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Conserved domains on  [gi|861303634|gb|KMQ47734|]
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GPN-loop GTPase [Trichophyton rubrum]

Protein Classification

ATP/GTP-binding protein( domain architecture ID 13027395)

ATP/GTP-binding protein such as GPN-loop GTPase, a small eukaryotic GTPase which is required for proper nuclear import of RNA polymerase II (RNAPII), and may act at an RNAP assembly step prior to nuclear import

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPN3 cd17872
GPN-loop GTPase 3; GPN-loop GTPase 3 (GPN3) is a small GTPase that is required for nuclear ...
 4-265 2.73e-108

GPN-loop GTPase 3; GPN-loop GTPase 3 (GPN3) is a small GTPase that is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN1.


:

Pssm-ID: 349781 [Multi-domain]  Cd Length: 196  Bit Score: 312.15  E-value: 2.73e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   4 FGVLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAESFSYEPDLDIRELITLEDVMEEMGLGPNGGLMYCFEFLL 83
Cdd:cd17872    1 YAQLVMGPAGSGKSTYCSTLQEHCETLGRSVHVVNLDPAAEEFEYPVSIDIRDLISLEDVMEELGLGPNGGLVYCMEYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  84 QNLDFLNDALDPLSEEYLiIFDMPGQIELYTHVPLLPSLVQYLSRSGalnISLCAAYLLESSFVVDRPKFFAGTLSAMSA 163
Cdd:cd17872   81 ENLDWLEEQLGDYEDDYL-IFDCPGQIELYTHLPVMKRLVDALQRWG---FRLCAVYLLDSQFISDASKFISGVLSALSA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634 164 MIMLEIPHVNILSKMDqikgvigkkelkqftsvdvnliepgneeestgrdpsstaevltgssfnrlnkavarliddfsMV 243
Cdd:cd17872  157 MIQLELPHVNVLTKMD--------------------------------------------------------------LV 174

                        250       260
                 ....*....|....*....|..
gi 861303634 244 SFLKLDAQDEDSISAVLSYIDD 265
Cdd:cd17872  175 SFLPLDITDEESINNVLSQIDN 196
 
Name Accession Description Interval E-value
GPN3 cd17872
GPN-loop GTPase 3; GPN-loop GTPase 3 (GPN3) is a small GTPase that is required for nuclear ...
 4-265 2.73e-108

GPN-loop GTPase 3; GPN-loop GTPase 3 (GPN3) is a small GTPase that is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN1.


Pssm-ID: 349781 [Multi-domain]  Cd Length: 196  Bit Score: 312.15  E-value: 2.73e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   4 FGVLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAESFSYEPDLDIRELITLEDVMEEMGLGPNGGLMYCFEFLL 83
Cdd:cd17872    1 YAQLVMGPAGSGKSTYCSTLQEHCETLGRSVHVVNLDPAAEEFEYPVSIDIRDLISLEDVMEELGLGPNGGLVYCMEYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  84 QNLDFLNDALDPLSEEYLiIFDMPGQIELYTHVPLLPSLVQYLSRSGalnISLCAAYLLESSFVVDRPKFFAGTLSAMSA 163
Cdd:cd17872   81 ENLDWLEEQLGDYEDDYL-IFDCPGQIELYTHLPVMKRLVDALQRWG---FRLCAVYLLDSQFISDASKFISGVLSALSA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634 164 MIMLEIPHVNILSKMDqikgvigkkelkqftsvdvnliepgneeestgrdpsstaevltgssfnrlnkavarliddfsMV 243
Cdd:cd17872  157 MIQLELPHVNVLTKMD--------------------------------------------------------------LV 174

                        250       260
                 ....*....|....*....|..
gi 861303634 244 SFLKLDAQDEDSISAVLSYIDD 265
Cdd:cd17872  175 SFLPLDITDEESINNVLSQIDN 196
ATP_bind_1 pfam03029
Conserved hypothetical ATP binding protein; Members of this family are found in a range of ...
 8-269 1.50e-84

Conserved hypothetical ATP binding protein; Members of this family are found in a range of archaea and eukaryotes and have hypothesized ATP binding activity.


