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Conserved domains on  [gi|674227943|gb|KFK01307|]
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multidrug transporter [Klebsiella variicola]

Protein Classification

efflux RND transporter periplasmic adaptor subunit( domain architecture ID 1001665)

efflux RND transporter periplasmic adaptor subunit similar to Escherichia coli Multidrug export protein AcrE, part of the tripartite efflux system AcrEF-TolC, which is involved in the efflux of indole and organic solvents

CATH:  1.20.1600.10
Gene Ontology:  GO:0022857|GO:0055085
SCOP:  4003096
TCDB:  8.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK15030 super family cl33066
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
1-368 0e+00

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


The actual alignment was detected with superfamily member PRK15030:

Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 511.18  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943   1 MTTHARVTLLSGliisALLLTGCDNSGNPQPHAQAPQVTVHVVNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFV 80
Cdd:PRK15030   7 FTPLAVVLMLSG----SLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  81 EGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKA 160
Cdd:PRK15030  83 EGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 161 AVDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGQSDALATVQQLDPIYVDVTESSNDFMRLKQE----SLQRGGDTK 236
Cdd:PRK15030 163 AVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQElangTLKQENGKA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 237 SVELVMENGQAYPLKGSLQFSDVTVDESTGSITLRAIFPNPQHALLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDAS 316
Cdd:PRK15030 243 KVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDAT 322

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 674227943 317 VMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQKVRPGVTVK 368
Cdd:PRK15030 323 VLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVK 374
 
Name Accession Description Interval E-value
PRK15030 PRK15030
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
1-368 0e+00

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 511.18  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943   1 MTTHARVTLLSGliisALLLTGCDNSGNPQPHAQAPQVTVHVVNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFV 80
Cdd:PRK15030   7 FTPLAVVLMLSG----SLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  81 EGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKA 160
Cdd:PRK15030  83 EGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 161 AVDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGQSDALATVQQLDPIYVDVTESSNDFMRLKQE----SLQRGGDTK 236
Cdd:PRK15030 163 AVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQElangTLKQENGKA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 237 SVELVMENGQAYPLKGSLQFSDVTVDESTGSITLRAIFPNPQHALLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDAS 316
Cdd:PRK15030 243 KVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDAT 322

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 674227943 317 VMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQKVRPGVTVK 368
Cdd:PRK15030 323 VLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVK 374
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 43-368 3.04e-97

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 292.23  E-value: 3.04e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  43 VNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHL 122
Cdd:COG0845    3 VERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAKA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 123 TVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKAAVDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGQsdALA 202
Cdd:COG0845   83 ELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT--PLF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 203 TVQQLDPIYVDVTESSNDFMRLKQeslqrgGDTksVELVMENGQAYPLKGSLQFSDVTVDESTGSITLRAIFPNPQHALL 282
Cdd:COG0845  161 TIADLDPLEVEFDVPESDLARLKV------GQP--VTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDGLLR 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 283 PGMFVRARIDEGVDPQAILVPQQGVTRTPRGDaSVMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQKVR 362
Cdd:COG0845  233 PGMFVRVRIVLGERENALLVPASAVVRDGGGA-YVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLR 311


                 ....*.
gi 674227943 363 PGVTVK 368
Cdd:COG0845  312 DGAKVR 317
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 38-368 4.09e-82

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 253.39  E-value: 4.09e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943   38 VTVHVVNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAA 117
Cdd:TIGR01730   1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  118 AIAHLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKAAVDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGQ 197
Cdd:TIGR01730  81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  198 sdALATVQQLDPIYVDVTESSNDFMRLKQeslqrgGDTKSVELVMENGQAYplKGSLQFSDVTVDESTGSITLRAIFPNP 277
Cdd:TIGR01730 161 --TLATIVDLDPLEADFSVPERDLPQLRR------GQTLTVELDALPGEEF--KGKLRFIDPRVDSGTGTVRVRATFPNP 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  278 QHALLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDAsVMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSG 357
Cdd:TIGR01730 231 DGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNGKY-VYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAG 309

