NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|976214094|gb|KVB23013|]
View 

hypothetical protein WI55_01715 [Burkholderia cepacia]

Protein Classification

O-linked N-acetylglucosamine transferase; glycosyltransferase; glycosyltransferase family 41 protein; O-linked N-acetylglucosamine transferase; glycosyltransferase; glycosyltransferase family 41 protein; tetratricopeptide repeat protein; O-linked N-acetylglucosamine transferase; glycosyltransferase; glycosyltransferase family 41 protein; O-linked N-acetylglucosamine transferase; glycosyltransferase; glycosyltransferase family 41 protein; tetratricopeptide repeat protein; O-linked N-acetylglucosamine transferase; glycosyltransferase; glycosyltransferase family 41 protein; tetratricopeptide repeat protein( domain architecture ID 11419357)

O-linked N-acetylglucosamine transferase (OGT) catalyzes the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; glycosyltransferase similar to UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase, which catalyzes the addition of nucleotide-activated sugars directly onto a polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; uncharacterized glycosyltransferase containing tetratricopeptide repeats; glycosyltransferase family 41 protein containing tetratricopeptide (TPR) repeats, similar to Oryza sativa probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY, an O-linked N-acetylglucosamine transferase (OGT) that catalyzes the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; O-linked N-acetylglucosamine transferase (OGT) catalyzes the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; glycosyltransferase similar to UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase, which catalyzes the addition of nucleotide-activated sugars directly onto a polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; uncharacterized glycosyltransferase containing tetratricopeptide repeats; glycosyltransferase family 41 protein containing tetratricopeptide (TPR) repeats, similar to Oryza sativa probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY, an O-linked N-acetylglucosamine transferase (OGT) that catalyzes the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; tetratricopeptide repeat (TPR) protein such as human tetratricopeptide repeat protein 24 (TTC24); O-linked N-acetylglucosamine transferase (OGT) catalyzes the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; glycosyltransferase similar to UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase, which catalyzes the addition of nucleotide-activated sugars directly onto a polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; uncharacterized glycosyltransferase containing tetratricopeptide repeats; glycosyltransferase family 41 protein containing tetratricopeptide (TPR) repeats, similar to Oryza sativa probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY, an O-linked N-acetylglucosamine transferase (OGT) that catalyzes the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; O-linked N-acetylglucosamine transferase (OGT) catalyzes the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; glycosyltransferase similar to UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase, which catalyzes the addition of nucleotide-activated sugars directly onto a polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; uncharacterized glycosyltransferase containing tetratricopeptide repeats; glycosyltransferase family 41 protein containing tetratricopeptide (TPR) repeats, similar to Oryza sativa probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY, an O-linked N-acetylglucosamine transferase (OGT) that catalyzes the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; tetratricopeptide repeat (TPR) protein such as human tetratricopeptide repeat protein 24 (TTC24); O-linked N-acetylglucosamine transferase (OGT) catalyzes the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; glycosyltransferase similar to UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase, which catalyzes the addition of nucleotide-activated sugars directly onto a polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; uncharacterized glycosyltransferase containing tetratricopeptide repeats; glycosyltransferase family 41 protein containing tetratricopeptide (TPR) repeats, similar to Oryza sativa probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY, an O-linked N-acetylglucosamine transferase (OGT) that catalyzes the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine; tetratricopeptide repeat (TPR) protein such as human tetratricopeptide repeat protein 24 (TTC24)

CATH:  1.25.40.10
Gene Ontology:  GO:0016757|GO:0005515
PubMed:  12691742|16037492|21153002|10517866|30708253
SCOP:  3001586|4001344

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 21-225 2.73e-26

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 113.16  E-value: 2.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  21 QAADAQARGEAAAHDLWLAAAAHLHAVDADALAQLTGALVTRQRTAD----AVALAECAARVQPGATAYFNLGYALQMAG 96
Cdd:COG3914   13 AAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALlalaAGEAAAAAAALLLLAALLELAALLLQALG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  97 RHADAVAPYRAALALDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAAR 176
Cdd:COG3914   93 RYEEALALYRRALALNPDNAEALFNLGNLLLALG-RLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRR 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 976214094 177 LVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYRFNL 225
Cdd:COG3914  172 ALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
RfaF COG0859
ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];
353-490 3.77e-07

ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440620  Cd Length: 336  Bit Score: 52.29  E-value: 3.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 353 MLGMEASTLASSVPYLHADPAARDAWRARLAGDSRLKVGLVwTGSaghqRNPFRRVGLERYADAFRGIDGVAFHSLQPGA 432
Cdd:COG0859  142 ALGIPLPDPRPDLPLPEEDRAEARALLARLGLPGKPYIVLH-PGA----SWPAKRWPAERFAELARALAARGLRVVLLGG 216

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 976214094 433 QADVTAA----RAAGFAIEDFTAElTSFDDTAAYIGALDLVITVCTSVAHLAGALGARTWVL 490
Cdd:COG0859  217 PGERELAeeiaAALGPPVINLAGK-TSLRELAALLARADLVVGNDTGPMHLAAALGTPTVAL 277
PksD super family cl43841
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 240-551 2.61e-04

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


The actual alignment was detected with superfamily member COG3321:

Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 44.09  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  240 RGHEARWDGAGELRGRRPV-LPGPRWQGEPLAGKTLLVWGEQGLGDVLQFCRFVAPLAERVHREGGRLIWNTFPQVGTLM 318
Cdd:COG3321   843 AGVPVDWSALYPGRGRRRVpLPTYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALA 922

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  319 QRSLGAHADAFSAGGGVDVLPAFDYEVPLIGLPLMLGMEASTLASSVPYLHADPAARDAWRARLAGDSRLKVGLVWTGSA 398
Cdd:COG3321   923 AAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAL 1002

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  399 GHQrnPFRRVGLERYADAFRGIDGVAFHSLQPGAQADVTAARAAGFAIEDFTAELTSFDDTAAYIGALDLVITVCTSVAH 478
Cdd:COG3321  1003 ALL--AAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALA 1080

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 976214094  479 LAGALGARTWVLLDVNPHWPWLLERTDSPWYPTATLYRQPAFGAWEPVMDAVSRDLRRLSAQPVQAAESARRA 551
Cdd:COG3321  1081 AAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALA 1153
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 21-225 2.73e-26

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 113.16  E-value: 2.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  21 QAADAQARGEAAAHDLWLAAAAHLHAVDADALAQLTGALVTRQRTAD----AVALAECAARVQPGATAYFNLGYALQMAG 96
Cdd:COG3914   13 AAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALlalaAGEAAAAAAALLLLAALLELAALLLQALG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  97 RHADAVAPYRAALALDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAAR 176
Cdd:COG3914   93 RYEEALALYRRALALNPDNAEALFNLGNLLLALG-RLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRR 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 976214094 177 LVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYRFNL 225
Cdd:COG3914  172 ALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 64-234 2.33e-10

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 63.56  E-value: 2.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094   64 RTADAVALAECAARVQPGATAYFN-LGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIaLRLSGSDRAEEIALLDA 142
Cdd:TIGR02917 344 RVDEAIATLSPALGLDPDDPAALSlLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI-SKLSQGDPSEAIADLET 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  143 AVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYR 222
Cdd:TIGR02917 423 AAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAA 502

                         170
                  ....*....|..
gi 976214094  223 FNLAIIQLVRGN 234
Cdd:TIGR02917 503 ANLARIDIQEGN 514
RfaF COG0859
ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];
353-490 3.77e-07

ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440620  Cd Length: 336  Bit Score: 52.29  E-value: 3.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 353 MLGMEASTLASSVPYLHADPAARDAWRARLAGDSRLKVGLVwTGSaghqRNPFRRVGLERYADAFRGIDGVAFHSLQPGA 432
Cdd:COG0859  142 ALGIPLPDPRPDLPLPEEDRAEARALLARLGLPGKPYIVLH-PGA----SWPAKRWPAERFAELARALAARGLRVVLLGG 216

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 976214094 433 QADVTAA----RAAGFAIEDFTAElTSFDDTAAYIGALDLVITVCTSVAHLAGALGARTWVL 490
Cdd:COG0859  217 PGERELAeeiaAALGPPVINLAGK-TSLRELAALLARADLVVGNDTGPMHLAAALGTPTVAL 277
GT9_LPS_heptosyltransferase cd03789
lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide ...
 376-490 1.40e-04

lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340821  Cd Length: 277  Bit Score: 43.87  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 376 DAWRARLAGDSRLKVGLVWTGSAGHqrnPFRRVGLERYADAfrgIDGVAFHSLQP---GAQADVTAARAAGFAIEDFTAE 452
Cdd:cd03789  107 DREKRRFLLNHPVKPLVVIPPGASG---PAKRWPAERFAEL---ADRLADEGYRVvlfGGPAEEELAEEIAAALGARVVN 180

