N-terminal dimerization domain of Chs5 and similar proteins; Chs5/6 is a multi-protein complex conserved in fungi that interacts with chitin synthase III (Chs3p) and is involved in its transport to the cell surface from the trans-Golgi network, functioning as an exomer cargo adapter. Chs5p appears to form a complex with Chs6p and its paralogs Bch1p, Bud7p, and Bch2p. In this complex, Chs5p may act as a central scaffold. The N-terminal domain characterized by this model forms a homodimer and has been shown to interact with Chs6p and Bch1p. It may function as a flexible hinge domain that allows the exomer to interact with both proteins and the Golgi membrane as the latter undergoes changes in curvature during the formation of transport vesicles. The dimerization domain sits N-terminally to a conserved FBE (FN3-BRCT) unit, which binds Arf1 an is involved in the recruitment of the exomer to the membrane.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2299838830   1 MLVSLTVGKVDAGVTVLLTPDKRLIEFPSILLPPDIESGSIVDITVSRNTASEVKAEQLFRALQDRIYQSFG 72
Cdd:cd13945     1 VEVSLTVGKLDAGLAILLTSDHHLIEFPSVLLPPGIKAGSIVKITVSRNLEAEKKEEEEFQSLQKEILETYG 72

N-terminal dimerization domain of Chs5 and similar proteins; Chs5/6 is a multi-protein complex conserved in fungi that interacts with chitin synthase III (Chs3p) and is involved in its transport to the cell surface from the trans-Golgi network, functioning as an exomer cargo adapter. Chs5p appears to form a complex with Chs6p and its paralogs Bch1p, Bud7p, and Bch2p. In this complex, Chs5p may act as a central scaffold. The N-terminal domain characterized by this model forms a homodimer and has been shown to interact with Chs6p and Bch1p. It may function as a flexible hinge domain that allows the exomer to interact with both proteins and the Golgi membrane as the latter undergoes changes in curvature during the formation of transport vesicles. The dimerization domain sits N-terminally to a conserved FBE (FN3-BRCT) unit, which binds Arf1 an is involved in the recruitment of the exomer to the membrane.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2299838830   1 MLVSLTVGKVDAGVTVLLTPDKRLIEFPSILLPPDIESGSIVDITVSRNTASEVKAEQLFRALQDRIYQSFG 72
Cdd:cd13945     1 VEVSLTVGKLDAGLAILLTSDHHLIEFPSVLLPPGIKAGSIVKITVSRNLEAEKKEEEEFQSLQKEILETYG 72

Chitin biosynthesis protein CHS5 N-terminus; This domain is found at the N-terminus of fungal chitin biosynthesis protein CHS5. It functions as a dimerization domain.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2299838830   3 VSLTVGKVDAGVTVLLTPDKRLIEFPSILLPPDIESGSIVDITVSRN 49
Cdd:pfam16892   2 VTFTVGKLDAGMAILLTSDHHLIEFPSVLLPPGVTAGSIVDISVSRN 48

breast cancer carboxy-terminal domain;

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2299838830  165 MTDLSGITIT-TGILPASMREGLAAAVERIGAKMVDSV-RIDTTHFV--TTEGRGIQWEKAVEMNIPVVRPEWVEAC 237
Cdd:smart00292   1 PKLFKGKTFYiTGSFDKEERDELKELIEALGGKVTSSLsSKTTTHVIvgSPEGGKLELLKAIALGIPIVKEEWLLDC 77

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2299838830   76 PSQPV-LRCRNATQTSVVLEWDPIQLATADLISLALYRNGQKAG----NIPRPMNMHSTKISGLAVDTEYTFHLVLRTTA 150
Cdd:smart00060   1 PSPPSnLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGsewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80

                   .
gi 2299838830  151 G 151
Cdd:smart00060  81 G 81

N-terminal dimerization domain of Chs5 and similar proteins; Chs5/6 is a multi-protein complex conserved in fungi that interacts with chitin synthase III (Chs3p) and is involved in its transport to the cell surface from the trans-Golgi network, functioning as an exomer cargo adapter. Chs5p appears to form a complex with Chs6p and its paralogs Bch1p, Bud7p, and Bch2p. In this complex, Chs5p may act as a central scaffold. The N-terminal domain characterized by this model forms a homodimer and has been shown to interact with Chs6p and Bch1p. It may function as a flexible hinge domain that allows the exomer to interact with both proteins and the Golgi membrane as the latter undergoes changes in curvature during the formation of transport vesicles. The dimerization domain sits N-terminally to a conserved FBE (FN3-BRCT) unit, which binds Arf1 an is involved in the recruitment of the exomer to the membrane.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2299838830   1 MLVSLTVGKVDAGVTVLLTPDKRLIEFPSILLPPDIESGSIVDITVSRNTASEVKAEQLFRALQDRIYQSFG 72
Cdd:cd13945     1 VEVSLTVGKLDAGLAILLTSDHHLIEFPSVLLPPGIKAGSIVKITVSRNLEAEKKEEEEFQSLQKEILETYG 72