                         330
                  ....*....|.
gi 674227943  358 LQKVRPGVTVK 368
Cdd:TIGR01730 310 VVKLRDGAKVK 320
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 45-355 1.01e-79

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 247.34  E-value: 1.01e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943   45 SAPLSVTTELPGRTSAFRVAE-VRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLT 123
Cdd:pfam00529   1 LAPLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  124 VKRYVPLLGTKYISQQEYDQAVATARQADADVIATKAAVDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGQSDALAT 203
Cdd:pfam00529  81 LDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLAT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  204 VQQLDPIYVDVTESSNDFMR-----LKQESLQRGGDTKSVELVMENGQAYPLK----GSLQFSDVTVDESTGSITLRAIF 274
Cdd:pfam00529 161 VAQLDQIYVQITQSAAENQAevrseLSGAQLQIAEAEAELKLAKLDLERTEIRapvdGTVAFLSVTVDGGTVSAGLRLMF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  275 PNP-QHALLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDASVMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKV 353
Cdd:pfam00529 241 VVPeDNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSAGALV 320


                  ..
gi 674227943  354 IV 355
Cdd:pfam00529 321 RL 322
 
Name Accession Description Interval E-value
PRK15030 PRK15030
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
1-368 0e+00

multidrug efflux RND transporter periplasmic adaptor subunit AcrA;


Pssm-ID: 184990 [Multi-domain]  Cd Length: 397  Bit Score: 511.18  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943   1 MTTHARVTLLSGliisALLLTGCDNSGNPQPHAQAPQVTVHVVNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFV 80
Cdd:PRK15030   7 FTPLAVVLMLSG----SLALTGCDDKQAQQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  81 EGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKA 160
Cdd:PRK15030  83 EGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 161 AVDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGQSDALATVQQLDPIYVDVTESSNDFMRLKQE----SLQRGGDTK 236
Cdd:PRK15030 163 AVETARINLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQElangTLKQENGKA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 237 SVELVMENGQAYPLKGSLQFSDVTVDESTGSITLRAIFPNPQHALLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDAS 316
Cdd:PRK15030 243 KVSLITSDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDAT 322

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 674227943 317 VMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQKVRPGVTVK 368
Cdd:PRK15030 323 VLVVGADDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVK 374
PRK09859 PRK09859
multidrug transporter subunit MdtE;
6-368 7.44e-130

multidrug transporter subunit MdtE;


Pssm-ID: 137559 [Multi-domain]  Cd Length: 385  Bit Score: 377.90  E-value: 7.44e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943   6 RVTLLSGLIISALLLTGCDNSGNPQPHAQAPQVTVHVVNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFVEGSDV 85
Cdd:PRK09859   4 RRKLLIPLLFCGAMLTACDDKSAENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  86 EAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKAAVDTA 165
Cdd:PRK09859  84 NQGDSLYQIDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 166 RINLAYTKVTSPISGRIGKSSVTEGALVTNGQSDALATVQQLDPIYVDVTESSNDFMRLKQE----SLQRGGDTKSVELV 241
Cdd:PRK09859 164 TINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEvasgQIKQVQGSTPVQLN 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 242 MENGQAYPLKGSLQFSDVTVDESTGSITLRAIFPNPQHALLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDASVMLVN 321
Cdd:PRK09859 244 LENGKRYSQTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILD 323

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 674227943 322 DKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQKVRPGVTVK 368
Cdd:PRK09859 324 KDDVVQLREIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKAR 370
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 43-368 3.04e-97

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 292.23  E-value: 3.04e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  43 VNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHL 122
Cdd:COG0845    3 VERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAKA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 123 TVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKAAVDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGQsdALA 202
Cdd:COG0845   83 ELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT--PLF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 203 TVQQLDPIYVDVTESSNDFMRLKQeslqrgGDTksVELVMENGQAYPLKGSLQFSDVTVDESTGSITLRAIFPNPQHALL 282
Cdd:COG0845  161 TIADLDPLEVEFDVPESDLARLKV------GQP--VTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPDGLLR 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 283 PGMFVRARIDEGVDPQAILVPQQGVTRTPRGDaSVMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQKVR 362
Cdd:COG0845  233 PGMFVRVRIVLGERENALLVPASAVVRDGGGA-YVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGLQRLR 311