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 976214094 453 L---TSFDDTAAYIGALDLVITVCTSVAHLAGALGARTWVL 490
Cdd:cd03789  181 LagkTSLRELAALLARADLVVGNDSGPMHLAAALGTPTVAL 221
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 240-551 2.61e-04

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 44.09  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  240 RGHEARWDGAGELRGRRPV-LPGPRWQGEPLAGKTLLVWGEQGLGDVLQFCRFVAPLAERVHREGGRLIWNTFPQVGTLM 318
Cdd:COG3321   843 AGVPVDWSALYPGRGRRRVpLPTYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALA 922

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  319 QRSLGAHADAFSAGGGVDVLPAFDYEVPLIGLPLMLGMEASTLASSVPYLHADPAARDAWRARLAGDSRLKVGLVWTGSA 398
Cdd:COG3321   923 AAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAL 1002

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  399 GHQrnPFRRVGLERYADAFRGIDGVAFHSLQPGAQADVTAARAAGFAIEDFTAELTSFDDTAAYIGALDLVITVCTSVAH 478
Cdd:COG3321  1003 ALL--AAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALA 1080

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 976214094  479 LAGALGARTWVLLDVNPHWPWLLERTDSPWYPTATLYRQPAFGAWEPVMDAVSRDLRRLSAQPVQAAESARRA 551
Cdd:COG3321  1081 AAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALA 1153
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 162-244 5.29e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 42.23  E-value: 5.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 162 IATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDD--ASYrFNLAiiQLVRGNHAAGW 239
Cdd:cd24142   11 LDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGgyEKY-LYLG--QLSGGEEALQY 87


                 ....*..
gi 976214094 240 --RGHEA 244
Cdd:cd24142   88 yeKGIEI 94
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 22-150 5.56e-04

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 42.98  E-value: 5.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  22 AADAQARGEAAAHDLWLAAAAHLHAVDADALAQLTGALVTRQRTADAVALAECAARVQPGATAYFNLGYALQMAGRHADA 101
Cdd:PRK09782 549 ANTAQAAGNGAARDRWLQQAEQRGLGDNALYWWLHAQRYIPGQPELALNDLTRSLNIAPSANAYVARATIYRQRHNVPAA 628

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 976214094 102 VAPYRAALALDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCD 150
Cdd:PRK09782 629 VSDLRAALELEPNNSNYQAALGYALWDSG-DIAQSREMLERAHKGLPDD 676
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 82-112 5.69e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 34.73  E-value: 5.69e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 976214094    82 ATAYFNLGYALQMAGRHADAVAPYRAALALD 112
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELD 31
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 86-211 8.12e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 39.13  E-value: 8.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  86 FNLGYALQMAGRHADAVApyRAALALDAGRPSL----------RNNLAIALRLSGS-DRAEEI-----ALLDAAVRAD-P 148
Cdd:NF040586 651 LSLANDLRALGDADEARE--LAREVLDRYRRVLgedhpftlacRNNLAVLLRALGDpEEARELaeaalEGLRERLGPDhP 728

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 976214094 149 CDVQAWINLVVARIATHDLDGAL--ACAARLVELA----------PDNALAMNNVAMAMKEAQRWDDAERCAARA 211
Cdd:NF040586 729 YTLAAAVNLANDLAALGDLDAALgeEALERLRRLLgedlragpdhPDTLACAANLALDLRATGRTEEAEELRADT 803
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 21-225 2.73e-26

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 113.16  E-value: 2.73e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  21 QAADAQARGEAAAHDLWLAAAAHLHAVDADALAQLTGALVTRQRTAD----AVALAECAARVQPGATAYFNLGYALQMAG 96
Cdd:COG3914   13 AAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALlalaAGEAAAAAAALLLLAALLELAALLLQALG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  97 RHADAVAPYRAALALDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAAR 176
Cdd:COG3914   93 RYEEALALYRRALALNPDNAEALFNLGNLLLALG-RLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRR 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 976214094 177 LVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYRFNL 225
Cdd:COG3914  172 ALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 20-220 4.31e-23

