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Conserved domains on  [gi|1775891845|gb|KGN60121|]
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hypothetical protein Csa_000943 [Cucumis sativus]

Protein Classification

C1_2 and Jacalin domain-containing protein( domain architecture ID 12041861)

C1_2 and Jacalin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 1161-1288 1.32e-38

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


:

Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 140.39  E-value: 1.32e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1161 GDPWDE--NFTTIRKLVINHGQW-IDSIQMEYEDeNGEVVLSEKHGGNGGSESEVVLNFPDEHIVTIRGYYDNLRDwgld 1237
Cdd:cd09612      1 GSAWDDgvFPDGLRKITVRSGENgIDSIKFEYDK-DGQHVVGPWHGGGGGTPEEIVLDYPDEYITSVSGTYGPVSG---- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1775891845 1238 TIVIQSLTVETNTTSYGPFGVENGTKFSFPSDGVKVVGIHGRSGLYLDAIG 1288
Cdd:cd09612     76 SNVITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIG 126
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 856-984 4.36e-38

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


:

Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 138.85  E-value: 4.36e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  856 WDDGAYST-IRRIVVYEKEW-ICSIQIEYDGNGESIMSETHGENEGSMSEVVFEYPDEFLVSISGYYGSIrnwgVDRIVI 933
Cdd:cd09612      4 WDDGVFPDgLRKITVRSGENgIDSIKFEYDKDGQHVVGPWHGGGGGTPEEIVLDYPDEYITSVSGTYGPV----SGSNVI 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1775891845  934 RSLTFESNGRYYGPFGIQEGKYFKSPGTEGKIIGFHGISDPYLNAIGVHVQ 984
Cdd:cd09612     80 TSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIGVYVS 130
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 1009-1141 2.78e-35

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


:

Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 130.76  E-value: 2.78e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1009 GNPWKETFET--IKRVRIYHGLW-IDSFQIQYeevDEMGTLVWTEIYGGEGGFLATVDLEF-DEYFISVEGYYSDlqkwG 1084
Cdd:cd09612      1 GSAWDDGVFPdgLRKITVRSGENgIDSIKFEY---DKDGQHVVGPWHGGGGGTPEEIVLDYpDEYITSVSGTYGP----V 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1775891845 1085 MDATVIRSLTLKTNQNTYGPFGIEDGTKFSFPFKGLKLVGFHGRSGVYLDAIGLYLR 1141
Cdd:cd09612     74 SGSNVITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIGVYVS 130
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 690-802 1.34e-29

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


:

Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 114.59  E-value: 1.34e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  690 GNSWEEKVFTT-VRTFVVYH-QQCVHAIQIYYEKNGKAIWSAKHGGDGGTKYEVVFDYPYEYLVSIHGSYNNVMelERVV 767
Cdd:cd09612      1 GSAWDDGVFPDgLRKITVRSgENGIDSIKFEYDKDGQHVVGPWHGGGGGTPEEIVLDYPDEYITSVSGTYGPVS--GSNV 78

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1775891845  768 IESLTLETNKRVYGPFGIEDGTKFSIPNKRVKIIG 802
Cdd:cd09612     79 ITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVG 113
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 540-585 2.57e-06

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


:

Pssm-ID: 427141  Cd Length: 48  Bit Score: 45.45  E-value: 2.57e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1775891845  540 HPLNLTFVEEEESDEYYCDVCEEEREPWLWSYSCRICCFEAHLGCV 585
Cdd:pfam03107    3 HPHPLTLTGSPRDGSFTCDACGLKIDGFFGFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 294-342 1.74e-05

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


:

Pssm-ID: 427141  Cd Length: 48  Bit Score: 43.14  E-value: 1.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1775891845  294 HLHDLTLTyfrDNVPNHTRYCKICGEKLEMKFAGYGCYECNYFTHLDCA 342
Cdd:pfam03107    3 HPHPLTLT---GSPRDGSFTCDACGLKIDGFFGFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 483-527 6.83e-05

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


:

Pssm-ID: 427141  Cd Length: 48  Bit Score: 41.59  E-value: 6.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1775891845  483 PGHQHPLSLDRT--NEEHNCEACGEGVRNRVSF-RCVDCNFYLDAKCA 527
Cdd:pfam03107    1 PSHPHPLTLTGSprDGSFTCDACGLKIDGFFGFySCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 129-177 1.32e-04

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


:

Pssm-ID: 427141  Cd Length: 48  Bit Score: 40.82  E-value: 1.32e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1775891845  129 FSHPHPLTLQLEENRGKNRvvCFVCDLLIKST-PSYFCSQCDNHFHQGCA 177
Cdd:pfam03107    1 PSHPHPLTLTGSPRDGSFT--CDACGLKIDGFfGFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 377-421 6.44e-04

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


:

Pssm-ID: 427141  Cd Length: 48  Bit Score: 38.90  E-value: 6.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1775891845  377 HSHNLNLTmGIRRKGDRICDGCLKGL--LSSSYGCQQCDFYVHKECA 421
Cdd:pfam03107    3 HPHPLTLT-GSPRDGSFTCDACGLKIdgFFGFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 188-234 1.33e-03

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


:

Pssm-ID: 427141  Cd Length: 48  Bit Score: 37.74  E-value: 1.33e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1775891845  188 FHQHPLFLLPNLSFANFLCDSC--NNNCRKFVYSCPhprHCKFNLHVAC 234
Cdd:pfam03107    2 SHPHPLTLTGSPRDGSFTCDACglKIDGFFGFYSCS---ECDFVLHERC 47
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 67-109 1.39e-03

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


:

Pssm-ID: 427141  Cd Length: 48  Bit Score: 37.74  E-value: 1.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1775891845   67 PFHPlHPLFL----ETNNYFCTVCWQMPSGD--VYRCRKCNFQIDIKCV 109
Cdd:pfam03107    1 PSHP-HPLTLtgspRDGSFTCDACGLKIDGFfgFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 430-473 2.41e-03

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


:

Pssm-ID: 427141  Cd Length: 48  Bit Score: 36.97  E-value: 2.41e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1775891845  430 FLHQHLLTLISIPNFI-FHCEACHEYFHGF--AYHCKTCLSTFDIRC 473
Cdd:pfam03107    1 PSHPHPLTLTGSPRDGsFTCDACGLKIDGFfgFYSCSECDFVLHERC 47
 