                 ....*.
gi 674227943 363 PGVTVK 368
Cdd:COG0845  312 DGAKVR 317
PRK09578 PRK09578
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
6-368 5.34e-96

MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 169982 [Multi-domain]  Cd Length: 385  Bit Score: 291.31  E-value: 5.34e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943   6 RVTLLSGLIISALLLTGCDNSGNPQPHAQAPQVTVHVVNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFVEGSDV 85
Cdd:PRK09578   6 RRRLLLAALVALFVLAGCGKGDSDAAAAAPREATVVTVRPTSVPMTVELPGRLDAYRQAEVRARVAGIVTARTYEEGQEV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  86 EAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKAAVDTA 165
Cdd:PRK09578  86 KQGAVLFRIDPAPLKAARDAAAGALAKAEAAHLAALDKRRRYDDLVRDRAVSERDYTEAVADERQAKAAVASAKAELARA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 166 RINLAYTKVTSPISGRIGKSSVTEGALVTNGQSDALATVQQLDPIYVDVTESSNDFMRLK---QESLQRGGDTKSVE--L 240
Cdd:PRK09578 166 QLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVEALRravKSGRATGIAQQDVAvtL 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 241 VMENGQAYPLKGSLQFSDVTVDESTGSITLRAIFPNPQHALLPGMFVRARIDEGVDPQAILVPQQGVTRTPrGDASVMLV 320
Cdd:PRK09578 246 VRADGSEYPLKGKLLFSDLAVDPTTDTVAMRALFPNPERELLPGAYVRIALDRAVNPRAILVPRDALLRTA-DSASVKVV 324

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 674227943 321 NDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQKVRPGVTVK 368
Cdd:PRK09578 325 GQNGKVRDVEVEADQMSGRDWIVTRGLAGGERVIVDNAAQFAPGTAVK 372
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 38-368 4.09e-82

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 253.39  E-value: 4.09e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943   38 VTVHVVNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAA 117
Cdd:TIGR01730   1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  118 AIAHLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKAAVDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGQ 197
Cdd:TIGR01730  81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  198 sdALATVQQLDPIYVDVTESSNDFMRLKQeslqrgGDTKSVELVMENGQAYplKGSLQFSDVTVDESTGSITLRAIFPNP 277
Cdd:TIGR01730 161 --TLATIVDLDPLEADFSVPERDLPQLRR------GQTLTVELDALPGEEF--KGKLRFIDPRVDSGTGTVRVRATFPNP 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  278 QHALLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDAsVMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSG 357
Cdd:TIGR01730 231 DGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNGKY-VYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIVTAG 309

                         330
                  ....*....|.
gi 674227943  358 LQKVRPGVTVK 368
Cdd:TIGR01730 310 VVKLRDGAKVK 320
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 45-355 1.01e-79

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 247.34  E-value: 1.01e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943   45 SAPLSVTTELPGRTSAFRVAE-VRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLT 123
Cdd:pfam00529   1 LAPLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  124 VKRYVPLLGTKYISQQEYDQAVATARQADADVIATKAAVDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGQSDALAT 203
Cdd:pfam00529  81 LDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLAT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  204 VQQLDPIYVDVTESSNDFMR-----LKQESLQRGGDTKSVELVMENGQAYPLK----GSLQFSDVTVDESTGSITLRAIF 274
Cdd:pfam00529 161 VAQLDQIYVQITQSAAENQAevrseLSGAQLQIAEAEAELKLAKLDLERTEIRapvdGTVAFLSVTVDGGTVSAGLRLMF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  275 PNP-QHALLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDASVMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKV 353
Cdd:pfam00529 241 VVPeDNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSAGALV 320


                  ..
gi 674227943  354 IV 355
Cdd:pfam00529 321 RL 322
PRK11556 PRK11556
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
56-367 1.33e-43

MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;


Pssm-ID: 183194 [Multi-domain]  Cd Length: 415  Bit Score: 156.10  E-value: 1.33e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  56 GRTSAFRVAEVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLTVKRYVPLLGTKY 135
Cdd:PRK11556  80 GTVTAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKVALAQAQGQLAKDQATLANARRDLARYQQLAKTNL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 136 ISQQEYDQAVATARQADADVIATKAAVDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGQSDALATVQQLDPIYVDVT 215
Cdd:PRK11556 160 VSRQELDAQQALVSETEGTIKADEASVASAQLQLDYSRITAPISGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFT 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 216 ESSNDFMRLKQEslQRGGDTKSVELVMENGQAYPLKGSLQFSDVTVDESTGSITLRAIFPNPQHALLPGMFVRARIDEGV 295
Cdd:PRK11556 240 LPESDIATVVQA--QKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQFVNARMLVDT 317

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 674227943 296 DPQAILVPQQGVTRTPRGDAsVMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQKVRPGVTV 367
Cdd:PRK11556 318 LQNAVVIPTAALQMGNEGHF-VWVLNDENKVSKHLVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKV 388
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
43-294 5.72e-22

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 95.50  E-value: 5.72e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  43 VNSAPLSVTTELPGRTSAfRVAEVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAA-------------------- 102
Cdd:COG1566   26 AGRNGPDEPVTADGRVEA-RVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAAlaqaeaqlaaaeaqlarlea 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 103 -------WNSAKGDEAKAEAAAAIAHLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIA------------------ 157
Cdd:COG1566  105 elgaeaeIAAAEAQLAAAQAQLDLAQRELERYQALYKKGAVSQQELDEARAALDAAQAQLEAaqaqlaqaqaglreeeel 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 158 ---------TKAAVDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGQSdaLATVQQLDPIYVD--VTESSNDFMRLKQ 226
Cdd:COG1566  185 aaaqaqvaqAEAALAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQP--LLTIVPLDDLWVEayVPETDLGRVKPGQ 262

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 674227943 227 EslqrggdtksVELVMENGQAYPLKGSLQF------SDVTVDESTGSITLR-----AIFPNPQHALLPGMFVRARIDEG 294
Cdd:COG1566  263 P----------VEVRVDAYPDRVFEGKVTSispgagFTSPPKNATGNVVQRypvriRLDNPDPEPLRPGMSATVEIDTE 331
PRK11578 PRK11578
macrolide transporter subunit MacA; Provisional
 32-356 9.86e-15

macrolide transporter subunit MacA; Provisional


Pssm-ID: 183211 [Multi-domain]  Cd Length: 370  Bit Score: 74.81  E-value: 9.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  32 HAQAPQVTVHVVNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQ-------AAWN 104
Cdd:PRK11578  30 NAPVPTYQTLIVRPGDLQQSVLATGKLDALRKVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQAEnqikeveATLM 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 105 SAKGDEAKAEAAAAIAHLTVKRYVPLLGTKYISQQEYDQAVA--TARQA-----DADVIATKAAVDTARINLAYTKVTSP 177
Cdd:PRK11578 110 ELRAQRQQAEAELKLARVTLSRQQRLAKTQAVSQQDLDTAATelAVKQAqigtiDAQIKRNQASLDTAKTNLDYTRIVAP 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 178 ISGRIGKSSVTEGALVTNGQ-SDALATVQQLDPIYVDVTESSNDFMRLKQeslqrgGDTKSVELVMENGQAYPlkGSLQF 256
Cdd:PRK11578 190 MAGEVTQITTLQGQTVIAAQqAPNILTLADMSTMLVKAQVSEADVIHLKP------GQKAWFTVLGDPLTRYE--GVLKD 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 257 SDVTVDESTGSITLRAIF--PNPQHALLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDASVMLVNDKNQVETREVVAT 334
Cdd:PRK11578 262 ILPTPEKVNDAIFYYARFevPNPNGLLRLDMTAQVHIQLTDVKNVLTIPLSALGDPVGDNRYKVKLLRNGETREREVTIG 341

                        330       340
                 ....*....|....*....|..
gi 674227943 335 QAVGDKWLITSGLKPGDKVIVS 356
Cdd:PRK11578 342 ARNDTDVEIVKGLEAGDEVIIG 363
HlyD_D23 pfam16576
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ...
 47-287 1.23e-12

Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.


