|
Name |
Accession |
Description |
Interval |
E-value |
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
20-928 |
0e+00 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 840.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 20 LSLPIILFWVALTIVVNVVAPQLQSVARTHSVALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLLEGQEKLGDEAHRFYD 99
Cdd:TIGR00833 2 SAYGIIGVWIATAISLQLLAPLLEDVSYFRLQAELPGGAASSIAVKEMSAAFQEAIRDPKIILVLESNERLGDKDYATYD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 100 VLVTKLSQDTTHVQHIENFWGDPLTAAGSQSADGKAAYVQLNLTGDQGGSQANESVAAVQRIVDSVPPPPGIKAYVTGPG 179
Cdd:TIGR00833 82 ALIAKLRADIMHVISVVDFWGPPEAAEGLRSDDGKATIIIVNLAGEKGQKEAQEAINAVRRIVEQTNAPDGLTVHVTGPL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 180 PLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALT 259
Cdd:TIGR00833 162 ATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLIGVNAQTTVLLTALV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 260 IAASTDYIIFLVGRYQEARATGQNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLAS 339
Cdd:TIGR00833 242 IGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 340 LTLAPAIIAVASRFGLFDPKRATTKRR-WRRIGTVVVRWPGPVLAATLLIALIGLLALPKYQTNYNERYYIPSAAPSNIG 418
Cdd:TIGR00833 322 VTLTPALLTLEGREGLMKPGRKSKIRFiWRRLGTAVVRRPWPILVTTLIISGVSLLALPLIRTGYDDEKMIPTDLESVQG 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 419 YLASDRHFPQARMEPEVLMVEADHDLRNPTDMLILDRIAKTVFHTPGIARVQSITRPLGAPIDHSSIPFQLGMQSTMTIE 498
Cdd:TIGR00833 402 YEAADRHFPGNSMDPMVVMIKSDHDVRNPALLADIDRFEREIKAVPGINMVQETQRPDGVVIKKTYLTFQAGNLGDQLDE 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 499 NLQNLKDRVADLSTLTDQLQRMIDITQRTQELTRQLTDATHDMNAHTRQMRDNANELRDRIADFDDFWRPLRSFTYWERH 578
Cdd:TIGR00833 482 FSDQLTSRQAYLLQDAEKIAEAIAGLRLVQAGMRLDGENLGQVSLAVRLMQQAISKLQGSAGDVFDIFDPLRRFVAAIPE 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 579 CFDIPICWSMRSLLNSMDNVDKLTEDLANLTDDTERMDTTQRQLLAQLDPTIATMQTVKDLAQTLTSAFSGLVTQMEDMT 658
Cdd:TIGR00833 562 CRANPVCSVAREIVQAADTVVSSAAKLADAAGQLARGIADVASALSQVSGLPNALDGIGTQLAQMRESAAGVQDLLNELS 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 659 RNATVMGRTFDAANNDDsFYLPPEAFQNPDFQRGLKLFLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGTP 738
Cdd:TIGR00833 642 DYSMTMGKLKGNAMGVD-FYAPPRIFTDPNFKAVLDYFLSPDGHAARLLVYGDGSPAGDQGAQEFNAIRTVAEEAIQRAD 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 739 LQAASIYLAGTSSTYKDIHEGTLYDVMIAVVASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLSVLIWQHILHMP 818
Cdd:TIGR00833 721 LEPAKVELAGVSAVNRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLWALGLSVLAFQHILGAE 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 819 LHWLVLPMAIIVMLAVGSDYNLLLIARFQEEIGAGLKTGMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTI 898
Cdd:TIGR00833 801 LHWSVLAGVFVLLVALGVDYNMLLVSRIKEESPAGNRTGIIRALGSTGGVITAAGLVFAGTMAALASAQLTAIAQFGFTV 880
|
890 900 910
....*....|....*....|....*....|
gi 623094611 899 MIGLLFDTLVVRSYMTPALATLLGRWFWWP 928
Cdd:TIGR00833 881 GVGILLDTFIVRSVTVPALTLLLGRWIWWP 910
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
52-381 |
1.03e-130 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 397.05 E-value: 1.03e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 52 ALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLL-EGQEKLGD-EAHRFYDVLVTKLSQDTTHVQHIENFWGDPLTAAGSQ 129
Cdd:pfam03176 1 ALSPADAPSVRAMDRLGAAFPQADSDPIIVVVLgEGDQALGDaAAEAGYDTLVDALRADTGHVGSVQDFWGDPDTAALFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 130 SADGKAAYVQLNLTGDQGGSQANESVAAVQRIVDSVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLF 209
Cdd:pfam03176 81 SPDGKAAYVVVTLEGDPGTTEADESVAAVRDAVEQAPPPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 210 IAYRSLSAALIMLLTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALTIAASTDYIIFLVGRYQEARATGQNREAAYY 289
Cdd:pfam03176 161 IVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIGLSTFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 290 TMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLASLTLAPAIIAVASRFGLFDPKRATTKRRWRR 369
Cdd:pfam03176 241 RAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRWGLWPPKRDRTARWWRR 320
|
330
....*....|..
