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Conserved domains on  [gi|678144524|gb|KFV13690|]
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Major facilitator superfamily domain-containing protein 10 [Pterocles gutturalis]

Protein Classification

major facilitator superfamily domain-containing protein 10( domain architecture ID 13024405)

major facilitator superfamily domain-containing protein 10 (MFSD10) may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 22-452 0e+00

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 605.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  22 ITIVFLALFIDLLGFALILPLFPSILDYYSQTEDGFYLSLQRG-VDWFAEMVGMPPERKYNSVLFGGLIGSVFSILQFFS 100
Cdd:cd17389    1 ITIVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 101 SPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGIA 180
Cdd:cd17389   81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 181 FSLGFTLGPMIGAYLAMETEK-GEVFYVRSALLALMFAVADLIFIFFLLPETLPkekrvssvtsgfqaavdllsplalfq 259
Cdd:cd17389  161 FSLGFIIGPMIGAYFASFTRSlGEVFFSMPALFALVLALADLLFIFFFLPETLP-------------------------- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 260 fsavtrgkespsegnlQNLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPG 339
Cdd:cd17389  215 ----------------SNLRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPG 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 340 NEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPV 419
Cdd:cd17389  279 KEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPI 358

                        410       420       430
                 ....*....|....*....|....*....|...
gi 678144524 420 LSATVYWLAGAEVCFTVCGALFLIPFILLGSIK 452
Cdd:cd17389  359 VACTVYWLAGSEACYTIGALLFLLPLLLLARLK 391
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 22-452 0e+00

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 605.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  22 ITIVFLALFIDLLGFALILPLFPSILDYYSQTEDGFYLSLQRG-VDWFAEMVGMPPERKYNSVLFGGLIGSVFSILQFFS 100
Cdd:cd17389    1 ITIVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 101 SPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGIA 180
Cdd:cd17389   81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 181 FSLGFTLGPMIGAYLAMETEK-GEVFYVRSALLALMFAVADLIFIFFLLPETLPkekrvssvtsgfqaavdllsplalfq 259
Cdd:cd17389  161 FSLGFIIGPMIGAYFASFTRSlGEVFFSMPALFALVLALADLLFIFFFLPETLP-------------------------- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 260 fsavtrgkespsegnlQNLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPG 339
Cdd:cd17389  215 ----------------SNLRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPG 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 340 NEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPV 419
Cdd:cd17389  279 KEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPI 358

                        410       420       430
                 ....*....|....*....|....*....|...
gi 678144524 420 LSATVYWLAGAEVCFTVCGALFLIPFILLGSIK 452
Cdd:cd17389  359 VACTVYWLAGSEACYTIGALLFLLPLLLLARLK 391
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
20-416 2.60e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 103.52  E-value: 2.60e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  20 RVITIVFLALFIDLLGFALILPLFPSILDYYSQtedgfylslqrgvdwfaemvgmpperkynSVLFGGLIGSVFSILQFF 99
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGA-----------------------------SPAQAGLVVTAYLLGAAL 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 100 SSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKG-NVSLSTAIIADLHSPKARSKGMAMIG 178
Cdd:COG2814   61 GAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLG 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 179 IAFSLGFTLGPMIGAYLAmetekgEVFYVRSA-LLALMFAVADLIFIFFLLPETLPKEKRvssvtSGFQAAVDLLSPLAL 257
Cdd:COG2814  141 AGLGLGPALGPLLGGLLA------DLFGWRWVfLVNAVLALLALLLLLRLLPESRPAARA-----RLRGSLRELLRRPRL 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 258 FqfsavtrgkespsegnlqnlkILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIK 337
Cdd:COG2814  210 L---------------------LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 678144524 338 PGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARAL 416
Cdd:COG2814  269 RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
82-418 2.23e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 92.10  E-value: 2.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524   82 SVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNV-SLSTAI 160
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALfPAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  161 IADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFavadlifIFFLLPETLPKEKRVSS 240
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA-------VLLLLPRPPPESKRPKP 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  241 VTSGFQAAVDLLSPLalfqfsavtrgkespsegnLQNLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFF 320
Cdd:pfam07690 183 AEEARLSLIVAWKAL-------------------LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  321 IGITMAVIQ---GGYARRIKPGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSAS 397
Cdd:pfam07690 244 GGLLGAIGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKE 323

                         330       340
                  ....*....|....*....|.
gi 678144524  398 QKGRVMGILRSLGALARALGP 418
Cdd:pfam07690 324 ERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
93-231 3.41e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 74.99  E-value: 3.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524   93 FSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLST-AIIADLHSPKARS 171
Cdd:TIGR00880   7 YALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIYPPEERG 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  172 KGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYvrsalLALMFAVADLIFIFFLLPET 231
Cdd:TIGR00880  87 VALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFL-----FLAILALAAFILLAFLLPET 141
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
93-237 6.42e-10

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 60.70  E-value: 6.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  93 FSILQFFSSPLtgavSDCLGRRPVILM-TVMGLITSYALwAASRTFGVFLLSRIIGGISKGNVS-LSTAIIADLHSPKAR 170
Cdd:PRK11102  39 FAIGQLFYGPM----ADSFGRKPVILGgTLVFALAAVAC-ALAQTIDQLIYMRFLHGLAAAAASvVINALMRDMFPKEEF 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 678144524 171 SKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVrsalLALMfAVADLIFIFFLLPETLPKEKR 237
Cdd:PRK11102 114 SRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV----LALA-AILAAALVFFFIPETLPKERR 175
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 22-452 0e+00

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 605.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  22 ITIVFLALFIDLLGFALILPLFPSILDYYSQTEDGFYLSLQRG-VDWFAEMVGMPPERKYNSVLFGGLIGSVFSILQFFS 100
Cdd:cd17389    1 ITIVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 101 SPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGIA 180
Cdd:cd17389   81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 181 FSLGFTLGPMIGAYLAMETEK-GEVFYVRSALLALMFAVADLIFIFFLLPETLPkekrvssvtsgfqaavdllsplalfq 259
Cdd:cd17389  161 FSLGFIIGPMIGAYFASFTRSlGEVFFSMPALFALVLALADLLFIFFFLPETLP-------------------------- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 260 fsavtrgkespsegnlQNLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPG 339
Cdd:cd17389  215 ----------------SNLRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPG 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 340 NEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPV 419
Cdd:cd17389  279 KEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPI 358

                        410       420       430
                 ....*....|....*....|....*....|...
gi 678144524 420 LSATVYWLAGAEVCFTVCGALFLIPFILLGSIK 452
Cdd:cd17389  359 VACTVYWLAGSEACYTIGALLFLLPLLLLARLK 391
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 25-449 4.70e-61

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 202.42  E-value: 4.70e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  25 VFLALFIDLLGFALILPLFPSILDYYSQTEDgfylslqrgvdwfaemvgmpperkynSVLFGGLIGSVFSILQFFSSPLT 104
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGA--------------------------SGYYVGLLQSSYSLGQFLASPLW 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 105 GAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGIAFSLG 184
Cdd:cd17330   55 GRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLG 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 185 FTLGPMIGAYLAmeTEKGevfYVRSALLALMFAVADLIFIFFLLPetlpkekrvssvtsgfqaavdllsplalfqfsavt 264
Cdd:cd17330  135 FILGPALGGFLS--TPYG---YALPFLVAAALALLNLVLVLFFLP----------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 265 rgkespsegnlqNLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKP-GNEIR 343
Cdd:cd17330  175 ------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKrLGERK 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 344 AVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSAT 423
Cdd:cd17330  243 LLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGP 322

                        410       420
                 ....*....|....*....|....*.
gi 678144524 424 VYWLAGAEVCFTVCGALFLIPFILLG 449
Cdd:cd17330  323 LYSFLGPGVPFLLAAGLLLIALFLLS 348
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 22-447 1.97e-41