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 103.53  E-value: 4.31e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  20 GQAADAQARGEAAAHDLWLAAAAHLHAVDADALAQLTGALVTRQRTADAVALAECAARVQPG-ATAYFNLGYALQMAGRH 98
Cdd:COG3914   49 AALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDnAEALFNLGNLLLALGRL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  99 ADAVAPYRAALALDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLV 178
Cdd:COG3914  129 EEALAALRRALALNPDFAEAYLNLGEALRRLG-RLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRAL 207

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 976214094 179 ELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDAS 220
Cdd:COG3914  208 ELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSE 249
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
82-253 8.17e-23

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 97.77  E-value: 8.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  82 ATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCDVQAWINLVVAR 161
Cdd:COG0457    8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLG-RYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 162 IATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYRFNLAIIQLVRGNHAAGWRG 241
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALEL 166

                        170
                 ....*....|..
gi 976214094 242 HEARWDGAGELR 253
Cdd:COG0457  167 LEKLEAAALAAL 178
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
48-253 5.22e-19

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 86.60  E-value: 5.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  48 DADALAQLTGALVTRQRTADAVALAECAARVQPG-ATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIAL 126
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDdAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 127 RLSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAER 206
Cdd:COG0457   87 QALG-RYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALE 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 976214094 207 CAARACELAPDDASYRFNLAIIQLVRGNHAAGWRGHEARWDGAGELR 253
Cdd:COG0457  166 LLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLA 212
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 48-238 3.25e-17

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 85.04  E-value: 3.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  48 DADALAQLTGALVTRQRTADAVALAECAARVQPGATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIALR 127
Cdd:COG3914   13 AAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 128 lsgsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERC 207
Cdd:COG3914   93 ----RYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAA 168

                        170       180       190
                 ....*....|....*....|....*....|.
gi 976214094 208 AARACELAPDDASYRFNLAIIQLVRGNHAAG 238
Cdd:COG3914  169 LRRALELDPDNAEALNNLGNALQDLGRLEEA 199
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 63-237 4.71e-17

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 81.31  E-value: 4.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  63 QRTADAVALAECAARVQPG-ATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIALRLSGS-DRAEEiaLL 140
Cdd:COG2956   22 GQPDKAIDLLEEALELDPEtVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLlDRAEE--LL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 141 DAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDAS 220
Cdd:COG2956  100 EKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCAR 179

                        170
                 ....*....|....*..
gi 976214094 221 YRFNLAIIQLVRGNHAA 237
Cdd:COG2956  180 ALLLLAELYLEQGDYEE 196
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 49-237 5.54e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 72.45  E-value: 5.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  49 ADALAQLTGALVTRQRTADAVALAECAARVQPG-ATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIALR 127
Cdd:COG2956   76 AEALLELAQDYLKAGLLDRAEELLEKLLELDPDdAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 128 LSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERC 207
Cdd:COG2956  156 EQG-DYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALEL 234

                        170       180       190
                 ....*....|....*....|....*....|
gi 976214094 208 AARACELAPDDASYRFNLAIIQLVRGNHAA 237
Cdd:COG2956  235 LRKALELDPSDDLLLALADLLERKEGLEAA 264
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
109-236 6.05e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 71.58  E-value: 6.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 109 LALDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAM 188
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLG-RYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 976214094 189 NNVAMAMKEAQRWDDAERCAARACELAPDDASYRFNLAIIQLVRGNHA 236
Cdd:COG0457   80 NNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYD 127
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 48-238 4.05e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 69.76  E-value: 4.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  48 DADALAQLTGALVTRQRTADAVALAECAARVQP-GATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIAL 126
Cdd:COG2956   41 TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPdRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIY 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 127 RLSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAER 206
Cdd:COG2956  121 EQEG-DWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIA 199

                        170       180       190
                 ....*....|....*....|....*....|..
gi 976214094 207 CAARACELAPDDASYRFNLAIIQLVRGNHAAG 238
Cdd:COG2956  200 ALERALEQDPDYLPALPRLAELYEKLGDPEEA 231
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 82-218 4.38e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.37  E-value: 4.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  82 ATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCDVQAWINLVVAR 161
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLG-DLDEAIVLLHEALELDPDEPEARLNLGLAL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 976214094 162 IATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDD 218
Cdd:COG4783   83 LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 113-237 1.03e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 65.60  E-value: 1.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 113 AGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVA 192
Cdd:COG4783    1 AACAEALYALAQALLLAG-DYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLG 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 976214094 193 MAMKEAQRWDDAERCAARACELAPDDASYRFNLAIIQLVRGNHAA 237
Cdd:COG4783   80 LALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 135-237 1.86e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 64.64  E-value: 1.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 135 EEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACEL 214
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100
                 ....*....|....*....|...
gi 976214094 215 APDDASYRFNLAIIQLVRGNHAA 237
Cdd:COG4235   81 DPDNPEALYLLGLAAFQQGDYAE 103
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 67-188 3.84e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 63.49  E-value: 3.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  67 DAVALAECAARVQPG-ATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVR 145
Cdd:COG4235    1 EAIARLRQALAANPNdAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAG-DTEEAEELLERALA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 976214094 146 ADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAM 188
Cdd:COG4235   80 LDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPAR 122
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 64-234 2.33e-10