gi 623094611 370 IGTVVVRWPGPV 381
Cdd:pfam03176 321 IGRLVVRRPAPV 332
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
17-479 |
5.35e-121 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 384.50 E-value: 5.35e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 17 IHALSLPIILFWVALTIVVNVVAPQLQSVARTHSVALGphDAPSLIAMKRIGKDFQQFDSDTtAMVLLEGQE-KLGDEA- 94
Cdd:COG2409 1 VARHRWLVLLAWLVLLVALGVLAPQLGGSLSSNGFFLP--GSESQRAADLLAEAFPESDGAS-AVVVVEAPDgTLTDPAf 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 95 HRFYDVLVTKLSQDTtHVQHIENFWGDPltAAGSQSADGKAAYVQLNLTGDQGgSQANESVAAVQRIVDSVPPPpGIKAY 174
Cdd:COG2409 78 RAAVAALVARLRADP-GVAGVQDPWDDP--AAGLVSEDGKAALVTVTLDGDAG-DEAAEAVDALRDAVAAAPAP-GLTVY 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 175 VTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAVRGIISTFAvnDLMGLSTFTVNV 254
Cdd:COG2409 153 VTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLA--AFTDVSSFAPNL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 255 LVALTIAASTDYIIFLVGRYQEARATGQNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVT 334
Cdd:COG2409 231 LTMLGLGVGIDYALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 335 VMLASLTLAPAIIAVASRFgLFDPKR-------ATTKRRWRRIGTVVVRWPGPVLAATLLIALIGLLALPKYQTNYNERY 407
Cdd:COG2409 311 AVLAALTLLPALLALLGRR-VFWPRRprrrraaAPESGFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDAD 389
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 623094611 408 YIPSAAPSNIGYLASDRHFPQARMEPEVLMVEADHDLrNPTDMLILDRIAKTVFHTPGIARVQSITRPLGAP 479
Cdd:COG2409 390 SLPADSPSRQGYDALAEHFPPGSNGPLTVVVESDDDL-DPADLAALDALAAALAAVPGVASVQPPTRPEGTD 460
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
130-564 |
1.05e-04 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 46.16 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 130 SADGKAAyVQLNLtgdQGGSQAN--ESVAAVQRIVDSVPP--PPGIKAYVTgpgplgADRVVYGDRSLHTIT---GISIA 202
Cdd:NF033617 272 WANGVPA-VVLGI---NRQPGANpiEVADEIRALLPELQEtlPKNIKVNVL------YDRTRFIRASIDEVEstlLEAVA 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 203 VIAIMLFIAYRSLSAALIMLLTVGLELlavrgiISTFAVNDLMGlstFTVNV--LVALTIAAS---TDYIIFL--VGRYQ 275
Cdd:NF033617 342 LVILVVFLFLRNLRATLIPAVTVPLSL------IGTFAVMYLFG---FSINLltLMALVLAIGlvvDDAIVVVenIHRHI 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 276 EAratGQNREAAYYTmfgGTAHV---VLASGLTVAGAMYCLGFT-----RLpyFNTLASPCAIGLVTVMLASLTLAPAII 347
Cdd:NF033617 413 EE---GESPLEAALK---GAREIgftVIAMTLTLVAVYLPILFMggltgRL--FREFAVTLAGAVIISGIVALTLTPMMC 484
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 348 AV-------ASRFG-LFDPKRATTKRRWRRIGTVVVRWP---GPVLAATLLIALIGLLALPKYQTNYNER----YYIPSA 412
Cdd:NF033617 485 SRllkanekPGRFArAVDRFFDGLTARYGRGLKWVLKHRpltLVVALATLALLPLLYVFIPKELAPSEDRgvifGMIQAP 564
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 413 APSNIGYLASD-RHFPQARME-PEV--------------------LMVEADHDLRNPTDMLILDRIAKTVFHTPGIA-RV 469
Cdd:NF033617 565 QSISLDYMSAKmRDVEKILSSdPEVqsltsfngvggnpgdntgfgIINLKPWDERDVSAQEIIDRLRPKLAKVPGMDlFL 644
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 470 QSItrPLGAPIDHSSIPFQlgmQSTMTIENLQNLKDRVADLSTLTDQLQrmiditqrtqeltrQLTDATHDMNAHTRQM- 548
Cdd:NF033617 645 FPL--QDLPGGAGSSLPQY---QVTLTPSDYDSLFTWAEKLKEKLRKSP--------------QFADVDSDLQDKGPELn 705
|
490 500
....*....|....*....|
gi 623094611 549 ----RDNANELRDRIADFDD 564
Cdd:NF033617 706 vdidRDKAARLGISMQDIGS 725
|
|
| PRK10551 |
PRK10551 |
cyclic di-GMP phosphodiesterase; |
722-813 |
1.06e-03 |
|
cyclic di-GMP phosphodiesterase;
Pssm-ID: 182541 [Multi-domain] Cd Length: 518 Bit Score: 42.67 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 722 HIDPIMQAAdeaVKGTPLQaasIYLAGTSSTYKDIHEGTLYDVMIA-VVASLC-LIFI--------IMLGITRS---VVA 788
Cdd:PRK10551 208 PDMPLRETT---IPGYPLT---IRLYADSWTANDIWYALLLGLLSGiLVGLLCyYLLSlrmrpgkeILTGIKRGqfyVEY 281
|
90 100
....*....|....*....|....*.