Name Accession Description Interval E-value
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 1161-1288 1.32e-38

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 140.39  E-value: 1.32e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1161 GDPWDE--NFTTIRKLVINHGQW-IDSIQMEYEDeNGEVVLSEKHGGNGGSESEVVLNFPDEHIVTIRGYYDNLRDwgld 1237
Cdd:cd09612      1 GSAWDDgvFPDGLRKITVRSGENgIDSIKFEYDK-DGQHVVGPWHGGGGGTPEEIVLDYPDEYITSVSGTYGPVSG---- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1775891845 1238 TIVIQSLTVETNTTSYGPFGVENGTKFSFPSDGVKVVGIHGRSGLYLDAIG 1288
Cdd:cd09612     76 SNVITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIG 126
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 856-984 4.36e-38

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 138.85  E-value: 4.36e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  856 WDDGAYST-IRRIVVYEKEW-ICSIQIEYDGNGESIMSETHGENEGSMSEVVFEYPDEFLVSISGYYGSIrnwgVDRIVI 933
Cdd:cd09612      4 WDDGVFPDgLRKITVRSGENgIDSIKFEYDKDGQHVVGPWHGGGGGTPEEIVLDYPDEYITSVSGTYGPV----SGSNVI 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1775891845  934 RSLTFESNGRYYGPFGIQEGKYFKSPGTEGKIIGFHGISDPYLNAIGVHVQ 984
Cdd:cd09612     80 TSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIGVYVS 130
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 1009-1141 2.78e-35

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 130.76  E-value: 2.78e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1009 GNPWKETFET--IKRVRIYHGLW-IDSFQIQYeevDEMGTLVWTEIYGGEGGFLATVDLEF-DEYFISVEGYYSDlqkwG 1084
Cdd:cd09612      1 GSAWDDGVFPdgLRKITVRSGENgIDSIKFEY---DKDGQHVVGPWHGGGGGTPEEIVLDYpDEYITSVSGTYGP----V 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1775891845 1085 MDATVIRSLTLKTNQNTYGPFGIEDGTKFSFPFKGLKLVGFHGRSGVYLDAIGLYLR 1141
Cdd:cd09612     74 SGSNVITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIGVYVS 130
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 856-983 4.91e-31

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 118.92  E-value: 4.91e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  856 WDDGAYSTIRRIVV-YEKEWICSIQIEYDGNGESIMSETHGEN-EGSMSEVVFEYPDEFLVSISGYYGSIrnWGVDRIVI 933
Cdd:pfam01419    4 WDDGVYDGVRKVYVgQGGDGITYIKFEYVKGGGKVEGDEHGKKgLLGPEEFEIDYPDEYITSVEGTYDKV--FGSDSEVI 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1775891845  934 RSLTFESN-GRYYGPFGIQEGKYFKSPGTEGKIIGFHGISDPYLNAIGVHV 983
Cdd:pfam01419   82 TSLTFKTNkGRTSPFFGTPSGTKFSLEVKGKKIVGFHGRAGNALNALGAYF 132
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 856-985 9.23e-30

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 115.02  E-value: 9.23e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845   856 WDDGAYSTIRRIVV-YEKEWICSIQIEYDgNGESIMSETHGENEGSMSEVVfEYPDEFLVSISGYYGSIrnwgvdrIVIR 934
Cdd:smart00915    4 WDDGAFDGVRKIYVgQGGEGIKSIQFDYD-KGGKVWGDEHGGKGGTGEEIL-LYPGEYITSVEGTYDKS-------GVIT 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1775891845   935 SLTFESN-GRYYGPFGIQEGKYFKSPGTEG-KIIGFHGI-SDPYLNAIGVHVQT 985
Cdd:smart00915   75 SLTFKTNkGRTSPFGGYEGGTKFVLESKEGkKIVGFHGRsSGDGLDSLGAYFSP 128
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 690-802 1.34e-29

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 114.59  E-value: 1.34e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  690 GNSWEEKVFTT-VRTFVVYH-QQCVHAIQIYYEKNGKAIWSAKHGGDGGTKYEVVFDYPYEYLVSIHGSYNNVMelERVV 767
Cdd:cd09612      1 GSAWDDGVFPDgLRKITVRSgENGIDSIKFEYDKDGQHVVGPWHGGGGGTPEEIVLDYPDEYITSVSGTYGPVS--GSNV 78

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1775891845  768 IESLTLETNKRVYGPFGIEDGTKFSIPNKRVKIIG 802
Cdd:cd09612     79 ITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVG 113
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 1161-1288 9.16e-28

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 109.24  E-value: 9.16e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  1161 GDPWDE-NFTTIRKLVINHGQ-WIDSIQMEYEdeNGEVVLSEKHGGNGGSESEVvLNFPDEHIVTIRGYYDNlrdwgldT 1238
Cdd:smart00915    1 GTEWDDgAFDGVRKIYVGQGGeGIKSIQFDYD--KGGKVWGDEHGGKGGTGEEI-LLYPGEYITSVEGTYDK-------S 70

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1775891845  1239 IVIQSLTVETNTTSYGP-FGVENGTKFSFPS-DGVKVVGIHGR-SGLYLDAIG 1288
Cdd:smart00915   71 GVITSLTFKTNKGRTSPfGGYEGGTKFVLESkEGKKIVGFHGRsSGDGLDSLG 123
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 1161-1288 1.17e-27

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 109.29  E-value: 1.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1161 GDPWDEN-FTTIRKLVINHGQW-IDSIQMEYEDENGEVVLSEkHGGNGGSES-EVVLNFPDEHIVTIRGYYDNLrdWGLD 1237
Cdd:pfam01419    1 GASWDDGvYDGVRKVYVGQGGDgITYIKFEYVKGGGKVEGDE-HGKKGLLGPeEFEIDYPDEYITSVEGTYDKV--FGSD 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1775891845 1238 TIVIQSLTVETN-TTSYGPFGVENGTKFSFPSDGVKVVGIHGRSGLYLDAIG 1288
Cdd:pfam01419   78 SEVITSLTFKTNkGRTSPFFGTPSGTKFSLEVKGKKIVGFHGRAGNALNALG 129
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 1009-1142 4.02e-26