Pssm-ID: 397252 [Multi-domain]  Cd Length: 238  Bit Score: 253.45  E-value: 1.50e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634    8 VMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAESFSYEPDLDIRELITLEDVMEEMGLGPNGGLMYCFEFLLQNLD 87
Cdd:pfam03029   1 VVGPAGSGKTTFVGALSEILPLRGRPVYVVNLDPAAENLPYPADIDIRELITVADVMEDYGLGPNGALTVAMDFGRITLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   88 FLNDALDPLSEeyLIIFDMPGQIELYTHVPLLPSLVQYLSRSGAlnisLCAAYLLESSFVVDRPKFFAGTLSAMSAMIML 167
Cdd:pfam03029  81 WLDEELKREDD--YYLFDTPGQIELFTHWDSLAIIVEALESRGA----LGAVYLVDTRRLTDPTDFFSGLLYALSIMLRL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  168 EIPHVNILSKMDQIKgviGKKELKQFTSVdvnliepgneeestgrDPSSTAEVLTGSSFNRLNKAVARLIDDFSMV-SFL 246
Cdd:pfam03029 155 GLPFVVALNKFDLLS---LEFALKWFTDP----------------EDLQLLLELDDGKYRKLNEAIREALDLFYLVpVFL 215

                         250       260
                  ....*....|....*....|...
gi 861303634  247 KLDAQDEDSISAVLSYIDDAIQY 269
Cdd:pfam03029 216 PDARERGESMEDLLTLIDEALQY 238
PRK13768 PRK13768
GTPase; Provisional
 6-179 6.85e-39

GTPase; Provisional


Pssm-ID: 237498 [Multi-domain]  Cd Length: 253  Bit Score: 136.92  E-value: 6.85e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   6 VLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAESFSYEPDLDIRELITLEDVMEEMGLGPNGGLMYCFEFLLQN 85
Cdd:PRK13768   5 VFFLGTAGSGKTTLTKALSDWLEEQGYDVAIVNLDPAVEYLPYTPDFDVRDYVTAREIMKKYGLGPNGALIASVDLLLTK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  86 LDFLNDALDPLSEEYLIIfDMPGQIELYTHVPLLPSLVQYLSRSGalniSLCAAYLLESSFVVDRPKFFAGTLSAMSAMI 165
Cdd:PRK13768  85 ADEIKEEIESLDADYVLV-DTPGQMELFAFRESGRKLVERLSGSS----KSVVVFLIDAVLAKTPSDFVSLLLLALSVQL 159

                        170
                 ....*....|....
gi 861303634 166 MLEIPHVNILSKMD 179
Cdd:PRK13768 160 RLGLPQIPVLNKAD 173
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 6-44 9.94e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.59  E-value: 9.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 861303634     6 VLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAE 44
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILE 43
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
6-168 1.25e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 39.13  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   6 VLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLD--PA-----AESFSYEPDLDIRE-LITLEDV-MEEMGLGPNgglm 76
Cdd:COG0467   23 TLLSGPPGTGKTTLALQFLAEGLRRGEKGLYVSFEesPEqllrrAESLGLDLEEYIESgLLRIIDLsPEELGLDLE---- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  77 ycfEFLLQNLDFLND------ALDPLSeEYLIIFDMPGQIELYTHvpllpSLVQYLSRSGALnislcaAYLLESSFVVDR 150
Cdd:COG0467   99 ---ELLARLREAVEEfgakrvVIDSLS-GLLLALPDPERLREFLH-----RLLRYLKKRGVT------TLLTSETGGLED 163

                        170
                 ....*....|....*...
gi 861303634 151 PKFFAGTLSAMSAMIMLE 168
Cdd:COG0467  164 EATEGGLSYLADGVILLR 181
 
Name Accession Description Interval E-value
GPN3 cd17872
GPN-loop GTPase 3; GPN-loop GTPase 3 (GPN3) is a small GTPase that is required for nuclear ...
 4-265 2.73e-108

GPN-loop GTPase 3; GPN-loop GTPase 3 (GPN3) is a small GTPase that is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN1.


