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Conserved domains on  [gi|632169994|gb|KDA65767|]
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hypothetical protein AA99_0224 [Escherichia coli 2-052-05_S1_C1]

Protein Classification

C40 family peptidase( domain architecture ID 229557)

C40 family peptidase is a cell-wall hydrolase that cleaves peptide cross-bridges between glycan chains and is essential for bacterial growth and viability; typically cleaves the linkage between D-Glu and diaminopimelic acid (or Lys) within peptidoglycan stem peptides; contains a Cys-His-His catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NLPC_P60 super family cl21534
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 1-78 5.44e-54

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


The actual alignment was detected with superfamily member PRK11479:

Pssm-ID: 473902  Cd Length: 274  Bit Score: 168.12  E-value: 5.44e-54
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 632169994   1 MGEGDKKSWFCSEFVTDAFAKAGHPLTLAQSGWISPADLMHMRIGDVSAFKPETQLQYVGHLKPGIYIKAGRFVGLTQ 78
Cdd:PRK11479 197 VGEGDKKSWFCSEFVTEAFAKAGHPLTLAQSGWISPADLLHMREGDVSAFKPETQLQYVGHLKPGIYIKAGRFVGLTQ 274
 
Name Accession Description Interval E-value
PRK11479 PRK11479
YaeF family permuted papain-like enzyme;
1-78 5.44e-54

YaeF family permuted papain-like enzyme;


Pssm-ID: 183157  Cd Length: 274  Bit Score: 168.12  E-value: 5.44e-54
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 632169994   1 MGEGDKKSWFCSEFVTDAFAKAGHPLTLAQSGWISPADLMHMRIGDVSAFKPETQLQYVGHLKPGIYIKAGRFVGLTQ 78
Cdd:PRK11479 197 VGEGDKKSWFCSEFVTEAFAKAGHPLTLAQSGWISPADLLHMREGDVSAFKPETQLQYVGHLKPGIYIKAGRFVGLTQ 274
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
11-74 8.69e-03

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 33.13  E-value: 8.69e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632169994  11 CSEFVTDAFAKAGHPL---TLAQSGW---ISPADLmhmRIGDVSAFKpeTQLQYVGHLkpGIYIKAGRFV 74
Cdd:COG0791  127 CSGLVQYVYRQAGISLprtSADQAAAgtpVSRSEL---QPGDLVFFR--TGGGGISHV--GIYLGNGKFI 189
 
Name Accession Description Interval E-value
PRK11479 PRK11479
YaeF family permuted papain-like enzyme;
1-78 5.44e-54

YaeF family permuted papain-like enzyme;


Pssm-ID: 183157  Cd Length: 274  Bit Score: 168.12  E-value: 5.44e-54
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 632169994   1 MGEGDKKSWFCSEFVTDAFAKAGHPLTLAQSGWISPADLMHMRIGDVSAFKPETQLQYVGHLKPGIYIKAGRFVGLTQ 78
Cdd:PRK11479 197 VGEGDKKSWFCSEFVTEAFAKAGHPLTLAQSGWISPADLLHMREGDVSAFKPETQLQYVGHLKPGIYIKAGRFVGLTQ 274
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
11-74 8.69e-03

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 33.13  E-value: 8.69e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632169994  11 CSEFVTDAFAKAGHPL---TLAQSGW---ISPADLmhmRIGDVSAFKpeTQLQYVGHLkpGIYIKAGRFV 74
Cdd:COG0791  127 CSGLVQYVYRQAGISLprtSADQAAAgtpVSRSEL---QPGDLVFFR--TGGGGISHV--GIYLGNGKFI 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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