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 104.62  E-value: 4.02e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  1009 GNPWKET-FETIKRVRIYHG-LWIDSFQIQYEEvdemGTLVWTEIYGGEGGFLATVDLEFDEYFISVEGYYSDLqkwgmd 1086
Cdd:smart00915    1 GTEWDDGaFDGVRKIYVGQGgEGIKSIQFDYDK----GGKVWGDEHGGKGGTGEEILLYPGEYITSVEGTYDKS------ 70

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1775891845  1087 aTVIRSLTLKTNQNTYGP-FGIEDGTKFSFPFK-GLKLVGFHGR-SGVYLDAIGLYLRP 1142
Cdd:smart00915   71 -GVITSLTFKTNKGRTSPfGGYEGGTKFVLESKeGKKIVGFHGRsSGDGLDSLGAYFSP 128
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 1009-1142 1.99e-25

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 102.74  E-value: 1.99e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1009 GNPWKE-TFETIKRV-RIYHGLWIDSFQIQYEEVDEMgtlVWTEIYGGEGGFLATvdlEF-----DEYFISVEGYYSDLq 1081
Cdd:pfam01419    1 GASWDDgVYDGVRKVyVGQGGDGITYIKFEYVKGGGK---VEGDEHGKKGLLGPE---EFeidypDEYITSVEGTYDKV- 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1775891845 1082 kWGMDATVIRSLTLKTNQN-TYGPFGIEDGTKFSFPFKGLKLVGFHGRSGVYLDAIGLYLRP 1142
Cdd:pfam01419   74 -FGSDSEVITSLTFKTNKGrTSPFFGTPSGTKFSLEVKGKKIVGFHGRAGNALNALGAYFAP 134
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 690-802 1.10e-21

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 92.34  E-value: 1.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  690 GNSWEEKVFTTVRTFVV-YHQQCVHAIQIYYEKNGKAIWSAKHGGDGGTKY-EVVFDYPYEYLVSIHGSYNNVMELERVV 767
Cdd:pfam01419    1 GASWDDGVYDGVRKVYVgQGGDGITYIKFEYVKGGGKVEGDEHGKKGLLGPeEFEIDYPDEYITSVEGTYDKVFGSDSEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1775891845  768 IESLTLETNKRVYGP-FGIEDGTKFSIPNKRVKIIG 802
Cdd:pfam01419   81 ITSLTFKTNKGRTSPfFGTPSGTKFSLEVKGKKIVG 116
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 690-802 1.15e-21

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 91.91  E-value: 1.15e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845   690 GNSWEEKVFTTVRTFVVYH-QQCVHAIQIYYEKNGKaIWSAKHGGDGGTKYEVVfDYPYEYLVSIHGSYNNVmelerVVI 768
Cdd:smart00915    1 GTEWDDGAFDGVRKIYVGQgGEGIKSIQFDYDKGGK-VWGDEHGGKGGTGEEIL-LYPGEYITSVEGTYDKS-----GVI 73

                            90       100       110
                    ....*....|....*....|....*....|....*.
gi 1775891845   769 ESLTLETNK-RVYGPFGIEDGTKFSIPNKRV-KIIG 802
Cdd:smart00915   74 TSLTFKTNKgRTSPFGGYEGGTKFVLESKEGkKIVG 109
PLN02193 PLN02193
nitrile-specifier protein
 1157-1288 4.00e-13

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 73.45  E-value: 4.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1157 GGEGGDPWDEN-FTTIRKLVINHGQW-IDSIQMEYEdeNG-EVVLSEKHGGN---GGSESEVVlnfPDEHIVTIRGYYDN 1230
Cdd:PLN02193     9 GGETGDVWDDGvYDNVRKVYVGQGQYgIAFVKFEYV--NGsQVVVGDEHGKKtelGVEEFEID---ADDYIVYVEGYREK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1775891845 1231 LRDWGLDTIVIQSLTVETNTTSYgPFGVENGTKFSFpsDGVKVVGIHGRSGLYLDAIG 1288
Cdd:PLN02193    84 VNDMTSEMITFLSFKTYKGKTSH-PIEKRPGVKFVL--QGGKIVGFHGRSTDVLHSLG 138
PLN02193 PLN02193
nitrile-specifier protein
 1005-1160 4.46e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 69.98  E-value: 4.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1005 GGKGGNPWKE-TFETIKRVRIYHGLWIDSFqIQYEEVDEMGTLVWTEiyGGEGGFLATVDLEFD--EYFISVEGYYSDLQ 1081
Cdd:PLN02193     9 GGETGDVWDDgVYDNVRKVYVGQGQYGIAF-VKFEYVNGSQVVVGDE--HGKKTELGVEEFEIDadDYIVYVEGYREKVN 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1082 kwGMDATVIRSLTLKTNQ-NTYGPFGIEDGTKFSFpfKGLKLVGFHGRSGVYLDAIGLYL-RPTPINGTEKFSLGECGGE 1159
Cdd:PLN02193    86 --DMTSEMITFLSFKTYKgKTSHPIEKRPGVKFVL--QGGKIVGFHGRSTDVLHSLGAYIsLPSTPKLLGKWIKVEQKGE 161


                   .
gi 1775891845 1160 G 1160
Cdd:PLN02193   162 G 162
PLN02193 PLN02193
nitrile-specifier protein
 856-997 2.61e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 67.67  E-value: 2.61e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  856 WDDGAYSTIRRIVVYEKEW-ICSIQIEYDGNGESIMSETHGE-NEGSMSEvvFEY-PDEFLVSISGYYGSIRnwGVDRIV 932
Cdd:PLN02193    16 WDDGVYDNVRKVYVGQGQYgIAFVKFEYVNGSQVVVGDEHGKkTELGVEE--FEIdADDYIVYVEGYREKVN--DMTSEM 91

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1775891845  933 IRSLTFES-NGRYYGPFGIQEGKYFKSPGteGKIIGFHGISDPYLNAIGVHVQTvqklgiqPEPPK 997
Cdd:PLN02193    92 ITFLSFKTyKGKTSHPIEKRPGVKFVLQG--GKIVGFHGRSTDVLHSLGAYISL-------PSTPK 148
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 540-585 2.57e-06