gi 623094611 789 SAVivgtVALSLGSAFGLSVLI-WQH 813
Cdd:PRK10551 282 QPV----VDTQTLRVTGLEALLrWRH 303
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
20-928 |
0e+00 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 840.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 20 LSLPIILFWVALTIVVNVVAPQLQSVARTHSVALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLLEGQEKLGDEAHRFYD 99
Cdd:TIGR00833 2 SAYGIIGVWIATAISLQLLAPLLEDVSYFRLQAELPGGAASSIAVKEMSAAFQEAIRDPKIILVLESNERLGDKDYATYD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 100 VLVTKLSQDTTHVQHIENFWGDPLTAAGSQSADGKAAYVQLNLTGDQGGSQANESVAAVQRIVDSVPPPPGIKAYVTGPG 179
Cdd:TIGR00833 82 ALIAKLRADIMHVISVVDFWGPPEAAEGLRSDDGKATIIIVNLAGEKGQKEAQEAINAVRRIVEQTNAPDGLTVHVTGPL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 180 PLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALT 259
Cdd:TIGR00833 162 ATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLIGVNAQTTVLLTALV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 260 IAASTDYIIFLVGRYQEARATGQNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLAS 339
Cdd:TIGR00833 242 IGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 340 LTLAPAIIAVASRFGLFDPKRATTKRR-WRRIGTVVVRWPGPVLAATLLIALIGLLALPKYQTNYNERYYIPSAAPSNIG 418
Cdd:TIGR00833 322 VTLTPALLTLEGREGLMKPGRKSKIRFiWRRLGTAVVRRPWPILVTTLIISGVSLLALPLIRTGYDDEKMIPTDLESVQG 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 419 YLASDRHFPQARMEPEVLMVEADHDLRNPTDMLILDRIAKTVFHTPGIARVQSITRPLGAPIDHSSIPFQLGMQSTMTIE 498
Cdd:TIGR00833 402 YEAADRHFPGNSMDPMVVMIKSDHDVRNPALLADIDRFEREIKAVPGINMVQETQRPDGVVIKKTYLTFQAGNLGDQLDE 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 499 NLQNLKDRVADLSTLTDQLQRMIDITQRTQELTRQLTDATHDMNAHTRQMRDNANELRDRIADFDDFWRPLRSFTYWERH 578
Cdd:TIGR00833 482 FSDQLTSRQAYLLQDAEKIAEAIAGLRLVQAGMRLDGENLGQVSLAVRLMQQAISKLQGSAGDVFDIFDPLRRFVAAIPE 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 579 CFDIPICWSMRSLLNSMDNVDKLTEDLANLTDDTERMDTTQRQLLAQLDPTIATMQTVKDLAQTLTSAFSGLVTQMEDMT 658
Cdd:TIGR00833 562 CRANPVCSVAREIVQAADTVVSSAAKLADAAGQLARGIADVASALSQVSGLPNALDGIGTQLAQMRESAAGVQDLLNELS 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 659 RNATVMGRTFDAANNDDsFYLPPEAFQNPDFQRGLKLFLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGTP 738
Cdd:TIGR00833 642 DYSMTMGKLKGNAMGVD-FYAPPRIFTDPNFKAVLDYFLSPDGHAARLLVYGDGSPAGDQGAQEFNAIRTVAEEAIQRAD 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 739 LQAASIYLAGTSSTYKDIHEGTLYDVMIAVVASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLSVLIWQHILHMP 818
Cdd:TIGR00833 721 LEPAKVELAGVSAVNRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLWALGLSVLAFQHILGAE 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 819 LHWLVLPMAIIVMLAVGSDYNLLLIARFQEEIGAGLKTGMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTI 898
Cdd:TIGR00833 801 LHWSVLAGVFVLLVALGVDYNMLLVSRIKEESPAGNRTGIIRALGSTGGVITAAGLVFAGTMAALASAQLTAIAQFGFTV 880
|
890 900 910
....*....|....*....|....*....|
gi 623094611 899 MIGLLFDTLVVRSYMTPALATLLGRWFWWP 928
Cdd:TIGR00833 881 GVGILLDTFIVRSVTVPALTLLLGRWIWWP 910
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
52-381 |
1.03e-130 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 397.05 E-value: 1.03e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 52 ALGPHDAPSLIAMKRIGKDFQQFDSDTTAMVLL-EGQEKLGD-EAHRFYDVLVTKLSQDTTHVQHIENFWGDPLTAAGSQ 129
Cdd:pfam03176 1 ALSPADAPSVRAMDRLGAAFPQADSDPIIVVVLgEGDQALGDaAAEAGYDTLVDALRADTGHVGSVQDFWGDPDTAALFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 130 SADGKAAYVQLNLTGDQGGSQANESVAAVQRIVDSVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLF 209
Cdd:pfam03176 81 SPDGKAAYVVVTLEGDPGTTEADESVAAVRDAVEQAPPPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 210 IAYRSLSAALIMLLTVGLELLAVRGIISTFAVNDLMGLSTFTVNVLVALTIAASTDYIIFLVGRYQEARATGQNREAAYY 289
Cdd:pfam03176 161 IVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIGLSTFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 290 TMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLASLTLAPAIIAVASRFGLFDPKRATTKRRWRR 369
Cdd:pfam03176 241 RAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRWGLWPPKRDRTARWWRR 320
|
330
....*....|..
gi 623094611 370 IGTVVVRWPGPV 381
Cdd:pfam03176 321 IGRLVVRRPAPV 332
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
17-479 |
5.35e-121 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 384.50 E-value: 5.35e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 17 IHALSLPIILFWVALTIVVNVVAPQLQSVARTHSVALGphDAPSLIAMKRIGKDFQQFDSDTtAMVLLEGQE-KLGDEA- 94
Cdd:COG2409 1 VARHRWLVLLAWLVLLVALGVLAPQLGGSLSSNGFFLP--GSESQRAADLLAEAFPESDGAS-AVVVVEAPDgTLTDPAf 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 95 HRFYDVLVTKLSQDTtHVQHIENFWGDPltAAGSQSADGKAAYVQLNLTGDQGgSQANESVAAVQRIVDSVPPPpGIKAY 174
Cdd:COG2409 78 RAAVAALVARLRADP-GVAGVQDPWDDP--AAGLVSEDGKAALVTVTLDGDAG-DEAAEAVDALRDAVAAAPAP-GLTVY 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 175 VTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAVRGIISTFAvnDLMGLSTFTVNV 254
Cdd:COG2409 153 VTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLA--AFTDVSSFAPNL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 255 LVALTIAASTDYIIFLVGRYQEARATGQNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVT 334
Cdd:COG2409 231 LTMLGLGVGIDYALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 335 VMLASLTLAPAIIAVASRFgLFDPKR-------ATTKRRWRRIGTVVVRWPGPVLAATLLIALIGLLALPKYQTNYNERY 407
Cdd:COG2409 311 AVLAALTLLPALLALLGRR-VFWPRRprrrraaAPESGFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDAD 389
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 623094611 408 YIPSAAPSNIGYLASDRHFPQARMEPEVLMVEADHDLrNPTDMLILDRIAKTVFHTPGIARVQSITRPLGAP 479
Cdd:COG2409 390 SLPADSPSRQGYDALAEHFPPGSNGPLTVVVESDDDL-DPADLAALDALAAALAAVPGVASVQPPTRPEGTD 460
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
601-938 |
1.70e-101 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 320.39 E-value: 1.70e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 601 LTEDLANLTDDTERMDTTQRQllAQLDPTIATMQTVKDLAQTLTSAFSGLVTQMEDMTRNATVMGRTFDAannddsfylp 680
Cdd:pfam03176 2 LSPADAPSVRAMDRLGAAFPQ--ADSDPIIVVVLGEGDQALGDAAAEAGYDTLVDALRADTGHVGSVQDF---------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 681 peaFQNPDfqrGLKLFLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVkgtPLQAASIYLAGTSSTYKDIHEGT 760
Cdd:pfam03176 70 ---WGDPD---TAALFVSPDGKAAYVVVTLEGDPGTTEADESVAAVRDAVEQAP---PPEGLKAYLTGPAATVADLRDAG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 761 LYDVMIAVVASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLsVLIWQHILHMPLHWLVLPMAIIVMLAVGSDYNL 840
Cdd:pfam03176 141 DRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGL-VAILAHILGIGLSTFALNLLVVLLIAVGTDYAL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 841 LLIARFQEEIGAGLKT--GMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVRSYMtPALA 918
Cdd:pfam03176 220 FLVSRYREELRAGEDReeAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLL-PALL 298
|
330 340 350
....*....|....*....|....*....|.