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 63.56  E-value: 2.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094   64 RTADAVALAECAARVQPGATAYFN-LGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIaLRLSGSDRAEEIALLDA 142
Cdd:TIGR02917 344 RVDEAIATLSPALGLDPDDPAALSlLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI-SKLSQGDPSEAIADLET 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  143 AVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYR 222
Cdd:TIGR02917 423 AAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAA 502

                         170
                  ....*....|..
gi 976214094  223 FNLAIIQLVRGN 234
Cdd:TIGR02917 503 ANLARIDIQEGN 514
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
49-237 6.76e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 59.16  E-value: 6.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  49 ADALAQLTGALVTRQRTADAVALAECAARVQPGATAYFNLGYALQMAGRHADAVAPYRAALALDAGRP---SLRNNLAIA 125
Cdd:COG4785    3 ALALALLLALALAAAAASKAAILLAALLFAAVLALAIALADLALALAAAALAAAALAAERIDRALALPdlaQLYYERGVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 126 LRLSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAE 205
Cdd:COG4785   83 YDSLG-DYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAI 161

                        170       180       190
                 ....*....|....*....|....*....|..
gi 976214094 206 RCAARACELAPDDASYRFNLAIIQLVRGNHAA 237
Cdd:COG4785  162 ADLEKALELDPNDPERALWLYLAERKLDPEKA 193
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
144-237 1.18e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 144 VRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYRF 223
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                         90
                 ....*....|....
gi 976214094 224 NLAIIQLVRGNHAA 237
Cdd:COG0457   81 NLGLALQALGRYEE 94
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 100-222 8.02e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 54.24  E-value: 8.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 100 DAVAPYRAALALDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVE 179
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLG-RYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALA 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 976214094 180 LAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYR 222
Cdd:COG4235   80 LDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPAR 122
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 51-238 3.26e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 56.63  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094   51 ALAQLtgaLVTRQRTADAVALAECAARVQPGATAYFNLGYALQMA-GRHADAVAPYRAALALDAGRPSLRNnLAIALRLS 129
Cdd:TIGR02917 674 GLAQL---LLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRqKDYPAAIQAYRKALKRAPSSQNAIK-LHRALLAS 749

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  130 GsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAmkEAQRWD-DAERCA 208
Cdd:TIGR02917 750 G-NTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWL--YLELKDpRALEYA 826

                         170       180       190
                  ....*....|....*....|....*....|
gi 976214094  209 ARACELAPDDASYRFNLAIIQLVRGNHAAG 238
Cdd:TIGR02917 827 ERALKLAPNIPAILDTLGWLLVEKGEADRA 856
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 31-182 4.12e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.66  E-value: 4.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  31 AAAHDLWLAAAAHLHAVDADALAQLTGALVTRQRTADAVALAECAARVQPGATAYFNLGYALQMAGRHADAVAPYRAALA 110
Cdd:COG5010    3 ALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 976214094 111 LDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAP 182
Cdd:COG5010   83 LDPNNPELYYNLALLYSRSG-DKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 64-217 6.26e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 55.47  E-value: 6.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094   64 RTADAVALAECAARVQPGATAYFNLGYALQMA-GRHADAVAPYRAALALDAGRPSLRNNLAIALRLSGsDRAEEIALLDA 142
Cdd:TIGR02917 514 NPDDAIQRFEKVLTIDPKNLRAILALAGLYLRtGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKG-QLKKALAILNE 592

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 976214094  143 AVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPD 217
Cdd:TIGR02917 593 AADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPD 667
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
91-183 7.59e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.17  E-value: 7.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  91 ALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIALRLSGsdRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGA 170
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQG--RYDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEA 78