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 151.63  E-value: 1.97e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  22 ITIVFLALFIDLLGFALILPLFPSILDYYSQTEDgfylslqrgvdwfaemvgmpperkyNSVLFGGLIGSVFSILQFFSS 101
Cdd:cd17388    1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSA-------------------------DAATHYGVLLALYALMQFIFA 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 102 PLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGIAF 181
Cdd:cd17388   56 PILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAF 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 182 SLGFTLGPMIGAYLAmETEKGEVFYVRSALLALMFAVAdlifiFFLLPETLPKEKRVSSVTSGFQaavdllsPLALFQFS 261
Cdd:cd17388  136 GLGFIAGPALGGLLG-EISPRAPFLVAAGLNGLNFLLG-----LFVLPESLPPERRRAFRWRRAN-------PFGSLRWL 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 262 AVTRGkespsegnlqnLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPG-N 340
Cdd:cd17388  203 TGFPG-----------LLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRlG 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 341 EIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSfAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVL 420
Cdd:cd17388  272 EKRAILLGLAADALGFLLLAFATQGWMVFPILILLA-LGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLL 350

                        410       420
                 ....*....|....*....|....*..
gi 678144524 421 SATVYWLAGaevcFTVCGALFLIPFIL 447
Cdd:cd17388  351 FTGIFAASP----ATWPGLAWIIGAAL 373
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 25-421 4.59e-38

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 141.60  E-value: 4.59e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  25 VFLALFIDLLGFALILPLFPSildyysqtedgfylslqrgvdwFAEMVGMPPerkynsvLFGGLIGSVFSILQFFSSPLT 104
Cdd:cd17390    1 LYLVGFLDLFGVSMILPLLST----------------------HIRSLGASP-------TVIGLIGSVYGALQLFSSPLV 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 105 GAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGIAFSLG 184
Cdd:cd17390   52 GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLG 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 185 FTLGPMIGAYLaMETEKGevFYVRSALLALMFaVADLIFIFFLLPETLpkekrvssvtsgfqaavDLLSPLALFQFSAvt 264
Cdd:cd17390  132 FILGPVVGGHL-AETDGG--FYYVALLCSAIF-ILNAGLVWFLLSKLW-----------------DLLLVRFLMGFSV-- 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 265 rgkespsegnlqnlkilgltyflyLFLFSgleyTLSFLTHQRFQFSSMQQGKMFFFIGItMAVIQGGYARRIK---PGNE 341
Cdd:cd17390  189 ------------------------LLFRS----NFSLYLEERFDLSPKTIGYLISYSGV-LGALSGFLVGRILklyKNNE 239

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 342 IRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLS 421
Cdd:cd17390  240 YLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLS 319
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 25-448 1.76e-34

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 132.31  E-value: 1.76e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  25 VFLALFIDLLGFALILPLFPSildyysqtedgfylslqrgvdwFAEMVGMpperkynSVLFGGLIGSVFSILQFFSSPLT 104
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPL----------------------YAESLGA-------SVAQIGLIVAAYALAQLLFSPPA 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 105 GAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKG-NVSLSTAIIADLHSPKARSKGMAMIGIAFSL 183
Cdd:cd17325   52 GRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGL 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 184 GFTLGPMIGAYLAMETEKGEVFYVRSALlalmfAVADLIFIFFLLPETLPKEKRVSSVTSGFQAAVDLLSplalfqfsav 263
Cdd:cd17325  132 GFLIGPLLGGLLADALGYRAPFLVCAAL-----ALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLL---------- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 264 trgkespsegNLQNLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIkpgN 340
Cdd:cd17325  197 ----------RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQppaGKLSDRI---G 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 341 EIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVL 420
Cdd:cd17325  264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343

                        410       420
                 ....*....|....*....|....*...
gi 678144524 421 SATVYWLAGAEVCFTVCGALFLIPFILL 448
Cdd:cd17325  344 GGFLYDAFGFATPFLAAAALLLLAAVLF 371
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 22-448 2.16e-28

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 115.36  E-value: 2.16e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  22 ITIVFLALFIDLLGFALILPLFPSILDYYSQTEdgfylslqrgvdwfaemvgmpperkynsvLFGGLIGSVFSILQFFSS 101
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASP-----------------------------AQVGLLITAFTLPAAVLM 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 102 PLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGI-SKGNVSLSTAIIADLHSPKARSKGMAMIGIA 180
Cdd:cd17474   52 PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAA 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 181 FSLGFTLGPMIGAYLAMetekgEVFYVRSALLALMFAVAdLIFIFFLLPETLPKEKRVSSVTSGFQAAVDLLSPLALFQF 260
Cdd:cd17474  132 LGLGIAVGPLLGGLLAA-----ISWRYPFFLLAALIPVA-FLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLV 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 261 SAvtrgkespsegnlqnlkilgltyFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPGN 340
Cdd:cd17474  206 SA-----------------------FLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRF 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 341 EIRAV-KRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPV 419
Cdd:cd17474  263 GARRIlVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPL 342

                        410       420
                 ....*....|....*....|....*....
gi 678144524 420 LSATVYWLAGAEVCFTVCGALFLIPFILL 448
Cdd:cd17474  343 LFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
20-416 2.60e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 103.52  E-value: 2.60e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  20 RVITIVFLALFIDLLGFALILPLFPSILDYYSQtedgfylslqrgvdwfaemvgmpperkynSVLFGGLIGSVFSILQFF 99
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGA-----------------------------SPAQAGLVVTAYLLGAAL 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 100 SSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKG-NVSLSTAIIADLHSPKARSKGMAMIG 178
Cdd:COG2814   61 GAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLG 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 179 IAFSLGFTLGPMIGAYLAmetekgEVFYVRSA-LLALMFAVADLIFIFFLLPETLPKEKRvssvtSGFQAAVDLLSPLAL 257
Cdd:COG2814  141 AGLGLGPALGPLLGGLLA------DLFGWRWVfLVNAVLALLALLLLLRLLPESRPAARA-----RLRGSLRELLRRPRL 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 258 FqfsavtrgkespsegnlqnlkILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIK 337
Cdd:COG2814  210 L---------------------LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 678144524 338 PGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARAL 416
Cdd:COG2814  269 RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
82-418 2.23e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 92.10  E-value: 2.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524   82 SVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNV-SLSTAI 160
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALfPAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  161 IADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFavadlifIFFLLPETLPKEKRVSS 240
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA-------VLLLLPRPPPESKRPKP 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  241 VTSGFQAAVDLLSPLalfqfsavtrgkespsegnLQNLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFF 320
Cdd:pfam07690 183 AEEARLSLIVAWKAL-------------------LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  321 IGITMAVIQ---GGYARRIKPGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSAS 397
Cdd:pfam07690 244 GGLLGAIGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKE 323

                         330       340
                  ....*....|....*....|.
gi 678144524  398 QKGRVMGILRSLGALARALGP 418
Cdd:pfam07690 324 ERGTASGLYNTAGSLGGALGP 344
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 81-442 1.04e-19

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 90.36  E-value: 1.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  81 NSVLFGGLIgSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIiGGISKGNVSLSTAI 160
Cdd:cd17331   33 DSVVFGYLQ-TTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRL-PSVFMHAMQAAQMV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 161 IADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAmetekGEVFYVRSALLALMFAVADLIFIFFLLPE-TLPKEKRVS 239
Cdd:cd17331  111 VTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLT-----KKFGEQAAALVAAVGSLLSIVLVILLIPSnTKSKREKEA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 240 SVTSGFQAAVDLLSPLALFQFSAVTRgkespsegnlqnlkiLGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFF 319
Cdd:cd17331  186 KESASPPSVFNLKEILRLLRLPGVAF---------------LLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMS 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 320 FIGITMAVIQGGYARR-IKPGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQ 398
Cdd:cd17331  251 YAGVLGMVVQGLLVGPlTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPED 330

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 678144524 399 KGRVMGILRSLGALARALGPVLSATVY--------WLAGAEVCFTVCGALFL 442
Cdd:cd17331  331 TGTALGLSHALFSLVRTVSPTIGGALLqaygfpsfGLLGAAINGLLTVYLLL 382
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 87-451 6.40e-19

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 88.05  E-value: 6.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNV-SLSTAIIADLH 165
Cdd:cd17329   38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFePASEAMIADVT 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 166 SPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETekgevFYVRSALLALMFAVAdLIFIFFLLPETLPKeKRVSSVTSGF 245
Cdd:cd17329  118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS-----FRLLFLAAAVLFLLA-ALVLLFLLPETRPK-RRAAEKTEIL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 246 QAAVDLLsplalfqfsavtrgkespsegNLQNLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 325
Cdd:cd17329  191 RGYKIVL---------------------RDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLI 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 326 AVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGI 405
Cdd:cd17329  250 VLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGF 329

