e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLVIGGKKVtlQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd06328 1 KIGVITSLTGPLAAYGKQTERGFELGLEYATDGTMEVDGRKI--EVIVKDDQGDPDTAKAAATELIgDDGVDILVGTVSS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGF-KTTYRVVATDAQQGPALAMYAAKNMGiRTVAVVDDSTAYGQGLATEF 188
Cdd:cd06328 79 AVALALAPVAEQNKKILIVGPAAADSITGENWnKYTFRTSRNSWQDAIAGAKALADPLG-KSVAFLAQDYAFGQDGVAAF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 189 EKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVcsTDLP--KL 266
Cdd:cd06328 158 KKALEAKGGKIVGEELVPVTTTDFTPYLQRILDAKPDVLFVAWAGTGALTLWQQLADQGVLDDIKVVTGG--PDIAtlAA 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 979337434 267 AGPASDNVVcseaGIA-----LEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANS-TDPAKVLAAM 337
Cdd:cd06328 236 LGDALPGIE----GLTyyyygLPKNPVNDWLVKAHKERYNAPPDLFTAGGFAAAQAVVRALEKAGGdTDVEKLIAAL 308
|
|
| PBP1_Nba-like |
cd06359 |
type 1 periplasmic binding component of active transport systems predicted to be involved in ... |
31-351 |
6.79e-26 |
|
type 1 periplasmic binding component of active transport systems predicted to be involved in 2-nitrobenzoic acid degradation pathway; This group includes the type 1 periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; their substrate specificities are not well characterized.
Pssm-ID: 380582 [Multi-domain] Cd Length: 333 Bit Score: 106.18 E-value: 6.79e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKglvIGGKKVTLQldAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHNS 109
Cdd:cd06359 1 KIGFITTLSGPAAVLGQDMRDGFNLALEQLGGK---LGGLPVEVV--VEDDQLKPDVAKQAAERLIErDKVDFVTGIIFS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVAT-DAQQGPALAMYAAKnMGIRTVAVVDDSTAYGQGLATEF 188
Cdd:cd06359 76 NVMLAVVKPVVDSKVFYISANAGPSDLAGKGCNPNFFVTSWqNDQLHEAAGKYAND-KGYKRVYLLAPNYQAGKDALAGF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 189 EKAAKAagmKVVSRDATNDKAIDFRAILTKIKGTNPDAI---MYGGMdatGGPLAKQARQLGMRAKI-LAGDG-VCSTDL 263
Cdd:cd06359 155 KRTYKG---EVVGEIYTPLGQLDFSAELAQIRAAKPDAVfafYPGGM---GVNFVKQYAQAGLKKKIpLYTVGtLDDEDL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 264 PKLAGPASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANS--TDPAKVLAAMPATD 341
Cdd:cd06359 229 LPAMGDAALGVLSVSQWSPDLDNPENKRFVAAFRKKYGRPPSNYAAQGYDAALLIDAAVKAVGGdlSDKDALRAALRKAD 308
|
330
....*....|
gi 979337434 342 YRGVIGETSF 351
Cdd:cd06359 309 FKSVRGAFRF 318
|
|
| ANF_receptor |
pfam01094 |
Receptor family ligand binding region; This family includes extracellular ligand binding ... |
50-368 |
1.53e-25 |
|
Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.
Pssm-ID: 460062 [Multi-domain] Cd Length: 347 Bit Score: 105.55 E-value: 1.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 50 ENGARLAVEEINAKGLVIGGkkVTLQLDAQDDAGDPRTATQVAQRLVDDKVIGVVGHHNSGTSIPASRVYRDGGVVQISQ 129
Cdd:pfam01094 3 LLAVRLAVEDINADPGLLPG--TKLEYIILDTCCDPSLALAAALDLLKGEVVAIIGPSCSSVASAVASLANEWKVPLISY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 130 AATNPTYT-QQGFKTTYRVVATDAQQGPALAMyAAKNMGIRTVAVVDDSTAYGQGLATEFEKAAKAAGMKVVSRDA---- 204
Cdd:pfam01094 81 GSTSPALSdLNRYPTFLRTTPSDTSQADAIVD-ILKHFGWKRVALIYSDDDYGESGLQALEDALRERGIRVAYKAVippa 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 205 -TNDKAIDfraILTKIKGTNPDAI---MYGGmdaTGGPLAKQARQLGM---RAKILAGDGVcSTDLPKLAGP---ASDNV 274
Cdd:pfam01094 160 qDDDEIAR---KLLKEVKSRARVIvvcCSSE---TARRLLKAARELGMmgeGYVWIATDGL-TTSLVILNPStleAAGGV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 275 VcseaGIALeKMPGGAAFAKR-----------YEARYHQPMqVYAPFSYDAVHIIVDAMKRANSTDP------------- 330
Cdd:pfam01094 233 L----GFRL-HPPDSPEFSEFfweklsdekelYENLGGLPV-SYGALAYDAVYLLAHALHNLLRDDKpgracgalgpwng 306
|
330 340 350
....*....|....*....|....*....|....*....
gi 979337434 331 -AKVLAAMPATDYRGVIGETSFTSQGDLKHGAISVFTYK 368
Cdd:pfam01094 307 gQKLLRYLKNVNFTGLTGNVQFDENGDRINPDYDILNLN 345
|
|
| PBP1_ABC_ligand_binding-like |
cd19979 |
amino acid amide ABC transporter substrate binding protein haat family; This subgroup includes ... |
31-346 |
2.10e-25 |
|
amino acid amide ABC transporter substrate binding protein haat family; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380634 [Multi-domain] Cd Length: 350 Bit Score: 105.39 E-value: 2.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLVIGGKkvtLQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd19979 1 VIGLDADLSGGSAASGEAIKRGIQLAIDEINAAGGLLGRK---LELVAKDHRGNPARGVDNLREFAaDPDVLAVFGGLHS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 gtsiPASRVYRDggVVQISQA------ATNPTYTQQGFKTTY--RVVATDAQQGPALAMYAAKnMGIRTVAVVDDSTAYG 181
Cdd:cd19979 78 ----PVLLAELD--FIHELKIpylvpwAAATPITRNGYSPNYifRLSVDDSLAGPFLVEYALK-KGCKRPALLLENTGWG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 182 QGLATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCST 261
Cdd:cd19979 151 RSNLKAMTKALAKKGLQPVGVEWFNWGDTDAKPQLRALKAAGADAILLVANAPEGAAIVKALAALPERLPIISHWGITGG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 262 DLPKLAGPASDNV------VCSEAGIALEkmPGGAAFAKRYEARY---HQPMQVYAPF----SYDAVHIIVDAMKRANST 328
Cdd:cd19979 231 DFPELPREALSKIdlrfiqTFSFFDANQS--PRGKQVLARYKRRYpveDPESDIPAPVgfahAYDLTHLLALAIEQAGST 308
|
330
....*....|....*....