                         90
                 ....*....|...
gi 976214094 171 LACAARLVELAPD 183
Cdd:COG3063   79 LAYLERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 75-216 2.54e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.34  E-value: 2.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  75 AARVQPGATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIALRLSGSDRAEEIALLDAAVRADPCDVQAW 154
Cdd:COG5010   12 LYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELY 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 976214094 155 INLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAP 216
Cdd:COG5010   92 YNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 66-236 3.21e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.16  E-value: 3.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094   66 ADAVALAECAARVQPGATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAiALRLSGSDRAEEIALLDAAVR 145
Cdd:TIGR02917 720 PAAIQAYRKALKRAPSSQNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALA-ELYLAQKDYDKAIKHYQTVVK 798

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  146 ADPCDVQAWINLvvARIAtHDLDG--ALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYRF 223
Cdd:TIGR02917 799 KAPDNAVVLNNL--AWLY-LELKDprALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAIRY 875

                         170
                  ....*....|...
gi 976214094  224 NLAIIQLVRGNHA 236
Cdd:TIGR02917 876 HLALALLATGRKA 888
RfaF COG0859
ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];
353-490 3.77e-07

ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440620  Cd Length: 336  Bit Score: 52.29  E-value: 3.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 353 MLGMEASTLASSVPYLHADPAARDAWRARLAGDSRLKVGLVwTGSaghqRNPFRRVGLERYADAFRGIDGVAFHSLQPGA 432
Cdd:COG0859  142 ALGIPLPDPRPDLPLPEEDRAEARALLARLGLPGKPYIVLH-PGA----SWPAKRWPAERFAELARALAARGLRVVLLGG 216

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 976214094 433 QADVTAA----RAAGFAIEDFTAElTSFDDTAAYIGALDLVITVCTSVAHLAGALGARTWVL 490
Cdd:COG0859  217 PGERELAeeiaAALGPPVINLAGK-TSLRELAALLARADLVVGNDTGPMHLAAALGTPTVAL 277
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 99-237 4.96e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.57  E-value: 4.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  99 ADAVAPYRAALALDAGRPSLRNNLAIALRLSGSDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLV 178
Cdd:COG5010    2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 976214094 179 ELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYRFNLAIIQLVRGNHAA 237
Cdd:COG5010   82 QLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDE 140
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
160-240 6.37e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.47  E-value: 6.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 160 ARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCaARACELAPDDASYRFNLAIIQLVRGNHAAGW 239
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEAL 79


                 .
gi 976214094 240 R 240
Cdd:COG3063   80 A 80
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 55-237 2.46e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.47  E-value: 2.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094   55 LTGALVTRQRTADAVALAECAARVQPG-ATAYFNLG-YALQmAGRHADAVAPYRAALALDAGRPSLRNNLAiALRLSGSD 132
Cdd:TIGR02917 471 LGAIYLGKGDLAKAREAFEKALSIEPDfFPAAANLArIDIQ-EGNPDDAIQRFEKVLTIDPKNLRAILALA-GLYLRTGN 548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  133 RAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARAC 212
Cdd:TIGR02917 549 EEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLL 628

                         170       180
                  ....*....|....*....|....*
gi 976214094  213 ELAPDDASYRFNLAIIQLVRGNHAA 237
Cdd:TIGR02917 629 ALQPDSALALLLLADAYAVMKNYAK 653
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 48-163 4.42e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.15  E-value: 4.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  48 DADALAQLTGALVTRQRTADAVALAECAARVQPG-ATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIAL 126
Cdd:COG4235   16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDnADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAA 95

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 976214094 127 RLSGsDRAEEIALLDAAVRADPCDVQAWinLVVARIA 163
Cdd:COG4235   96 FQQG-DYAEAIAAWQKLLALLPADAPAR--LLEASIA 129
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 150-240 6.23e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.95  E-value: 6.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 150 DVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYRFNLAIIQ 229
Cdd:COG4783    3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLAL 82

                         90
                 ....*....|.
gi 976214094 230 LVRGNHAAGWR 240
Cdd:COG4783   83 LKAGDYDEALA 93
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
132-217 6.31e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 44.78  E-value: 6.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 132 DRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAaRLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARA 211
Cdd:COG3063    7 DLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALE-KALKLDPNNAEALLNLAELLLELGDYDEALAYLERA 85


                 ....*.
gi 976214094 212 CELAPD 217
Cdd:COG3063   86 LELDPS 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 138-238 4.25e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 4.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  138 ALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPD 217
Cdd:TIGR02917 316 QYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPE 395