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 45.45  E-value: 2.57e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1775891845  540 HPLNLTFVEEEESDEYYCDVCEEEREPWLWSYSCRICCFEAHLGCV 585
Cdd:pfam03107    3 HPHPLTLTGSPRDGSFTCDACGLKIDGFFGFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 294-342 1.74e-05

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 43.14  E-value: 1.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1775891845  294 HLHDLTLTyfrDNVPNHTRYCKICGEKLEMKFAGYGCYECNYFTHLDCA 342
Cdd:pfam03107    3 HPHPLTLT---GSPRDGSFTCDACGLKIDGFFGFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 483-527 6.83e-05

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 41.59  E-value: 6.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1775891845  483 PGHQHPLSLDRT--NEEHNCEACGEGVRNRVSF-RCVDCNFYLDAKCA 527
Cdd:pfam03107    1 PSHPHPLTLTGSprDGSFTCDACGLKIDGFFGFySCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 129-177 1.32e-04

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 40.82  E-value: 1.32e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1775891845  129 FSHPHPLTLQLEENRGKNRvvCFVCDLLIKST-PSYFCSQCDNHFHQGCA 177
Cdd:pfam03107    1 PSHPHPLTLTGSPRDGSFT--CDACGLKIDGFfGFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 377-421 6.44e-04

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 38.90  E-value: 6.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1775891845  377 HSHNLNLTmGIRRKGDRICDGCLKGL--LSSSYGCQQCDFYVHKECA 421
Cdd:pfam03107    3 HPHPLTLT-GSPRDGSFTCDACGLKIdgFFGFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 188-234 1.33e-03

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 37.74  E-value: 1.33e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1775891845  188 FHQHPLFLLPNLSFANFLCDSC--NNNCRKFVYSCPhprHCKFNLHVAC 234
Cdd:pfam03107    2 SHPHPLTLTGSPRDGSFTCDACglKIDGFFGFYSCS---ECDFVLHERC 47
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 67-109 1.39e-03

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 37.74  E-value: 1.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1775891845   67 PFHPlHPLFL----ETNNYFCTVCWQMPSGD--VYRCRKCNFQIDIKCV 109
Cdd:pfam03107    1 PSHP-HPLTLtgspRDGSFTCDACGLKIDGFfgFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 430-473 2.41e-03

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 36.97  E-value: 2.41e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1775891845  430 FLHQHLLTLISIPNFI-FHCEACHEYFHGF--AYHCKTCLSTFDIRC 473
Cdd:pfam03107    1 PSHPHPLTLTGSPRDGsFTCDACGLKIDGFfgFYSCSECDFVLHERC 47
 
Name Accession Description Interval E-value
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 1161-1288 1.32e-38

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 140.39  E-value: 1.32e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1161 GDPWDE--NFTTIRKLVINHGQW-IDSIQMEYEDeNGEVVLSEKHGGNGGSESEVVLNFPDEHIVTIRGYYDNLRDwgld 1237
Cdd:cd09612      1 GSAWDDgvFPDGLRKITVRSGENgIDSIKFEYDK-DGQHVVGPWHGGGGGTPEEIVLDYPDEYITSVSGTYGPVSG---- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1775891845 1238 TIVIQSLTVETNTTSYGPFGVENGTKFSFPSDGVKVVGIHGRSGLYLDAIG 1288
Cdd:cd09612     76 SNVITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIG 126
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 856-984 4.36e-38

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 138.85  E-value: 4.36e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  856 WDDGAYST-IRRIVVYEKEW-ICSIQIEYDGNGESIMSETHGENEGSMSEVVFEYPDEFLVSISGYYGSIrnwgVDRIVI 933
Cdd:cd09612      4 WDDGVFPDgLRKITVRSGENgIDSIKFEYDKDGQHVVGPWHGGGGGTPEEIVLDYPDEYITSVSGTYGPV----SGSNVI 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1775891845  934 RSLTFESNGRYYGPFGIQEGKYFKSPGTEGKIIGFHGISDPYLNAIGVHVQ 984
Cdd:cd09612     80 TSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIGVYVS 130
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 1009-1141 2.78e-35

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 130.76  E-value: 2.78e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1009 GNPWKETFET--IKRVRIYHGLW-IDSFQIQYeevDEMGTLVWTEIYGGEGGFLATVDLEF-DEYFISVEGYYSDlqkwG 1084
Cdd:cd09612      1 GSAWDDGVFPdgLRKITVRSGENgIDSIKFEY---DKDGQHVVGPWHGGGGGTPEEIVLDYpDEYITSVSGTYGP----V 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1775891845 1085 MDATVIRSLTLKTNQNTYGPFGIEDGTKFSFPFKGLKLVGFHGRSGVYLDAIGLYLR 1141
Cdd:cd09612     74 SGSNVITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVGFHGRSGDYLDAIGVYVS 130
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 856-983 4.91e-31

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 118.92  E-value: 4.91e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  856 WDDGAYSTIRRIVV-YEKEWICSIQIEYDGNGESIMSETHGEN-EGSMSEVVFEYPDEFLVSISGYYGSIrnWGVDRIVI 933
Cdd:pfam01419    4 WDDGVYDGVRKVYVgQGGDGITYIKFEYVKGGGKVEGDEHGKKgLLGPEEFEIDYPDEYITSVEGTYDKV--FGSDSEVI 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1775891845  934 RSLTFESN-GRYYGPFGIQEGKYFKSPGTEGKIIGFHGISDPYLNAIGVHV 983
Cdd:pfam01419   82 TSLTFKTNkGRTSPFFGTPSGTKFSLEVKGKKIVGFHGRAGNALNALGAYF 132
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 856-985 9.23e-30

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 115.02  E-value: 9.23e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845   856 WDDGAYSTIRRIVV-YEKEWICSIQIEYDgNGESIMSETHGENEGSMSEVVfEYPDEFLVSISGYYGSIrnwgvdrIVIR 934
Cdd:smart00915    4 WDDGAFDGVRKIYVgQGGEGIKSIQFDYD-KGGKVWGDEHGGKGGTGEEIL-LYPGEYITSVEGTYDKS-------GVIT 74

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1775891845   935 SLTFESN-GRYYGPFGIQEGKYFKSPGTEG-KIIGFHGI-SDPYLNAIGVHVQT 985
Cdd:smart00915   75 SLTFKTNkGRTSPFGGYEGGTKFVLESKEGkKIVGFHGRsSGDGLDSLGAYFSP 128
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 690-802 1.34e-29

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 114.59  E-value: 1.34e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  690 GNSWEEKVFTT-VRTFVVYH-QQCVHAIQIYYEKNGKAIWSAKHGGDGGTKYEVVFDYPYEYLVSIHGSYNNVMelERVV 767
Cdd:cd09612      1 GSAWDDGVFPDgLRKITVRSgENGIDSIKFEYDKDGQHVVGPWHGGGGGTPEEIVLDYPDEYITSVSGTYGPVS--GSNV 78

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1775891845  768 IESLTLETNKRVYGPFGIEDGTKFSIPNKRVKIIG 802
Cdd:cd09612     79 ITSLTFKTNKRTYGPFGVESGTPFSLPVEGGKIVG 113
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 1161-1288 9.16e-28

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 109.24  E-value: 9.16e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  1161 GDPWDE-NFTTIRKLVINHGQ-WIDSIQMEYEdeNGEVVLSEKHGGNGGSESEVvLNFPDEHIVTIRGYYDNlrdwgldT 1238
Cdd:smart00915    1 GTEWDDgAFDGVRKIYVGQGGeGIKSIQFDYD--KGGKVWGDEHGGKGGTGEEI-LLYPGEYITSVEGTYDK-------S 70

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1775891845  1239 IVIQSLTVETNTTSYGP-FGVENGTKFSFPS-DGVKVVGIHGR-SGLYLDAIG 1288
Cdd:smart00915   71 GVITSLTFKTNKGRTSPfGGYEGGTKFVLESkEGKKIVGFHGRsSGDGLDSLG 123
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 1161-1288 1.17e-27

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 109.29  E-value: 1.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1161 GDPWDEN-FTTIRKLVINHGQW-IDSIQMEYEDENGEVVLSEkHGGNGGSES-EVVLNFPDEHIVTIRGYYDNLrdWGLD 1237
Cdd:pfam01419    1 GASWDDGvYDGVRKVYVGQGGDgITYIKFEYVKGGGKVEGDE-HGKKGLLGPeEFEIDYPDEYITSVEGTYDKV--FGSD 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1775891845 1238 TIVIQSLTVETN-TTSYGPFGVENGTKFSFPSDGVKVVGIHGRSGLYLDAIG 1288
Cdd:pfam01419   78 SEVITSLTFKTNkGRTSPFFGTPSGTKFSLEVKGKKIVGFHGRAGNALNALG 129
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 1009-1142 4.02e-26

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 104.62  E-value: 4.02e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  1009 GNPWKET-FETIKRVRIYHG-LWIDSFQIQYEEvdemGTLVWTEIYGGEGGFLATVDLEFDEYFISVEGYYSDLqkwgmd 1086
Cdd:smart00915    1 GTEWDDGaFDGVRKIYVGQGgEGIKSIQFDYDK----GGKVWGDEHGGKGGTGEEILLYPGEYITSVEGTYDKS------ 70

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1775891845  1087 aTVIRSLTLKTNQNTYGP-FGIEDGTKFSFPFK-GLKLVGFHGR-SGVYLDAIGLYLRP 1142
Cdd:smart00915   71 -GVITSLTFKTNKGRTSPfGGYEGGTKFVLESKeGKKIVGFHGRsSGDGLDSLGAYFSP 128
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 1009-1142 1.99e-25

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 102.74  E-value: 1.99e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1009 GNPWKE-TFETIKRV-RIYHGLWIDSFQIQYEEVDEMgtlVWTEIYGGEGGFLATvdlEF-----DEYFISVEGYYSDLq 1081
Cdd:pfam01419    1 GASWDDgVYDGVRKVyVGQGGDGITYIKFEYVKGGGK---VEGDEHGKKGLLGPE---EFeidypDEYITSVEGTYDKV- 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1775891845 1082 kWGMDATVIRSLTLKTNQN-TYGPFGIEDGTKFSFPFKGLKLVGFHGRSGVYLDAIGLYLRP 1142
Cdd:pfam01419   74 -FGSDSEVITSLTFKTNKGrTSPFFGTPSGTKFSLEVKGKKIVGFHGRAGNALNALGAYFAP 134
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 690-802 1.10e-21

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 92.34  E-value: 1.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  690 GNSWEEKVFTTVRTFVV-YHQQCVHAIQIYYEKNGKAIWSAKHGGDGGTKY-EVVFDYPYEYLVSIHGSYNNVMELERVV 767
Cdd:pfam01419    1 GASWDDGVYDGVRKVYVgQGGDGITYIKFEYVKGGGKVEGDEHGKKGLLGPeEFEIDYPDEYITSVEGTYDKVFGSDSEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1775891845  768 IESLTLETNKRVYGP-FGIEDGTKFSIPNKRVKIIG 802
Cdd:pfam01419   81 ITSLTFKTNKGRTSPfFGTPSGTKFSLEVKGKKIVG 116
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 690-802 1.15e-21

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 91.91  E-value: 1.15e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845   690 GNSWEEKVFTTVRTFVVYH-QQCVHAIQIYYEKNGKaIWSAKHGGDGGTKYEVVfDYPYEYLVSIHGSYNNVmelerVVI 768
Cdd:smart00915    1 GTEWDDGAFDGVRKIYVGQgGEGIKSIQFDYDKGGK-VWGDEHGGKGGTGEEIL-LYPGEYITSVEGTYDKS-----GVI 73

                            90       100       110
                    ....*....|....*....|....*....|....*.
gi 1775891845   769 ESLTLETNK-RVYGPFGIEDGTKFSIPNKRV-KIIG 802
Cdd:smart00915   74 TSLTFKTNKgRTSPFGGYEGGTKFVLESKEGkKIVG 109
Jacalin_like cd09302
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
 1018-1141 4.18e-17

Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.


Pssm-ID: 187706  Cd Length: 128  Bit Score: 78.98  E-value: 4.18e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1018 TIKRVRIYHGLWIDSFQIQYeevdemgTLVWTEIYGGEGGF-LATVDLEFDEYFISVEGYYSDLQkwgmDATVIRSLTLK 1096
Cdd:cd09302     13 RLTEIRVRSGGAVDAIRVVL-------RDYTDGRHGGNGGPnTSSVFLDPGEYITITSVSSGDNG----GGTRIDAIQFT 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1775891845 1097 TNQNTYGPFG---IEDGTKFSFPFKGlKLVGFHGRSGVYLDAIGLYLR 1141
Cdd:cd09302     82 TNKGRSGTYGttsGALGTEFTVPVGG-EIVGIYGRAGDDVDAFGFILS 128
Jacalin_like cd09302
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
 1165-1289 1.97e-16

Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.


Pssm-ID: 187706  Cd Length: 128  Bit Score: 77.06  E-value: 1.97e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1165 DENFTTIRKLVINHGQWIDSIQMEYEDENGEvvlseKHGGNGGSESEVVLNFPDEHIVTIRGYYDnlrDWGLDTIvIQSL 1244
Cdd:cd09302      8 GGDGARLTEIRVRSGGAVDAIRVVLRDYTDG-----RHGGNGGPNTSSVFLDPGEYITITSVSSG---DNGGGTR-IDAI 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1775891845 1245 TVETNTTSYGPFGV---ENGTKFSFPSdGVKVVGIHGRSGLYLDAIGL 1289
Cdd:cd09302     79 QFTTNKGRSGTYGTtsgALGTEFTVPV-GGEIVGIYGRAGDDVDAFGF 125
griffithsin_like cd09614
Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin ...
 1157-1289 3.07e-13

Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin isolated from a red alga, which has shown potential as an inhibitor of viral entry, exhibiting antiviral activity against HIV and SARS. The biological functions of griffithsin and griffithsin-like proteins with respect to their source organisms are not known.


Pssm-ID: 187710  Cd Length: 128  Bit Score: 67.81  E-value: 3.07e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1157 GGEGGDPWDENftTIRKLVINHGQWIDSIQMEYEDENGEvvLSEKHGGNGGSESEVvLNFP-DEHIVTIRGYYDNLRDwg 1235
Cdd:cd09614      3 GGSPGSDFDIL--TVSAIQLRSGSYVDQIITDYQDLNGT--QNFHHGGGGGNLSPT-LNFSsGEYITEVTGRSGDRVD-- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1775891845 1236 ldtiviqSLTVETNT-TSYGPFGVENGTKFSF-PSDGVKVVGIHGRSGLYLDAIGL 1289
Cdd:cd09614     76 -------QVQFTTNYgGRTLPGGGGGGSAFTWtVPDNQKVIGFAGRSGSYLDQLQV 124
PLN02193 PLN02193
nitrile-specifier protein
 1157-1288 4.00e-13

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 73.45  E-value: 4.00e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1157 GGEGGDPWDEN-FTTIRKLVINHGQW-IDSIQMEYEdeNG-EVVLSEKHGGN---GGSESEVVlnfPDEHIVTIRGYYDN 1230
Cdd:PLN02193     9 GGETGDVWDDGvYDNVRKVYVGQGQYgIAFVKFEYV--NGsQVVVGDEHGKKtelGVEEFEID---ADDYIVYVEGYREK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1775891845 1231 LRDWGLDTIVIQSLTVETNTTSYgPFGVENGTKFSFpsDGVKVVGIHGRSGLYLDAIG 1288
Cdd:PLN02193    84 VNDMTSEMITFLSFKTYKGKTSH-PIEKRPGVKFVL--QGGKIVGFHGRSTDVLHSLG 138
PLN02193 PLN02193
nitrile-specifier protein
 1005-1160 4.46e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 69.98  E-value: 4.46e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1005 GGKGGNPWKE-TFETIKRVRIYHGLWIDSFqIQYEEVDEMGTLVWTEiyGGEGGFLATVDLEFD--EYFISVEGYYSDLQ 1081
Cdd:PLN02193     9 GGETGDVWDDgVYDNVRKVYVGQGQYGIAF-VKFEYVNGSQVVVGDE--HGKKTELGVEEFEIDadDYIVYVEGYREKVN 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1082 kwGMDATVIRSLTLKTNQ-NTYGPFGIEDGTKFSFpfKGLKLVGFHGRSGVYLDAIGLYL-RPTPINGTEKFSLGECGGE 1159
Cdd:PLN02193    86 --DMTSEMITFLSFKTYKgKTSHPIEKRPGVKFVL--QGGKIVGFHGRSTDVLHSLGAYIsLPSTPKLLGKWIKVEQKGE 161


                   .
gi 1775891845 1160 G 1160
Cdd:PLN02193   162 G 162
PLN02193 PLN02193
nitrile-specifier protein
 856-997 2.61e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 67.67  E-value: 2.61e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  856 WDDGAYSTIRRIVVYEKEW-ICSIQIEYDGNGESIMSETHGE-NEGSMSEvvFEY-PDEFLVSISGYYGSIRnwGVDRIV 932
Cdd:PLN02193    16 WDDGVYDNVRKVYVGQGQYgIAFVKFEYVNGSQVVVGDEHGKkTELGVEE--FEIdADDYIVYVEGYREKVN--DMTSEM 91

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1775891845  933 IRSLTFES-NGRYYGPFGIQEGKYFKSPGteGKIIGFHGISDPYLNAIGVHVQTvqklgiqPEPPK 997
Cdd:PLN02193    92 ITFLSFKTyKGKTSHPIEKRPGVKFVLQG--GKIVGFHGRSTDVLHSLGAYISL-------PSTPK 148
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 1002-1139 6.66e-11

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 61.18  E-value: 6.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1002 GQYGGKGGNPWKETFETIKRVRIYHG-LWIDSFQIQYEEVdemgtlvWTEIYGGEGGFLATVDLEFDEYFISVEGYYsdl 1080
Cdd:cd09611      1 GSGGGKYFSDVGEGGGPITGIRVSVGnNYIKGIQVRYGSN-------WSDVYGGRGGNEQEIVLEPGESITKVSGSY--- 70

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1775891845 1081 qkwgmdATVIRSLTLKTNQNTYGPFGIEDGTKFSF--PFKGLKLVGFHGRSGV-YLDAIGLY 1139
Cdd:cd09611     71 ------KIYLHGLVFTTNKGRYLSFGKLRGRSFNAtpPPSNYVLRGISGRYGGlGIKSIGFH 126
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 1157-1289 8.75e-10

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 58.10  E-value: 8.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1157 GGEGGDPW---DENFTTIRKLVINHG-QWIDSIQMEYEDengevVLSEKHGGNGGSESEVVLNfPDEHIVTIRGYYDnlr 1232
Cdd:cd09611      1 GSGGGKYFsdvGEGGGPITGIRVSVGnNYIKGIQVRYGS-----NWSDVYGGRGGNEQEIVLE-PGESITKVSGSYK--- 71

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1233 dwgldtIVIQSLTVETNTTSYGPFGVENGTKFS-FPSDGVKV-VGIHGRS-GLYLDAIGL 1289
Cdd:cd09611     72 ------IYLHGLVFTTNKGRYLSFGKLRGRSFNaTPPPSNYVlRGISGRYgGLGIKSIGF 125
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 854-982 1.42e-09

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 57.33  E-value: 1.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  854 FTWDDGAYSTIRRIVVYEKE-WICSIQIEYDGNgesiMSETHGENEGSMSEVVFEyPDEFLVSISGYYgsirnwgvdRIV 932
Cdd:cd09611      8 FSDVGEGGGPITGIRVSVGNnYIKGIQVRYGSN----WSDVYGGRGGNEQEIVLE-PGESITKVSGSY---------KIY 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1775891845  933 IRSLTFESN-GRYYGpFGIQEGKYF-KSPGTEGK-IIGFHGISDP-YLNAIGVH 982
Cdd:cd09611     74 LHGLVFTTNkGRYLS-FGKLRGRSFnATPPPSNYvLRGISGRYGGlGIKSIGFH 126
Jacalin_like cd09302
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
 695-802 2.38e-09

Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.


Pssm-ID: 187706  Cd Length: 128  Bit Score: 56.64  E-value: 2.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  695 EKVFTTVRTFVVYHQQCVHAIQIYYEKngkaIWSAKHGGDGGTKYEVVFDYPYEYLVSIHGSYNNVMELERVVieSLTLE 774
Cdd:cd09302      8 GGDGARLTEIRVRSGGAVDAIRVVLRD----YTDGRHGGNGGPNTSSVFLDPGEYITITSVSSGDNGGGTRID--AIQFT 81

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1775891845  775 TNKRVYGPFG---IEDGTKFSIPNKRvKIIG 802
Cdd:cd09302     82 TNKGRSGTYGttsGALGTEFTVPVGG-EIVG 111
griffithsin_like cd09614
Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin ...
 1006-1139 4.74e-09

Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin isolated from a red alga, which has shown potential as an inhibitor of viral entry, exhibiting antiviral activity against HIV and SARS. The biological functions of griffithsin and griffithsin-like proteins with respect to their source organisms are not known.


Pssm-ID: 187710  Cd Length: 128  Bit Score: 55.87  E-value: 4.74e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1006 GKGGNPWKE-TFETIKRVRIYHGLWIDSFQIQYEEVDEMGTLVWTeiyGGEGGFLATVDLEFDEYFISVEGYYSDLqkwg 1084
Cdd:cd09614      1 GFGGSPGSDfDILTVSAIQLRSGSYVDQIITDYQDLNGTQNFHHG---GGGGNLSPTLNFSSGEYITEVTGRSGDR---- 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1775891845 1085 mdatvIRSLTLKTNQNT-YGPFGIEDGTKFSF-PFKGLKLVGFHGRSGVYLDAIGLY 1139
Cdd:cd09614     74 -----VDQVQFTTNYGGrTLPGGGGGGSAFTWtVPDNQKVIGFAGRSGSYLDQLQVY 125
griffithsin_like cd09614
Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin ...
 856-983 1.65e-08

Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin isolated from a red alga, which has shown potential as an inhibitor of viral entry, exhibiting antiviral activity against HIV and SARS. The biological functions of griffithsin and griffithsin-like proteins with respect to their source organisms are not known.


Pssm-ID: 187710  Cd Length: 128  Bit Score: 54.33  E-value: 1.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  856 WDDGAYSTIRRIVVYEKEWICSIQIEYDGNGESiMSETHGENEGSMSEVVFEYPDEFLVSISGYYGSirnwGVDRIVIRS 935
Cdd:cd09614      7 GSDFDILTVSAIQLRSGSYVDQIITDYQDLNGT-QNFHHGGGGGNLSPTLNFSSGEYITEVTGRSGD----RVDQVQFTT 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1775891845  936 ltfeSNGRYYGPFGIQEGKYFK-SPGTEGKIIGFHGISDPYLNAIGVHV 983
Cdd:cd09614     82 ----NYGGRTLPGGGGGGSAFTwTVPDNQKVIGFAGRSGSYLDQLQVYY 126
Jacalin_like cd09302
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
 853-981 3.49e-07

Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.


Pssm-ID: 187706  Cd Length: 128  Bit Score: 50.48  E-value: 3.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  853 SFTWDDGAYSTIRRIVVYEKEWICSIQIEYDgngeSIMSETHGENEGSMSEVVFEYPDEFLVSISGYYGsirnWGVDRIV 932
Cdd:cd09302      3 PFSDTGGDGARLTEIRVRSGGAVDAIRVVLR----DYTDGRHGGNGGPNTSSVFLDPGEYITITSVSSG----DNGGGTR 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1775891845  933 IRSLTFESNGRYYGPFGI--QEGKYFKSPGTEGKIIGFHGISDPYLNAIGV 981
Cdd:cd09302     75 IDAIQFTTNKGRSGTYGTtsGALGTEFTVPVGGEIVGIYGRAGDDVDAFGF 125
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 540-585 2.57e-06

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 45.45  E-value: 2.57e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1775891845  540 HPLNLTFVEEEESDEYYCDVCEEEREPWLWSYSCRICCFEAHLGCV 585
Cdd:pfam03107    3 HPHPLTLTGSPRDGSFTCDACGLKIDGFFGFYSCSECDFVLHERCA 48
Jacalin_metallopeptidase_like cd09613
Jacalin-like lectin domain of putative metalloproteases and similar proteins; Members of this ...
 1013-1138 1.19e-05

Jacalin-like lectin domain of putative metalloproteases and similar proteins; Members of this family, which appears restricted to fungi, co-occur with protein domains that contain an HExxH motif characteristic of metallopeptidases. They have not been functionally characterized.


Pssm-ID: 187709  Cd Length: 124  Bit Score: 45.87  E-value: 1.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1013 KETFEtIKRVRIYHGLWIDSFQIQYEEVDemgtlvwTEIYGGEGGFLATVDLEFDEYFIsveGYYSDLQKWgMDATVIrs 1092
Cdd:cd09613     10 IEKRL-LTAVRVYHGYALDGIEFVYGDDA-------SVLFGNRGGSPTDFELQPGEQIL---GFNVRCGAW-IDAIQI-- 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1775891845 1093 ltLKTNQNTYGPFGIEDGTKFS--FPFKGLKLVGFHGRSGVYLDAIGL 1138
Cdd:cd09613     76 --LTSLGRTSPFYGNANGGGLHtlIPPRGYTILGVYGSCGQWVDGFGI 121
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 294-342 1.74e-05

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 43.14  E-value: 1.74e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1775891845  294 HLHDLTLTyfrDNVPNHTRYCKICGEKLEMKFAGYGCYECNYFTHLDCA 342
Cdd:pfam03107    3 HPHPLTLT---GSPRDGSFTCDACGLKIDGFFGFYSCSECDFVLHERCA 48
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 712-792 3.68e-05

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 44.62  E-value: 3.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845  712 VHAIQIYYEKNgkaiWSAKHGGDGGTKYEVVFDyPYEYLVSIHGSYNNVMelervviESLTLETNKRVYGPFGIEDGTKF 791
Cdd:cd09611     30 IKGIQVRYGSN----WSDVYGGRGGNEQEIVLE-PGESITKVSGSYKIYL-------HGLVFTTNKGRYLSFGKLRGRSF 97


                   .
gi 1775891845  792 S 792
Cdd:cd09611     98 N 98
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 483-527 6.83e-05

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 41.59  E-value: 6.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1775891845  483 PGHQHPLSLDRT--NEEHNCEACGEGVRNRVSF-RCVDCNFYLDAKCA 527
Cdd:pfam03107    1 PSHPHPLTLTGSprDGSFTCDACGLKIDGFFGFySCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 129-177 1.32e-04

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 40.82  E-value: 1.32e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1775891845  129 FSHPHPLTLQLEENRGKNRvvCFVCDLLIKST-PSYFCSQCDNHFHQGCA 177
Cdd:pfam03107    1 PSHPHPLTLTGSPRDGSFT--CDACGLKIDGFfGFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 377-421 6.44e-04

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 38.90  E-value: 6.44e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1775891845  377 HSHNLNLTmGIRRKGDRICDGCLKGL--LSSSYGCQQCDFYVHKECA 421
Cdd:pfam03107    3 HPHPLTLT-GSPRDGSFTCDACGLKIdgFFGFYSCSECDFVLHERCA 48
Jacalin_metallopeptidase_like cd09613
Jacalin-like lectin domain of putative metalloproteases and similar proteins; Members of this ...
 1173-1290 8.58e-04

Jacalin-like lectin domain of putative metalloproteases and similar proteins; Members of this family, which appears restricted to fungi, co-occur with protein domains that contain an HExxH motif characteristic of metallopeptidases. They have not been functionally characterized.


Pssm-ID: 187709  Cd Length: 124  Bit Score: 40.48  E-value: 8.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775891845 1173 KLVINHGQWIDSIQMEYEDENgevvlSEKHGGNGGSESEVVLNfPDEHIVtirGYydNLRDwGLDTIVIQSLTVETNTTS 1252
Cdd:cd09613     17 AVRVYHGYALDGIEFVYGDDA-----SVLFGNRGGSPTDFELQ-PGEQIL---GF--NVRC-GAWIDAIQILTSLGRTSP 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1775891845 1253 YgpFGVENGTKFS--FPSDGVKVVGIHGRSGLYLDAIGLM 1290
Cdd:cd09613     85 F--YGNANGGGLHtlIPPRGYTILGVYGSCGQWVDGFGII 122
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 188-234 1.33e-03

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 37.74  E-value: 1.33e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1775891845  188 FHQHPLFLLPNLSFANFLCDSC--NNNCRKFVYSCPhprHCKFNLHVAC 234
Cdd:pfam03107    2 SHPHPLTLTGSPRDGSFTCDACglKIDGFFGFYSCS---ECDFVLHERC 47
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 67-109 1.39e-03

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 37.74  E-value: 1.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1775891845   67 PFHPlHPLFL----ETNNYFCTVCWQMPSGD--VYRCRKCNFQIDIKCV 109
Cdd:pfam03107    1 PSHP-HPLTLtgspRDGSFTCDACGLKIDGFfgFYSCSECDFVLHERCA 48
C1_2 pfam03107
C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation ...
 430-473 2.41e-03

C1 domain; This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in pfam00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.


Pssm-ID: 427141  Cd Length: 48  Bit Score: 36.97  E-value: 2.41e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1775891845  430 FLHQHLLTLISIPNFI-FHCEACHEYFHGF--AYHCKTCLSTFDIRC 473
Cdd:pfam03107    1 PSHPHPLTLTGSPRDGsFTCDACGLKIDGFfgFYSCSECDFVLHERC 47
PHD smart00249
PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in ...
 149-209 8.60e-03

PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. The PHD finger binds two zinc ions using the so-called 'cross-brace' motif and is thus structurally related to the RING finger and the FYVE finger. It is not yet known if PHD fingers have a common molecular function. Several reports suggest that it can function as a protein-protein interacton domain and it was recently demonstrated that the PHD finger of p300 can cooperate with the adjacent BROMO domain in nucleosome binding in vitro. Other reports suggesting that the PHD finger is a ubiquitin ligase have been refuted as these domains were RING fingers misidentified as PHD fingers.


Pssm-ID: 214584 [Multi-domain]  Cd Length: 47  Bit Score: 35.65  E-value: 8.60e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1775891845   149 VCFVCDLLIKSTPSYFCSQCDNHFHQGCAELPRELYDVRFHqhplfllpnlsfanFLCDSC 209
Cdd:smart00249    1 YCSVCGKPDDGGELLQCDGCDRWYHQTCLGPPLLEEEPDGK--------------WYCPKC 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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