Pssm-ID: 349781 [Multi-domain]  Cd Length: 196  Bit Score: 312.15  E-value: 2.73e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   4 FGVLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAESFSYEPDLDIRELITLEDVMEEMGLGPNGGLMYCFEFLL 83
Cdd:cd17872    1 YAQLVMGPAGSGKSTYCSTLQEHCETLGRSVHVVNLDPAAEEFEYPVSIDIRDLISLEDVMEELGLGPNGGLVYCMEYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  84 QNLDFLNDALDPLSEEYLiIFDMPGQIELYTHVPLLPSLVQYLSRSGalnISLCAAYLLESSFVVDRPKFFAGTLSAMSA 163
Cdd:cd17872   81 ENLDWLEEQLGDYEDDYL-IFDCPGQIELYTHLPVMKRLVDALQRWG---FRLCAVYLLDSQFISDASKFISGVLSALSA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634 164 MIMLEIPHVNILSKMDqikgvigkkelkqftsvdvnliepgneeestgrdpsstaevltgssfnrlnkavarliddfsMV 243
Cdd:cd17872  157 MIQLELPHVNVLTKMD--------------------------------------------------------------LV 174

                        250       260
                 ....*....|....*....|..
gi 861303634 244 SFLKLDAQDEDSISAVLSYIDD 265
Cdd:cd17872  175 SFLPLDITDEESINNVLSQIDN 196
ATP_bind_1 pfam03029
Conserved hypothetical ATP binding protein; Members of this family are found in a range of ...
 8-269 1.50e-84

Conserved hypothetical ATP binding protein; Members of this family are found in a range of archaea and eukaryotes and have hypothesized ATP binding activity.


Pssm-ID: 397252 [Multi-domain]  Cd Length: 238  Bit Score: 253.45  E-value: 1.50e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634    8 VMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAESFSYEPDLDIRELITLEDVMEEMGLGPNGGLMYCFEFLLQNLD 87
Cdd:pfam03029   1 VVGPAGSGKTTFVGALSEILPLRGRPVYVVNLDPAAENLPYPADIDIRELITVADVMEDYGLGPNGALTVAMDFGRITLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   88 FLNDALDPLSEeyLIIFDMPGQIELYTHVPLLPSLVQYLSRSGAlnisLCAAYLLESSFVVDRPKFFAGTLSAMSAMIML 167
Cdd:pfam03029  81 WLDEELKREDD--YYLFDTPGQIELFTHWDSLAIIVEALESRGA----LGAVYLVDTRRLTDPTDFFSGLLYALSIMLRL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  168 EIPHVNILSKMDQIKgviGKKELKQFTSVdvnliepgneeestgrDPSSTAEVLTGSSFNRLNKAVARLIDDFSMV-SFL 246
Cdd:pfam03029 155 GLPFVVALNKFDLLS---LEFALKWFTDP----------------EDLQLLLELDDGKYRKLNEAIREALDLFYLVpVFL 215

                         250       260
                  ....*....|....*....|...
gi 861303634  247 KLDAQDEDSISAVLSYIDDAIQY 269
Cdd:pfam03029 216 PDARERGESMEDLLTLIDEALQY 238
GPN2 cd17871
GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization ...
 4-179 2.14e-74

GPN-loop GTPase 2; GPN-loop GTPase 2 (GPN2) is a small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). It forms heterodimers with GPN1 or GPN3.


Pssm-ID: 349780  Cd Length: 196  Bit Score: 225.88  E-value: 2.14e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   4 FGVLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAESFSYEPDLDIRELITLEDVMEEMGLGPNGGLMYCFEFLL 83
Cdd:cd17871    1 FGQVVIGPPGSGKTTYCKGMQQFLSALGRKVAVVNLDPANEFLPYPCDVDIRELITVEDVMEELKLGPNGGLLYCMEYLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  84 QNLDFLNDALDPLSEEYLiIFDMPGQIELYTHVPLLPSLVQYLSRsgaLNISLCAAYLLESSFVVDRPKFFAGTLSAMSA 163
Cdd:cd17871   81 KNIDWLIDKLKKLKDSYL-IFDCPGQVELYTHHNSLRNILDKLQK---WLYRLVAVHLVDSHYCSDPSKFISALLLSLST 156

                        170
                 ....*....|....*.
gi 861303634 164 MIMLEIPHVNILSKMD 179
Cdd:cd17871  157 MLRLELPHVNVLSKID 172
GPN cd17868
GPN-loop GTPase; GPN-loop GTPases are deeply evolutionarily conserved family of three small ...
 4-179 2.07e-60

GPN-loop GTPase; GPN-loop GTPases are deeply evolutionarily conserved family of three small GTPases, Gpn1, 2, and 3. They form heterodimers, interact with RNA polymerase II and may function in nuclear import of RNA polymerase II.