gi 623094611 919 TLLGRW-----------FWWPRRVDRLARQP 938
Cdd:pfam03176 299 ALLGRWglwppkrdrtaRWWRRIGRLVVRRP 329
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
697-933 |
8.46e-73 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 254.30 E-value: 8.46e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 697 LSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGtplqaASIYLAGTSSTYKDIHEGTLYDVMIAVVASLCLIF 776
Cdd:COG2409 457 EGTDGDAARLQVVPDGDPDSPEAIDLVDRLRDAAAPALEG-----AEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIF 531
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 777 IIMLGITRSVVASAVIVGTVALSLGSAFGLSVLIWQH---ILHM---PLHWLVLPMAIIVMLAVGSDYNLLLIARFQEEI 850
Cdd:COG2409 532 LLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVLVFQHgwlLLGFtpgPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEY 611
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 851 --GAGLKTGMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVRSYMTPALATLLGRWFWW- 927
Cdd:COG2409 612 drGGGTREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWNWWl 691
|
....*.
gi 623094611 928 PRRVDR 933
Cdd:COG2409 692 PRWLDR 697
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
14-929 |
1.81e-44 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 173.12 E-value: 1.81e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 14 ARTIHALSLPIILFWVALTIVVNVVAPQLQSvaRTHSVALGPHDAPSLIAMKRIGKDFQqfdSDTTAMVLLEGQEKLGDE 93
Cdd:COG1033 8 ARFILRHRKLVLLLFLLLTLLLAYGAPKLEV--DTDFESLLPEDDPSVQAYDEFEEEFG---GDDTVVVAVEGKDDIFTP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 94 AH-RFYDVLVTKLSQ--------DTTHVQHIENFWGD-----------PLTAAGSQ-----------------SADGKAA 136
Cdd:COG1033 83 ETlEALRELTEELEEipgvdsvtSLTNVRATEGTEDGltveplipdelPASPEELAelrekvlssplyvgrlvSPDGKAT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 137 --YVQLNLTGDQGGSQANESVAAVQRIVDSVPPPpGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRS 214
Cdd:COG1033 163 liVVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDP-GVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 215 LSAALIMLLTVGLellavrGIISTFAVNDLMGLS-TFTVNVLVALTIAASTDYIIFLVGRYQEARATGQNREAAYYTMFG 293
Cdd:COG1033 242 LRGVLLPLLVVLL------AVIWTLGLMGLLGIPlSPLTILVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALREALR 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 294 GTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLASLTLAPAIIAVASRF---GLFDPKRATTKRRWRRI 370
Cdd:COG1033 316 KLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPkpkTRRLKKPPELGRLLAKL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 371 GTVVVRWPGPVLAATLLIALIGLLALPKYQTNYNERYYIPSAAPSNIGYLASDRHFPQarMEPEVLMVEADHD--LRNPT 448
Cdd:COG1033 396 ARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGG--SDPLEVVVDTGEPdgLKDPE 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 449 DMLILDRIAKTVFHTPGIARVQSITrplgapidhssipfqlgmqstmtienlqnlkdrvadlstltdqlqrmiditqrtq 528
Cdd:COG1033 474 VLKEIDRLQDYLESLPEVGKVLSLA------------------------------------------------------- 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 529 ELTRQLTDATHDMNAHTRQMRDNanelrdriadfddfwrplrsftywerhcfdipicwsmrsllnsmdnvdkltedlanl 608
Cdd:COG1033 499 DLVKELNQALNEGDPKYYALPES--------------------------------------------------------- 521
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 609 tddtermdttqRQLLAQLdptiatmqtvkdlaqtltsafsglvtqmedmtrnatvmgrtfdaanNDDSFYLPPEAFQNpd 688
Cdd:COG1033 522 -----------RELLAQL----------------------------------------------LLLLSSPPGDDLSR-- 542
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 689 fqrglklFLSPDGTCARFVIthRGDPASAEGISHIdpIMQAADEAVKGTPLQAASIYLAGTSSTYKDIHEGTLYDVMIAV 768
Cdd:COG1033 543 -------FVDEDYSAARVTV--RLKDLDSEEIKAL--VEEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSL 611
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 769 VASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLSVLiwqhiLHMPLHWLVLPMAIIVmLAVGSDYNLLLIARFQE 848
Cdd:COG1033 612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGL-----LGIPLNIATAVVASIA-LGIGVDYTIHFLSRYRE 685
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 849 EI--GAGLKTGMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGT----TIMIGLLFDTLVVrsymtPALATLLG 922
Cdd:COG1033 686 ERrkGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLllalGLLVALLAALLLL-----PALLLLLD 760
|
....*..
