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Conserved domains on  [gi|624383325|gb|KBT42221|]
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hypothetical protein Z548_02564 [Mycobacterium tuberculosis 2233BH]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TDT super family cl04176
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 19-78 1.61e-12

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).


The actual alignment was detected with superfamily member cd09319:

Pssm-ID: 470964  Cd Length: 317  Bit Score: 60.40  E-value: 1.61e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 624383325  19 ALSVVLLWVTCTAYAVLIAVSTTRIVIFRKEFADDLADPRRGFGMFTFVAASDVLGTRLV 78
Cdd:cd09319   24 VLSRALLVLNLVAYVVLWVLTLARLLFYPRALRADLADPARGPGFFTAVAGTNVLGSQLV 83
 
Name Accession Description Interval E-value
TDT_like_1 cd09319
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 19-78 1.61e-12

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).


Pssm-ID: 187759  Cd Length: 317  Bit Score: 60.40  E-value: 1.61e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 624383325  19 ALSVVLLWVTCTAYAVLIAVSTTRIVIFRKEFADDLADPRRGFGMFTFVAASDVLGTRLV 78
Cdd:cd09319   24 VLSRALLVLNLVAYVVLWVLTLARLLFYPRALRADLADPARGPGFFTAVAGTNVLGSQLV 83
 
Name Accession Description Interval E-value
TDT_like_1 cd09319
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ...
 19-78 1.61e-12

The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).


Pssm-ID: 187759  Cd Length: 317  Bit Score: 60.40  E-value: 1.61e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 624383325  19 ALSVVLLWVTCTAYAVLIAVSTTRIVIFRKEFADDLADPRRGFGMFTFVAASDVLGTRLV 78
Cdd:cd09319   24 VLSRALLVLNLVAYVVLWVLTLARLLFYPRALRADLADPARGPGFFTAVAGTNVLGSQLV 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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