                          90       100
                  ....*....|....*....|.
gi 976214094  218 DASYRFNLAIIQLVRGNHAAG 238
Cdd:TIGR02917 396 NAAARTQLGISKLSQGDPSEA 416
GT9_LPS_heptosyltransferase cd03789
lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide ...
 376-490 1.40e-04

lipopolysaccharide heptosyltransferase and similar proteins; Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340821  Cd Length: 277  Bit Score: 43.87  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 376 DAWRARLAGDSRLKVGLVWTGSAGHqrnPFRRVGLERYADAfrgIDGVAFHSLQP---GAQADVTAARAAGFAIEDFTAE 452
Cdd:cd03789  107 DREKRRFLLNHPVKPLVVIPPGASG---PAKRWPAERFAEL---ADRLADEGYRVvlfGGPAEEELAEEIAAALGARVVN 180

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 976214094 453 L---TSFDDTAAYIGALDLVITVCTSVAHLAGALGARTWVL 490
Cdd:cd03789  181 LagkTSLRELAALLARADLVVGNDSGPMHLAAALGTPTVAL 221
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 48-125 1.46e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.92  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  48 DADALAQLTGALVTRQRTADAVALAECAARVQPG-ATAYFNLGYALQMAGRHADAVAPYRAALAL---DAGRPSLRNNLA 123
Cdd:COG4235   50 NADALLDLAEALLAAGDTEEAEELLERALALDPDnPEALYLLGLAAFQQGDYAEAIAAWQKLLALlpaDAPARLLEASIA 129


                 ..
gi 976214094 124 IA 125
Cdd:COG4235  130 EA 131
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 240-551 2.61e-04

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 44.09  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  240 RGHEARWDGAGELRGRRPV-LPGPRWQGEPLAGKTLLVWGEQGLGDVLQFCRFVAPLAERVHREGGRLIWNTFPQVGTLM 318
Cdd:COG3321   843 AGVPVDWSALYPGRGRRRVpLPTYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALA 922

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  319 QRSLGAHADAFSAGGGVDVLPAFDYEVPLIGLPLMLGMEASTLASSVPYLHADPAARDAWRARLAGDSRLKVGLVWTGSA 398
Cdd:COG3321   923 AAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAL 1002

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  399 GHQrnPFRRVGLERYADAFRGIDGVAFHSLQPGAQADVTAARAAGFAIEDFTAELTSFDDTAAYIGALDLVITVCTSVAH 478
Cdd:COG3321  1003 ALL--AAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALA 1080

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 976214094  479 LAGALGARTWVLLDVNPHWPWLLERTDSPWYPTATLYRQPAFGAWEPVMDAVSRDLRRLSAQPVQAAESARRA 551
Cdd:COG3321  1081 AAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALA 1153
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 84-236 4.58e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094   84 AYFNLGYALQmaGRHADAVAPYRAALALDAGRPSLRNNLAIaLRLSGSDRAEEIALLDAAVRADPCDVQAWINLVVARIA 163
Cdd:TIGR02917 129 ALRGLAYLGL--GQLELAQKSYEQALAIDPRSLYAKLGLAQ-LALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLS 205

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 976214094  164 THDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDDASYRFNLAIIQLVRGNHA 236
Cdd:TIGR02917 206 LGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYE 278
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 162-244 5.29e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 42.23  E-value: 5.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 162 IATHDLDGALACAARLVELAPDNALAMNNVAMAMKEAQRWDDAERCAARACELAPDD--ASYrFNLAiiQLVRGNHAAGW 239
Cdd:cd24142   11 LDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGgyEKY-LYLG--QLSGGEEALQY 87


                 ....*..
gi 976214094 240 --RGHEA 244
Cdd:cd24142   88 yeKGIEI 94
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 22-150 5.56e-04

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 42.98  E-value: 5.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  22 AADAQARGEAAAHDLWLAAAAHLHAVDADALAQLTGALVTRQRTADAVALAECAARVQPGATAYFNLGYALQMAGRHADA 101
Cdd:PRK09782 549 ANTAQAAGNGAARDRWLQQAEQRGLGDNALYWWLHAQRYIPGQPELALNDLTRSLNIAPSANAYVARATIYRQRHNVPAA 628

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 976214094 102 VAPYRAALALDAGRPSLRNNLAIALRLSGsDRAEEIALLDAAVRADPCD 150
Cdd:PRK09782 629 VSDLRAALELEPNNSNYQAALGYALWDSG-DIAQSREMLERAHKGLPDD 676
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 48-187 2.91e-03