Pssm-ID: 435440 [Multi-domain]  Cd Length: 214  Bit Score: 66.38  E-value: 1.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943   47 PLSVTTELPGRTSA--FRVAEVRPQVSGII--LKRNFVeGSDVEAGQSLYQIdpatyqaawnsakgdeakaeaaaaiahl 122
Cdd:pfam16576   1 PLSRTIRAVGRVAYdeRRLAHVHARVEGWIekLYVNAT-GDPVKKGQPLAEL---------------------------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  123 tvkrYVPLLGTkyiSQQEYDQAVATARQADADVIATKAA-------VDTARIN-LAYTK-------VTSPISGRIGKSSV 187
Cdd:pfam16576  52 ----YSPELVA---AQQEYLLALRSGDALSKSELLRAARqrlrllgMPEAQIAeLERTGkvqptvtVYAPISGVVTELNV 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  188 TEGALVTNGqsDALATVQQLDP--IYVDVTESsndfmrlkQESLQRGGDTKSVELvmengQAYP---LKGSLQFSDVTVD 262
Cdd:pfam16576 125 REGMYVQPG--DTLFTIADLSTvwVEADVPEQ--------DLALVKVGQPAEVTL-----PALPgktFEGKVDYIYPTLD 189

                         250       260
                  ....*....|....*....|....*
gi 674227943  263 ESTGSITLRAIFPNPQHALLPGMFV 287
Cdd:pfam16576 190 PKTRTVRVRIELPNPDGRLKPGMFA 214
PRK10559 PRK10559
p-hydroxybenzoic acid efflux pump subunit AaeA;
52-212 1.46e-08

p-hydroxybenzoic acid efflux pump subunit AaeA;


Pssm-ID: 182548 [Multi-domain]  Cd Length: 310  Bit Score: 55.52  E-value: 1.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  52 TELP----GRTSAFRVAeVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLTVKRY 127
Cdd:PRK10559  33 TESPwtrdARFSADVVA-IAPDVSGLITQVNVHDNQLVKKGQVLFTIDQPRYQKALAEAEADVAYYQVLAQEKRREAGRR 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 128 VPlLGTKYISQQEYDQA---VATARQADADVIATKaavDTARINLAYTKVTSPISGRIGKSSVTEGALVTNGqSDALATV 204
Cdd:PRK10559 112 NR-LGVQAMSREEIDQAnnvLQTVLHQLAKAQATR---DLAKLDLERTVIRAPADGWVTNLNVYTGEFITRG-STAVALV 186


                 ....*...
gi 674227943 205 QQlDPIYV 212
Cdd:PRK10559 187 KQ-NSFYV 193
PRK10476 PRK10476
multidrug transporter subunit MdtN;
63-198 3.09e-08

multidrug transporter subunit MdtN;


Pssm-ID: 182488 [Multi-domain]  Cd Length: 346  Bit Score: 54.65  E-value: 3.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  63 VAEVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGD-------------------------EAKAEAAA 117
Cdd:PRK10476  48 VVHVASEVGGRIVELAVTENQAVKKGDLLFRIDPRPYELTVAQAQADlaladaqimttqrsvdaersnaasaNEQVERAR 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 118 AIAHL---TVKRYVPLLGTKYISQQEYDQAVATARQADAD------------------------VIATKAAVDTARINLA 170
Cdd:PRK10476 128 ANAKLatrTLERLEPLLAKGYVSAQQVDQARTAQRDAEVSlnqallqaqaaaaavggvdalvaqRAAREAALAIAELHLE 207