Pssm-ID: 349777 [Multi-domain]  Cd Length: 198  Bit Score: 190.61  E-value: 2.07e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   4 FGVLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAESFSYEPDLDIRELITLEDVMEEMGLGPNGGLMYCFEFLL 83
Cdd:cd17868    1 YAILVIGPAGSGKTTFCKNMKEHLRARKRNPYVINLDPGNINEPLDYDIDIRDLIKYDDIMEELDLGPNGSIVYSLEYFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  84 QNLDFLNDALDPL-SEEYLIIFDMPGQIELYTHVPLLPSLVQYLSRSgalNISLCAAYLLESSFVVDRPKFFAGTLSAMS 162
Cdd:cd17868   81 KNFDWFEKKLENEdKNPHYILFDCPGQIELFTHSDSLPKIIERFASW---FISVVIVNLIDSQFLSDKSKFLSNLLIALS 157

                        170
                 ....*....|....*..
gi 861303634 163 AMIMLEIPHVNILSKMD 179
Cdd:cd17868  158 SMFRLELPQINVISKMD 174
PRK13768 PRK13768
GTPase; Provisional
 6-179 6.85e-39

GTPase; Provisional


Pssm-ID: 237498 [Multi-domain]  Cd Length: 253  Bit Score: 136.92  E-value: 6.85e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   6 VLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAESFSYEPDLDIRELITLEDVMEEMGLGPNGGLMYCFEFLLQN 85
Cdd:PRK13768   5 VFFLGTAGSGKTTLTKALSDWLEEQGYDVAIVNLDPAVEYLPYTPDFDVRDYVTAREIMKKYGLGPNGALIASVDLLLTK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  86 LDFLNDALDPLSEEYLIIfDMPGQIELYTHVPLLPSLVQYLSRSGalniSLCAAYLLESSFVVDRPKFFAGTLSAMSAMI 165
Cdd:PRK13768  85 ADEIKEEIESLDADYVLV-DTPGQMELFAFRESGRKLVERLSGSS----KSVVVFLIDAVLAKTPSDFVSLLLLALSVQL 159

                        170
                 ....*....|....
gi 861303634 166 MLEIPHVNILSKMD 179
Cdd:PRK13768 160 RLGLPQIPVLNKAD 173
GPN1 cd17870
GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, ...
 6-179 2.64e-33

GPN-loop GTPase 1; GPN-loop GTPase 1 (GPN1, also kown as MBD2-interacting protein or MBDin, RNAPII-associated protein 4, and XPA-binding protein 1) is a GTPase is required for nuclear targeting of RNA polymerase II. It forms heterodimers with GPN3.


Pssm-ID: 349779 [Multi-domain]  Cd Length: 241  Bit Score: 121.91  E-value: 2.64e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   6 VLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAESFSYEPDLDIRELITLEDVMEEMGLGPNGGLMYCFEFLLQN 85
Cdd:cd17870    3 IIVVGMAGSGKTTFVQRLNAYLHDNKKPPYVINLDPAVKSLPYPPNIDIRDTVNYKEVMKQYGLGPNGAIVTSLNLFATK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  86 LDFLNDALDPLSEEY-LIIFDMPGQIELYThvpllpslvqyLSRSGALnISLCAAYLLES--SFVVDRPK------FFAG 156
Cdd:cd17870   83 FDQVINLIEKRASELdYVIIDTPGQIEVFT-----------WSASGSI-ITEALASSFPTvvVYVVDTPRctspitFMSN 150

                        170       180
                 ....*....|....*....|...
gi 861303634 157 TLSAMSAMIMLEIPHVNILSKMD 179
Cdd:cd17870  151 MLYACSILYKTKLPFILVFNKTD 173
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 6-44 9.94e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 41.59  E-value: 9.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 861303634     6 VLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDPAAE 44
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILE 43
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 6-66 2.79e-04