gi 623094611 923 RWFWWPR 929
Cdd:COG1033 761 PRIAKKR 767
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
689-938 |
1.85e-28 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 122.57 E-value: 1.85e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 689 FQRGLKLFLSPDGTCARFVITHRGDPASAegishIDPIMQAADEAVKGTPLQAASIYLAGTSSTYKDIHEGTLYDVMIAV 768
Cdd:COG2409 101 WDDPAAGLVSEDGKAALVTVTLDGDAGDE-----AAEAVDALRDAVAAAPAPGLTVYVTGPAALAADLNEAFEEDLGRAE 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 769 VASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLSVLIwqhILHMPLHWLVLPMAIIVMLAVGSDYNLLLIARFQE 848
Cdd:COG2409 176 LITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALL---AAFTDVSSFAPNLLTMLGLGVGIDYALFLVSRYRE 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 849 EIGAGL--KTGMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVrsyMT--PALATLLGRW 924
Cdd:COG2409 253 ELRAGEdrEEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAA---LTllPALLALLGRR 329
|
250
....*....|....
gi 623094611 925 FWWPRRVDRLARQP 938
Cdd:COG2409 330 VFWPRRPRRRRAAA 343
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
10-364 |
4.20e-25 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 112.26 E-value: 4.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 10 LSAAARTIHALSLPIILFWVALTIVVNVVAPQLQSvaRTHSVALGPHDAPSLIAMKRIGkdfQQFDSDTTAMVLLEGQEK 89
Cdd:COG1033 392 LAKLARFVLRRPKVILVVALVLAVVSLYGISRLKV--EYDFEDYLPEDSPIRQDLDFIE---ENFGGSDPLEVVVDTGEP 466
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 90 LGDEAHRFYDVL--VTKLSQDTTHVQHI------------------------------------ENFWGDPLTAAGSQSA 131
Cdd:COG1033 467 DGLKDPEVLKEIdrLQDYLESLPEVGKVlsladlvkelnqalnegdpkyyalpesrellaqlllLLSSPPGDDLSRFVDE 546
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 132 DGKAAYVQLNLTgDQGGSQANESVAAVQRIVDSVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIA 211
Cdd:COG1033 547 DYSAARVTVRLK-DLDSEEIKALVEEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLA 625
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 212 YRSLSAALIMLLTVGLellavrGIISTFAVNDLMGLSTFTVNVLV-ALTIAASTDYIIFLVGRYQEARATGQNREAAYYT 290
Cdd:COG1033 626 FRSLRLGLISLIPNLL------PILLTFGLMGLLGIPLNIATAVVaSIALGIGVDYTIHFLSRYREERRKGGDLEEAIRR 699
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 623094611 291 MFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLASLTLAPAIIAvasrfgLFDPKRATTK 364
Cdd:COG1033 700 ALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLL------LLDPRIAKKR 767
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
130-473 |
1.43e-20 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 97.60 E-value: 1.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 130 SADGKAAYVQLNLTGDQGGSQANESVAAVQRIVDSVPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLF 209
Cdd:TIGR00921 132 SKDHTVAIIIVQLKSDADYKQVVPIYNDVERSLERTNPPSGKFLDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 210 IAYRSLSAALIMLLTVglellaVRGIISTFAVNDLMGLS-TFTVNVLVALTIAASTDYIIFLVGRYQEARATGQNREAAY 288
Cdd:TIGR00921 212 LDFKRWWRPLLPLVII------LFGVAWVLGIMGWLGIPlYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAI 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 289 YTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTVMLASLTLAPAII--------AVASRFGLFDPKR 360
Cdd:TIGR00921 286 VTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLqsidigreKVKKEIIAIGGKS 365
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 361 ATTKRRWRRIGTVVVRWPGPVLAATLLIALIGLLALPKY--QTNYNEryYIPSAAPSNIGYLASDRHFPQARMEPEVLmV 438
Cdd:TIGR00921 366 SEIEEELSKVLSITVRHPVPALVAALIITGLGLYGAAGIkpEVNIEK--FIPQDLPSLQARKVIESHMGGSHDFATIL-V 442
|
330 340 350
....*....|....*....|....*....|....*...
gi 623094611 439 EADhDLRNPTDMLILDRIAKTVFHTPGIARV---QSIT 473
Cdd:TIGR00921 443 KAD-DVRDPELVRFMDELSRDIKATGVAARVfgaPSII 479
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
21-349 |
1.50e-20 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 97.22 E-value: 1.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 21 SLPIILFWVALTIVVNVVAPQLQSVARTHSVAlgPHDAPSLIAMKRIGKDFQQFDSDTTAMVL---------------LE 85
Cdd:TIGR00921 383 PVPALVAALIITGLGLYGAAGIKPEVNIEKFI--PQDLPSLQARKVIESHMGGSHDFATILVKaddvrdpelvrfmdeLS 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 86 GQEKLGDEAHRFYDVL-VTKLSQDTTHVQHIENFWGDPLTAA---GSQSADG-KAAYVQLNLTGDQGGSQANESVAAVQR 160
Cdd:TIGR00921 461 RDIKATGVAARVFGAPsIIDLVKEVEGLPAPERSALEPIPEDeegGYISGGQiKVAVIQVQLKQGEPKVQGRKILRDVQH 540
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 161 IvdsvPPPPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAVRGIIStfa 240
Cdd:TIGR00921 541 E----HPPPGVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMG--- 613
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 241 vndLMGL-STFTVNVLVALTIAASTDYIIFLVGRYQEARATGQNREAAYYTMfGGTAHVVLASGLTVAGAMYCLGFTRLP 319
Cdd:TIGR00921 614 ---LRGIpSFLAMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAITHTM-ERTGPGILFSGLTTAGGFLSLLLSHFP 689
|
330 340 350
....*....|....*....|....*....|
gi 623094611 320 YFNTLASPCAIGLVTVMLASLTLAPAIIAV 349
Cdd:TIGR00921 690 IMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
698-944 |
1.54e-17 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 88.10 E-value: 1.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 698 SPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAVKGTPLQAasiYLAGTSSTYKDIHEGTLYDVMIAVVASLCLIFI 777
Cdd:TIGR00833 112 SDDGKATIIIVNLAGEKGQKEAQEAINAVRRIVEQTNAPDGLTV---HVTGPLATIADILESGDKDMNRITATTGIIVLI 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 778 IMLGITRSVVASAVIVGTVALSLGSAFG-LSVLIWQHILHMPLHWLVLPMAiiVMLAVGSDYNLLLIARFQEEIGAG--L 854
Cdd:TIGR00833 189 ILLLVYRSPITMLVPLVSVGFSVVVAQGiVSLLGIPGLIGVNAQTTVLLTA--LVIGAGTDYAVFLTGRYHEERRKGesL 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 855 KTGMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMIGLLFDTLVVRSyMTPALATLLGRWFWW-PRRVDR 933
Cdd:TIGR00833 267 EEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVT-LTPALLTLEGREGLMkPGRKSK 345
|
250
....*....|.