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 40.45  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094   48 DADALAQLTGALvtRQRTADAVALaecaarvqpGAtayfnLGYALQMAGRHADAVAPYRAALALDAGRPSL--------- 118
Cdd:PRK11447  285 GGKAIPELQQAV--RANPKDSEAL---------GA-----LGQAYSQQGDRARAVAQFEKALALDPHSSNRdkwesllkv 348

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 976214094  119 -RNNLAI-----ALRLSGSDRAEeiALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPDNALA 187
Cdd:PRK11447  349 nRYWLLIqqgdaALKANNLAQAE--RLYQQARQVDNTDSYAVLGLGDVAMARKDYAAAERYYQQALRMDPGNTNA 421
StaR_like cd05804
StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member ...
 82-254 3.66e-03

StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been speculated that StaR could be a flavoprotein hydroxylating a tyrosine sidechain. Some family members have been annotated as proteins containing tetratricopeptide (TPR) repeats, which may at least indicate mostly alpha-helical secondary structure.


Pssm-ID: 100115 [Multi-domain]  Cd Length: 355  Bit Score: 39.57  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  82 ATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNL---AIALRLSGsDRAEEIALLDAAVRADPCDVQAWiNLV 158
Cdd:cd05804    6 ALGHAAAALLLLLGGERPAAAAKAAAAAQALAARATERERAhveALSAWIAG-DLPKALALLEQLLDDYPRDLLAL-KLH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094 159 VARIATHDLDGALACAARLVEL-APDNA-----LAMnnVAMAMKEAQRWDDAERCAARACELAPDDASYRFNLAIIQLVR 232
Cdd:cd05804   84 LGAFGLGDFSGMRDHVARVLPLwAPENPdywylLGM--LAFGLEEAGQYDRAEEAARRALELNPDDAWAVHAVAHVLEMQ 161

                        170       180
                 ....*....|....*....|....*
gi 976214094 233 GNHAAG--W-RGHEARWDGAGELRG 254
Cdd:cd05804  162 GRFKEGiaFmESWRDTWDCSSMLRG 186
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 82-112 5.69e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 34.73  E-value: 5.69e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 976214094    82 ATAYFNLGYALQMAGRHADAVAPYRAALALD 112
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELD 31
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
48-183 8.03e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.06  E-value: 8.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  48 DADALAQLTGALVTRQRTADAVALAECAARVQPG-ATAYFNLGYALQMAGRHADAVAPYRAALALDAGRPSLRNNLAIAL 126
Cdd:COG0457  109 DAEALYNLGLALLELGRYDEAIEAYERALELDPDdADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAAL 188

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 976214094 127 RLSGSDRAEEIALLDAAVRADPCDVQAWINLVVARIATHDLDGALACAARLVELAPD 183
Cdd:COG0457  189 ALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
FxSxx_TPR NF040586
FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about ...
 86-211 8.12e-03

FxSxx-COOH system tetratricopeptide repeat protein; Members of this family are typically about 850 amino acids long, or 1300 long because of an additional N-terminal domain. Proteins have a P-loop motif, GxGGxGKT, near the N-terminus of the region covered by this HMM, and a region over 400 residues long of tetratricopeptide repeat sequence. The family is found regularly next to other components of FxSxx-COOH systems, which feature an FxsB family radical SAM protein and a protein modified by it, FxsA. Members of this FxsA family typically have an FxSxx motif as the final five amino acids.


Pssm-ID: 468560 [Multi-domain]  Cd Length: 836  Bit Score: 39.13  E-value: 8.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 976214094  86 FNLGYALQMAGRHADAVApyRAALALDAGRPSL----------RNNLAIALRLSGS-DRAEEI-----ALLDAAVRAD-P 148
Cdd:NF040586 651 LSLANDLRALGDADEARE--LAREVLDRYRRVLgedhpftlacRNNLAVLLRALGDpEEARELaeaalEGLRERLGPDhP 728

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 976214094 149 CDVQAWINLVVARIATHDLDGAL--ACAARLVELA----------PDNALAMNNVAMAMKEAQRWDDAERCAARA 211
Cdd:NF040586 729 YTLAAAVNLANDLAALGDLDAALgeEALERLRRLLgedlragpdhPDTLACAANLALDLRATGRTEEAEELRADT 803
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH