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Conserved domains on  [gi|978205915|gb|KVL06732|]
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AsnC family transcriptional regulator [Burkholderia cepacia]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
5-141 2.30e-26

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 96.77  E-value: 2.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205915   5 LDRVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLERDGHIRGYTVRRgSPLADAVPIRALMFVY-RKDRMRga 83
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVV-DPEKLGLGVTAFVEVKvPPHRLD-- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 978205915  84 DVIGHVRTVPEVVACDVMSGELDVVLHIEAASSERIHKLW-EEVAALQGVLNTVTSFVL 141
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
5-141 2.30e-26

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 96.77  E-value: 2.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205915   5 LDRVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLERDGHIRGYTVRRgSPLADAVPIRALMFVY-RKDRMRga 83
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVV-DPEKLGLGVTAFVEVKvPPHRLD-- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 978205915  84 DVIGHVRTVPEVVACDVMSGELDVVLHIEAASSERIHKLW-EEVAALQGVLNTVTSFVL 141
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 5-113 1.31e-19

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 78.33  E-value: 1.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205915     5 LDRVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLERDGHIRGYTVRRgSPLADAVPIRALMFVYRKDRMRGAD 84
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVL-NPKKLGLSVTAFVGVTLENPDKLEE 79

                           90       100
                   ....*....|....*....|....*....
gi 978205915    85 VIGHVRTVPEVVACDVMSGELDVVLHIEA 113
Cdd:smart00344  80 FLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
6-46 5.01e-10

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 51.99  E-value: 5.01e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 978205915    6 DRVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLE 46
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
5-146 3.57e-08

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 49.76  E-value: 3.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205915   5 LDRVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLERDGHIRGYTVRRGSPLADAvpirALMFVYRKDRMRGA- 83
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDA----SLLVFVEITLNRGAp 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 978205915  84 DVIGH----VRTVPEVVACDVMSGELDVVLHIEAASSERIHKLW-EEVAALQGVLNTVTSFVLTRSKD 146
Cdd:PRK11169  88 DVFEQfnaaVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLgETLLRLPGVNDTRTYVVMEEVKQ 155
birA_repr_reg TIGR00122
BirA biotin operon repressor domain; This model represents the amino-terminal helix-turn-helix ...
 8-69 7.10e-04

BirA biotin operon repressor domain; This model represents the amino-terminal helix-turn-helix repressor region of the biotin--acetyl-CoA-carboxylase ligase/biotin operon repressor bifunctional protein BirA. In many species, the biotin--acetyl-CoA-carboxylase ligase ortholog lacks this DNA-binding repressor region and therefore is not equivalent to the well-characterized BirA of E. coli. This model may recognize some other putative repressor proteins, such as DnrO of Streptomyces peucetius with scores below the noise cutoff but with significance shown by low E-value. [Regulatory functions, DNA interactions]


Pssm-ID: 272918 [Multi-domain]  Cd Length: 69  Bit Score: 36.29  E-value: 7.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 978205915    8 VDTKILTLLTENaRLSHNDIAASVNLSRNAVRLRIERLERDG-----HIRGYTVRRGSPLADAVPIR 69
Cdd:TIGR00122   1 MPLRLLALLADN-PFSGEKLGEALGMSRTAVNKHIQTLREWGvdvltVGKGYRLPPPIPLLNAKQIR 66
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-58 6.89e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.81  E-value: 6.89e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 978205915   2 KRVLDRVDTKILTLLTENaRLSHNDIAASVNLSRNAVRLRIERLERDGHIRGYTVRR 58
Cdd:cd00090    2 KALSDPTRLRILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGR 57
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
5-141 2.30e-26

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 96.77  E-value: 2.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205915   5 LDRVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLERDGHIRGYTVRRgSPLADAVPIRALMFVY-RKDRMRga 83
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVV-DPEKLGLGVTAFVEVKvPPHRLD-- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 978205915  84 DVIGHVRTVPEVVACDVMSGELDVVLHIEAASSERIHKLW-EEVAALQGVLNTVTSFVL 141
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 5-113 1.31e-19