gi 623094611 934 LARQPQVLGPR 944
Cdd:TIGR00833 346 IRFIWRRLGTA 356
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
55-348 |
1.80e-16 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 84.05 E-value: 1.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 55 PHDAPSLIAMKRIGKDFQQfDSDTTAMVLLEGQEKLGDEAHRFYDVLVTKLSQ--DTTHVQhienfwgdplTAAGSQSAD 132
Cdd:COG2409 392 PADSPSRQGYDALAEHFPP-GSNGPLTVVVESDDDLDPADLAALDALAAALAAvpGVASVQ----------PPTRPEGTD 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 133 GKAAYVQLNLTGDqggSQANESVAAVQRIVDSVPP-PPGIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIA 211
Cdd:COG2409 461 GDAARLQVVPDGD---PDSPEAIDLVDRLRDAAAPaLEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLLLL 537
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 212 YRSLSAALIMLLTVGLELLAVRGiISTFAVND---LMGLST---------FTVNVLVALtiaaSTDYIIFLVGRYQEAR- 278
Cdd:COG2409 538 FRSVVAPLKAVLTNLLSLGAALG-VLVLVFQHgwlLLGFTPgpldsfvplLLFVILFGL----GMDYEVFLVSRIREEYd 612
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 623094611 279 ATGQNREAAYYTMfGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPCAIG-LVTVMLASLTLAPAIIA 348
Cdd:COG2409 613 RGGGTREAVIRGL-ARTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGvLLDAFVVRMLLVPALMA 682
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
689-933 |
7.81e-11 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 66.01 E-value: 7.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 689 FQRGLKLFLSPDGTCARFVITHRGDPASAEGISHIDPIMQAADEAvkgTPLQAASIYLAGTSSTYKDIHEGTLYD----V 764
Cdd:TIGR00921 123 YPRSKEMFLSKDHTVAIIIVQLKSDADYKQVVPIYNDVERSLERT---NPPSGKFLDVTGSPAINYDIEREFGKDmgttM 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 765 MIAVVASLCLIFIIMLGITRSVVASAVIVGTVALSLGSAFGLSVLIWQHILhmplhwLVLPMaiivMLAVGSDYNLLLIA 844
Cdd:TIGR00921 200 AISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTL------LAVPM----LIGVGIDYGIQTLN 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 845 RFQEEIGAG--LKTGMIRAMAGTGRVVTIAGLVFAFTMGSMVASDLRVVGQIGTTIMIGLL---FDTLVVrsymTPALAT 919
Cdd:TIGR00921 270 RYEEERDIGraKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLItayLLTLLV----LPALLQ 345
|
250
....*....|....
gi 623094611 920 LLGrwfWWPRRVDR 933
Cdd:TIGR00921 346 SID---IGREKVKK 356
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
170-385 |
5.48e-10 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 63.48 E-value: 5.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 170 GIKAYVTGPGPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAVRGIiSTFAVNDLMGLST 249
Cdd:TIGR03480 248 GVTVRLTGEVALSDEELATVSEGATVAGLLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAAF-ATLAVGHLNLISV 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 250 -FTVnvlvaLTIAASTDYIIFLVGRYQEARATGQNREAAYYTMFGGTAHVVLASGLTVAGAMYCLGFTRLPYFNTLASPC 328
Cdd:TIGR03480 327 aFAV-----LFIGLGVDFAIQFSLRYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIA 401
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 329 AIGLVTVMLASLTLAPAIIavasrfGLFDPKRATTKRRWRRIG---TVVVRWPGPVLAAT 385
Cdd:TIGR03480 402 GTGMFIALFVTLTVLPALL------RLLRPPRRRKPPGYATLApldAFLRRHRRPVLGVT 455
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
146-927 |
1.93e-06 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 52.03 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 146 QGGSQANESVAAVQRIVDSVPP--PPGIKAYVTgpgplgADRVVYGDRSLHT-----ITGISIAVIAIMLFIayRSLSAA 218
Cdd:COG0841 287 QPGANALEVADAVRAKLEELQAslPEGVELTIV------YDQSEFIRASIEEvvktlLEAILLVVLVVFLFL--RSWRAT 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 219 LIMLLTVGLELLAvrgiisTFAVNDLMGlstFTVNVLV--ALTIAastdyIIFLVG----------RYQEAratGQNREA 286
Cdd:COG0841 359 LIPAVAIPVSLIG------TFAVMYLLG---FSLNILTlfALVLA-----IGIVVDdaivvvenieRHMEE---GLSPLE 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 287 AYYTmfgGTAHV---VLASGLT-------------VAGAMYclgftrlpyfntlaSPCAIGLVTVMLAS----LTLAPAI 346
Cdd:COG0841 422 AAIK---GAREVagaVIASTLTlvavflplafmggITGQLF--------------RQFALTVAIALLISlfvaLTLTPAL 484
