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Conserved domains on  [gi|621797907|gb|KAT89824|]
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hypothetical protein AL99_00768 [Mycobacterium tuberculosis TKK_04_0078]

Protein Classification

PNPOx family protein( domain architecture ID 1004)

PNPOx family protein similar to Escherichia coli pyridoxamine 5'-phosphate oxidase (PNPOx), a FMN flavoprotein that catalyzes the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PNPOx/FlaRed_like super family cl00381
Pyridoxine 5'-phosphate (PNP) oxidase-like and flavin reductase-like proteins; The PNPOx-like ...
 2-87 1.87e-08

Pyridoxine 5'-phosphate (PNP) oxidase-like and flavin reductase-like proteins; The PNPOx-like superfamily is composed of pyridoxine 5'-phosphate (PNP) oxidases and other flavin mononucleotide (FMN) binding proteins, which catalyze FMN-mediated redox reactions. Flavin reductases catalyze the reduction of FMN or FAD using NAD(P)H as a cofactor. They are part of a two-component enzyme system, composed of a smaller component (flavin reductase) and a larger component (an oxidase), which uses the reduced flavin to hydroxylate substrates.


The actual alignment was detected with superfamily member pfam12900:

Pssm-ID: 469750  Cd Length: 143  Bit Score: 48.95  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 621797907    2 VQGRTVLFRTAEGAKLFSAVAK---CAVAFEADDHNVAEG-------W-SVIVKVRAQVLTTDAGVREAERAQLLPWTAT 70
Cdd:pfam12900  34 VDGDTLYFHGATGSKLAAALRGapvCVVVFEVDGLVLARSafhhsmnWrSVVVRGTAELVTDPEEKAAALEALTDRIVPG 113

                          90       100       110
                  ....*....|....*....|....*....|
gi 621797907   71 LKRHC-------------VRVIPWEITGRH 87
Cdd:pfam12900 114 RWDNLrpptrkelaatavLRITPDEISGRR 143
 
Name Accession Description Interval E-value
Pyridox_ox_2 pfam12900
Pyridoxamine 5'-phosphate oxidase; Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein ...
 2-87 1.87e-08

Pyridoxamine 5'-phosphate oxidase; Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyzes the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This entry contains several pyridoxamine 5'-phosphate oxidases, and related proteins.


Pssm-ID: 432864  Cd Length: 143  Bit Score: 48.95  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 621797907    2 VQGRTVLFRTAEGAKLFSAVAK---CAVAFEADDHNVAEG-------W-SVIVKVRAQVLTTDAGVREAERAQLLPWTAT 70
Cdd:pfam12900  34 VDGDTLYFHGATGSKLAAALRGapvCVVVFEVDGLVLARSafhhsmnWrSVVVRGTAELVTDPEEKAAALEALTDRIVPG 113

                          90       100       110
                  ....*....|....*....|....*....|
gi 621797907   71 LKRHC-------------VRVIPWEITGRH 87
Cdd:pfam12900 114 RWDNLrpptrkelaatavLRITPDEISGRR 143
NimA COG3467
Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5 ...
 4-90 6.26e-07

Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5'-phosphate oxidase superfamily [Defense mechanisms];


Pssm-ID: 442690 [Multi-domain]  Cd Length: 144  Bit Score: 44.91  E-value: 6.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 621797907   4 GRTVLFRTA-EGAKLFSAVAKCAVAFEADDHN---VAEGWSVIVKVRAQVLTTDAGVREAERAQLLPWTATLKR------ 73
Cdd:COG3467   44 GDTIYFHTAkEGRKLDNLRRNPRVCFEVDELDglhSTNYRSVVVFGRAEEVEDPEEKARALRLLLEKYAPGRWRpfsdke 123

                         90       100
                 ....*....|....*....|.
gi 621797907  74 ----HCVRVIPWEITGRHFRF 90
Cdd:COG3467  124 ldatAVIRIDPEEISGKRRAG 144
 
Name Accession Description Interval E-value
Pyridox_ox_2 pfam12900
Pyridoxamine 5'-phosphate oxidase; Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein ...
 2-87 1.87e-08

Pyridoxamine 5'-phosphate oxidase; Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyzes the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This entry contains several pyridoxamine 5'-phosphate oxidases, and related proteins.


Pssm-ID: 432864  Cd Length: 143  Bit Score: 48.95  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 621797907    2 VQGRTVLFRTAEGAKLFSAVAK---CAVAFEADDHNVAEG-------W-SVIVKVRAQVLTTDAGVREAERAQLLPWTAT 70
Cdd:pfam12900  34 VDGDTLYFHGATGSKLAAALRGapvCVVVFEVDGLVLARSafhhsmnWrSVVVRGTAELVTDPEEKAAALEALTDRIVPG 113

                          90       100       110
                  ....*....|....*....|....*....|
gi 621797907   71 LKRHC-------------VRVIPWEITGRH 87
Cdd:pfam12900 114 RWDNLrpptrkelaatavLRITPDEISGRR 143
NimA COG3467
Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5 ...
 4-90 6.26e-07

Nitroimidazole reductase NimA or a related FMN-containing flavoprotein, pyridoxamine 5'-phosphate oxidase superfamily [Defense mechanisms];


Pssm-ID: 442690 [Multi-domain]  Cd Length: 144  Bit Score: 44.91  E-value: 6.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 621797907   4 GRTVLFRTA-EGAKLFSAVAKCAVAFEADDHN---VAEGWSVIVKVRAQVLTTDAGVREAERAQLLPWTATLKR------ 73
Cdd:COG3467   44 GDTIYFHTAkEGRKLDNLRRNPRVCFEVDELDglhSTNYRSVVVFGRAEEVEDPEEKARALRLLLEKYAPGRWRpfsdke 123

                         90       100
                 ....*....|....*....|.
gi 621797907  74 ----HCVRVIPWEITGRHFRF 90
Cdd:COG3467  124 ldatAVIRIDPEEISGKRRAG 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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