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 678144524 406 LRSLGALARALGPVLSATVYWLAGAEVCFTVCGALFLIPFILLGSI 451
Cdd:cd17329  330 YALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 81-427 8.37e-19

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 88.25  E-value: 8.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  81 NSVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSriIGGISKGNVSLSTAI 160
Cdd:cd17387   33 HTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMIS--VSGIFSVTFSVIFAY 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 161 IADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLaMETeKGEVFYVrsaLLALMFAVADLIFIFFLLPETLPKEKRVSS 240
Cdd:cd17387  111 VADITTEEERSTAYGLVSATFAASLVTSPALGAYL-SES-YGDNLVV---LVATIVALLDICFILLAVPESLPEKMRPAS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 241 VTSGFQ-AAVDLLSPLALFqfsavtrGKESpsegnlqNLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFF 319
Cdd:cd17387  186 WGAPISwEQADPFASLRKV-------GKDK-------TVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 320 FIGITMAVIQG--GYARRIKPGNeiravKRAIML-LIPAFLLIGWAANVT----MLSAGLLlySFAAAIVIPCLSAVVSG 392
Cdd:cd17387  252 VVGILSITAQTllLSILMRSIGA-----KNTILLgLGFQMLQLAWYGFGSqhwmMWAAGAV--AAMSSITFPAISALVSR 324

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 678144524 393 YGSASQKGRVMGILRSLGALARALGPVLSATVYWL 427
Cdd:cd17387  325 YADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYL 359
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 87-447 1.55e-17

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 83.75  E-value: 1.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNV-SLSTAIIADLH 165
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFwAIAAAYAADLV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 166 SPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVrSALLALMFAVAdlifIFFLLPETLPKEKRVSSVTSGF 245
Cdd:cd17324  117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA-IAVLALLAALL----LWRLLPSLPPKKPGSLGLLSSL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 246 QAAvdLLSPLALFQFsavtrgkespsegnlqnlkilgLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 325
Cdd:cd17324  192 LLL--LRNPRLRLAY----------------------LITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAG 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 326 AV---IQGGYARRIKPGNEIRAvkrAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASqKGRV 402
Cdd:cd17324  248 VVgspLAGRLADRGGRRALLIA---LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLA 323

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 678144524 403 MGILRSLGALARALGPVLSATVYWLAGAEVCFTVCGALFLIPFIL 447
Cdd:cd17324  324 SSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
2_A_01_02 TIGR00880
Multidrug resistance protein;
93-231 3.41e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 74.99  E-value: 3.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524   93 FSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLST-AIIADLHSPKARS 171
Cdd:TIGR00880   7 YALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIYPPEERG 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  172 KGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYvrsalLALMFAVADLIFIFFLLPET 231
Cdd:TIGR00880  87 VALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFL-----FLAILALAAFILLAFLLPET 141
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 81-448 4.14e-16

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 79.54  E-value: 4.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  81 NSVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVIL--MTVMGLITSYALWAASrtFGVFLLSRIIGGISKGNV-SLS 157
Cdd:cd17473   32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIagLLLYGIGGVAGLFLDS--LYALLASRALLGIGVAGImTLA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 158 TAIIADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAmetekgeVFYVRSALLALMFAVADLIFIFFLLPEtlPKEKR 237
Cdd:cd17473  110 TALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-------EIGWRAPFLVYLLALPVLILVLLFLPE--PARKS 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 238 VSSVTSGFQAAVDLLSPLALFqfsavtrgkespsegnlqnlkILGLTYFLYLFLFSGLEYtLSFLTHQRFQFSSMQQGKM 317
Cdd:cd17473  181 KSAASPGAATAAALPWKRVLP---------------------IYFLAFLAMLLFYVIPIQ-LPFLLQERGGGSAALIGLA 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 318 FFFIGITMAVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSAS 397
Cdd:cd17473  239 LAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPE 318

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 678144524 398 QKGRVMGILRSLGALARALGPVLSATVYWLA-GAEVCFTVCGALFLIPFILL 448
Cdd:cd17473  319 LRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVL 370
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 85-449 2.72e-14

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 74.17  E-value: 2.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  85 FGGLIGSVFSILQFFSSPLTGAVSDCLG--RRPVI----LMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLST 158
Cdd:cd17326   37 FFGWVVAAYSLGQLVFSPVFGYWSNKTSsvKEPLIvsilIAIVGNILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLR 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 159 AIIADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVF--------YVRSALLALMFAVADLIFIFFLLPE 230
Cdd:cd17326  117 AYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPGYVIgiklrfnmYTAPAWLMAILGIINIILILFFFKE 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 231 TlpkekrvssvtsgfqaavdllsplalfqfsavtrgkespsegnlqnlkILGLTYFLYLFLFSGLEYTLSFLTHQRFQFS 310
Cdd:cd17326  197 V------------------------------------------------VCIFLFFVVLFIFANLETIGTPLTMDMYGWT 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 311 SMQQ----GKMFFFIGITMAVIQGGYarriKPGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCL 386
Cdd:cd17326  229 REEAvlynGIILAVSGVLSVLVFLLF----KFLSLGLIDERKILLGGLILFFLGFVVTLPWGITGVILFGLGYPIGNVML 304

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 678144524 387 SAVVSGYGSASQKGRVMGILRSLGALARALGPVLSATVYWLAGAEVCFTVCGALFLIPFILLG 449
Cdd:cd17326  305 YTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLI 367
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 87-447 6.17e-14

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 73.01  E-value: 6.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLHS 166
Cdd:cd17489   34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 167 PKAR-SKGMAMIGIAFSLGFTLGPMIGAYLAMETEkgevfYVRSALLALMFAVADLIFIFFLLPETLPKEKRVSSVTSGF 245
Cdd:cd17489  114 PPSRrGEGIGYYGLATTLAMALGPALGLFLYQHLG-----FAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAF 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 246 QAAVD--LLSPLALFQFSAVTRGkespsegnlqnlkilGLTYFLYLFLFS-GLEYTLSFLThqrfqfssmqqgkmffFIG 322
Cdd:cd17489  189 RRLVEkkVLPPALILFLASIAYG---------------AISTFLPLYAAErGISNAGLFFT----------------VYA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 323 ITMAVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRV 402
Cdd:cd17489  238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 678144524 403 MGILRSLGALARALGPVLSATVYWLAGAEVCFTVCGALFLIPFIL 447
Cdd:cd17489  318 NGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 87-448 2.65e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 70.92  E-value: 2.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLST-AIIADLH 165
Cdd:cd06174   34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVlALIADLF 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 166 SPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGevfyVRSALLALMFAVADLIFIFFLLPETLPKEKRVSSVTSGF 245
Cdd:cd06174  114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG----WRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 246 QAAVDLLSPLALFqfsavtrgkespsegnlQNLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKM---FFFIG 322
Cdd:cd06174  190 KSVLKLLKRVLKN-----------------PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLlslFGLAG 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 323 ITMAVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAglLLYSFAAAIVIPCLSAVVSGYGSASQKGRV 402
Cdd:cd06174  253 ALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL--LLLGFGLGGLLPLSFALIAELFPPEIRGTA 330

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 678144524 403 MGILRSLGALARALGPVLSATVY-WLAGAEVCFTVCGALFLIPFILL 448
Cdd:cd06174  331 FGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAILL 377
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 93-443 5.50e-13

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 70.30  E-value: 5.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  93 FSILQFFSSPLtgavSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVS-LSTAIIADLHSPKARS 171
Cdd:cd17320   47 FALGQLLYGPL----SDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSvVARAIVRDLYSGAELA 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 172 KGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFAVadlifIFFLLPETLPKEKRVSSVTSGFQAAVDL 251
Cdd:cd17320  123 KIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLL-----VLLFLPETLPEEKRKPLLSSLLRAYKRV 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 252 L-SPLALFqfsavtrgkespsegnlqNLKILGLTY-FLYLFLFSGleytlSFLTHQRFQFSSMQQGKMFFFIGITM---A 326
Cdd:cd17320  198 LkNRRFLG------------------YALALGLSFaGLFAYLAAA-----PFIYIEQLGLSPAQFGLLFALNAIALilgS 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 327 VIQGGYARRIKPGneiRAVKRAIMLLIPAFLLIGWAANVTMLS-----AGLLLYSFAAAIVIP-CLSAVVSGYGS-ASQK 399
Cdd:cd17320  255 LLNGRLVRRFGPR---RLLRLGLLLLLAAALVLLLAALLGGLSlwplvAPLFLIFFGFGLIFPnATSLALEPFPHvAGTA 331

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 678144524 400 GRVMGILR----SLGALARALGPVLSATVYWLAGAEVCFTVCGALFLI 443
Cdd:cd17320  332 SALLGFLQfligALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
87-448 2.60e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 67.97  E-value: 2.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKG-NVSLSTAIIADLH 165
Cdd:COG2271   48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWF 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 166 SPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVrSALLALMFAVADLIFIFfllpetlpkekrvssvtsgf 245
Cdd:COG2271  128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI-LGLPGLLLALLRFWLLA-------------------- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 246 qaavdllsplalfqfsavtrgkespsegnlqnlkilgLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 325
Cdd:COG2271  187 -------------------------------------LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAG 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 326 AVIQ--GGY-ARRIKPGNeIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRV 402
Cdd:COG2271  230 IVGSllGGWlSDRLGRRR-KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTA 308

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 678144524 403 MGILRSLGALARALGPVLSATVYWLAGAEVCFTVCGALFLIPFILL 448
Cdd:COG2271  309 SGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
16-458 4.59e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 67.19  E-value: 4.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  16 QNSSRVITIVFLALFIDLLGFALILPLFPSILDYYSQTEDgfylslqrgvdwfaemvgmpperkynsvlFGGLIGSVFSI 95
Cdd:COG0738    4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDA-----------------------------QAGLLLFAFFL 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  96 LQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMA 175
Cdd:COG0738   55 GYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLN 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 176 MIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFAVAdLIFIFFLLPETLPKEKRVSSVTSgfqaavdllSPL 255
Cdd:COG0738  135 LLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLA-LLFLRSKLPEIEEEEEEAAGSAA---------SLK 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 256 ALFQFSAvtrgkespsegnlqnLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAV---IQGGY 332
Cdd:COG0738  205 SLLKNPR---------------LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIgrfLGGFL 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 333 ARRIKPGneiRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCL-SAVVSGYGSASQKGrvMGILRSLGA 411
Cdd:COG0738  270 LKRFGPV---RLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIfSLALDGLGKRTAAA--VSAVLIMGI 344

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 678144524 412 LARALGPVLSATVYWLAGAEVCFTVCGALFLIPFILLGSIKQQIKAE 458
Cdd:COG0738  345 VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 81-448 5.89e-12

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 66.87  E-value: 5.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  81 NSVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFG------VFLLSRIIGGISKGNV 154
Cdd:cd06173   31 GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGslslwlLLVLAFLLGIASAFFG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 155 SLSTAIIADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFyvrsALLALMFAVAdLIFIFFLlpetlPK 234
Cdd:cd06173  111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF----AINALSFLLS-ALLLLFI-----RR 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 235 EKRVSSVTSGFQAAVDLLSPLALFQFSAVtrgkespsegnlqnLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQ 314
Cdd:cd06173  181 PPPAAPGESSSLLLRDLREGLRYLRRSPL--------------LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGY 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 315 GKMFFFIGITMAVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYG 394
Cdd:cd06173  247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV 326

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 678144524 395 SASQKGRVMGILRSLGALARALGPVLSATVYWLAGAEVCFTVCGALFLIPFILL 448
Cdd:cd06173  327 PDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
93-237 6.42e-10

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 60.70  E-value: 6.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  93 FSILQFFSSPLtgavSDCLGRRPVILM-TVMGLITSYALwAASRTFGVFLLSRIIGGISKGNVS-LSTAIIADLHSPKAR 170
Cdd:PRK11102  39 FAIGQLFYGPM----ADSFGRKPVILGgTLVFALAAVAC-ALAQTIDQLIYMRFLHGLAAAAASvVINALMRDMFPKEEF 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 678144524 171 SKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVrsalLALMfAVADLIFIFFLLPETLPKEKR 237
Cdd:PRK11102 114 SRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV----LALA-AILAAALVFFFIPETLPKERR 175
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 91-395 9.18e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 60.28  E-value: 9.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  91 SVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNV-SLSTAIIADLHSPKA 169
Cdd:cd17323   41 SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPlAIGAGTIADLFTPEE 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 170 RSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVrsaLLALMFAVadLIFIFFLLPETLpkekrVSSVTSGFQAAV 249
Cdd:cd17323  121 RGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWF---LAIISGFC--LILIFLFLPIVL-----LLGLYVGLVYAI 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 250 dllsplalfqfsavtrgkespsegnlqnlkilgltyfLYLFLFsgleyTLSFLTHQRFQFSSMQQGKMFFFIGITMaVIQ 329
Cdd:cd17323  191 -------------------------------------LYLFLT-----AFPYVFGEVYGFSPGEVGLMYLPIGIGA-LIG 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 330 GGYARRIKPGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAA----IVIPCLSAVVSGYGS 395
Cdd:cd17323  228 SIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYphihWIVPIIGSAFFGFGL 297
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
87-458 2.23e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 59.12  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKG-NVSLSTAIIADLH 165
Cdd:COG2223   43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGgSFAVGIALVSKWF 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 166 SPKARSKGMAMIGIAFSLGFTLGPMIGAYLAmetekgEVFYVRSALLALMFAVADLIFIFFLLPETLPKEKRVSsvtsgf 245
Cdd:COG2223  123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLI------AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA------ 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 246 qAAVDLLSPLALFQFSAVTrgkespsegnlqnlkILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 325
Cdd:COG2223  191 -AKASLRDQLEALRDPRFW---------------LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLG 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 326 AVIQ--GGY-ARRIKPGNEIRAVkrAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRV 402
Cdd:COG2223  255 ALGRplGGWlSDRIGGRRVLLIV--FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAV 332

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 678144524 403 MGILRSLGALARALGPVLSATVYWLAGA-EVCFTVCGALFLIPFILLGSIKQQIKAE 458
Cdd:COG2223  333 YGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRRPRRA 389
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 8-302 5.18e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 57.13  E-value: 5.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524   8 TSSNDKQEQNSSRVITIVFLALFIDLLGFALILPLFPSILDYYSQTEDGFylslqrgvdwfaemvgmpperkynsvlfgG 87
Cdd:COG0477    2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL-----------------------------G 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  88 LIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKG-NVSLSTAIIADLHS 166
Cdd:COG0477   53 WIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGgLMPGALALIAELFP 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 167 PKARSKGMAMIGIAFSLGFTLGPMIGAYLAmetekgEVFYVRSALLALMFAVADLIFIFFLLPETLPKEKRVSSVTSGFQ 246
Cdd:COG0477  133 ARERGRALGLWGAAIGLGLALGPLLGGLLV------AALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAAL 206

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 678144524 247 AAVDLLSPLALFQFSAVTRGKESPSEGNLQNLKILGLTYFLYLFLFSGLEYTLSFL 302
Cdd:COG0477  207 LLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAAL 262
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 86-264 5.41e-09

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 58.02  E-value: 5.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  86 GGLIGSVFSILQFFSSPLTGAVSDCLGRRPVIL--MTVMGLITsyALWAASRTFGVFLLSRIIGGISKGNVS-LSTAIIA 162
Cdd:cd17328   36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAvgILIWSAAT--LLSSFAPNFWQLLLFRALVGIGEASYSpIAPTIIA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 163 DLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFAvadlIFIFFLLPET-----LPKEKR 237
Cdd:cd17328  114 DLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLA----ILLLLFVREPprgaaEGGVMA 189

                        170       180       190
                 ....*....|....*....|....*....|.
gi 678144524 238 VSSVTSGFQAAVDLLSP----LALFQFSAVT 264
Cdd:cd17328  190 KSTATSFLADLKALAKNpsfiLSTLGFTAVS 220
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 84-446 3.56e-08