                        170       180
                 ....*....|....*....|....*...
gi 674227943 171 YTKVTSPISGRIGKSSVTEGALVTNGQS 198
Cdd:PRK10476 208 DTTVRAPFDGRVVGLKVSVGEFAAPMQP 235
PRK09783 PRK09783
copper/silver efflux system membrane fusion protein CusB; Provisional
 164-358 5.95e-07

copper/silver efflux system membrane fusion protein CusB; Provisional


Pssm-ID: 236625 [Multi-domain]  Cd Length: 409  Bit Score: 51.02  E-value: 5.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 164 TARINLAYTkVTSPISGRIGKSSVTEGALVTngQSDALATVQQLDPIYVDVTESSNDFMRLKqeslqrggDTKSVELVME 243
Cdd:PRK09783 203 TRKIQTRFT-LKAPIDGVITAFDLRAGMNIA--KDNVVAKIQGMDPVWVTAAIPESIAWLVK--------DASQFTLTVP 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 244 ngqAYPLKgSLQFSDVT----VDESTGSITLRAIFPNPQHALLPGMFVRARIDEGVDPQaILVPQQGVTRTPRgDASVML 319
Cdd:PRK09783 272 ---ARPDK-TFTIRKWTllpsVDAATRTLQLRLEVDNADEALKPGMNAWLQLNTASEPM-LLIPSQALIDTGS-EQRVIT 345

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 674227943 320 VNDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGL 358
Cdd:PRK09783 346 VDADGRFVPKRVAVFQESQGVTAIRSGLAEGEKVVSSGL 384
PRK03598 PRK03598
putative efflux pump membrane fusion protein; Provisional
 60-212 1.36e-05

putative efflux pump membrane fusion protein; Provisional


Pssm-ID: 235136 [Multi-domain]  Cd Length: 331  Bit Score: 46.49  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  60 AFRVaevrpqvSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAH------------------ 121
Cdd:PRK03598  47 GFRV-------GGRLASLAVDEGDAVKAGQVLGELDAAPYENALMQAKANVSVAQAQLDLMLagyrdeeiaqaraavkqa 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943 122 --------LTVKRYVPLLGTKYISQQEYD-------QAVATAR-------------------QADADVIATKAAVDTARI 167
Cdd:PRK03598 120 qaaydyaqNFYNRQQGLWKSRTISANDLEnarssrdQAQATLKsaqdklsqyregnrpqdiaQAKASLAQAQAALAQAEL 199

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 674227943 168 NLAYTKVTSPISGRIGKSSVTEGALVTNGqsDALATVQQLDPIYV 212
Cdd:PRK03598 200 NLQDTELIAPSDGTILTRAVEPGTMLNAG--STVFTLSLTRPVWV 242
HlyD_3 pfam13437
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ...
 173-284 9.80e-05

HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.


Pssm-ID: 433206 [Multi-domain]  Cd Length: 104  Bit Score: 41.19  E-value: 9.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674227943  173 KVTSPISGRIGKSSVTEGALVTNGqsDALATVQQLDPIYVDVTESSNDFMRLKQESlqrggdtkSVELVMENGQAYPLKG 252
Cdd:pfam13437   1 TIRAPVDGVVAELNVEEGQVVQAG--DPLATIVPPDRLLVEAFVPAADLGSLKKGQ--------KVTLKLDPGSDYTLEG 70

                          90       100       110
                  ....*....|....*....|....*....|....
gi 674227943  253 SLQFSDVTVDESTGSITLRAIFPNPQH--ALLPG 284
Cdd:pfam13437  71 KVVRISPTVDPDTGVIPVRVSIENPKTpiPLLPG 104
Biotin_lipoyl_2 pfam13533
Biotin-lipoyl like;
62-108 1.21e-04

Biotin-lipoyl like;


Pssm-ID: 433286  Cd Length: 50  Bit Score: 39.35  E-value: 1.21e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 674227943   62 RVAEVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKG 108
Cdd:pfam13533   1 PVVKIASPVSGKVVAVNVKEGQQVKKGDVLATLDSPELQLQLQQAEA 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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