gi 979337434 329 DPAKVLAAMPA-TDYRGVI 346
Cdd:cd19979 309 DRAAVRAALELlPPHEGLI 327
|
|
| PBP1_SBP-like |
cd06329 |
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins ... |
31-350 |
3.08e-24 |
|
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins or SBPs); Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380552 [Multi-domain] Cd Length: 343 Bit Score: 101.97 E-value: 3.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKvtLQLDAQDDAGDPRTATQVAQRLVDDK---VIGVVGHH 107
Cdd:cd06329 1 KIAFIDPLSGPFASVGEIYLKGLQFAIEEINAGG-GLLGRK--IELVPFDNKGSPQEALIQLKKAIDQGirfVLQGNSSA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 108 NSGTSIPASRVYR----DGGVVQISQAATNPTYTQQGFKT-TYRVVATDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQ 182
Cdd:cd06329 78 VAGALIDAIEKHNqrnpDKRVLFLNYGAEAPELTGAKCSFwHFRFDANADMKMAALADYMKKDGSIKKVYLINQDYSFGR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 183 GLATEFEKAAKAA--GMKVVSRDATN-DKAIDFRAILTKIKGTNPDAIMYG--GMDATGgpLAKQARQLGMRAKI----L 253
Cdd:cd06329 158 DVAAAAKKNLKKKrpDIEIVGEDLHPlGKVKDFSPYIAKIKASGADTVITGnwGNDLTL--LMKAARDSGLKAPFytyyA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 254 AGDGVcstdlPKLAGPASDNVVCSEA-GIALEKMPGGAAFAKRYEARY-HQPMQVYAPFSYdAVHIIVDAMKRANSTDPA 331
Cdd:cd06329 236 DGPGA-----PAAIGEAGVGRLVAVAyWHPNPKTPELEKFAEAFRAKYgRYPDFNIGRTYM-GVEMLAAAIKKAGSTDPE 309
|
330
....*....|....*....
gi 979337434 332 KVLAAMPATDYRGVIGETS 350
Cdd:cd06329 310 KVAKALEGLSFDTPGGPVT 328
|
|
| PBP1_ABC_ligand_binding-like |
cd06341 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
31-309 |
4.12e-24 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380564 [Multi-domain] Cd Length: 340 Bit Score: 101.61 E-value: 4.12e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKVtlQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHNS 109
Cdd:cd06341 1 KIGLIYPDTGPGAASFSAARAGAEARFGLANAAG-GINGRKV--EYVWCDDQSDPATNLQAARQLVEdEKVFALVGSSSA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIpASRVYRDGGVVQISQAATNPTYTQQGFKTTYRVVATDAQQgpALAMYAAKNMGIRTVAVVDDSTAYGQGLATEFE 189
Cdd:cd06341 78 ASGS-ANDYLAQAGIPVVGGAGVSVWCFRNMFSNFFSLGGGGSTT--TYGQYAAALGGTKAAVVVTDIPAASQQLAQQLA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 190 KAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAImYGGMDATG-GPLAKQARQLGMRAKILAGDGVCSTDLPKLAG 268
Cdd:cd06341 155 ASLRAAGVEVVGTAPYAAAAPDYTAVAQAAKAAGADAV-VGVLDPDVaARVLKAARAQGLDLKVALSPSGYDPSVLAAYG 233
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 979337434 269 PASDNVVcseAGIALEKMPGGAAFAKryeaRYHQPMQVYAP 309
Cdd:cd06341 234 AALAGVS---VASTFLPFEADTPAVK----AYRAAMAKYAP 267
|
|
| PBP1_SBP-like |
cd20378 |
periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
31-350 |
5.35e-22 |
|
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380668 [Multi-domain] Cd Length: 357 Bit Score: 95.87 E-value: 5.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlvigGKKvtLQLDAQDDAGDPRTATQVAQRLVDDKVIGV-VGHHNS 109
Cdd:cd20378 1 TLGGLVSMSGAFAAAGKLADRGMRLAVEEYGGAL----GRP--LKYITRDTEGKPGTGVRKVQEAIAQDGARFfIGGTLS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATN----------------PTYTqqGFKTTYRVVATdaqqgpalAMYAAKnmgirTVAV 173
Cdd:cd20378 75 SVALAVSEEAEKAGGVYITSGGADeitgsrcnrstfrwsvPTYG--AIRQTVRPVIK--------AMPKAK-----RWYT 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 174 VDDSTAYGQGLATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPD--AIMYGGMDATGGplAKQARQLGM--R 249
Cdd:cd20378 140 ITPQYVFGESLLKNAKEVLKEKGIEHVGNSYHSLGEREFSGYLTKAMAARPDvlLILNFGSQAVDA--LRQAVSFGLkrK 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 250 AKILagdGVCSTDLPKLAGPASDnvVCSeaGIAL-------EKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAM 322
Cdd:cd20378 218 MKIL---VAWSSGLDQFQELGPD--ICE--GVYFgaqywhdVDTPANKALVKVYQAKFKETPSYALAAGYACTRMLLDAI 290
|
330 340
....*....|....*....|....*...
gi 979337434 323 KRANSTDPAKVLAAMPATDYRGVIGETS 350
Cdd:cd20378 291 DKAGSTDPAAVIKALEGLKYDGITGDEE 318
|
|
| PBP1_ABC_ligand_binding-like |
cd19978 |
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to ... |
30-354 |
2.99e-21 |
|
periplasmic ligand-binding domain of uncharacterized ABC-type transport systems predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; This group includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); its ligand specificity has not been determined experimentally, however.
Pssm-ID: 380633 [Multi-domain] Cd Length: 341 Bit Score: 93.41 E-value: 2.99e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 30 VRIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLvIGGKKvtLQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGhhN 108
Cdd:cd19978 1 IRLGMSAALSGPAAELGNEMKRGIEAAFNEVNAQGG-VNGRK--IKLIALDDGYEPDRTVKNTKKLIeEDKVFALIG--Y 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 109 SGT--SIPASRVYRDGGVVQI-----SQAATNPTYtqqgfKTTYRVVATDAQQGPALAMYAAKNMGIRTVAVV--DDSta 179
Cdd:cd19978 76 VGTptALAALPLANEKKIPLFgpftgAEFLRTPFL-----PYVFNLRASYADETEALVDYLVKTLGPKRIAIFyqNDA-- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 180 YGQGLATEFEKAAKAAGMKVV-----SRDATNdkaidFRAILTKIKGTNPDAIMyggMDATGGPLA---KQARQLGMRAK 251
Cdd:cd19978 149 FGLAGLEGAKKALKKRGLTPVaegsyTRNTLD-----VEEALAKILKAKPEAII---LVGTYAPAAefiRLARAAGLNPL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 252 ILAGDGVCSTDLPKLAGPASDNVVCSEA--GIALEKMPGgaafAKryeaRYHQPMQVYAPFS---------YDAVHIIVD 320
Cdd:cd19978 221 FANVSFVGSEALALELGDYGEGVIVSQVvpDPNDSSLPI----VK----EYREAMKKYGPNAppdfvslegYLAARLLVE 292
|
330 340 350
....*....|....*....|....*....|....*.
gi 979337434 321 AMKRANST-DPAKVLAAMPATDYRGVIGET-SFTSQ 354
Cdd:cd19978 293 ALKKAGPPlTREKLLALEESLKNDLGKGLTlTFSPN 328
|
|
| PBP1_amide_urea_BP-like |
cd06356 |
periplasmic component (FmdD) of an active transport system for short-chain amides and urea ... |
31-337 |
7.68e-21 |
|
periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); This group includes the type 1 periplasmic-binding proteins that are predicted to have a function similar to that of an active transport system for short chain amides and/or urea in bacteria and Archaea, by sequence comparison and phylogenetic analysis.
Pssm-ID: 380579 [Multi-domain] Cd Length: 334 Bit Score: 91.98 E-value: 7.68e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLVIGGKkvtLQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd06356 1 KIGSIFDLSGGLNIYGKPMVHAMKLAVEEINAAGGLLGRQ---IELVAYDTQSDMQKYTQYAQQLIlRDKVDVVFGGITS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 gtsipASR-VYRdggvvQISQAATNPT-YTQQGF-----KTTYRVVATDAQQGPALAMYAAKNMGiRTVAVVDDSTAYGQ 182
Cdd:cd06356 78 -----ASReAIR-----PILRRNKILYfYNTQYEggvcdKNTFCTGSTPEQQVSPLIEWAIKKYG-KKVYIIAADYNFGQ 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 183 GLATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGgmdATGGPLAKQARQ---LGMRAKIlagdGVC 259
Cdd:cd06356 147 ISADWVKKYAKKNGGEVVGEEFFPLDVTDFGPTIQKIQAAKPDFVVSL---LVGGNHISFYRQwaaAGLKKKI----PIV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 260 STDL------PKLAGPASDNVVCSEAGIALEKMPGGAAFAKRYEARY--HQPMQVYAPFSYDAVHIIVDAMKRANSTDPA 331
Cdd:cd06356 220 STVFgagnehKVLSPPELEGMYVSYSYFEELDTPANKAFVAKWRAKYgdEPYINQEAVGVYNAVYLWAEAVEKAGSTERE 299
|
....*.
gi 979337434 332 KVLAAM 337
Cdd:cd06356 300 AVIAAL 305
|
|
| PBP1_SBP-like |
cd19987 |
periplasmic substrate-binding domain of active transport proteins; Periplasmic ... |
31-351 |
2.61e-20 |
|
periplasmic substrate-binding domain of active transport proteins; Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380642 [Multi-domain] Cd Length: 353 Bit Score: 90.85 E-value: 2.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLVIG-----------GKKVtlQLDAQDDAGDPRTATQVAQRLVD-D 98
Cdd:cd19987 1 TIGLNVPLSGPYAPQGEDQRRGFELAVDHLNNGGGLVDkdsrlsgdgilGKKV--ELVTADTETKADTAVDNAKRLIEqD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 99 KVIGVVGHHNSGTSIPASRVYRDGGVVQISQAAT-NPTYTQQGFKTTYRVVATDAQQGPALAMYAAKNMGI-RTVAVVDD 176
Cdd:cd19987 79 GAVMITGGSSSAVAVAAQKLAQKEGVLYFAGLSHsNDTTGKDCHRYGFRECFNAHMSAKALAPYLVEKFGKdRKYFYLTA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 177 STAYGQGLATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIM--YGGMDATGGplAKQARQLGMRAKILA 254
Cdd:cd19987 159 DYTWGHSTEQSMREYTEAHGWKTVGNPATPLGETDFSAALLNAADSGADVLVlvLFGRDMVNA--LKQAKQFGLLKKMDI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 255 GDGVCSTDLPKLAGP-ASDNVVCSEA---GIAlEKMPGGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTDP 330
Cdd:cd19987 237 VVPLLTAFMAESVGPeIMEGVLGTVNwhwSLP-DDYSYAFGKAEAFEKEYGAYPSQAAASAYVQVLQYAAAVERAGSFDP 315
|
330 340
....*....|....*....|.
gi 979337434 331 AKVLAAMPATDYRGVIGETSF 351
Cdd:cd19987 316 PAVIRALEGHEYTLLKGEQYW 336
|
|
| PBP1_ABC_ligand_binding-like |
cd06337 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
31-355 |
4.35e-20 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380560 [Multi-domain] Cd Length: 354 Bit Score: 90.44 E-value: 4.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLVIGGKKVTLQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd06337 1 KIGRVSPLTGPLAAFGEADPWVLEQIREAFADGGIKVGGKKYPVEIVVRDSQSDPNRAGEAARDLIlRDKVDLMLASGTP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGGVVQISQAATNPTY-------TQQGFKTTYRVVATDAQQGPA-LAMYAAKNMGiRTVAVVDDSTAYG 181
Cdd:cd06337 81 DTVNPVADQCEANGVPCISTDAPWQAWffgrggdPAKGFKWTFHFFWGLEDIAANfLGMWDQVPTN-KVVGLLWPNDPDG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 182 QGLATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDaIMYGGM---DATGgpLAKQARQLGMRAKILAGDGV 258
Cdd:cd06337 160 TAFADAFLGLPAAAGYTLVDPGRFPPGTDDFSSIINAFKKAGVE-IVTGVMippDFAT--FWRQAAQQGFKPKVVTIGKA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 259 CS-TDLPKLAGPASDNvVCSEAGIAlEKMPG--------GAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKRANSTD 329
Cdd:cd06337 237 LLfPSAVAALGDLGDG-LSTEVWWS-PAHPFkssltgqtAAELADAYEKATGKQWTQPLGYAHALFEVAVDALKRAGSPD 314
|
330 340
....*....|....*....|....*.
gi 979337434 330 PAKVLAAMPATDYRGVIGETSFTSQG 355
Cdd:cd06337 315 DEAVRAALADTDLDTIVGPVDFTSGP 340
|
|
| PBP1_GPCR_family_C-like |
cd06350 |
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory ... |
56-315 |
2.25e-19 |
|
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate; categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (m; Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region, the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further divided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP, which is a bacterial periplasmic protein (PBP), as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA, AMPA, and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.
Pssm-ID: 380573 Cd Length: 350 Bit Score: 88.12 E-value: 2.25e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 56 AVEEINAKGLVIGGkkVTLQLDAQDDAGDPRTATQVAQRLVDD-----------------KVIGVVGHHNSGTSIPASRV 118
Cdd:cd06350 36 AIEEINNDSSLLPN--VTLGYDIRDTCSSSSVALESSLEFLLDngikllansngqnigppNIVAVIGAASSSVSIAVANL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 119 YRDGGVVQISQAATNPTYT-QQGFKTTYRVVATDAQQgpALAMYA-AKNMGIRTVAVVDDSTAYGQGLATEFEKAAKAAG 196
Cdd:cd06350 114 LGLFKIPQISYASTSPELSdKIRYPYFLRTVPSDTLQ--AKAIADlLKHFNWNYVSTVYSDDDYGRSGIEAFEREAKERG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 197 M-----KVVSRDATNDkaiDFRAILTKIKG-TNPDAIMYGGMDATGGPLAKQARQLGMRAKI-LAGDGvCSTDLPKLAGP 269
Cdd:cd06350 192 IciaqtIVIPENSTED---EIKRIIDKLKSsPNAKVVVLFLTESDARELLKEAKRRNLTGFTwIGSDG-WGDSLVILEGY 267
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 979337434 270 ASdnvvcseagiALEKMPGGAAFAKRYEArYHQPMQVYAPFSYDAV 315
Cdd:cd06350 268 ED----------VLGGAIGVVPRSKEIPG-FDDYLKSYAPYVIDAV 302
|
|
| PBP1_YraM_LppC_lipoprotein-like |
cd06339 |
periplasmic binding component of lipoprotein LppC, an immunodominant antigen; This subgroup ... |
31-355 |
6.84e-19 |
|
periplasmic binding component of lipoprotein LppC, an immunodominant antigen; This subgroup includes periplasmic binding component of lipoprotein LppC, an immunodominant antigen, whose molecular function is not characterized. Members of this subgroup are predicted to be involved in transport of lipid compounds, and they are sequence similar to the family of ABC-type hydrophobic amino acid transporters (HAAT).
Pssm-ID: 380562 [Multi-domain] Cd Length: 331 Bit Score: 86.56 E-value: 6.84e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINakglvigGKKVTLQLDaqdDAGDPRTATQVAQRLVDDKVIGVVGHHNSG 110
Cdd:cd06339 1 RIALLLPLSGPYAAAGQAIRDGIELALFDAG-------GSRPELRVY---DTGGPEGAAAAYQQAVAEGADLIIGPLLKS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 111 TSIPASRVYRDGGVVQISQAATNPTYTQQGFkttYRVVATDAQQGPALAMYAAKNmGIRTVAVVDDSTAYGQGLATEFEK 190
Cdd:cd06339 71 SVAALAAAAQALGVPVLALNNDESATAGPGL---FQFGLSPEDEARQAARYAVQQ-GLRRFAVLAPDNAYGQRVANAFRE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 191 AAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNP--DAIMYGGMDATGGPL-------------AKQARQL--------G 247
Cdd:cd06339 147 AWQALGGTVVAVESYDPDETDFSAAIRRLLGVDQseARIRQLGELLEFEPRrrqdfdaiflpagPEQARLIapqlafygA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 248 MRAKILAGDGVCSTDLPKLAGPASDNVVCSEagialekMP---GGAAFAKRYEARYHQPMQVYAPFSYDAVHIIVDAMKR 324
Cdd:cd06339 227 GDVPLLGTSLWYSGKLNLLRDPDLNGAWFAD-------PPwllSPRAFPLRYRLAYGWPPPRLAALGYDAYRLAARLARL 299
|
330 340 350
....*....|....*....|....*....|.
gi 979337434 325 ANSTDPAKVlaampatdYRGVIGETSFTSQG 355
Cdd:cd06339 300 GGGLTPGAG--------FSGLTGLLRLDPDG 322
|
|
| PBP1_AmiC |
cd06357 |
periplasmic binding domain of amidase (AmiC) that belongs to the type 1 periplasmic binding ... |
31-337 |
7.27e-19 |
|
periplasmic binding domain of amidase (AmiC) that belongs to the type 1 periplasmic binding fold protein family; This group includes the periplasmic binding domain of amidase (AmiC) that belongs to the type 1 periplasmic binding fold protein family. AmiC controls expression of the amidase operon by the ligand-triggered conformational switch. In the absence of ligand or presence of butyramide (repressor), AmiC (the ligand sensor and negative regulator) adopts an open conformation and inhibits the transcription antitermination function of AmiR by direct protein-protein interaction. In the presence of inducing ligands such as acetamide, AmiC adopts a closed conformation which disrupts a silencing AmiC-AmiR complex and the expression of amidase and other genes of the operon are induced.
Pssm-ID: 380580 [Multi-domain] Cd Length: 357 Bit Score: 86.86 E-value: 7.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLViGGKKVTLQLdaQDDAGDPRTATQVAQRLV-DDKVIGVVGHHNS 109
Cdd:cd06357 1 RVGLLFSQTGVTAIIEQSMLNGALLAIEEINAAGGV-NGRPIEPVV--YDPASDPDRYRELAERLLlEDGVRHIFGCYTS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 gtsipASRVyrdgGVVQISQAATN----PTYtQQGFKTTYRVVATDA---QQGPALAMYAAKNMGIRtVAVVDDSTAYGQ 182
Cdd:cd06357 78 -----ASRK----AVLPVVERHNAllwyPTP-YEGFEYSPNVIYTGAvpnQHLLPLARYLLAHFGKR-VFLVGSNYVYPW 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 183 GLATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAI---MYGgmdATGGPLAKQARQLGM-RAKILagdgV 258
Cdd:cd06357 147 ESNRVARELIEASGGEVVGERYVPLGDTDFAEIIEEIKSLKPDVVfstLVG---DSIYAFYRAYAEAGLdPADMP----I 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 259 CS-----TDLPKLAGPASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQVYAPF--SYDAVHIIVDAMKRANSTDPA 331
Cdd:cd06357 220 ASlttseAEVAAIGAEAAAGHYTSAPYFQSIDTPENRAFVEAYRARFGDDAVTSAVAeaAYFQVHLLARAIERAGSDDPE 299
|
....*.
gi 979337434 332 KVLAAM 337
Cdd:cd06357 300 AIRAAL 305
|
|
| PBP1_RPA0985_benzoate-like |
cd20013 |
type 1 periplasmic binding-protein component of an ABC system (RPA0985), involved in the ... |
31-337 |
5.08e-18 |
|
type 1 periplasmic binding-protein component of an ABC system (RPA0985), involved in the active transport of lignin-derived benzoate derivative compounds, and its close homologs; This group includes RPA0985 from Rhodopseudomonas palustris and its close homologs in other bacteria. Rpa0985 is the periplasmic binding-protein component of an ABC system that is involved in the active transport of lignin-derived benzoate derivative compounds. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).
Pssm-ID: 380666 [Multi-domain] Cd Length: 356 Bit Score: 84.23 E-value: 5.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEinaKGLVIGGKKVtlQLDAQDDAG-DPRTATQVAQRL-VDDKVIGVVGHHN 108
Cdd:cd20013 1 KVGVIGPFSGPFADYGKQFDRGIDLYLKL---HGDKVGGRKV--EVIYRDDGGpNPAVAKRLAQELiVRDKVQILIGFGF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 109 SGTSIPASRVYRDGGVVQISQAATNPTYTQqgfKTTY--RVVATDAQQGPALAMYAAKNmGIRTVAVVDDSTAYGQGLAT 186
Cdd:cd20013 76 TPNALAVAPVATEAKTPTVIMNAATSSITR---KSPYfvRTSFTMWQVAYPMGKWAAKN-GIKKAYTAVADYAPGHDAET 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 187 EFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAI---MYGGMDATGgpLAKQARQLGMRAK----ILAGDGVC 259
Cdd:cd20013 152 AFKKAFEAAGGKIVGSIRVPLATPDFAPFMQRIKDAKPDAVfvfVPAGAPSIG--FLKAYAERGLKEAgiklLGTGDATD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 260 STDLPkLAGPASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQV--YAPFSYDAVHIIVDAMKRAN-STDPAKVLAA 336
Cdd:cd20013 230 DDDLP-AMGDAALGLITAGHYSAALDSPENKAFVAAYQKAYGPDARPdfMAVAAYDGMALIYKMIKATGgKFDGDKAMAA 308
|
.
gi 979337434 337 M 337
Cdd:cd20013 309 V 309
|
|
| PBP1_ABC_ligand_binding-like |
cd06334 |
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type ... |
31-325 |
6.43e-17 |
|
type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions; This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.
Pssm-ID: 380557 [Multi-domain] Cd Length: 360 Bit Score: 81.13 E-value: 6.43e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLvIGGKKVTLQLdaQDDAGDPRTATQVAQRLVD-DKVIGVVGHHNS 109
Cdd:cd06334 1 KIGLLTDLTGPTADVGKPYAQGVRDYLNYVNEEGG-INGVKIELEE--CDTGYKVPRAVACYKRLKAqDGVVAILGWGTG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYRDGgVVQISqAATNPTYTQQGFKTTYR--VVATDAQQGPALAMYAAKNMGIR----TVAVVDDSTAYGQG 183
Cdd:cd06334 78 DTEALAPRVAKDK-IPYIS-ASYGRSLADDGKVFPYNffVGATYSSQARALLKYIAQEWGGKlkgpKVAFVYHDSPFGRE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 184 LATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKILAGDGVCSTDL 263
Cdd:cd06334 156 PIPALKAYAKELGFEVVAEQVPSPGALDATAQWLRIRRAGPDYVIIQGTGGSVAVIIKDAKRLGLKTKFIGNIWGGDEDL 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 979337434 264 PKLAGPASDNVVCSEAGIALEKMPGGAAFAKRYEARYHQPMQV-YAPFSYD----AVHIIVDAMKRA 325
Cdd:cd06334 236 IKLAGDAAEGYVGVSPFAFGTDDPPGKEIVEEVAKKGKGDGPEeVGTVYYNrgwaTAMLAVEAIRRA 302
|
|
| Peripla_BP_5 |
pfam13433 |
Periplasmic binding protein domain; This domain is found in a variety of bacterial periplasmic ... |
30-337 |
1.15e-14 |
|
Periplasmic binding protein domain; This domain is found in a variety of bacterial periplasmic binding proteins.
Pssm-ID: 463875 [Multi-domain] Cd Length: 363 Bit Score: 74.55 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 30 VRIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLVIGGKkvtLQLDAQDDAGDPRTATQVAQRLV-DDKVIGVVGHHN 108
Cdd:pfam13433 1 IKVGVLHSLTGTMAISERSLKDATLMAIEEINAAGGVLGRK---IEPVVVDPASDWPLFAEKARKLIdQDKVRVVFGCWT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 109 SgtsipASRvyrdGGVVQISQAATN----PTYtQQGFKTTYRVVATDA---QQGPALAMYAAKNMGIRTVAVVDDSTaYG 181
Cdd:pfam13433 78 S-----ASR----KAVLPVFERHNGllfyPVQ-YEGFESSRNIFYTGAapnQQAIPAVDYLLSELGKRFFLVGSDYV-YP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 182 QGLATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAKIL--AGDGVC 259
Cdd:pfam13433 147 RTTNRILRAYLKAKGGEVVGERYLPLGSSDWQSIVAKIKAAGPDVVFSTINGDSNVAFYRALRAAGITAEDIpvMSFSVA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 260 STDLPKL-AGPASDNVVCSEAGIALEKmPGGAAFAKRYEARYHQPMQVYAPF--SYDAVHIIVDAMKRANSTDPAKVLAA 336
Cdd:pfam13433 227 EEELAGMgPEPLVGHLAAWNYFQSLDT-PENKAFVAAFKARYGDDRVTNDPMeaAYIGVHLWAQAVEKAGTDDPDAVRQA 305
|
.
gi 979337434 337 M 337
Cdd:pfam13433 306 M 306
|
|
| PBP1_SBP-like |
cd06327 |
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins ... |
31-337 |
2.53e-14 |
|
periplasmic substrate-binding domain of active transport proteins (substrate binding proteins or SBPs); Periplasmic substrate-binding domain of active transport proteins found in gram-negative, gram-positive bacteria, and archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.
Pssm-ID: 380550 [Multi-domain] Cd Length: 336 Bit Score: 73.37 E-value: 2.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHL-GKDSENGARLAVEEINAKGLvigGKKVtlQLDAQDDAGDPRTATQVAQRLVD-DKVIGVVGHHN 108
Cdd:cd06327 1 RIGVLTDLSGVYADLsGPGSVEAAKMAVEDFGGKVL---GRPI--EVVSADHQNKPDVASAIAREWYDrDGVDAIVDVPN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 109 SGTSIPASRVYRDGGVVQISQAATNPTYTQQ-----GFKTTYrvvatDAQQGPALAMYAAKNMGIRTVAVVDDSTAYGQG 183
Cdd:cd06327 76 SAVALAVQKLAKEKKKIAIVTGAGSSDLTGKacspyGVHWAY-----DTYALARGTVKALVKQGGKSWFFITADYAFGHS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 184 LATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAIMYggmdATGGP----LAKQARQLGMRAK--ILAGDG 257
Cdd:cd06327 151 LEADATAAVKAAGGKVVGSVRHPLGTTDFSSFLLQAQASGADVIAL----ANAGAdlvnAVKQAREFGLTDGgqKLAALL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 258 VCSTDLpKLAGPASDNVVCSEAGIALEKMPGGAAFAKRYEARY-HQPMQVYAPfSYDAVHIIVDAMKRANSTDPAKVLAA 336
Cdd:cd06327 227 LFITDI-HALGLDAAQGLYLTTAFYWDRDDATRAWAKRFFARTgKMPTMLQAG-VYSAVLHYLKAVKAAGTDDADAVVAK 304
|
.
gi 979337434 337 M 337
Cdd:cd06327 305 M 305
|
|
| PBP1_GABAb_receptor |
cd06366 |
ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for ... |
32-356 |
1.16e-11 |
|
ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA); Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.
Pssm-ID: 380589 [Multi-domain] Cd Length: 404 Bit Score: 65.73 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 32 IGHVAPLTGAIAHL-GKDSENGARLAVEEINAKGLVIGGkkVTLQLDAQDDAGDPRTATQVAQRLV--DDKVIGVVGHHN 108
Cdd:cd06366 2 IGGLFPLSGSKGWWgGAGILPAAEMALEHINNRSDILPG--YNLELIWNDTQCDPGLGLKALYDLLytPPPKVMLLGPGC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 109 SGTSIPASRVYRDGGVVQISQAATNPTYT-QQGFKTTYRVVATDAQQGPA-LAMyaAKNMGIRTVAVVDDSTAYGQGLAT 186
Cdd:cd06366 80 SSVTEPVAEASKYWNLVQLSYAATSPALSdRKRYPYFFRTVPSDTAFNPArIAL--LKHFGWKRVATIYQNDEVFSSTAE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 187 EFEKAAKAAGMKVVSRdaTNDKAIDFRAILTKIKGTnpDA-IMYGGMDATGGplAK---QARQLGMRAK----ILAGdGV 258
Cdd:cd06366 158 DLEELLEEANITIVAT--ESFSSEDPTDQLENLKEK--DArIIIGLFYEDAA--RKvfcEAYKLGMYGPkyvwILPG-WY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 259 CstdlPKLAGPASDNVVCS--------EAGIALEKMP---------GG---AAFAKRYEARYHQPMQ---VYAPFSYDAV 315
Cdd:cd06366 231 D----DNWWDVPDNDVNCTpeqmlealEGHFSTELLPlnpdntktiSGltaQEFLKEYLERLSNSNYtgsPYAPFAYDAV 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 979337434 316 HIIVDAMKRANSTDPAK-----------------VLAAMPATDYRGVIGETSFTSQGD 356
Cdd:cd06366 307 WAIALALNKTIEKLAEYnktledftyndkemadlFLEAMNSTSFEGVSGPVSFDSKGD 364
|
|
| PBP1_FmdD-like |
cd06355 |
periplasmic component (FmdD) of an active transport system for short-chain amides and urea ... |
31-338 |
1.60e-11 |
|
periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); This group includes the periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF), found in Methylophilus methylotrophus, and its homologs from other bacteria. FmdD, a type 1 periplasmic binding protein, is induced by short-chain amides and urea and repressed by excess ammonia, while FmdE and FmdF are hydrophobic transmembrane proteins. FmdDEF is predicted to be an ATP-dependent transporter and closely resembles the periplasmic binding protein and the two transmembrane proteins present in various hydrophobic amino acid-binding transport systems.
Pssm-ID: 380578 [Multi-domain] Cd Length: 347 Bit Score: 64.90 E-value: 1.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGLVIGGKKVTLQLDAqddAGDPRTATQVAQRL-VDDKVIGVVGhhnS 109
Cdd:cd06355 1 KVGILHSLSGTMAISERPLVDATLLAIDEINAAGGLLGRKIEPVIEDG---ASDWPTFAEKAEKLiTQDKVAVIFG---C 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSipASR------VYRDGGV----VQisqaatnptYtqQGFKTTYRVV---ATDAQQG-PALAmYAAKNMGiRTVAVVD 175
Cdd:cd06355 75 WTS--ASRkavlpvIEKYNGLlfypVQ---------Y--EGLEQSPNIVytgATPNQQIlPAID-WLLENLG-KRFFLVG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 176 DSTAYGQGLATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDAImyggMDATGG----PLAKQarqlgmrak 251
Cdd:cd06355 140 SDYVFPRTANKIIRDQLKALGGEVVGEEYVPLGGTDFDAIVAKIKAFKPDVI----VNTLNGdsniAFFKQ--------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 252 iLAGDGVCSTDLPKLAGPASDNVVCSEAGIALE------------KMPGGAAFAKRYEARYHQPMQVYAPF--SYDAVHI 317
Cdd:cd06355 207 -LAAAGITASDLPVLSFSVSEAELRAIGPEELAghyaawnyfqslDTPENQAFVEAFKAKYGADRVTSDPMeaAYLGVYL 285
|
330 340
....*....|....*....|.
gi 979337434 318 IVDAMKRANSTDPAKVLAAMP 338
Cdd:cd06355 286 WAQAVEKAGSFDPDAVRAALK 306
|
|
| PBP1_NHase |
cd06358 |
type 1 periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively ... |
31-355 |
1.49e-10 |
|
type 1 periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; This group includes the type 1 periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides, which are subsequently converted by amidases to yield free carboxylic acids and ammonia. NHases from bacteria and fungi have been purified and characterized. In Rhodococcus sp., the nitrile hydratase operon consists of six genes encoding NHase regulator 2, NHase regulator 1, amidase, NHase alpha subunit, NHase beta subunit, and NHase activator. The operon produces a constitutive hydratase that has a broad substrate spectrum: aliphatic and aromatic nitriles, mononitriles and dinitriles, hydroxynitriles and amino-nitriles, and a constitutive amidase of equally low substrate specificity. NHases are metalloenzymes containing either cobalt or iron, and therefore can be classified into two subgroups: ferric NHases and cobalt NHases.
Pssm-ID: 380581 [Multi-domain] Cd Length: 333 Bit Score: 61.84 E-value: 1.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 31 RIGHVAPLTGAIAHLGKDSENGARLAVEEINAKGlVIGGKKVtlQLDAQDDAGDPRTATQVAQRLVDDKVI-GVVGHHNS 109
Cdd:cd06358 1 RIGLLIPLSGPAGLWGPSCEACAELAAAEINAAG-GILGREV--ELVLIDAGGPPAEVAAAARRLVDDGAVdAIVGMHTS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 110 GTSIPASRVYrDGGVVQIsqaatnptYTQQ--GFKTTYRVVA---TDAQQ-GPALAmYAAKNMGIRTVAVVDDSTAYGQG 183
Cdd:cd06358 78 AVRQALANAV-GGRVPYV--------YTPLyeGGERTPGVYAigeTPEEQlRPALR-WLADERRVRRWFLVGNDYVWPRA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 184 LATEFEKAAKAAGMKVVSRDATNDKAIDFRAILTKIKGTNPDA--IMYGGMDA-------TGGPLAKQARQLG--MRAKI 252
Cdd:cd06358 148 SHAAARRYIARLGGEVVGERFVPLGEDDFERVLARIRASRPDAvlISLVGQDAvdfnrafAAAGLAGRILRLSpaIDENV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979337434 253 LAGDGVCSTdlpklagpasDNVVCSEAGIALEKMPGGAAFAKRYEARY--HQPMQ-VYAPFSYDAVHIIVDAMKRANSTD 329
Cdd:cd06358 228 LLAIGADAT----------ENLYSASGYFASLRTAANLAFLERYHAAFgdRAPPLnALGESCYEGVHFLAALARRAGSLD 297
|
330 340
....*....|....*....|....*.
gi 979337434 330 PAKVLAAMPATDYRGVIGETSFTSQG 355
Cdd:cd06358 298 VRALAAAAEGLTYESPRGAVTLRGRH 323
|
|
| PBP1_glutamate_receptors-like |
cd06269 |
ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl ... |
32-251 |
6.05e-10 |
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ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as natriuretic peptide receptors (NPRs), and N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of ionotropic glutamate rece; This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs), and the N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the ionotropic glutamate receptors, all of which are structurally similar and related to the periplasmic-binding fold type 1 family. The family C GPCRs consists of metabotropic glutamate receptor (mGluR), a calcium-sensing receptor (CaSR), gamma-aminobutyric acid receptor (GABAbR), the promiscuous L-alpha-amino acid receptor GPR6A, families of taste and pheromone receptors, and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids, ions, and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors, AMPA receptors, and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B), the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E, GC-F), and olfactory receptors (GC-D and GC-G).
Pssm-ID: 380493 [Multi-domain] Cd Length: 332 Bit Score: 60.12 E-value: 6.05e-10
10 20 30 40 50 60 70 80
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gi 979337434 32 IGHVAPLTGAIaHLGKDSENGARLAVEEINAKGlvIGGKKVTLQLDAQDDAGDPRTATQVA-QRLVDDKVIGVVGHHNSG 110
Cdd:cd06269 2 IGALLPVHDYL-ESGAKVLPAFELALSDVNSRP--DLLPKTTLGLAIRDSECNPTQALLSAcDLLAAAKVVAILGPGCSA 78
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90 100 110 120 130 140 150 160
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gi 979337434 111 TSIPASRVYRDGGVVQISQAATNPTYT-QQGFKTTYRVVATDAQQGPA-LAMYaaKNMGIRTVAVVDDSTAYGQGLATEF 188
Cdd:cd06269 79 SAAPVANLARHWDIPVLSYGATAPGLSdKSRYAYFLRTVPPDSKQADAmLALV--RRLGWNKVVLIYSDDEYGEFGLEGL 156
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170 180 190 200 210 220
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gi 979337434 189 EKAAKAAGMKVVSRDA-TNDKAIDFRAILTKIKGTNPDAIMYGGMDATGGPLAKQARQLGMRAK 251
Cdd:cd06269 157 EELFQEKGGLITSRQSfDENKDDDLTKLLRNLRDTEARVIILLASPDTARSLMLEAKRLDMTSK 220
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| PBP1_mGluR |
cd06362 |
ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of ... |
93-197 |
6.39e-06 |
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ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of the metabotropic glutamate receptors (mGluR), which are members of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses. mGluRs bind to glutamate and function as an excitatory neurotransmitter; they are involved in learning, memory, anxiety, and the perception of pain. Eight subtypes of mGluRs have been cloned so far, and are classified into three groups according to their sequence similarities, transduction mechanisms, and pharmacological profiles. Group I is composed of mGlu1R and mGlu5R that both stimulate PLC hydrolysis. Group II includes mGlu2R and mGlu3R, which inhibit adenylyl cyclase, as do mGlu4R, mGlu6R, mGlu7R, and mGlu8R, which form group III.
Pssm-ID: 380585 [Multi-domain] Cd Length: 460 Bit Score: 48.06 E-value: 6.39e-06
10 20 30 40 50 60 70 80
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gi 979337434 93 QRLVDDKVIGVVGHHNSGTSIPASRVYRDGGVVQISQAATNPTYTQQG-FKTTYRVVATDAQQgpALAMYA-AKNMGIRT 170
Cdd:cd06362 101 ESFQFYDVVGVIGAESSSVSIQVANLLRLFKIPQISYASTSDELSDKErYPYFLRTVPSDSFQ--AKAIVDiLLHFNWTY 178
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90 100
....*....|....*....|....*..
gi 979337434 171 VAVVDDSTAYGQGLATEFEKAAKAAGM 197
Cdd:cd06362 179 VSVVYSEGSYGEEGYKAFKKLARKAGI 205
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| PBP1_mGluR_groupIII |
cd06376 |
ligand-binding domain of the group III metabotropic glutamate receptor; Ligand-binding domain ... |
79-196 |
1.30e-04 |
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ligand-binding domain of the group III metabotropic glutamate receptor; Ligand-binding domain of the group III metabotropic glutamate receptor, a family which contains mGlu4R, mGluR6R, mGluR7, and mGluR8; all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes.
Pssm-ID: 380599 [Multi-domain] Cd Length: 467 Bit Score: 43.64 E-value: 1.30e-04
10 20 30 40 50 60 70 80
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gi 979337434 79 QDDAGDPRTATQVAQRLVD-DKVIGVVGHHNSGTSIPASRVYRDGGVVQISQAATNPTYTQqgfKTTY----RVVATDAQ 153
Cdd:cd06376 86 QKDTSDVRCTNGDPPVFVKpEKVVGVIGASASSVSIMVANILRLFQIPQISYASTAPELSD---DRRYdffsRVVPPDSF 162
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90 100 110 120
....*....|....*....|....*....|....*....|...
gi 979337434 154 QGPALaMYAAKNMGIRTVAVVDDSTAYGQGLATEFEKAAKAAG 196
Cdd:cd06376 163 QAQAM-VDIVKALGWNYVSTLASEGNYGEKGVESFVQISREAG 204
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| PBP1_CaSR |
cd06364 |
ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors ... |
100-228 |
1.70e-03 |
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ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily. CaSR provides feedback control of extracellular calcium homeostasis by responding sensitively to acute fluctuations in extracellular ionized Ca2+ concentration. This ligand-binding domain has homology to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). CaSR is widely expressed in mammalian tissues and is active in tissues that are not directly involved in extracellular calcium homeostasis. Moreover, CaSR responds to aromatic, aliphatic, and polar amino acids, but not to positively charged or branched chain amino acids, which suggests that changes in plasma amino acid levels are likely to modulate whole body calcium metabolism. Additionally, the family C GPCRs includes at least two receptors with broad-spectrum amino acid-sensing properties: GPRC6A which recognizes basic and various aliphatic amino acids, its gold-fish homolog the 5.24 chemoreceptor, and a specific taste receptor (T1R) which responds to aliphatic, polar, charged, and branched amino acids, but not to aromatic amino acids.
Pssm-ID: 380587 [Multi-domain] Cd Length: 473 Bit Score: 40.32 E-value: 1.70e-03
10 20 30 40 50 60 70 80
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gi 979337434 100 VIGVVGHHNSGTSIPASRVYRDGGVVQISQAATNPTYT-QQGFKTTYRVVATDAQQGPALAMYaAKNMG---IRTVAVVD 175
Cdd:cd06364 101 VAAVIGESGSTLSIAVARTLGLFYIPQVSYFASCACLSdKKQFPSFLRTIPSDYYQSRALAQL-VKHFGwtwVGAIASDD 179
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90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 979337434 176 DstaYGQGLATEFEKAAKAAGM-----KVVSRDATNDKaidFRAILTKIKGTNPDAIM 228
Cdd:cd06364 180 D---YGRNGIKAFLEEAEKLGIciafsETIPRTYSQEK---ILRIVEVIKKSTAKVIV 231
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