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 78.33  E-value: 1.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205915     5 LDRVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLERDGHIRGYTVRRgSPLADAVPIRALMFVYRKDRMRGAD 84
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVL-NPKKLGLSVTAFVGVTLENPDKLEE 79

                           90       100
                   ....*....|....*....|....*....
gi 978205915    85 VIGHVRTVPEVVACDVMSGELDVVLHIEA 113
Cdd:smart00344  80 FLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
6-46 5.01e-10

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 51.99  E-value: 5.01e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 978205915    6 DRVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLE 46
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
7-51 9.52e-10

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 51.28  E-value: 9.52e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 978205915    7 RVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLERDGHI 51
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 74-141 1.77e-08

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 48.68  E-value: 1.77e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 978205915   74 VYRKDRMRGADVIGHVRTVPEVVACDVMSGELDVVLHIEAASSERIHKLWEE-VAALQGVLNTVTSFVL 141
Cdd:pfam01037   3 VKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREkLRSLPGVARTETSIVL 71
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
5-146 3.57e-08

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 49.76  E-value: 3.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205915   5 LDRVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLERDGHIRGYTVRRGSPLADAvpirALMFVYRKDRMRGA- 83
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDA----SLLVFVEITLNRGAp 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 978205915  84 DVIGH----VRTVPEVVACDVMSGELDVVLHIEAASSERIHKLW-EEVAALQGVLNTVTSFVLTRSKD 146
Cdd:PRK11169  88 DVFEQfnaaVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLgETLLRLPGVNDTRTYVVMEEVKQ 155
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
5-59 4.11e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 44.91  E-value: 4.11e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 978205915   5 LDRVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLERDGHIRGYTVRRG 59
Cdd:COG2345   11 ADPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRG 65
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 5-57 1.14e-04

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 40.08  E-value: 1.14e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 978205915   5 LDRVDTKILTLLTENARLSHNDIAASVNLSRNAVRLRIERLERDGHIRGYTVR 57
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVD 59
birA_repr_reg TIGR00122
BirA biotin operon repressor domain; This model represents the amino-terminal helix-turn-helix ...
 8-69 7.10e-04

BirA biotin operon repressor domain; This model represents the amino-terminal helix-turn-helix repressor region of the biotin--acetyl-CoA-carboxylase ligase/biotin operon repressor bifunctional protein BirA. In many species, the biotin--acetyl-CoA-carboxylase ligase ortholog lacks this DNA-binding repressor region and therefore is not equivalent to the well-characterized BirA of E. coli. This model may recognize some other putative repressor proteins, such as DnrO of Streptomyces peucetius with scores below the noise cutoff but with significance shown by low E-value. [Regulatory functions, DNA interactions]


Pssm-ID: 272918 [Multi-domain]  Cd Length: 69  Bit Score: 36.29  E-value: 7.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 978205915    8 VDTKILTLLTENaRLSHNDIAASVNLSRNAVRLRIERLERDG-----HIRGYTVRRGSPLADAVPIR 69
Cdd:TIGR00122   1 MPLRLLALLADN-PFSGEKLGEALGMSRTAVNKHIQTLREWGvdvltVGKGYRLPPPIPLLNAKQIR 66
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-58 6.89e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.81  E-value: 6.89e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 978205915   2 KRVLDRVDTKILTLLTENaRLSHNDIAASVNLSRNAVRLRIERLERDGHIRGYTVRR 58
Cdd:cd00090    2 KALSDPTRLRILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGR 57
PRK10553 PRK10553
chaperone NapD;
81-133 7.82e-03

chaperone NapD;


Pssm-ID: 182542  Cd Length: 87  Bit Score: 34.00  E-value: 7.82e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 978205915  81 RGADVIGHVRTVP--EVVACDVMSGELDVVLhiEAASSERIHKLWEEVAALQGVL 133
Cdd:PRK10553  18 RISDISTQLNAFPgcEVAVSDAPSGQLIVVV--EAEDSETLLQTIESVRNVEGVL 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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