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 347 IAVASR----------FGLFDPKRATTKRRWRRIGTVVVRWPGPVLAATLLIALIGLLALPKYQTNYneryyipsaapsn 416
Cdd:COG0841 485 CARLLKphpkgkkgrfFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEF------------- 551
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 417 igylasdrhFPQarMEPEVLMVeadhDLRNPTDM------LILDRIAKTVFHTPGIARVQSIT-RPLGAPIDHSSipfql 489
Cdd:COG0841 552 ---------FPE--EDQGQIIV----SVQLPPGTslerteAVVRQVEEILLEVPEVESVFSVVgFSGGGSGSNSG----- 611
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 490 gmqsTMTIeNLQNLKDRVADLSTLTDQLQRMI----DITQRTQELTR-----------QLTDATHDmnahtrQMRDNANE 554
Cdd:COG0841 612 ----TIFV-TLKPWDERDRSADEIIARLREKLakipGARVFVFQPPAgglgsgapievQLQGDDLE------ELAAAAEK 680
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 555 LRDRIADFDDfwrplrsftywerhcfdipicwsmrsllnsmdnvdkltedLANLTDDterMDTTQRQLLAQLDPTIATMQ 634
Cdd:COG0841 681 LLAALRQIPG----------------------------------------LVDVRSD---LQLGKPELQLDIDREKAAAL 717
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 635 --TVKDLAQTLTSAFSGL-VTQMEDMTRNATVMGRtfdaannddsfyLPPEAFQNPDFQRGLKLFlSPDG------TCAR 705
Cdd:COG0841 718 gvTVADVASTLRAALGGRyVNDFNRGGREYDVRVQ------------APEEDRNSPEDLENLYVR-TPDGemvplsSVAT 784
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 706 F-------VITHR---------GDPAsaEGIShIDPIMQAADEAVKGTPLQA-ASIYLAGTSSTYKDihegTLYDVMIAV 768
Cdd:COG0841 785 IeegtgpsSINRYngqrsvtvsANLA--PGVS-LGEALAAIEELAAELKLPPgVSIEFTGQAEEEQE----SFSSLGLAF 857
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 769 VASLCLIFIIMLGITRSVVASAVIVGTVALSL-GSAFGLSvliwqhILHMPlhwLVLPMAI-IVMLA--VGSDyNLLLIA 844
Cdd:COG0841 858 LLALLLVYLVLAAQFESFIQPLIILLTVPLALiGALLGLL------LTGTP---LNIYSQIgLIMLIgiVVKN-AILLVD 927
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 845 RFQEEIGAGLktGMIRAM--AGTGR--------VVTIAG---LVFAFTMGsmvaSDLRVvgQIGTTIMIGLLFDTLVVRs 911
Cdd:COG0841 928 FANQLREEGM--SLREAIleAARLRlrpilmtsLATILGllpLALGTGAG----AEFRQ--PLGIAVIGGLLFSTLLTL- 998
|
890
....*....|....*.
gi 623094611 912 YMTPALATLLGRWFWW 927
Cdd:COG0841 999 FVVPVLYVLLDRLRRR 1014
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
101-384 |
4.23e-06 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 50.62 E-value: 4.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 101 LVTKLSQDTTHVQHIENFWgdpltaagsQSADGKAAYVQLNLTGDQGGSQANES-VAAVQRIVDSV-PPPPGIKAYVTGP 178
Cdd:COG4258 166 LLEKLQPLGSRPRLRDGVL---------VSRDGTWALLLAETRASGFDTDAQQQlVAALRAAFAALnAAFPGAQLLLTGA 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 179 GPLGADRVVYGDRSLHTITGISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAvrGIISTFAVND---LMGLSTFTVNVL 255
Cdd:COG4258 237 GLFAVAAAQQIKHDISTIGLISLLGILLLLLLVFRSLRPLLLGLLPVAVGALA--GLAAVSLVFGsvhGITLGFGSSLIG 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 256 VALtiaastDYIIFLVGRYQeaRATGQNREAAYYTMFGGtahVVLASgLTVAGAMYCLGFTRLPYFNTLASPCAIGLVTV 335
Cdd:COG4258 315 VAV------DYSLHYLTHRR--AAGEWDPRAALRRIWPT---LLLGL-LTTVLGYLALLFSPFPGLRQLGVFAAAGLLAA 382
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 623094611 336 MLASLTLAPAII--AVASRFGLFDPKRATTKRRWRRigtvVVRWPGPVLAA 384
Cdd:COG4258 383 ALTTLLWLPLLLprAAPRPPAPALALLARLLARWPR----RLRWLLALLAV 429
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
146-384 |
1.68e-05 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 48.83 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 146 QGGSQANESVAAVQRIVDSVPP--PPGIKAYVTgpgplgADRVVYGDRSLHT-----ITGISIAVIAIMLFIayRSLSAA 218
Cdd:pfam00873 287 LPGANAIETADAVRAKLAELKPtfPQGVEIVVV------YDTTPFIRASIEEvvktlLEAIVLVILVMFLFL--QNWRAT 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 219 LIMLLTVGLELLAvrgiisTFAVNDLMGLS--TFTvnvLVALTIAAST---DYIIFL--VGRYQEARATGqNREAAYYTM 291
Cdd:pfam00873 359 LIPAIAIPLSLLG------TFAVMKAFGFSinTLT---LGGLVLAIGLvvdDAIVVVenIERVLEENGLK-PLEAAYKSM 428
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 292 fgGTAHVVLASGLTVAGAMYC--LGFTRLP--YFNTLASPCAIGLVTVMLASLTLAPAIIAV----------ASRFGLFD 357
Cdd:pfam00873 429 --GEIGGALVAIALVLSAVFLpiLFLGGLTgrIFRQFAITIVLAILLSVLVALTLTPALCATllkprrepkhGGFFRWFN 506
|
250 260
....*....|....*....|....*..