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 40.75  E-value: 2.79e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 861303634   6 VLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLD--------PAAESFSY--EPDLDIRELI-TLEDVMEE 66
Cdd:cd02028    2 VGIAGPSGSGKTTFAKKLSNQLRVNGIGPVVISLDdyyvprktPRDEDGNYdfESILDLDLLNkNLHDLLNG 73
AAA_14 pfam13173
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 6-67 7.72e-04

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 463799 [Multi-domain]  Cd Length: 128  Bit Score: 38.72  E-value: 7.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 861303634    6 VLVMGPAGAGKTTFCTSLIQHLqNTRRSCFYVNLDpaaesfsYEPDLDIRELITLEDVMEEM 67
Cdd:pfam13173   5 LVITGPRQVGKTTLLLQLIKEL-LPPENILYINLD-------DPRLLKLADFELLELFLELL 58
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
6-168 1.25e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 39.13  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634   6 VLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLD--PA-----AESFSYEPDLDIRE-LITLEDV-MEEMGLGPNgglm 76
Cdd:COG0467   23 TLLSGPPGTGKTTLALQFLAEGLRRGEKGLYVSFEesPEqllrrAESLGLDLEEYIESgLLRIIDLsPEELGLDLE---- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861303634  77 ycfEFLLQNLDFLND------ALDPLSeEYLIIFDMPGQIELYTHvpllpSLVQYLSRSGALnislcaAYLLESSFVVDR 150
Cdd:COG0467   99 ---ELLARLREAVEEfgakrvVIDSLS-GLLLALPDPERLREFLH-----RLLRYLKKRGVT------TLLTSETGGLED 163

                        170
                 ....*....|....*...
gi 861303634 151 PKFFAGTLSAMSAMIMLE 168
Cdd:COG0467  164 EATEGGLSYLADGVILLR 181
AAA_22 pfam13401
AAA domain;
6-39 1.69e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 37.71  E-value: 1.69e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 861303634    6 VLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNL 39
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQLPEVRDSVVFVDL 41
SRP_G cd18539
GTPase domain of signal recognition particle protein; The signal recognition particle (SRP) ...
 6-43 2.26e-03

GTPase domain of signal recognition particle protein; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognated receptor (SR). In mammals, SRP consists of six protein subunits and a 7SL RNA. One of these subunits is a 54 kd protein (SRP54), which is a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 is a multidomain protein that consists of an N-terminal domain, followed by a central G (GTPase) domain and a C-terminal M domain.


Pssm-ID: 349786  Cd Length: 193  Bit Score: 38.35  E-value: 2.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 861303634   6 VLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVNLD---PAA 43
Cdd:cd18539    3 ILLVGLQGSGKTTTAAKLALYLKKKGKKVLLVAADvyrPAA 43
CLP1_P pfam16575
mRNA cleavage and polyadenylation factor CLP1 P-loop; CLP1_P is the P-loop carrying domain of ...
 10-41 2.52e-03

mRNA cleavage and polyadenylation factor CLP1 P-loop; CLP1_P is the P-loop carrying domain of Clp1 mRNA cleavage and polyadenylation factor, Clp1, proteins in eukaryotes. Clp1 is essential for 3'-end processing of mRNAs. This region carries the P-loop suggesting it is the region that binds adenine or guanine nucleotide.


Pssm-ID: 406878  Cd Length: 187  Bit Score: 38.01  E-value: 2.52e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 861303634   10 GPAGAGKTTFCTSLIQHLQNTRRSCFYVNLDP 41
Cdd:pfam16575   1 GPKDSGKSTLCRILLNYAVRKGRKPVYVDLDV 32
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 6-28 2.63e-03

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 37.62  E-value: 2.63e-03
                         10        20
                 ....*....|....*....|...
gi 861303634   6 VLVMGPAGAGKTTFCTSLIQHLQ 28
Cdd:cd02021    2 IVVMGVSGSGKSTVGKALAERLG 24
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 2-38 8.74e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 35.97  E-value: 8.74e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 861303634   2 SKFGVLVMGPAGAGKTTFCTSLIQHLQNTRRSCFYVN 38
Cdd:cd00009   18 PPKNLLLYGPPGTGKTTLARAIANELFRPGAPFLYLN 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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