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 55.35  E-value: 3.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  84 LFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIAD 163
Cdd:cd17391   36 LWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIAS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 164 lHSPKARS-KGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFavadLIFIFFL----LPETLPKEKRV 238
Cdd:cd17391  116 -QTPKEKSgWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAF----LLTLFFVkedfKPVEKKKMVST 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 239 SSVTSGFQAAVDLLSPLALFQFSAVTRGKESPsegnLQNLKILGLTYFLY-LFLFSGLEytlsflthqrfqFSSMQQGKM 317
Cdd:cd17391  191 KEVWNSVPNPSLLISLFVTTFIIQLANQSIEP----ILTLYIRQLMGDASnLAFISGLV------------FSATGVSSL 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 318 FFfigitmAVIQGGYARRIKPGNEIravkrAIMLLIPAFLLIGWAANVTMLSAGLL--LYSFAAAIVIPCLSAVVSGYGS 395
Cdd:cd17391  255 LS------APRLGKLGDRIGHHRIL-----LGALLASALLYIPQAFVQTPWQLGILrfLLGLATGGLLPAINSLLAKITP 323

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 678144524 396 ASQKGRVMGILRSLGALARALGPVLSATVYWLAGAEVCFTVCGALFLIPFI 446
Cdd:cd17391  324 KEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAI 374
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 103-244 4.04e-08

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 55.08  E-value: 4.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  103 LTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIG--GISKGNVsLSTAIIADLHSPKARSKGMAMIGIA 180
Cdd:TIGR00710  59 LWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQafGASAGSV-ISQALVRDIYPGEELSRIYSILMPV 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 678144524  181 FSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFAVadlifIFFLLPETLPKEKRVSSVTSG 244
Cdd:TIGR00710 138 LALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSAL-----IFFILPETLPYEARIQISTYF 196
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 87-232 2.42e-07

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 53.01  E-value: 2.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMT-VMGLITSyALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLH 165
Cdd:cd06179   35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGnLLGVVGS-IVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELV 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 678144524 166 SPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKG--EVFYVRSALLALMFAvadLIFIFFLLPETL 232
Cdd:cd06179  114 PNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGwrWIFYINAIFNALALI---LLFFFYHPPPRP 179
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 87-413 3.74e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 51.79  E-value: 3.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLHS 166
Cdd:cd17478   34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 167 PKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETekgevFYVRSALLALMFAVADLIFIFFLLPETLPKEKRVSSVTSGFQ 246
Cdd:cd17478  114 GGRRGLAMSIFSVGGNLGFALGPLIAAALVALF-----GGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARS 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 247 AAVDLLSPLALFQFSAVTRGkespsegnlqnLKILGLTYFLYLFLfsgLEYTLSFLTHQRFQFssmqqgkMFFFIGITMA 326
Cdd:cd17478  189 TLKGVWRALLLLLIIVFLRS-----------WVLSSLTTFLPFYL---VQRGYSLVFAGLLLS-------LFLFAGAIGT 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 327 VIQGGYARRIKPgneiRAVKRAIMLLIPAFLLI-----GWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASqkGR 401
Cdd:cd17478  248 LIGGPLSDRFGR----RRVIIASLLLAAPFLLLflltpGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLAS--GL 321

                        330
                 ....*....|..
gi 678144524 402 VMGILRSLGALA 413
Cdd:cd17478  322 MMGLSFGLGGIG 333
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 87-196 4.78e-07

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 51.41  E-value: 4.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNV-SLSTAIIADLH 165
Cdd:cd17502   33 SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLV 112

                         90       100       110
                 ....*....|....*....|....*....|.
gi 678144524 166 SPKARSKGMAMIGIAFSLGFTLGPMIGAYLA 196
Cdd:cd17502  113 PPRERGKYQGYIGAVFGIASVAGPLIGGAFT 143
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 105-446 5.60e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 51.45  E-value: 5.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 105 GAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGiSKGNVSLSTAIIADLHSPKARSKGMAM----IGIA 180
Cdd:cd17472   53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVMALLADLTREENRTKAMALigasIGIA 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 181 FSLGFTLGPMIGAYLAMEtekgEVFYVRSALlalmfAVADLIFIFFLLPETLPKEKRVSSVTSGFQAavdLLSPLALFQF 260
Cdd:cd17472  132 FAISMVLGPLLAAHLGVS----GLFLITAIL-----SLVSLLILLFFVPDPPKIVQISEKEKKKLKK---LLKNKRLLRL 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 261 SAvtrgkespseGNLQNLKILGLTYFLYLFLFSGLEYTLSflthqrfqfssmQQGKMF---FFIGITMAVIQGGYARRI- 336
Cdd:cd17472  200 DF----------SIFILHFVLMAFFYILPLLLTQLGGGKG------------QLWKVYlpaILIGFILMVPFVIYAEKKg 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 337 KPGNEIRAvkrAIMLLIPAFLLIGWAA-NVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARA 415
Cdd:cd17472  258 KMKQVFVS---SILLIAVGFLLLLFAAtSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSF 334

                        330       340       350
                 ....*....|....*....|....*....|.
gi 678144524 416 LGPVLSATVYWLAGAEVCFTVCGALFLIPFI 446
Cdd:cd17472  335 LGGALGGLLWGLLGYSSVFLTILILALLWLL 365
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
82-231 9.99e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 50.64  E-value: 9.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  82 SVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRT---FGVFLLSRIIGGISKGNVSLST 158
Cdd:COG2271  214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLpspALAIALLFLAGFGLGGAFGLLW 293

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 678144524 159 AIIADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVrsalLALMFAVAdLIFIFFLLPET 231
Cdd:COG2271  294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL----LAALALLA-ALLALLLLRET 361
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 88-228 1.25e-06

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 50.35  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  88 LIGSVFSIlqfFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTF------GVFLLSRIIGGISKGNVSLSTAI- 160
Cdd:cd17386   37 LMGSIPPL---FSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYFttvpsvWWFYLSAIPLALFGGFTAFLSASf 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 161 --IADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMfavadLIFIFFLL 228
Cdd:cd17386  114 ayISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIA-----LLYILFFL 178
Sugar_tr pfam00083
Sugar (and other) transporter;
79-231 3.86e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 49.19  E-value: 3.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524   79 KYNSVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAAS---RTFGVFLLSRIIGGISKGNVS 155
Cdd:pfam00083  41 LAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGAS 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 678144524  156 -LSTAIIADLHSPKARSKgmamIGIAFSLGFTLGPMIGA--YLAMETEKGEVFYVRSALLALMFAVADLIFIFFlLPET 231
Cdd:pfam00083 121 vLAPMYISEIAPKKLRGA----LGSLYQLAITFGILLAYifGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLF-LPES 194
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
348-448 4.66e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.43  E-value: 4.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 348 AIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSATVYWL 427
Cdd:COG2814   81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                         90       100
                 ....*....|....*....|.
gi 678144524 428 AGAEVCFTVCGALFLIPFILL 448
Cdd:COG2814  161 FGWRWVFLVNAVLALLALLLL 181
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 85-229 5.50e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 48.35  E-value: 5.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  85 FGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLST-AIIAD 163
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGfVLGME 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 678144524 164 LHSPKARSkgmaMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFavadlIFIFFLLP 229
Cdd:cd17317  106 IVGPKYRS----FVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLF-----LLLLWWLP 162
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 87-232 5.69e-06

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 48.90  E-value: 5.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524   87 GLIGSVFSILQFFSSPLTGAVSDCLGRRP-VILMTVMGLITSYALWAASRtFGVFLLSRIIGGISKGNVSLSTAIIADLH 165
Cdd:pfam06609  81 GLFSTLWTMGQAVSILMMGRLTDRFGRRPfVIATHIIGLVGAIVGCTANK-FNTLLAAMTLLGVAAGPAGASPLFIGELM 159

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 678144524  166 SPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVrsalLALMFAVADLIFIFFLLPETL 232
Cdd:pfam06609 160 SNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYI----YIIMSAIAVLLIIIWYHPPSF 222
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 89-447 9.73e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 47.70  E-value: 9.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  89 IGSVFSILQ---FFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKG-NVSLSTAIIADL 164
Cdd:cd17333   33 VSVIFSSQNagyLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGiLDTGANTFVGAL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 165 hSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAmeTEKGEVFYVRSALLALMFAVAdLIFIFFLLPETLPKEKRVSSVTSG 244
Cdd:cd17333  113 -FEESSATRLNVLHGFFGLGALIGPLIATSLL--TSELSWSWAYLIIGLIYLLLA-ILILLTLFPELPSARNPQQSVGAF 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 245 FQAAVDLLSPLALFQFSavtrgkespsegnlqnlkilgltyfLYLFLFSGLEYTL-----SFLTHQRF-QFSSMQQGKMF 318
Cdd:cd17333  189 SASASRLLRNPSIILGA-------------------------LALFLYVGAETAFsswvpSYLVEKKHvSDGLAGYLLSG 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 319 FFIGITMAVIQGGY-ARRIKPGNEIRAVkraIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSAS 397
Cdd:cd17333  244 FWVGITIGRLLGGPiSRRIKPHTLLVLS---GSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYA 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 678144524 398 qKGRVMGILRSLGALARALGPVLSATVYWLAGAEVCFTVCGALFLIPFIL 447
Cdd:cd17333  321 -KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 102-222 1.12e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.57  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 102 PLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGN-VSLSTAIIADLHSPKARSKGMAMIGIA 180
Cdd:cd17503   49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLV 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 678144524 181 FSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFAVADLI 222
Cdd:cd17503  129 ILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL 170
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
17-237 1.25e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 47.22  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  17 NSSRVITIVFLALFIDLLGFALILPLFPsildyysqtedgfylslqrgvdWFAEMVGMPPERKYNsvLFGGLIGSVFSIL 96
Cdd:PRK09874  11 NWKRNLTVAWLGCFLTGAAFSLVMPFLP----------------------LYVEQLGVTGHSALN--MWSGLVFSITFLF 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  97 QFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADlHSPKARSK-GMA 175
Cdd:PRK09874  67 SAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIAT-QVPRNKSGwALG 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 678144524 176 MIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFavadLIFIFFLLPETLPKEKR 237
Cdd:PRK09874 146 TLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCF----LVTLFCIRENFQPVSKK 203
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 102-237 1.37e-05

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 47.37  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  102 PLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGN-VSLSTAIIADLHSPKARSKGMAMIGIA 180
Cdd:TIGR00711  55 PLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPlIPLSFSTLLNIYPPEKRGRAMAIWGLT 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 678144524  181 FSLGFTLGPMIGAYLAMETEKGEVFYVRsallaLMFAVADLIFIFFLLPETLPKEKR 237
Cdd:TIGR00711 135 VLVAPALGPTLGGWIIENYHWRWIFLIN-----VPIGIIVVVVAFFILPRDKPAASE 186
emrD PRK11652
multidrug transporter EmrD;
95-246 2.00e-05

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 46.82  E-value: 2.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  95 ILQFFSSPLtgavSDCLGRRPVIL--MTVMGLITSYALWAASrtFGVFLLSRIIGGISKGNV-SLSTAIIADLHSPKARS 171
Cdd:PRK11652  58 LSQLFYGPL----SDRVGRRPVILvgMSIFILGTLVALFAHS--LTVLIAASAIQGLGTGVGgVMARTLPRDLYEGTQLR 131

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 678144524 172 KGMAMIGIAFSLGFTLGPMIGAYLAmetekgEVFYVRSA-LLALMFAVADLIFIFFLLPETLPKEKRVSSVTSGFQ 246
Cdd:PRK11652 132 HANSLLNMGILVSPLLAPLIGGLLT------TLFGWRACyLFLLLLGAGVTFSMARWMPETRPADARRTRVLASYR 201
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 102-196 2.27e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 46.40  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 102 PLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGN-VSLSTAIIADLHSPKARSKGMAMIGIA 180
Cdd:cd17321   49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAiMPASLALIAATFPGERRGRALGLWGAV 128

                         90
                 ....*....|....*.
gi 678144524 181 FSLGFTLGPMIGAYLA 196
Cdd:cd17321  129 VGIGAALGPLLGGLLL 144
MFS_1 pfam07690
Major Facilitator Superfamily;
281-448 2.40e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 46.26  E-value: 2.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  281 LGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLIG 360
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  361 WAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSATVYWLAGAEVCFTVCGAL 440
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160


                  ....*...
gi 678144524  441 FLIPFILL 448
Cdd:pfam07690 161 SLLAAVLL 168
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
102-257 4.47e-05

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 45.40  E-value: 4.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 102 PLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLST-AIIADLHSPKARSKGMAMIGIA 180
Cdd:PRK10473  56 LFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAfAILRDTLDDRRRAKVLSLLNGI 135

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 678144524 181 FSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFavadlIFIFFLLPETLPKEKRVSSvTSGFQAAVDLLSPLAL 257
Cdd:PRK10473 136 TCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVL-----LLSLFILKETRPARAPAAS-SKPRENSESLLNRFFL 206
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 100-222 4.92e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 45.26  E-value: 4.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 100 SSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGI 179
Cdd:cd17504   47 STPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSA 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 678144524 180 AFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFAVADLI 222
Cdd:cd17504  127 TFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI 169
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
87-443 5.10e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 45.25  E-value: 5.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGG--ISKGNVSLSTAIIADL 164
Cdd:COG2807   56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGagIAVGNVLLPGLIKRWF 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 165 hsPKARSKGMAMIGIAFSLGFTLGPMIGAYLAmetekgEVFYVRSALLAlmFAVADLIFIFFLLPETLPKEKRVSSVTSG 244
Cdd:COG2807  136 --PDRVGLMTGLYTAAMGLGAALAAGLTVPLA------AALGWRGALAV--WALLALLALLLWLPLLRRRPAAAAAAPAA 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 245 FQAAVDLLSPLALfqfsavtrgkespsegnlqnlkILGLTYFLYLFLFSGLeytLSFLTH--QRFQFSSMQQGKMFF--- 319
Cdd:COG2807  206 ASLRSLWRSPLAW----------------------LLTLFFGLQSLLYYAV---VAWLPPilRDAGLSAATAGLLLSlfq 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 320 FIGITMAVIQGGYARRIKPgneiravKRAIMLLIPAFLLIG----WAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGY-G 394
Cdd:COG2807  261 LAGIPGSLLVPLLADRLGD-------RRPLLLLLGLLGLAGllglLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRaR 333

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 678144524 395 SASQKGRVMGILRSLGALARALGPVLSATVY-WLAGAEVCFTVCGALFLI 443
Cdd:COG2807  334 TPAEAAALSGMAQSVGYLLAALGPLLVGALHdATGSWTAALLLLAALAVL 383
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 87-228 6.05e-05

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 45.39  E-value: 6.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524   87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGI-SKGNVSLSTAIIADLH 165
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMgIGGIWVQAVVLNTEFL 209

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 678144524  166 SPKARSKGMAMIGIAFSLGFTLGPMIgAYLAMETEkgevfyvrsallALMFAVADLIFIFFLL 228
Cdd:TIGR00898 210 PKKQRAIVGTLIQVFFSLGLVLLPLV-AYFIPDWR------------WLQLAVSLPTFLFFLL 259
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 99-236 6.84e-05

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 45.18  E-value: 6.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  99 FSSPLTGAVSDCLGRRPVILMTVMGLITSYALW----AASRTFGVFLLSRIIGGISkGNVSL----STAIIADLHSPKAR 170
Cdd:cd17449   80 FSVTLLGPWSDSVGRRPVLILPSLGLALQAAVYllvmYLQLHVAYFLIGRILSGLL-GDFNGilagCFAYVADVSDRRSR 158

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 678144524 171 SKGMAMIGIAFSLGFTLGPMIGAYlaMETEKGevfYVRSALLALMFAVADLIFIFFLLPETLPKEK 236
Cdd:cd17449  159 TFRVAVLEACLGLAGMLASIIGGQ--WRKAQG---YINPFWLVLALNLAAALYAAFCVGESVKEPK 219
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 68-231 9.21e-05

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 44.55  E-value: 9.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  68 FAEMVGMPPERKYNSVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYAL-WAASRTFGVFLLSRII 146
Cdd:cd17356   29 FQKYFADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIqVAAIGKWYQLIVGRII 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 147 GGISKGNVSLSTAIIADLHSPKARsKGMaMIGIaFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFAVADLIFIF- 225
Cdd:cd17356  109 AGLGVGFASVLVPVYQSEVAPKHI-RGT-LVSL-YQLAITIGILVAYCINYGTHKLDGSAQWRIPLGLQIVWGLLLLIGm 185


                 ....*.
gi 678144524 226 FLLPET 231
Cdd:cd17356  186 FFLPES 191
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
82-219 1.29e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.10  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  82 SVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPV--ILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTA 159
Cdd:COG2223  239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVllIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFA 318

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 678144524 160 IIADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEK-GEVFYVRSALLALMFAVA 219
Cdd:COG2223  319 LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLT 379
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 84-448 1.65e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 43.69  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  84 LFGGLIGSVFSILQFFSspltGAVSDCLGRR-PVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKG-NVSLSTAII 161
Cdd:cd17370   38 LIEGLAEALGSLLRLFS----GYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGiRTPPRDALL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 162 ADLHSPKARSKGMamiGIAFSLGfTLGPMIGAYLAMetekgevfyvrsALLALMFAVADLIFIFFLLPetlpkekrvssv 241
Cdd:cd17370  114 ADATPPSGRGKAF---GLHRALD-TLGAVLGPLLAA------------LLLYLLGGNYRTIFLLAAIP------------ 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 242 tsgfqaAVDLLSPLALFQFsavTRGKESPSEGNLQNLKILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFI 321
Cdd:cd17370  166 ------ALLALLILLFVVK---EYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALI 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 322 GITMAVIQGGYA----------RRIKPGNEIRAvkrAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVS 391
Cdd:cd17370  237 PLLYALFNLVYAlaaypagrlsDRIGRKKLLIL---GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVA 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 678144524 392 GYGSASQKGRVMGILRSLGALARALGPVLSATVYWLAGAEVCFTVCGALFLIPFILL 448
Cdd:cd17370  314 DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 87-228 2.14e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.35  E-value: 2.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSL-STAIIADLH 165
Cdd:cd17489  230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPaLQALAVDLV 309

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 678144524 166 SPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFyvrsaLLALMFAVADLIFIFFLL 228
Cdd:cd17489  310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF-----LLAAVVVLLALVLYIFLL 367
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 82-222 2.60e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.98  E-value: 2.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  82 SVLFGGLIGSVFSILQFFSSPLTGAVSDCLGR-RPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKG-NVSLSTA 159
Cdd:cd17353  247 DAGIAALAVSILSIFNGGGRPFWGWLSDKIGRkNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGgGFALFPA 326

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 678144524 160 IIADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFAVADLI 222
Cdd:cd17353  327 LTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 87-420 3.00e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 42.94  E-value: 3.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVIL--MTVMGLITsyALWAASRTFGVFLLSRIIGGISK-GNVSLSTAIIAD 163
Cdd:cd17319   41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAvsMLLWSLFT--ALTGFATSLTSLYVLRFLLGVAEaGFFPGAIKALAE 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 164 LHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLaMETEKGEVFYVRSALLALMFAVadliFIFFLLPETLpkekrvssvts 243
Cdd:cd17319  119 WFPARERGRATGLFNSGAPLGAAIGPPLSGWL-LLLFGWRWAFIIEGLLGLLLAV----LWWFYLRQVW----------- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 244 gfqaavdllsplalfqfsavtrgkespsegnlqnlkILGLTYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFF--FI 321
Cdd:cd17319  183 ------------------------------------GLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAipFL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 322 GITMAVIQGGY-ARRIKPGNEIRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKG 400
Cdd:cd17319  227 AGAIGMILGGRlSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAA 306

                        330       340
                 ....*....|....*....|
gi 678144524 401 RVMGILRSLGALARALGPVL 420
Cdd:cd17319  307 TAGGLINSGGNLGGFVAPLL 326
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 82-247 3.96e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 42.56  E-value: 3.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  82 SVLFGGLIGSVFSilqffsspltGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAI- 160
Cdd:cd17315   42 SLLLGAAIGSLFG----------GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLy 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 161 IADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAmetekgevfYVRSALLALMFAVADL-IFIFFLLPETLPkEKRVS 239
Cdd:cd17315  112 ISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALS---------LSPPGWWRLMFALAAVpALLQLLLMFFLP-ESRAL 181


                 ....*...
gi 678144524 240 SVTSGFQA 247
Cdd:cd17315  182 LVGVGLQL 189
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
280-447 5.31e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.16  E-value: 5.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 280 ILGLTYFLYLFLFSGLEYTLSFLThQRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIKPGneiRAVKRAIMLLIPAF 356
Cdd:COG2271   14 LLFLAYFLNYLDRSNLSVAAPPLQ-ADLGLSAAQLGLLASAFFLGYALGQipaGLLADRFGRR---RVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 357 LLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSATVYWLAGAEVCFTV 436
Cdd:COG2271   90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169

                        170
                 ....*....|.
gi 678144524 437 CGALFLIPFIL 447
Cdd:COG2271  170 LGLPGLLLALL 180
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 26-244 7.03e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 7.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  26 FLALFIDLLGFALILPlfpsildyysqtedgfYLSLqrgvdWFAEMVGMPPerkynsvLFGGLIGSVFSILQFFSSPLTG 105
Cdd:cd17471    2 LLATLLTGLAGAFVLP----------------YLSL-----FLTEELGASP-------LQIGIFMTLSALSGIVVSQWLG 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 106 AVSDCLG-RRPVILMTVMGLITSYALWAASRTFGVFLL-SRIIGGISKGNVSLSTAII---ADLHSPKARSKGMAMIGIA 180
Cdd:cd17471   54 RLSDRGGdRKPLILLALLAGALGYLLFAFLRNYWVLLLvGVVLLSLGAAAFPQLFALAreyADRSSGRDATLFNSVLRAA 133

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 678144524 181 FSLGFTLGPMIGAYLAMETEKGEVFYvrsaLLALMFAVADLIFIFFLLPETLPKEKRVSSVTSG 244
Cdd:cd17471  134 FSLAWVIGPPLAFLLLDVLGFTGLFL----LAALLYLVVALLVLFLLPSVKPPAQKATPASSLV 193
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 82-172 7.73e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 41.78  E-value: 7.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  82 SVLFGGLIGSVFSilqffsspltGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVS-LSTAI 160
Cdd:cd17359   44 SALLGAAIGALFA----------GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASaLVPMY 113

                         90
                 ....*....|..
gi 678144524 161 IADLHSPKARSK 172
Cdd:cd17359  114 IAEVAPAEIRGR 125
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 347-452 8.38e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.45  E-value: 8.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 347 RAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSATVYW 426
Cdd:cd06173   74 RALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVA 153

                         90       100
                 ....*....|....*....|....*.
gi 678144524 427 LAGAEVCFTVCGALFLIPFILLGSIK 452
Cdd:cd06173  154 LLGPGGAFAINALSFLLSALLLLFIR 179
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 88-195 1.10e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 41.18  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  88 LIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGI-SKGNVSLSTAIIADLHS 166
Cdd:cd17379   37 LFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLfGKGGWMTGYVLVTEFVG 116

                         90       100
                 ....*....|....*....|....*....
gi 678144524 167 PKARSKGMAMIGIAFSLGFTLGPMIgAYL 195
Cdd:cd17379  117 SKYRRTVGIVYQMFFTLGLLILPGI-AYF 144
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 305-458 1.52e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.62  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 305 QRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIKPGneiRAVKRAIMLLIPAFLLIGWAANVTMLSAGLLLYSFAAAI 381
Cdd:cd17478   24 AKLGLSYAQAGLLVSVFSITSSLLQplfGYLADRKPRR---YLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 678144524 382 VIPcLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSATVYWLAGAEVCFTVCGALFLIPFILLGSIKQQIKAE 458
Cdd:cd17478  101 FHP-EGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 82-219 1.55e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.60  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  82 SVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNV-SLSTAI 160
Cdd:cd17370  232 SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAA 311

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 678144524 161 IADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAmETEKGEVFYVRSALLALMFAVA 219
Cdd:cd17370  312 VADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLW-DLISPSAAFLFSAVLALIALLL 369
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 357-447 1.66e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.62  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 357 LLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSATVYWLAGAEVCFTV 436
Cdd:cd17321   76 LLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI 155

                         90
                 ....*....|.
gi 678144524 437 CGALFLIPFIL 447
Cdd:cd17321  156 NVPIGLVALLL 166
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 87-231 1.84e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 40.71  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPV-----ILMTVMGLITSYALWAASrtFGVFLLSRIIGGISKGnvsLSTAII 161
Cdd:cd17357   52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGllisnALLVVSSLLMFLSKSAKS--PELLIFGRFLVGIACG---LSTGFV 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 162 ADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFAVADLIFIFFLLPET 231
Cdd:cd17357  127 PMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPES 196
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 84-197 1.86e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 40.26  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  84 LFGGLIGSVFSilqffsspltGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNV-SLSTAIIA 162
Cdd:cd17365   44 LFGMAIGALLA----------GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAmPNAITLVS 113

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 678144524 163 DLHSPKARSkgmAMIGIAFSlGFTLGPMIGAYLAM 197
Cdd:cd17365  114 EYAPARRRS---LAVTLMFC-GYPLGAALGGFLAA 144
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 355-455 2.50e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 355 AFLLIGWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSATVYWLAGAEVCF 434
Cdd:cd17489   74 ATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLF 153

                         90       100
                 ....*....|....*....|.
gi 678144524 435 TVCGALFLIPFILLGSIKQQI 455
Cdd:cd17489  154 IVAAVLALLALLLVFLVKDPP 174
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-187 2.59e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  18 SSRVITIVFLALFIDLLGFALILPLFPsildyysqtedgFYLSLQRGVdwfaemvgmpperkynSVLFGGLIGSVFSILQ 97
Cdd:COG2814  205 RRPRLLLLLLLAFLLGFGFFALFTYLP------------LYLQEVLGL----------------SASAAGLLLALFGLGG 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  98 FFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKG-NVSLSTAIIADLHSPKARSKGMAM 176
Cdd:COG2814  257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGL 336

                        170
                 ....*....|.
gi 678144524 177 IGIAFSLGFTL 187
Cdd:COG2814  337 YNSAFFLGGPL 347
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 91-304 2.78e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 39.58  E-value: 2.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  91 SVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAI-IADLHSPKA 169
Cdd:cd17374   42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLIlGTEWTTPRH 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 170 RskgmAMIGIAFSLGFTLGPMIGAYLAmetekgevfYVRSALLALMFAVADLIFIFFLLPETLPKekrvssvtsgfqaaV 249
Cdd:cd17374  122 R----ALAITLTSCFFSIGQMLLAGLA---------YAIRDWRLLQLVVSVPFFLFFLYSWWLPK--------------R 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 678144524 250 DLLSPLALFQFSAvtrgkesPSEGNLQNLKILGLTYFLYLFLFSGLEYTLSFLTH 304
Cdd:cd17374  175 TLILSFVWFANSF-------SYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLAL 222
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
87-448 3.09e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLG-----RRPVIL-MTVMGLITSYALWAASR-----TFGVFLLSRIIGGISKGNVS 155
Cdd:COG2211   49 GLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILiGAIPLALSFVLLFTAPDlsptgKLIYALVTYLLLGLAYTLVN 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 156 LS-TAIIADL-HSPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRsaLLALMFAVADLIFIFFLLPETLP 233
Cdd:COG2211  129 IPySALGAELtPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYR--LTALIFAVLGLLAFLLTFFGTKE 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 234 KEKRVSSVTSGFQAAVDLLSPLALFQFSAVTrgkespsegnlqnlkilgLTYFLYLFLFSGLeytLSFLTHQRFQFSSMQ 313
Cdd:COG2211  207 RPVPEEEKVSLKESLKALLKNRPFLLLLLAY------------------LLFFLALALVAAL---LLYYFKYVLGLSAAL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 314 QGKMFFFIGITMAVIQ---GGYARRIKPgneiRAVKRAIMLLIPAFLLIGW---AANVTMLSAGLLLYSFAAAIVIPCLS 387
Cdd:COG2211  266 VGLLLALYFLAALLGAplwPRLAKRFGK----KKAFIIGLLLAALGLLLLFflgPGNLWLLLVLAALAGIGLGAILVLPW 341

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 678144524 388 AVVSG---YGSASQKGRVMGILRSLGALAR----ALGPVLSATVYWLAG--------AEVCFTVCGALFLIPFILL 448
Cdd:COG2211  342 AMLADvvdYDEWKTGRRREGLYFGIFTFAIklgqALAGALAGLLLALFGyvagaaqsPSALTGIRLLFFLLPAVLL 417
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 82-219 3.32e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.46  E-value: 3.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  82 SVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVIL-MTVMGLITSYALWAASRTFGVFL-LSRIIGGISKGNVSLSTA 159
Cdd:cd17477  221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLgCALLGALAALLLPLVPGLPLALLvLLFLWGGAAGPLYTLALA 300

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 160 IIADLHSPKARSKGMAMIGIAFSLGFTLGPMIGAyLAMETEKGEVFYVRSALLALMFAVA 219
Cdd:cd17477  301 LAGDRLPGDELVAANAALLLLYGLGSVIGPLLAG-ALMDAFGPHGLFLFLAAVALLFLLF 359
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
286-448 4.19e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.48  E-value: 4.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 286 FLYLFLFSGLEYTLSFLTH---QRFQFSSMQQG---KMFFFIGITMAVIQGGYARRIKPGneiRAVKRAIMLLIPAFLLI 359
Cdd:COG2223   11 TLAFFLAFGVWYLWSVLAPplaEEFGLSAAQLGllfAIPVLVGALLRIPLGFLVDRFGPR---RVLLIGLLLLGIGLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524 360 GWAANVTMLSAGLLLYSFAAAIVIPCLSAVVSGYGSASQKGRVMGILRSLGALARALGPVLSATVYWLAGAEVCFTVCGA 439
Cdd:COG2223   88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167


                 ....*....
gi 678144524 440 LFLIPFILL 448
Cdd:COG2223  168 LLLVVAVLA 176
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 88-231 4.36e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 39.03  E-value: 4.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  88 LIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLSTAIIADLHSP 167
Cdd:cd17441   38 LLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVTLYAEFLPM 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 678144524 168 KARSKGMAMIGIAFSLGfTLGPMIGAYLAMETEKGEVFYVRSALLALMFAVADlififFLLPET 231
Cdd:cd17441  118 KSRAKCILLIEVFWALG-TVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLC-----FWLPES 175
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 80-195 4.38e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.07  E-value: 4.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  80 YNSVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRII--GGISKGNVSLS 157
Cdd:cd17324  230 GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLwgLGFFAAHSALQ 309

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 678144524 158 TAIIAdlHSPKARSKGMAMIGIAFSLGFTLGPMIGAYL 195
Cdd:cd17324  310 TRVLR--LAPEARGLASSLYLAAYNLGGALGAALGGLV 345
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 79-193 4.98e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  79 KYNSVLFGGLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKGNVSLST 158
Cdd:cd17478  225 RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV 304

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 678144524 159 AIIADLhspKARSKGMA---MIGIAFSLGFTLGPMIGA 193
Cdd:cd17478  305 VLAQEL---LPGNVGLAsglMMGLSFGLGGIGAPVLGA 339
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 87-223 7.94e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.32  E-value: 7.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 678144524  87 GLIGSVFSILQFFSSPLTGAVSDCLGRRPVILMTVMGLITSYALWAASRTFGVFLLSRIIGGISKG-NVSLSTAIIADLH 165
Cdd:cd17473  236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGlLLPTLNSWAMSLV 315

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 678144524 166 SPKARSKGMAMIGIAFSLGFTLGPMIGAYLAMETEKGEVFYVRSALLALMFAVADLIF 223
Cdd:cd17473  316 PPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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