gi 623094611 358 PKRATTKRRWRRIGTVVVRWPGPVLAA 384
Cdd:pfam00873 507 RMFDRLTRGYAKLLAKVLRHTAVVLLV 533
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
130-564 |
1.05e-04 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 46.16 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 130 SADGKAAyVQLNLtgdQGGSQAN--ESVAAVQRIVDSVPP--PPGIKAYVTgpgplgADRVVYGDRSLHTIT---GISIA 202
Cdd:NF033617 272 WANGVPA-VVLGI---NRQPGANpiEVADEIRALLPELQEtlPKNIKVNVL------YDRTRFIRASIDEVEstlLEAVA 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 203 VIAIMLFIAYRSLSAALIMLLTVGLELlavrgiISTFAVNDLMGlstFTVNV--LVALTIAAS---TDYIIFL--VGRYQ 275
Cdd:NF033617 342 LVILVVFLFLRNLRATLIPAVTVPLSL------IGTFAVMYLFG---FSINLltLMALVLAIGlvvDDAIVVVenIHRHI 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 276 EAratGQNREAAYYTmfgGTAHV---VLASGLTVAGAMYCLGFT-----RLpyFNTLASPCAIGLVTVMLASLTLAPAII 347
Cdd:NF033617 413 EE---GESPLEAALK---GAREIgftVIAMTLTLVAVYLPILFMggltgRL--FREFAVTLAGAVIISGIVALTLTPMMC 484
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 348 AV-------ASRFG-LFDPKRATTKRRWRRIGTVVVRWP---GPVLAATLLIALIGLLALPKYQTNYNER----YYIPSA 412
Cdd:NF033617 485 SRllkanekPGRFArAVDRFFDGLTARYGRGLKWVLKHRpltLVVALATLALLPLLYVFIPKELAPSEDRgvifGMIQAP 564
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 413 APSNIGYLASD-RHFPQARME-PEV--------------------LMVEADHDLRNPTDMLILDRIAKTVFHTPGIA-RV 469
Cdd:NF033617 565 QSISLDYMSAKmRDVEKILSSdPEVqsltsfngvggnpgdntgfgIINLKPWDERDVSAQEIIDRLRPKLAKVPGMDlFL 644
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 470 QSItrPLGAPIDHSSIPFQlgmQSTMTIENLQNLKDRVADLSTLTDQLQrmiditqrtqeltrQLTDATHDMNAHTRQM- 548
Cdd:NF033617 645 FPL--QDLPGGAGSSLPQY---QVTLTPSDYDSLFTWAEKLKEKLRKSP--------------QFADVDSDLQDKGPELn 705
|
490 500
....*....|....*....|
gi 623094611 549 ----RDNANELRDRIADFDD 564
Cdd:NF033617 706 vdidRDKAARLGISMQDIGS 725
|
|
| PRK10551 |
PRK10551 |
cyclic di-GMP phosphodiesterase; |
722-813 |
1.06e-03 |
|
cyclic di-GMP phosphodiesterase;
Pssm-ID: 182541 [Multi-domain] Cd Length: 518 Bit Score: 42.67 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 722 HIDPIMQAAdeaVKGTPLQaasIYLAGTSSTYKDIHEGTLYDVMIA-VVASLC-LIFI--------IMLGITRS---VVA 788
Cdd:PRK10551 208 PDMPLRETT---IPGYPLT---IRLYADSWTANDIWYALLLGLLSGiLVGLLCyYLLSlrmrpgkeILTGIKRGqfyVEY 281
|
90 100
....*....|....*....|....*.
gi 623094611 789 SAVivgtVALSLGSAFGLSVLI-WQH 813
Cdd:PRK10551 282 QPV----VDTQTLRVTGLEALLrWRH 303
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
136-360 |
1.80e-03 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 42.32 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 136 AYVQLNLTG-DQGGSqanesVAAVQRIVDS-VPPPPGikaYvtgpgplgadRVVYG---------DRSLHTITGISIAVI 204
Cdd:COG3696 816 IVVQANVRGrDLGSF-----VAEAQAKVAEqVKLPPG---Y----------YIEWGgqfenlqraTARLAIVVPLALLLI 877
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 205 AIMLFIAYRSLSAALIMLLTV------GLELLAVRGIistfavndlmglsTFTVNVLV---ALT-IAASTDyiIFLVGRY 274
Cdd:COG3696 878 FLLLYLAFGSVRDALLILLNVpfaligGVLALWLRGM-------------PLSVSAGVgfiALFgVAVLNG--VVLVSYI 942
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 275 QEARATGQNREAAyyTMFGGTAHV--VLASGLTVAgamycLGFtrLPY-FNTLA-----SPCAI----GLVTVMLASLTL 342
Cdd:COG3696 943 NQLRAEGLDLREA--IIEGALERLrpVLMTALVAA-----LGL--LPMaLSTGPgsevqRPLATvvigGLITSTLLTLLV 1013
|
250
....*....|....*...
gi 623094611 343 APAIIAVASRFGLFDPKR 360
Cdd:COG3696 1014 LPALYLLFGRRRLRRAAA 1031
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
198-345 |
3.44e-03 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 41.38 E-value: 3.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 623094611 198 GISIAVIAIMLFIAYRSLSAALIMLLTVGLELLAVRGIistfavndlMGLSTFTVNV--LVALTIAA--STDYIIFLvgr 273
Cdd:COG4258 646 LLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAI---------LGLLGIPLNLfhLIALLLVLgiGIDYALFF--- 713
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 623094611 274 yQEARATGQNREAAYYTMFGGTAHVVLASGLtvagamycLGFTRLPYFNTLASPCAIGLVTVMLASLTLAPA 345
Cdd:COG4258 714 -TEGLLDKGELARTLLSILLAALTTLLGFGL--------LAFSSTPALRSFGLTVLLGILLALLLAPLLAPR 776
|
|
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