Chitin biosynthesis protein CHS5 N-terminus; This domain is found at the N-terminus of fungal chitin biosynthesis protein CHS5. It functions as a dimerization domain.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2299838830   3 VSLTVGKVDAGVTVLLTPDKRLIEFPSILLPPDIESGSIVDITVSRN 49
Cdd:pfam16892   2 VTFTVGKLDAGMAILLTSDHHLIEFPSVLLPPGVTAGSIVDISVSRN 48

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2299838830 163 HKMTDLSGITITTGILPASMREGLAAAVERIGAKMVDSVRIDTTHFVTTEgRGIQWEKAVEMNIPVVRPEWVEAC 237
Cdd:pfam00533   1 PKEKLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEA-RTKKYLKAKELGIPIVTEEWLLDC 74

first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2299838830 191 ERIGAKMVDSVRIDTTHFVTTEGRGIQWEKAVEMNIPVVRPEWVEACEKNGRIL 244
Cdd:cd17716    25 EELGAKVVKRLTKTVTHVVFKDGSQSTLEKAKKRNVKLVSPLWVEACKETGKRV 78

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2299838830 168 LSGITIT-TGILPASmREGLAAAVERIGAKMVDSVRIDTTHFVTTEGRGIQWEKAVEMN-IPVVRPEWVEACEKNG 241
Cdd:cd17731     3 FKGLVICvTGFDSEE-RKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYDSIEAG 77

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2299838830 169 SGITITTGILPASMREGLAAAVERIGAKMVDSVRIDTTHFVTTEGRGIQWEKAV---EMNIPVVRPEWVEAC 237
Cdd:cd18436     2 SGVVITCSDLPSGDKEAIYGGVLALGGQYSDELTRDVTHLIALSPDGDKYKTALkrpELNIKIVLPHWFDDC 73

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2299838830  76 PSQPV-LRCRNATQTSVVLEWDPIQLATADLISLALYRNGQKAGNI----PRPMNMHSTKISGLAVDTEYTFHLVLRTTA 150
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 2299838830 151 GT-FSSEKVTVRT 162
Cdd:cd00063    81 GEsPPSESVTVTT 93

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2299838830 168 LSGITIT-TGILPASM-----REGLAAavERIGAKMVDSVRIDTTHFVTTEGRGIQWEKAVEM-NIPVVRPEWVEAC 237
Cdd:cd17729    14 LKGCVIVfSGVIPTGIdpersRLWKLA--ESLGAKVVTDLSPRTTHLVAAKLGTEKVKQALKMpGIHVVHPDWLWAC 88

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2299838830 190 VERIGAKMVDSVRIDTTHFVTTEGRGIQWEKAVEMNIPVVRPEWVEAC 237
Cdd:cd18438    20 ILALGATYTKNLKPDNTHLITASPEGEKYEAAKEWNIPIVNHLWLYDS 67

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2299838830 179 PASMREGLAAAVERIGAKMVDSVRIDTTHFVTTEGRGIqwEKAVEMNIPVVRPEWVEACEKNGRILGVTKF 249
Cdd:pfam16589  16 PSPSRSKLKRLIEANGGTVVDNINPAVYIVIAPYNKTD--KLAENTKLGVVSPQWIFDCVKKGKLLPLENY 84

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system, which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the fourth one.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2299838830 189 AVERIGAKMVDSVRIDTTHFV--TTEGRGIQWEKAVEMNIPVVRPEWVEACEKNG 241
Cdd:cd17723    20 LIKLLGAKYHESLTKDRSLLIvnSTEKKSDKINFAKKWGIPVVSVEWLWDCLKEG 74

first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the first BRCT domain.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2299838830 194 GAKMVDSVRIDTTHFVTTEGRGIQWEKAVEM-NIPVVRPEWVEACEKNGRIL 244
Cdd:cd17714    24 GAKEVSYLSDMATHVIVDDNDNPEVGEARDLfELPVVTSSWVILSIKAGKLL 75

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2299838830   76 PSQPV-LRCRNATQTSVVLEWDPIQLATADLISLALYRNGQKAG----NIPRPMNMHSTKISGLAVDTEYTFHLVLRTTA 150
Cdd:smart00060   1 PSPPSnLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGsewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80

                   .
gi 2299838830  151 G 151
Cdd:smart00060  81 G 81